Lee P Lim

Summary

Affiliation: Merck Research Laboratories
Country: USA

Publications

  1. ncbi Prediction of plant microRNA targets
    Matthew W Rhoades
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, MA 02142, USA
    Cell 110:513-20. 2002
  2. ncbi Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs
    Lee P Lim
    Rosetta Inpharmatics, Merck and Co, 401 Terry Avenue N, Seattle, Washington 98109, USA
    Nature 433:769-73. 2005
  3. ncbi Mustering the micromanagers
    Lee P Lim
    Nat Biotechnol 25:996-7. 2007
  4. pmc microRNAs regulate human embryonic stem cell division
    Junlin Qi
    Department of Biochemistry and Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, USA
    Cell Cycle 8:3729-41. 2009
  5. doi Global survey of genomic imprinting by transcriptome sequencing
    Tomas Babak
    Rosetta Inpharmatics, LLC, a wholly owned subsidiary of Merck and Co, 401 Terry Avenue North, Seattle, WA 98109, USA
    Curr Biol 18:1735-41. 2008
  6. pmc Simple, quantitative primer-extension PCR assay for direct monitoring of microRNAs and short-interfering RNAs
    Christopher K Raymond
    Rosetta Inpharmatics, Seattle, WA 98109, USA
    RNA 11:1737-44. 2005
  7. pmc MicroRNA targeting specificity in mammals: determinants beyond seed pairing
    Andrew Grimson
    Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Mol Cell 27:91-105. 2007
  8. ncbi The widespread impact of mammalian MicroRNAs on mRNA repression and evolution
    Kyle Kai How Farh
    Whitehead Institute for Biomedical Research, Department of Biology, Massachusetts Institute of Technology, and Howard Hughes Medical Institute, 9 Cambridge Center, Cambridge, MA 02142, USA
    Science 310:1817-21. 2005
  9. pmc Patterns of flanking sequence conservation and a characteristic upstream motif for microRNA gene identification
    Uwe Ohler
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02142, USA
    RNA 10:1309-22. 2004
  10. ncbi A microRNA component of the p53 tumour suppressor network
    Lin He
    Watson School of Biological Sciences, Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
    Nature 447:1130-4. 2007

Collaborators

Detail Information

Publications12

  1. ncbi Prediction of plant microRNA targets
    Matthew W Rhoades
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, MA 02142, USA
    Cell 110:513-20. 2002
    ..The targeting of developmental transcription factors suggests that many plant miRNAs function during cellular differentiation to clear key regulatory transcripts from daughter cell lineages...
  2. ncbi Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs
    Lee P Lim
    Rosetta Inpharmatics, Merck and Co, 401 Terry Avenue N, Seattle, Washington 98109, USA
    Nature 433:769-73. 2005
    ..Moreover, miR-1 and miR-124, and presumably other tissue-specific miRNAs, seem to downregulate a far greater number of targets than previously appreciated, thereby helping to define tissue-specific gene expression in humans...
  3. ncbi Mustering the micromanagers
    Lee P Lim
    Nat Biotechnol 25:996-7. 2007
  4. pmc microRNAs regulate human embryonic stem cell division
    Junlin Qi
    Department of Biochemistry and Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, USA
    Cell Cycle 8:3729-41. 2009
    ..These data support a model for hESC cell cycle control in which miRNAs regulate negative cell cycle modulators at two phases of the cell cycle to ensure proper replenishment of the stem cell population...
  5. doi Global survey of genomic imprinting by transcriptome sequencing
    Tomas Babak
    Rosetta Inpharmatics, LLC, a wholly owned subsidiary of Merck and Co, 401 Terry Avenue North, Seattle, WA 98109, USA
    Curr Biol 18:1735-41. 2008
    ..Such an approach will allow researchers to study imprinting without restricting themselves to individual loci or specific transcripts...
  6. pmc Simple, quantitative primer-extension PCR assay for direct monitoring of microRNAs and short-interfering RNAs
    Christopher K Raymond
    Rosetta Inpharmatics, Seattle, WA 98109, USA
    RNA 11:1737-44. 2005
    ..We used the method for quantitative analysis of six microRNAs across 12 tissue samples. The data confirm striking variation in the patterns of expression of these noncoding regulatory RNAs...
  7. pmc MicroRNA targeting specificity in mammals: determinants beyond seed pairing
    Andrew Grimson
    Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Mol Cell 27:91-105. 2007
    ..Because it predicts site efficacy without recourse to evolutionary conservation, the model also identifies effective nonconserved sites and siRNA off-targets...
  8. ncbi The widespread impact of mammalian MicroRNAs on mRNA repression and evolution
    Kyle Kai How Farh
    Whitehead Institute for Biomedical Research, Department of Biology, Massachusetts Institute of Technology, and Howard Hughes Medical Institute, 9 Cambridge Center, Cambridge, MA 02142, USA
    Science 310:1817-21. 2005
    ....
  9. pmc Patterns of flanking sequence conservation and a characteristic upstream motif for microRNA gene identification
    Uwe Ohler
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02142, USA
    RNA 10:1309-22. 2004
    ..The improved analysis supports our previous assertion that miRNA gene identification is nearing completion in C. elegans with apparently no more than 20 miRNA genes now remaining to be identified...
  10. ncbi A microRNA component of the p53 tumour suppressor network
    Lin He
    Watson School of Biological Sciences, Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
    Nature 447:1130-4. 2007
    ..The p53 network suppresses tumour formation through the coordinated activation of multiple transcriptional targets, and miR-34 may act in concert with other effectors to inhibit inappropriate cell proliferation...
  11. pmc The microRNAs of Caenorhabditis elegans
    Lee P Lim
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Genes Dev 17:991-1008. 2003
    ..Our census of the worm miRNAs and their expression patterns helps define this class of noncoding RNAs, lays the groundwork for functional studies, and provides the tools for more comprehensive analyses of miRNA genes in other species...
  12. ncbi Vertebrate microRNA genes
    Lee P Lim
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 299:1540. 2003