David G McLaren

Summary

Affiliation: Merck Research Laboratories
Country: USA

Publications

  1. doi request reprint Use of [13C18] oleic acid and mass isotopomer distribution analysis to study synthesis of plasma triglycerides in vivo: analytical and experimental considerations
    David G McLaren
    Merck Research Laboratories, Merck and Co, Inc, Kenilworth, New Jersey 07033, USA
    Anal Chem 85:6287-94. 2013
  2. pmc The use of stable-isotopically labeled oleic acid to interrogate lipid assembly in vivo: assessing pharmacological effects in preclinical species
    David G McLaren
    Merck Research Laboratories, Merck and Co, Inc Rahway, NJ, USA
    J Lipid Res 52:1150-61. 2011
  3. pmc Tracking fatty acid kinetics in distinct lipoprotein fractions in vivo: a novel high-throughput approach for studying dyslipidemia in rodent models
    David G McLaren
    Merck Research Laboratories, Rahway, NJ 07065, USA
    J Lipid Res 54:276-81. 2013
  4. doi request reprint Small molecule activation of lecithin cholesterol acyltransferase modulates lipoprotein metabolism in mice and hamsters
    Zhu Chen
    Cardiovascular Diseases, Merck Research Laboratories, Rahway, NJ 07065, USA
    Metabolism 61:470-81. 2012
  5. doi request reprint Demonstration of diet-induced decoupling of fatty acid and cholesterol synthesis by combining gene expression array and 2H2O quantification
    Kristian K Jensen
    Department of Atherosclerosis, Merck Research Labs, Merck and Co, Inc, 126 E Lincoln Ave, Rahway, NJ 07065, USA
    Am J Physiol Endocrinol Metab 302:E209-17. 2012
  6. doi request reprint Headspace analyses of ²H labeling of acetone: enabling studies of fatty acid oxidation in vivo
    Ablatt Mahsut
    Exploratory Biomarkers Atherosclerosis, Merck Research Laboratories, Rahway, NJ 07065, USA
    Anal Biochem 408:351-3. 2011
  7. pmc Localization of fatty acyl and double bond positions in phosphatidylcholines using a dual stage CID fragmentation coupled with ion mobility mass spectrometry
    Jose Castro-Perez
    Department of Atherosclerosis Exploratory Biomarkers, Merck Research Laboratories, 126 E Lincoln Ave, 80Y 2D7, Rahway, NJ 07065, USA
    J Am Soc Mass Spectrom 22:1552-67. 2011
  8. doi request reprint Enhanced data-independent analysis of lipids using ion mobility-TOFMSE to unravel quantitative and qualitative information in human plasma
    Vinit Shah
    Analytical Biochemistry and Molecular Biomarkers, Merck Research Laboratories, Kenilworth, NJ 07033, USA
    Rapid Commun Mass Spectrom 27:2195-200. 2013
  9. doi request reprint An ultraperformance liquid chromatography method for the normal-phase separation of lipids
    David G McLaren
    Atherosclerosis Research, Merck Research Laboratories, Merck and Co Inc, Rahway, NJ 07065, USA
    Anal Biochem 414:266-72. 2011
  10. doi request reprint AAV8-mediated long-term expression of human LCAT significantly improves lipid profiles in hCETP;Ldlr(+/-) mice
    Zhu Chen
    Atherosclerosis, Cardiovascular Diseases, Merck Research Laboratories, RY80T A100, 126 E Lincoln Ave, Rahway, NJ 07065, USA
    J Cardiovasc Transl Res 4:801-10. 2011

Collaborators

Detail Information

Publications14

  1. doi request reprint Use of [13C18] oleic acid and mass isotopomer distribution analysis to study synthesis of plasma triglycerides in vivo: analytical and experimental considerations
    David G McLaren
    Merck Research Laboratories, Merck and Co, Inc, Kenilworth, New Jersey 07033, USA
    Anal Chem 85:6287-94. 2013
    ....
  2. pmc The use of stable-isotopically labeled oleic acid to interrogate lipid assembly in vivo: assessing pharmacological effects in preclinical species
    David G McLaren
    Merck Research Laboratories, Merck and Co, Inc Rahway, NJ, USA
    J Lipid Res 52:1150-61. 2011
    ....
  3. pmc Tracking fatty acid kinetics in distinct lipoprotein fractions in vivo: a novel high-throughput approach for studying dyslipidemia in rodent models
    David G McLaren
    Merck Research Laboratories, Rahway, NJ 07065, USA
    J Lipid Res 54:276-81. 2013
    ..We expect that it is possible to translate our approach for application in other systems, including studies in humans...
  4. doi request reprint Small molecule activation of lecithin cholesterol acyltransferase modulates lipoprotein metabolism in mice and hamsters
    Zhu Chen
    Cardiovascular Diseases, Merck Research Laboratories, Rahway, NJ 07065, USA
    Metabolism 61:470-81. 2012
    ....
  5. doi request reprint Demonstration of diet-induced decoupling of fatty acid and cholesterol synthesis by combining gene expression array and 2H2O quantification
    Kristian K Jensen
    Department of Atherosclerosis, Merck Research Labs, Merck and Co, Inc, 126 E Lincoln Ave, Rahway, NJ 07065, USA
    Am J Physiol Endocrinol Metab 302:E209-17. 2012
    ..In conclusion, by applying gene expression analysis and tracer methodology, we show that fatty acid and cholesterol synthesis are differentially regulated when the carbohydrate intake in mice is altered...
  6. doi request reprint Headspace analyses of ²H labeling of acetone: enabling studies of fatty acid oxidation in vivo
    Ablatt Mahsut
    Exploratory Biomarkers Atherosclerosis, Merck Research Laboratories, Rahway, NJ 07065, USA
    Anal Biochem 408:351-3. 2011
    ..This method enables routine measurements of fatty acid oxidation in rodents; that is, one administers a ²H-labeled fatty acid(s) and then quantifies the production of ²H-labeled water...
  7. pmc Localization of fatty acyl and double bond positions in phosphatidylcholines using a dual stage CID fragmentation coupled with ion mobility mass spectrometry
    Jose Castro-Perez
    Department of Atherosclerosis Exploratory Biomarkers, Merck Research Laboratories, 126 E Lincoln Ave, 80Y 2D7, Rahway, NJ 07065, USA
    J Am Soc Mass Spectrom 22:1552-67. 2011
    ..And was proven to be derived from the α-proximal (carboxylate) or distant ω-position (methyl) in the LPC...
  8. doi request reprint Enhanced data-independent analysis of lipids using ion mobility-TOFMSE to unravel quantitative and qualitative information in human plasma
    Vinit Shah
    Analytical Biochemistry and Molecular Biomarkers, Merck Research Laboratories, Kenilworth, NJ 07033, USA
    Rapid Commun Mass Spectrom 27:2195-200. 2013
    ....
  9. doi request reprint An ultraperformance liquid chromatography method for the normal-phase separation of lipids
    David G McLaren
    Atherosclerosis Research, Merck Research Laboratories, Merck and Co Inc, Rahway, NJ 07065, USA
    Anal Biochem 414:266-72. 2011
    ..6 to 10.5% CV with a variability in retention time of less than 6%. The utility of the method is demonstrated through the separation and quantitation of lipids in mouse plasma, liver, and heart tissue...
  10. doi request reprint AAV8-mediated long-term expression of human LCAT significantly improves lipid profiles in hCETP;Ldlr(+/-) mice
    Zhu Chen
    Atherosclerosis, Cardiovascular Diseases, Merck Research Laboratories, RY80T A100, 126 E Lincoln Ave, Rahway, NJ 07065, USA
    J Cardiovasc Transl Res 4:801-10. 2011
    ..Our findings thus shed new light on LCAT's mechanism of action and lend support to its therapeutic potential in treating dyslipidemia...
  11. pmc Anacetrapib promotes reverse cholesterol transport and bulk cholesterol excretion in Syrian golden hamsters
    Jose Castro-Perez
    Department of Cardiovascular Diseases, Atherosclerosis, Merck Research Laboratories, Rahway, NJ, USA
    J Lipid Res 52:1965-73. 2011
    ....
  12. doi request reprint Pharmacological inhibition of diacylglycerol acyltransferase 1 reduces body weight and modulates gut peptide release--potential insight into mechanism of action
    Jinqi Liu
    Merck Research Laboratories, Rahway, New Jersey, USA
    Obesity (Silver Spring) 21:1406-15. 2013
    ..Investigation was conducted to understand the mechanism of action of diacylglycerol acyltransferase 1 (DGAT1) using small molecules DGAT1 inhibitors, compounds K and L...
  13. pmc Plasma lipid profiling across species for the identification of optimal animal models of human dyslipidemia
    Wu Yin
    Department of Atherosclerosis, Merck Research Laboratories, Rahway, NJ 07065, USA
    J Lipid Res 53:51-65. 2012
    ..Most traditional models, including rabbit, Zucker diabetic fatty rat, and the majority of mouse models, did not demonstrate overall similarity to dyslipidemic humans in this study...
  14. pmc In vivo D2O labeling to quantify static and dynamic changes in cholesterol and cholesterol esters by high resolution LC/MS
    Jose Castro-Perez
    Atherosclerosis Exploratory Biomarkers Group, Merck and Co, Inc, Rahway, NJ, USA
    J Lipid Res 52:159-69. 2011
    ..We concluded that it is possible to readily obtain static and dynamic measurement of cholesterol and CEs in vivo by coupling novel LC/MS methods with stable isotope-based protocols...