Y M Li

Summary

Affiliation: Merck Research Laboratories
Country: USA

Publications

  1. pmc Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state
    Y M Li
    Department of Biological Chemistry, Merck Research Laboratories, West Point, PA 19486, USA
    Proc Natl Acad Sci U S A 97:6138-43. 2000
  2. ncbi request reprint Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1
    Y M Li
    Department of Biological Chemistry, Merck Research Laboratories, West Point, Pennsylvania 19486, USA
    Nature 405:689-94. 2000
  3. ncbi request reprint Gamma-secretase: a catalyst of Alzheimer disease and signal transduction
    Y M Li
    Department of Biological Chemistry, Merck Research Laboratories, West Point, PA 19486, USA
    Mol Interv 1:198-207. 2001
  4. ncbi request reprint The pro domain of beta-secretase does not confer strict zymogen-like properties but does assist proper folding of the protease domain
    X P Shi
    Departments of Biological Chemistry and Medicinal Chemistry, Merck Research Laboratories, West Point, Pennsylvania 19486, USA
    J Biol Chem 276:10366-73. 2001

Detail Information

Publications4

  1. pmc Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state
    Y M Li
    Department of Biological Chemistry, Merck Research Laboratories, West Point, PA 19486, USA
    Proc Natl Acad Sci U S A 97:6138-43. 2000
    ..0 x 10(6). Anti-PS1 antibody immunoprecipitates gamma-secretase activity from the solubilized gamma-secretase preparation. These data suggest that gamma-secretase activity is catalyzed by a PS1-containing macromolecular complex...
  2. ncbi request reprint Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1
    Y M Li
    Department of Biological Chemistry, Merck Research Laboratories, West Point, Pennsylvania 19486, USA
    Nature 405:689-94. 2000
    ..Interestingly, the intact, single-chain form of wild-type PS1 is not labelled by an active-site-directed photoaffinity probe, suggesting that intact wild-type PS1 may be an aspartyl protease zymogen...
  3. ncbi request reprint Gamma-secretase: a catalyst of Alzheimer disease and signal transduction
    Y M Li
    Department of Biological Chemistry, Merck Research Laboratories, West Point, PA 19486, USA
    Mol Interv 1:198-207. 2001
    ..These new insights underscore the role of the presenilins in regulated intramembrane proteolysis and could possibly lead to the inhibition of gamma-secretase activity as a therapy for AD...
  4. ncbi request reprint The pro domain of beta-secretase does not confer strict zymogen-like properties but does assist proper folding of the protease domain
    X P Shi
    Departments of Biological Chemistry and Medicinal Chemistry, Merck Research Laboratories, West Point, Pennsylvania 19486, USA
    J Biol Chem 276:10366-73. 2001
    ..These findings show that the Pro domain in ProBACE460 does not suppress activity as in a strict zymogen but does appear to facilitate proper folding of an active protease domain...