C D King
Affiliation: Merck Research Laboratories
- UDP-glucuronosyltransferasesC D King
Department of Drug Metabolism, Merck Research Laboratories, Rahway, New Jersey 07605, USA
Curr Drug Metab 1:143-61. 2000..This review discusses the two UGT gene families, substrate specificities, and the recent discoveries of UGTs in extrahepatic tissues...
- Glucuronidation of amines and other xenobiotics catalyzed by expressed human UDP-glucuronosyltransferase 1A3M D Green
Department of Pharmacology, The University of Iowa, Iwo City, IA 52242, USA
Drug Metab Dispos 26:507-12. 1998..g. menthol and borneol), and androgens, were not conjugated by expressed human UGT1A3. Of the compounds tested, scopoletin, naringenin, and norbuprenorphine appeared to be the best xenobiotic substrates for human UGT1A3...
- Cloning and stable expression of a cDNA encoding a rat liver UDP-glucuronosyltransferase (UDP-glucuronosyltransferase 1.1) that catalyzes the glucuronidation of opioids and bilirubinB L Coffman
Department of Pharmacology, University of Iowa, Iowa City 52242, USA
Mol Pharmacol 47:1101-5. 1995..Other opioids, such as nalorphine and morphine, were also substrates for the expressed UGT1.1r protein. These results show that bilirubin and opioids can be conjugated by the same rat liver UGT...
- Expression of UDP-glucuronosyltransferases (UGTs) 2B7 and 1A6 in the human brain and identification of 5-hydroxytryptamine as a substrateC D King
Department of Pharmacology, College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
Arch Biochem Biophys 365:156-62. 1999..UGT1A6 could play an important role in the glucuronidation of 5-hydroxytryptamine in vivo, therefore terminating the actions of the neurotransmitter...