Zhong Li

Summary

Affiliation: Merck Research Laboratories
Country: USA

Publications

  1. ncbi Static headspace gas chromatographic analysis of the residual solvents in gel extrusion module tablet formulations
    Zhong Li
    Merck Research Laboratories, West Point, PA 19486, USA
    J Pharm Biomed Anal 28:673-82. 2002
  2. ncbi Analysis of aldehydes in excipients used in liquid/semi-solid formulations by gas chromatography-negative chemical ionization mass spectrometry
    Zhong Li
    Merck Research Laboratories, West Point, PA 19486, USA
    J Chromatogr A 1160:299-305. 2007
  3. ncbi Detection and quantification of low-molecular-weight aldehydes in pharmaceutical excipients by headspace gas chromatography
    Zhong Li
    Merck Research Laboratories, West Point, PA 19486, USA
    J Chromatogr A 1104:1-10. 2006
  4. ncbi Profiling of medium chain glycerides used in pharmaceutical formulation development by reversed-phase HPLC
    Kyle A Fliszar
    Merck and Co, Sumneytown Pike, Merck Research Laboratories, WP78 210, West Point, PA 19486, USA
    J Pharm Biomed Anal 40:896-900. 2006
  5. ncbi Analysis of organic volatile impurities in pharmaceutical excipients by static headspace capillary gas chromatography
    Kyle Fliszar
    Merck Research Laboratories, West Point, PA 19486, USA
    J Chromatogr A 1027:83-91. 2004
  6. ncbi [In vitro bromodeoxyuridine labeling of rat bone marrow-derived mesenchymal stem cells]
    Shan Wei Feng
    Department of Neurology, First Affiliated Hospital, Sun Yat Sen University, Guangzhou 510080, China
    Di Yi Jun Yi Da Xue Xue Bao 25:184-6. 2005
  7. ncbi [Quantity study of cultivated and wild Rhizoma Polygonati Odorati]
    Tasi Liu
    Department of Pharmacy, Hunan College of Traditional Chinese Medicine, Changsha 410007
    Zhong Yao Cai 28:14-6. 2005
  8. ncbi Study on the determination of polyphenols in tobacco by HPLC coupled with ESI-MS after solid-phase extraction
    Zhong Li
    Key Laboratory of Chemistry and Engineering, Yunnan Academy of Tobacco Science, Kunming 650106, P R China
    J Chromatogr Sci 41:36-40. 2003
  9. ncbi Simultaneous hydrogenolysis of p-nitrobenzyl esters and carbamates side-chains in the THF 1beta-carbapenem OCA-983 in biphasic media
    Tarek S Mansour
    Medicinal Chemistry, Chemical and Screening Sciences, Pearl River, NY 10965, USA
    Med Chem 2:21-5. 2006
  10. ncbi Structure-activity relationship of 6-methylidene penems bearing 6,5 bicyclic heterocycles as broad-spectrum beta-lactamase inhibitors: evidence for 1,4-thiazepine intermediates with C7 R stereochemistry by computational methods
    Aranapakam M Venkatesan
    Wyeth Research, Chemical and Screening Sciences, Department of Infectious Disease and Biological Technologies, 401 N Middletown Road, Pearl River, New York 10965, USA
    J Med Chem 49:4623-37. 2006

Collaborators

  • W Peter Wuelfing
  • Robert A Reed
  • Kyle A Fliszar
  • F A Cotton
  • David M Shlaes
  • Phaik Eng Sum
  • Wei Liu
  • Tarek S Mansour
  • Aranapakam M Venkatesan
  • Yang I Lin
  • Tasi Liu
  • Shan Wei Feng
  • Gerry Francisco
  • Toshio Kumagai
  • Yansong Gu
  • Hideki Ushirogochi
  • William J Weiss
  • Osvaldo Dos Santos
  • Mihira Ado
  • James R Knox
  • Itsuka Yamamura
  • David How
  • Takasaki Tsuyoshi
  • Atul Agarwal
  • Takao Abe
  • Fuk Wah Sum
  • Youjun Yang
  • Peter J Petersen
  • Wen Huang
  • Xianguo Yang
  • Xiao Li Yao
  • Cheng Zhang
  • Limei Lin
  • Tai yun Liu
  • Xuehua Zheng

Detail Information

Publications12

  1. ncbi Static headspace gas chromatographic analysis of the residual solvents in gel extrusion module tablet formulations
    Zhong Li
    Merck Research Laboratories, West Point, PA 19486, USA
    J Pharm Biomed Anal 28:673-82. 2002
    ..The SHS-GC method was validated according to regulatory requirements and produced acceptable results with respect to specificity, linearity, range, detection and quantitation limits, precision, and accuracy...
  2. ncbi Analysis of aldehydes in excipients used in liquid/semi-solid formulations by gas chromatography-negative chemical ionization mass spectrometry
    Zhong Li
    Merck Research Laboratories, West Point, PA 19486, USA
    J Chromatogr A 1160:299-305. 2007
    ..An example case study on the formation and growth of aldehydes in these excipients under accelerated storage conditions is also reported...
  3. ncbi Detection and quantification of low-molecular-weight aldehydes in pharmaceutical excipients by headspace gas chromatography
    Zhong Li
    Merck Research Laboratories, West Point, PA 19486, USA
    J Chromatogr A 1104:1-10. 2006
    ....
  4. ncbi Profiling of medium chain glycerides used in pharmaceutical formulation development by reversed-phase HPLC
    Kyle A Fliszar
    Merck and Co, Sumneytown Pike, Merck Research Laboratories, WP78 210, West Point, PA 19486, USA
    J Pharm Biomed Anal 40:896-900. 2006
    ....
  5. ncbi Analysis of organic volatile impurities in pharmaceutical excipients by static headspace capillary gas chromatography
    Kyle Fliszar
    Merck Research Laboratories, West Point, PA 19486, USA
    J Chromatogr A 1027:83-91. 2004
    ..The proposed methodologies were demonstrated to be selective, accurate, and reproducible, and were successfully applied to the rapid screening of OVIs in typical excipients...
  6. ncbi [In vitro bromodeoxyuridine labeling of rat bone marrow-derived mesenchymal stem cells]
    Shan Wei Feng
    Department of Neurology, First Affiliated Hospital, Sun Yat Sen University, Guangzhou 510080, China
    Di Yi Jun Yi Da Xue Xue Bao 25:184-6. 2005
    ..To study the optimal dosage and timing for bromodeoxyuridine (BrdU) labeling of rat bone marrow-derived mesenchymal stem cells (MSCs) in vitro...
  7. ncbi [Quantity study of cultivated and wild Rhizoma Polygonati Odorati]
    Tasi Liu
    Department of Pharmacy, Hunan College of Traditional Chinese Medicine, Changsha 410007
    Zhong Yao Cai 28:14-6. 2005
    ..In this article, cultivated and wild Rhizoma Polygonati Odorati have been compared in macroscopical identificaation, microscopical identification, contents of odoratan of Rhizoma Polygonati Odorati...
  8. ncbi Study on the determination of polyphenols in tobacco by HPLC coupled with ESI-MS after solid-phase extraction
    Zhong Li
    Key Laboratory of Chemistry and Engineering, Yunnan Academy of Tobacco Science, Kunming 650106, P R China
    J Chromatogr Sci 41:36-40. 2003
    ..The recovery of tobacco polyphenols is 94-105%, and the relative standard deviations are 1.28-1.49%. This method is successfully applied to qualitatively and quantitatively analyze the polyphenols in tobacco with good results...
  9. ncbi Simultaneous hydrogenolysis of p-nitrobenzyl esters and carbamates side-chains in the THF 1beta-carbapenem OCA-983 in biphasic media
    Tarek S Mansour
    Medicinal Chemistry, Chemical and Screening Sciences, Pearl River, NY 10965, USA
    Med Chem 2:21-5. 2006
    ..This procedure is applicable to sensitive compounds that are soluble in water without the need to use a buffer and allows for ease of isolation from the aqueous phase...
  10. ncbi Structure-activity relationship of 6-methylidene penems bearing 6,5 bicyclic heterocycles as broad-spectrum beta-lactamase inhibitors: evidence for 1,4-thiazepine intermediates with C7 R stereochemistry by computational methods
    Aranapakam M Venkatesan
    Wyeth Research, Chemical and Screening Sciences, Department of Infectious Disease and Biological Technologies, 401 N Middletown Road, Pearl River, New York 10965, USA
    J Med Chem 49:4623-37. 2006
    ....
  11. ncbi Determination of transition metal ions in tobacco as their 2-(2-quinolinylazo)-5-dimethylaminophenol derivatives using reversed-phase liquid chromatography with UV-VIS detection
    Zhong Li
    J Chromatogr A 971:243-8. 2002
    ..This method had been applied to the determination of iron, cobalt, nickel, copper, zinc and manganese in tobacco with good results...
  12. ncbi Enhancement in electronic communication upon replacement of Mo-O by Mo-S bonds in tetranuclear clusters of the type [Mo2]2(mu-E-E)2 (E = O or S)
    F Albert Cotton
    Department of Chemistry, Laboratory for Molecular Structure and Bonding, Texas A and M University, College Station, TX 77842 3012, USA
    Inorg Chem 46:9294-302. 2007
    ..Density functional theory calculations show that the increase in electronic communication between the metal centers in 4 is due to a superexchange pathway involving d and p orbitals in the linker E atoms that is less important in 2...