D S Lorrain

Summary

Affiliation: Merck Research Laboratories
Country: USA

Publications

  1. doi request reprint Distribution of metabotropic glutamate 2 and 3 receptors in the rat forebrain: Implication in emotional responses and central disinhibition
    Guibao Gu
    Department of Neuropharmacology, Merck Research Laboratories, San Diego, CA 92121, USA
    Brain Res 1197:47-62. 2008
  2. ncbi request reprint Activation of spinal group I metabotropic glutamate receptors in rats evokes local glutamate release and spontaneous nociceptive behaviors: effects of 2-methyl-6-(phenylethynyl)-pyridine pretreatment
    Daniel S Lorrain
    Department of Neuropharmacology, Merck Research Laboratories, 3535 General Atomics Court, San Diego, CA 92121, USA
    Neurosci Lett 327:198-202. 2002
  3. ncbi request reprint Effects of ketamine and N-methyl-D-aspartate on glutamate and dopamine release in the rat prefrontal cortex: modulation by a group II selective metabotropic glutamate receptor agonist LY379268
    D S Lorrain
    Department of Neuropharmacology, Merck Research Laboratories, Avera Pharmaceuticals MRLSDB1, 3535 General Atomics Court, San Diego, CA 92121, USA
    Neuroscience 117:697-706. 2003
  4. ncbi request reprint Group II mGlu receptor activation suppresses norepinephrine release in the ventral hippocampus and locomotor responses to acute ketamine challenge
    Daniel S Lorrain
    Department of Neuropharmacology, Merck Research Laboratories, San Diego, CA 92121, USA
    Neuropsychopharmacology 28:1622-32. 2003
  5. ncbi request reprint Comparison of the effects of diazepam, the CRF1 antagonist CP-154,526 and the group II mGlu receptor agonist LY379268 on stress-evoked extracellular norepinephrine levels
    Daniel S Lorrain
    Department of Pharmacology, Merck Research Laboratories, 3535 General Atomics Court, San Diego, CA 92121, USA
    Neuropharmacology 48:927-35. 2005
  6. pmc A novel, orally active LPA(1) receptor antagonist inhibits lung fibrosis in the mouse bleomycin model
    J S Swaney
    Amira Pharmaceuticals, San Diego, CA 92121, USA
    Br J Pharmacol 160:1699-713. 2010
  7. ncbi request reprint Sensitization of midbrain dopamine neuron reactivity promotes the pursuit of amphetamine
    Paul Vezina
    Department of Psychiatry and Committee on Neurobiology, The University of Chicago, Chicago, Illinois 60637, USA
    J Neurosci 22:4654-62. 2002
  8. ncbi request reprint Phenyl-tetrazolyl acetophenones: discovery of positive allosteric potentiatiors for the metabotropic glutamate 2 receptor
    Anthony B Pinkerton
    Merck Research Laboratories San Diego, 3535 General Atomics Court, San Diego, California 92121, USA
    J Med Chem 47:4595-9. 2004

Detail Information

Publications8

  1. doi request reprint Distribution of metabotropic glutamate 2 and 3 receptors in the rat forebrain: Implication in emotional responses and central disinhibition
    Guibao Gu
    Department of Neuropharmacology, Merck Research Laboratories, San Diego, CA 92121, USA
    Brain Res 1197:47-62. 2008
    ..Local infusion of a non-selective mGlu2/3 agonist, LY379268, in the reticular nucleus of the thalamus, significantly reduced GABA release, suggesting that mGlu3 may also play a role in central disinhibition...
  2. ncbi request reprint Activation of spinal group I metabotropic glutamate receptors in rats evokes local glutamate release and spontaneous nociceptive behaviors: effects of 2-methyl-6-(phenylethynyl)-pyridine pretreatment
    Daniel S Lorrain
    Department of Neuropharmacology, Merck Research Laboratories, 3535 General Atomics Court, San Diego, CA 92121, USA
    Neurosci Lett 327:198-202. 2002
    ..These results suggest that stimulation of spinal mGluR5 leads to glutamate release within the spinal cord, a response that may in part account for the nociceptive behaviors evoked by i.t. (S)-3,5-DHPG...
  3. ncbi request reprint Effects of ketamine and N-methyl-D-aspartate on glutamate and dopamine release in the rat prefrontal cortex: modulation by a group II selective metabotropic glutamate receptor agonist LY379268
    D S Lorrain
    Department of Neuropharmacology, Merck Research Laboratories, Avera Pharmaceuticals MRLSDB1, 3535 General Atomics Court, San Diego, CA 92121, USA
    Neuroscience 117:697-706. 2003
    ..This suggests that ketamine acts outside of the mPFC to enhance glutamate, but within the mPFC to enhance DA release. The origin of the ketamine effect on mPFC glutamate is currently not known...
  4. ncbi request reprint Group II mGlu receptor activation suppresses norepinephrine release in the ventral hippocampus and locomotor responses to acute ketamine challenge
    Daniel S Lorrain
    Department of Neuropharmacology, Merck Research Laboratories, San Diego, CA 92121, USA
    Neuropsychopharmacology 28:1622-32. 2003
    ....
  5. ncbi request reprint Comparison of the effects of diazepam, the CRF1 antagonist CP-154,526 and the group II mGlu receptor agonist LY379268 on stress-evoked extracellular norepinephrine levels
    Daniel S Lorrain
    Department of Pharmacology, Merck Research Laboratories, 3535 General Atomics Court, San Diego, CA 92121, USA
    Neuropharmacology 48:927-35. 2005
    ..In addition they reveal a 'stress-like' increase in NE after high doses of LY379268 which may reflect mGlu3 receptor modulation of GABAergic transmission...
  6. pmc A novel, orally active LPA(1) receptor antagonist inhibits lung fibrosis in the mouse bleomycin model
    J S Swaney
    Amira Pharmaceuticals, San Diego, CA 92121, USA
    Br J Pharmacol 160:1699-713. 2010
    ....
  7. ncbi request reprint Sensitization of midbrain dopamine neuron reactivity promotes the pursuit of amphetamine
    Paul Vezina
    Department of Psychiatry and Committee on Neurobiology, The University of Chicago, Chicago, Illinois 60637, USA
    J Neurosci 22:4654-62. 2002
    ..Together, these results demonstrate a direct relation between drug-induced sensitization of midbrain dopamine neuron reactivity and the excessive pursuit and self-administration of an abused substance...
  8. ncbi request reprint Phenyl-tetrazolyl acetophenones: discovery of positive allosteric potentiatiors for the metabotropic glutamate 2 receptor
    Anthony B Pinkerton
    Merck Research Laboratories San Diego, 3535 General Atomics Court, San Diego, California 92121, USA
    J Med Chem 47:4595-9. 2004
    ..This represents the first example of the efficacy of mGlu2 receptor potentiators in these models...