Pek Yee Lum

Summary

Affiliation: Merck Research Laboratories
Country: USA

Publications

  1. ncbi request reprint Parallel analysis of tagged deletion mutants efficiently identifies genes involved in endoplasmic reticulum biogenesis
    Robin Wright
    University of Minnesota, Department of Genetics, Cell Biology and Development, 321 Church Street, 6 160 Jackson Hall, Minneapolis, MN 55455, USA
    Yeast 20:881-92. 2003
  2. ncbi request reprint Discovering modes of action for therapeutic compounds using a genome-wide screen of yeast heterozygotes
    Pek Yee Lum
    Rosetta Inpharmatics LLC, a wholly owned subsidiary of Merck and Co, Inc, 12040 115th Avenue NE, Kirkland, WA 98034, USA
    Cell 116:121-37. 2004
  3. ncbi request reprint From drug to protein: using yeast genetics for high-throughput target discovery
    Christopher D Armour
    Rosetta Inpharmatics LLC, Merck and Co, Inc, 401 Terry Avenue North, Seattle, Washington 98109, USA
    Curr Opin Chem Biol 9:20-4. 2005
  4. ncbi request reprint Elucidating the murine brain transcriptional network in a segregating mouse population to identify core functional modules for obesity and diabetes
    Pek Yee Lum
    Rosetta Inpharmatics, LLC, Merck and Co, Inc, Seattle, WA 98109, USA
    J Neurochem 97:50-62. 2006
  5. pmc Variations in DNA elucidate molecular networks that cause disease
    Yanqing Chen
    Rosetta Inpharmatics, LLC, Merck and Co, Inc, 401 Terry Avenue North, Seattle, Washington 98109, USA
    Nature 452:429-35. 2008
  6. ncbi request reprint Gene expression profiling of rat liver reveals a mechanistic basis for ritonavir-induced hyperlipidemia
    Pek Yee Lum
    Rosetta Inpharmatics LLC, 401 Terry Avenue North, Seattle, WA 98109, USA
    Genomics 90:464-73. 2007
  7. pmc Identification and validation of genes affecting aortic lesions in mice
    Xia Yang
    Department of Molecular Profiling, Rosetta Inpharmactics LLC, a Wholly Owned Subsidiary of Merck and Co Inc, Seattle, Washington, USA
    J Clin Invest 120:2414-22. 2010
  8. pmc Systems analysis of eleven rodent disease models reveals an inflammatome signature and key drivers
    I Ming Wang
    Informatics and Analysis, Merck Research Laboratories, Merck and Co, Inc, West Point, PA 19486, USA
    Mol Syst Biol 8:594. 2012
  9. pmc An integrative genomics approach to infer causal associations between gene expression and disease
    Eric E Schadt
    Rosetta Inpharmatics, Seattle, Washington 98109, USA
    Nat Genet 37:710-7. 2005
  10. ncbi request reprint Integrating QTL and high-density SNP analyses in mice to identify Insig2 as a susceptibility gene for plasma cholesterol levels
    Alessandra C Cervino
    Rosetta Inpharmatics, LLC, Seattle, WA 98109, USA
    Genomics 86:505-17. 2005

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Parallel analysis of tagged deletion mutants efficiently identifies genes involved in endoplasmic reticulum biogenesis
    Robin Wright
    University of Minnesota, Department of Genetics, Cell Biology and Development, 321 Church Street, 6 160 Jackson Hall, Minneapolis, MN 55455, USA
    Yeast 20:881-92. 2003
    ....
  2. ncbi request reprint Discovering modes of action for therapeutic compounds using a genome-wide screen of yeast heterozygotes
    Pek Yee Lum
    Rosetta Inpharmatics LLC, a wholly owned subsidiary of Merck and Co, Inc, 12040 115th Avenue NE, Kirkland, WA 98034, USA
    Cell 116:121-37. 2004
    ....
  3. ncbi request reprint From drug to protein: using yeast genetics for high-throughput target discovery
    Christopher D Armour
    Rosetta Inpharmatics LLC, Merck and Co, Inc, 401 Terry Avenue North, Seattle, Washington 98109, USA
    Curr Opin Chem Biol 9:20-4. 2005
    ..Several recent studies describing the use of yeast genetics for high-throughput drug target identification are discussed in this review...
  4. ncbi request reprint Elucidating the murine brain transcriptional network in a segregating mouse population to identify core functional modules for obesity and diabetes
    Pek Yee Lum
    Rosetta Inpharmatics, LLC, Merck and Co, Inc, Seattle, WA 98109, USA
    J Neurochem 97:50-62. 2006
    ..We identify core functional modules making up the brain transcriptional network in mice that are coherent for core biological processes associated with metabolic disease traits including obesity and diabetes...
  5. pmc Variations in DNA elucidate molecular networks that cause disease
    Yanqing Chen
    Rosetta Inpharmatics, LLC, Merck and Co, Inc, 401 Terry Avenue North, Seattle, Washington 98109, USA
    Nature 452:429-35. 2008
    ..Our analysis provides direct experimental support that complex traits such as obesity are emergent properties of molecular networks that are modulated by complex genetic loci and environmental factors...
  6. ncbi request reprint Gene expression profiling of rat liver reveals a mechanistic basis for ritonavir-induced hyperlipidemia
    Pek Yee Lum
    Rosetta Inpharmatics LLC, 401 Terry Avenue North, Seattle, WA 98109, USA
    Genomics 90:464-73. 2007
    ....
  7. pmc Identification and validation of genes affecting aortic lesions in mice
    Xia Yang
    Department of Molecular Profiling, Rosetta Inpharmactics LLC, a Wholly Owned Subsidiary of Merck and Co Inc, Seattle, Washington, USA
    J Clin Invest 120:2414-22. 2010
    ..Our findings therefore validate the ability of causality testing procedures to provide insights into the mechanisms underlying atherosclerosis development...
  8. pmc Systems analysis of eleven rodent disease models reveals an inflammatome signature and key drivers
    I Ming Wang
    Informatics and Analysis, Merck Research Laboratories, Merck and Co, Inc, West Point, PA 19486, USA
    Mol Syst Biol 8:594. 2012
    ..The identification of this inflammatome signature, its network architecture, and key drivers not only highlights the shared etiology but also pinpoints potential targets for intervention of various common diseases...
  9. pmc An integrative genomics approach to infer causal associations between gene expression and disease
    Eric E Schadt
    Rosetta Inpharmatics, Seattle, Washington 98109, USA
    Nat Genet 37:710-7. 2005
    ..We also demonstrate the utility of this approach by identifying and experimentally validating the involvement of three new genes in susceptibility to obesity...
  10. ncbi request reprint Integrating QTL and high-density SNP analyses in mice to identify Insig2 as a susceptibility gene for plasma cholesterol levels
    Alessandra C Cervino
    Rosetta Inpharmatics, LLC, Seattle, WA 98109, USA
    Genomics 86:505-17. 2005
    ....
  11. doi request reprint Genomics and cardiovascular drug development
    Andrew S Plump
    Cardiovascular Diseases, Merck Research Laboratories, Rahway, New Jersey 07065, USA
    J Am Coll Cardiol 53:1089-100. 2009
    ..The focus of the present review is the application of genomics to the development of novel atherosclerosis therapies...
  12. pmc Systematic genetic and genomic analysis of cytochrome P450 enzyme activities in human liver
    Xia Yang
    Rosetta Inpharmatics, LLC, Merck and Co, Inc, Seattle, Washington 98109, USA
    Genome Res 20:1020-36. 2010
    ..This systematic survey provides a comprehensive view of the functionality, genetic control, and interactions of P450s...
  13. ncbi request reprint Integrating genotypic and expression data in a segregating mouse population to identify 5-lipoxygenase as a susceptibility gene for obesity and bone traits
    Margarete Mehrabian
    Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095 1679, USA
    Nat Genet 37:1224-33. 2005
    ....