G Y Ng

Summary

Affiliation: Merck Research Laboratories
Country: USA

Publications

  1. ncbi request reprint Identification of a GABAB receptor subunit, gb2, required for functional GABAB receptor activity
    G Y Ng
    Merck Frosst Center for Therapeutic Research, Kirkland, Quebec H9H 3L1, Canada
    J Biol Chem 274:7607-10. 1999
  2. ncbi request reprint Gamma-aminobutyric acid type B receptors with specific heterodimer composition and postsynaptic actions in hippocampal neurons are targets of anticonvulsant gabapentin action
    G Y Ng
    Merck Frosst Center for Therapeutic Research, Kirkland, Canada
    Mol Pharmacol 59:144-52. 2001
  3. ncbi request reprint Coexpression of full-length gamma-aminobutyric acid(B) (GABA(B)) receptors with truncated receptors and metabotropic glutamate receptor 4 supports the GABA(B) heterodimer as the functional receptor
    R Sullivan
    Department of Biochemistry, Molecular Biology and Chemistry, Merck Frosst Center for Therapeutic Research, Kirkland, Quebec, Canada
    J Pharmacol Exp Ther 293:460-7. 2000
  4. ncbi request reprint Cloning of a novel G-protein-coupled receptor GPR 51 resembling GABAB receptors expressed predominantly in nervous tissues and mapped proximal to the hereditary sensory neuropathy type 1 locus on chromosome 9
    G Y Ng
    Department of Biochemistry and Molecular Biology, Merck Frosst Center for Therapeutic Research, 16711 TransCanada Highway, Kirkland, Quebec, H9H 3L1
    Genomics 56:288-95. 1999
  5. ncbi request reprint Synthesis of the nanomolar photoaffinity GABA(B) receptor ligand CGP 71872 reveals diversity in the tissue distribution of GABA(B) receptor forms
    M Belley
    Department of Chemistry, Merck Frosst Centre for Therapeutic Research, Kirkland, Quebec, Canada
    Bioorg Med Chem 7:2697-704. 1999
  6. ncbi request reprint The identification of NP25: a novel protein that is differentially expressed by neuronal subpopulations
    W Z Ren
    Department of Physiology, University of Toronto, Ont, Canada
    Brain Res Mol Brain Res 22:173-85. 1994
  7. ncbi request reprint Human serotonin1B receptor expression in Sf9 cells: phosphorylation, palmitoylation, and adenylyl cyclase inhibition
    G Y Ng
    Department of Pharmacology, University of Toronto, Ontario, Canada
    Biochemistry 32:11727-33. 1993
  8. ncbi request reprint The anticonvulsant, antihyperalgesic agent gabapentin is an agonist at brain gamma-aminobutyric acid type B receptors negatively coupled to voltage-dependent calcium channels
    S Bertrand
    , , , , Canada
    J Pharmacol Exp Ther 298:15-24. 2001

Collaborators

Detail Information

Publications8

  1. ncbi request reprint Identification of a GABAB receptor subunit, gb2, required for functional GABAB receptor activity
    G Y Ng
    Merck Frosst Center for Therapeutic Research, Kirkland, Quebec H9H 3L1, Canada
    J Biol Chem 274:7607-10. 1999
    ..In COS-7 cells coexpressing gb1a and gb2 receptors, co-immunoprecipitation of gb1a and gb2 receptors was demonstrated, indicating that gb1a and gb2 act as subunits in the formation of a functional GABAB receptor...
  2. ncbi request reprint Gamma-aminobutyric acid type B receptors with specific heterodimer composition and postsynaptic actions in hippocampal neurons are targets of anticonvulsant gabapentin action
    G Y Ng
    Merck Frosst Center for Therapeutic Research, Kirkland, Canada
    Mol Pharmacol 59:144-52. 2001
    ..This selective agonism of postsynaptic GABA(B) receptor subtypes by gabapentin in hippocampal neurons may be its key therapeutic advantage as an anticonvulsant...
  3. ncbi request reprint Coexpression of full-length gamma-aminobutyric acid(B) (GABA(B)) receptors with truncated receptors and metabotropic glutamate receptor 4 supports the GABA(B) heterodimer as the functional receptor
    R Sullivan
    Department of Biochemistry, Molecular Biology and Chemistry, Merck Frosst Center for Therapeutic Research, Kirkland, Quebec, Canada
    J Pharmacol Exp Ther 293:460-7. 2000
    ..Taken together with the truncated receptor studies, the data suggest that a high degree of structural specificity is required to form the functional GABA(B) receptor that is a gb1-gb2 heterodimer...
  4. ncbi request reprint Cloning of a novel G-protein-coupled receptor GPR 51 resembling GABAB receptors expressed predominantly in nervous tissues and mapped proximal to the hereditary sensory neuropathy type 1 locus on chromosome 9
    G Y Ng
    Department of Biochemistry and Molecular Biology, Merck Frosst Center for Therapeutic Research, 16711 TransCanada Highway, Kirkland, Quebec, H9H 3L1
    Genomics 56:288-95. 1999
    ..Gene GPR 51 was localized by radiation hybrid mapping to chromosome 9, 4.81 cR from the WI-8684 marker, and proximal to the hereditary sensory neuropathy type 1 locus...
  5. ncbi request reprint Synthesis of the nanomolar photoaffinity GABA(B) receptor ligand CGP 71872 reveals diversity in the tissue distribution of GABA(B) receptor forms
    M Belley
    Department of Chemistry, Merck Frosst Centre for Therapeutic Research, Kirkland, Quebec, Canada
    Bioorg Med Chem 7:2697-704. 1999
    ....
  6. ncbi request reprint The identification of NP25: a novel protein that is differentially expressed by neuronal subpopulations
    W Z Ren
    Department of Physiology, University of Toronto, Ont, Canada
    Brain Res Mol Brain Res 22:173-85. 1994
    ..The wide and differential distribution of NP25 in the brain suggests that it may play a particular important role in the function of specific neuronal systems...
  7. ncbi request reprint Human serotonin1B receptor expression in Sf9 cells: phosphorylation, palmitoylation, and adenylyl cyclase inhibition
    G Y Ng
    Department of Pharmacology, University of Toronto, Ontario, Canada
    Biochemistry 32:11727-33. 1993
    ..abstract truncated at 250 words)..
  8. ncbi request reprint The anticonvulsant, antihyperalgesic agent gabapentin is an agonist at brain gamma-aminobutyric acid type B receptors negatively coupled to voltage-dependent calcium channels
    S Bertrand
    , , , , Canada
    J Pharmacol Exp Ther 298:15-24. 2001
    ....