Richard A Klinghoffer

Summary

Affiliation: Merck Research Laboratories
Country: USA

Publications

  1. doi An optimized lentivirus-mediated RNAi screen reveals kinase modulators of kinesin-5 inhibitor sensitivity
    Richard A Klinghoffer
    Rosetta Inpharmatics LLC, Merck and Co, Inc, Seattle, WA 98109, USA
    Assay Drug Dev Technol 6:105-19. 2008
  2. pmc A lentivirus-mediated genetic screen identifies dihydrofolate reductase (DHFR) as a modulator of beta-catenin/GSK3 signaling
    Richard A Klinghoffer
    Rosetta Inpharmatics, LLC, Seattle, Washington, United States of America
    PLoS ONE 4:e6892. 2009
  3. pmc Reduced seed region-based off-target activity with lentivirus-mediated RNAi
    Richard A Klinghoffer
    Presage Biosciences, Seattle, WA 98109, USA
    RNA 16:879-84. 2010
  4. ncbi An allelic series at the PDGFalphaR locus indicates unequal contributions of distinct signaling pathways during development
    Richard A Klinghoffer
    Program in Developmental Biology, Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Dev Cell 2:103-13. 2002
  5. pmc SRC catalytic but not scaffolding function is needed for integrin-regulated tyrosine phosphorylation, cell migration, and cell spreading
    Leslie A Cary
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Mol Cell Biol 22:2427-40. 2002

Detail Information

Publications5

  1. doi An optimized lentivirus-mediated RNAi screen reveals kinase modulators of kinesin-5 inhibitor sensitivity
    Richard A Klinghoffer
    Rosetta Inpharmatics LLC, Merck and Co, Inc, Seattle, WA 98109, USA
    Assay Drug Dev Technol 6:105-19. 2008
    ..These results demonstrate the feasibility of screening with large collections of lentiviral vectors to identify drug enhancers and suppressors...
  2. pmc A lentivirus-mediated genetic screen identifies dihydrofolate reductase (DHFR) as a modulator of beta-catenin/GSK3 signaling
    Richard A Klinghoffer
    Rosetta Inpharmatics, LLC, Seattle, Washington, United States of America
    PLoS ONE 4:e6892. 2009
    ..Our data establish DHFR as a novel modulator of beta-catenin and GSK3 signaling and raise several implications for clinical use of combined methotrexate and GSK3 inhibitors as treatment for inflammatory disease...
  3. pmc Reduced seed region-based off-target activity with lentivirus-mediated RNAi
    Richard A Klinghoffer
    Presage Biosciences, Seattle, WA 98109, USA
    RNA 16:879-84. 2010
    ....
  4. ncbi An allelic series at the PDGFalphaR locus indicates unequal contributions of distinct signaling pathways during development
    Richard A Klinghoffer
    Program in Developmental Biology, Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Dev Cell 2:103-13. 2002
    ..Our results indicate that PI3K has a predominant role in PDGFalphaR signaling in vivo and that RTK-activated signaling pathways execute both specific and overlapping functions during mammalian development...
  5. pmc SRC catalytic but not scaffolding function is needed for integrin-regulated tyrosine phosphorylation, cell migration, and cell spreading
    Leslie A Cary
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Mol Cell Biol 22:2427-40. 2002
    ..These results indicate that the primary role of Src in integrin signaling is as a kinase. Indirect models for Src function are proposed...