Bennett Ma

Summary

Affiliation: Merck Research Laboratories
Country: USA

Publications

  1. ncbi Non-peptide alpha(v)beta(3) antagonists. Part 3: identification of potent RGD mimetics incorporating novel beta-amino acids as aspartic acid replacements
    Paul J Coleman
    Department of Medicinal Chemistry, Merck Research Laboratories, West Point, PA 19486, USA
    Bioorg Med Chem Lett 12:31-4. 2002
  2. ncbi Cytotoxicity of a Quinone-containing Cockroach Sex Pheromone in Human Lung Adenocarcinoma Cells
    Bennett Ma
    Department of Drug Metabolism, Merck Research Laboratories, West Point, Pennsylvania 19486, USA
    Chem Res Toxicol 20:72-8. 2007
  3. ncbi Purification and cloning of a Delta class glutathione S-transferase displaying high peroxidase activity isolated from the German cockroach Blattella germanica
    Bennett Ma
    Department of Drug Metabolism, Merck Research Laboratories, West Point, PA 19486, USA
    FEBS J 274:1793-1803. 2007
  4. ncbi Cytochrome P450 2C8 (CYP2C8)-mediated hydroxylation of an endothelin ETA receptor antagonist in human liver microsomes
    Bennett Ma
    Department of Drug Metabolism, WP 75A 203, Merck Research Laboratories, West Point, PA 19486, USA
    Drug Metab Dispos 32:473-8. 2004
  5. ncbi Cytochrome P450 3A-dependent metabolism of a potent and selective gamma-aminobutyric acid Aalpha2/3 receptor agonist in vitro: involvement of cytochrome P450 3A5 displaying biphasic kinetics
    Bennett Ma
    Department of Drug Metabolism, Merck Research Laboratories, West Point, PA 19486, USA
    Drug Metab Dispos 35:1301-7. 2007
  6. ncbi Mechanistic studies on metabolic interactions between gemfibrozil and statins
    Thomayant Prueksaritanont
    Department of Drug Metabolism, WP75 100, Merck Research Laboratories, West Point, PA 19486, USA
    J Pharmacol Exp Ther 301:1042-51. 2002
  7. ncbi CYP2C75-involved autoinduction of metabolism in rhesus monkeys of methyl 3-chloro-3'-fluoro-4'-{(1R)-1-[({1-[(trifluoroacetyl)amino]cyclopropyl}carbonyl)amino]ethyl}-1,1'-biphenyl-2-carboxylate (MK-0686), a bradykinin B1 receptor antagonist
    Cuyue Tang
    Department of Drug Metabolism and Pharmacokinetics, Merck Research Laboratories, WP75A 203, Merck and Co, Inc, West Point, PA 19486, USA
    J Pharmacol Exp Ther 325:935-46. 2008
  8. ncbi Acyl glucuronidation and glucosidation of a new and selective endothelin ET(A) receptor antagonist in human liver microsomes
    Cuyue Tang
    Department of Drug Metabolism, West Point, Pennsylvania 19486 0004, USA
    Drug Metab Dispos 31:37-45. 2003
  9. ncbi Sulfotransferase 1E1 is a low km isoform mediating the 3-O-sulfation of ethinyl estradiol
    Michael L Schrag
    Drug Metabolism Department, Merck Research Laboratories, West Point, Pennsylvania, USA
    Drug Metab Dispos 32:1299-303. 2004
  10. ncbi Glycosidation of an endothelin ET(A) receptor antagonist and diclofenac in human liver microsomes: aglycone-dependent UDP-sugar selectivity
    Cuyue Tang
    Department of Drug Metabolism, Merck Research Laboratories, Sumneytown Pike, P O Box 4, WP75 100, West Point, Pennsylvania 19486 0004, USA
    Drug Metab Dispos 33:1796-802. 2005

Collaborators

Detail Information

Publications15

  1. ncbi Non-peptide alpha(v)beta(3) antagonists. Part 3: identification of potent RGD mimetics incorporating novel beta-amino acids as aspartic acid replacements
    Paul J Coleman
    Department of Medicinal Chemistry, Merck Research Laboratories, West Point, PA 19486, USA
    Bioorg Med Chem Lett 12:31-4. 2002
    ..Modification of the beta-alanine 3-substituents alters the potency and physicochemical properties of these receptor antagonists and in some cases provides orally bioavailable alpha(v)beta(3) inhibitors...
  2. ncbi Cytotoxicity of a Quinone-containing Cockroach Sex Pheromone in Human Lung Adenocarcinoma Cells
    Bennett Ma
    Department of Drug Metabolism, Merck Research Laboratories, West Point, Pennsylvania 19486, USA
    Chem Res Toxicol 20:72-8. 2007
    ..Future experiments may be needed to evaluate the overall safety of BTQ before the commercialization of the compound as a cockroach attractant...
  3. ncbi Purification and cloning of a Delta class glutathione S-transferase displaying high peroxidase activity isolated from the German cockroach Blattella germanica
    Bennett Ma
    Department of Drug Metabolism, Merck Research Laboratories, West Point, PA 19486, USA
    FEBS J 274:1793-1803. 2007
    ..ELISA showed that BgGSTD1 bound to serum IgE obtained from patients with cockroach allergy, indicating that the protein may be a cockroach allergen...
  4. ncbi Cytochrome P450 2C8 (CYP2C8)-mediated hydroxylation of an endothelin ETA receptor antagonist in human liver microsomes
    Bennett Ma
    Department of Drug Metabolism, WP 75A 203, Merck Research Laboratories, West Point, PA 19486, USA
    Drug Metab Dispos 32:473-8. 2004
    ..It is concluded that the hydroxylation of compound A is mainly catalyzed by CYP2C8, and thus the reaction can possibly serve as an alternative marker assay for CYP2C8 in human liver microsomes...
  5. ncbi Cytochrome P450 3A-dependent metabolism of a potent and selective gamma-aminobutyric acid Aalpha2/3 receptor agonist in vitro: involvement of cytochrome P450 3A5 displaying biphasic kinetics
    Bennett Ma
    Department of Drug Metabolism, Merck Research Laboratories, West Point, PA 19486, USA
    Drug Metab Dispos 35:1301-7. 2007
    ..It is concluded that CYP3A4 plays a major role in TPA023 metabolism, and CYP3A5 may also contribute at higher concentrations of the compound...
  6. ncbi Mechanistic studies on metabolic interactions between gemfibrozil and statins
    Thomayant Prueksaritanont
    Department of Drug Metabolism, WP75 100, Merck Research Laboratories, West Point, PA 19486, USA
    J Pharmacol Exp Ther 301:1042-51. 2002
    ..Collectively, the results of these studies provide metabolic insight into the nature of drug-drug interaction between GFZ and statins, and a possible explanation for the enhanced susceptibility of CVA to interactions with GFZ...
  7. ncbi CYP2C75-involved autoinduction of metabolism in rhesus monkeys of methyl 3-chloro-3'-fluoro-4'-{(1R)-1-[({1-[(trifluoroacetyl)amino]cyclopropyl}carbonyl)amino]ethyl}-1,1'-biphenyl-2-carboxylate (MK-0686), a bradykinin B1 receptor antagonist
    Cuyue Tang
    Department of Drug Metabolism and Pharmacokinetics, Merck Research Laboratories, WP75A 203, Merck and Co, Inc, West Point, PA 19486, USA
    J Pharmacol Exp Ther 325:935-46. 2008
    ..Therefore, MK-0686, both a substrate and inducer for CYP2C75, caused autoinduction of its own metabolism in rhesus monkeys by increasing the expression of this enzyme...
  8. ncbi Acyl glucuronidation and glucosidation of a new and selective endothelin ET(A) receptor antagonist in human liver microsomes
    Cuyue Tang
    Department of Drug Metabolism, West Point, Pennsylvania 19486 0004, USA
    Drug Metab Dispos 31:37-45. 2003
    ....
  9. ncbi Sulfotransferase 1E1 is a low km isoform mediating the 3-O-sulfation of ethinyl estradiol
    Michael L Schrag
    Drug Metabolism Department, Merck Research Laboratories, West Point, Pennsylvania, USA
    Drug Metab Dispos 32:1299-303. 2004
    ..Collectively, these data are consistent with SULT1E1 as the primary sulfotransferase involved in EE sulfation at clinically relevant concentrations (<10 nM)...
  10. ncbi Glycosidation of an endothelin ET(A) receptor antagonist and diclofenac in human liver microsomes: aglycone-dependent UDP-sugar selectivity
    Cuyue Tang
    Department of Drug Metabolism, Merck Research Laboratories, Sumneytown Pike, P O Box 4, WP75 100, West Point, Pennsylvania 19486 0004, USA
    Drug Metab Dispos 33:1796-802. 2005
    ..The mechanism may involve enzyme conformational changes associated with Compound A binding to the enzyme...
  11. ncbi The human hepatic metabolism of simvastatin hydroxy acid is mediated primarily by CYP3A, and not CYP2D6
    Thomayant Prueksaritanont
    Department of Drug Metabolism, Merck Research Laboratories, West Point, PA 19486, USA
    Br J Clin Pharmacol 56:120-4. 2003
    ..To identify the cytochrome P450 (CYP) isoforms responsible for the metabolism of simvastatin hydroxy acid (SVA), the most potent metabolite of simvastatin (SV)...
  12. ncbi Glucuronidation of statins in animals and humans: a novel mechanism of statin lactonization
    Thomayant Prueksaritanont
    Department of Drug Metabolism, Merck Research Laboratories, West Point, Pennsylvania 19486, USA
    Drug Metab Dispos 30:505-12. 2002
    ....
  13. ncbi Solvent effect on cDNA-expressed human sulfotransferase (SULT) activities in vitro
    Bennett Ma
    Department of Drug Metabolism, WP 75A-203, Merck Research Laboratories, West Point, PA 19486, USA
    Drug Metab Dispos 31:1300-5. 2003
    ..4%, v/v) was reduced to <15% for all solvents examined. Thus, it is recommended that ethanol is used as the preferred solvent vehicle and that incubations with expressed enzyme contain >12 microg/ml total protein...
  14. ncbi Discovery of tetrahydropyridopyrimidine phosphodiesterase 10A inhibitors for the treatment of schizophrenia
    Izzat T Raheem
    Discovery Chemistry, Merck Research Laboratories, West Point, PA 19486, USA
    Bioorg Med Chem Lett 22:5903-8. 2012
    ..Further, THPP-1 displays significantly fewer preclinical adverse events in assays measuring prolactin secretion, catalepsy, and weight gain, in contrast to the typical and atypical antipsychotics haloperidol and olanzapine...
  15. ncbi Novel cytochrome P450-mediated ring opening of the 1,3,4-oxadiazole in setileuton, a 5-lipoxygenase inhibitor
    Cheri M Maciolek
    Department of Drug Metabolism and Pharmacokinetics, Merck Research Laboratories, WP75A 203, P O Box 4, West Point, PA 19486, USA
    Drug Metab Dispos 39:763-70. 2011
    ..An alternative, comparatively slow pathway of chemical hydrolysis also was identified and described. Three potential mechanisms for the two-step metabolic ring opening of the 1,3,4-oxadizole are proposed...