C D King

Summary

Affiliation: Merck Research Laboratories
Country: USA

Publications

  1. ncbi UDP-glucuronosyltransferases
    C D King
    Department of Drug Metabolism, Merck Research Laboratories, Rahway, New Jersey 07605, USA
    Curr Drug Metab 1:143-61. 2000
  2. ncbi Glucuronidation of amines and other xenobiotics catalyzed by expressed human UDP-glucuronosyltransferase 1A3
    M D Green
    Department of Pharmacology, The University of Iowa, Iwo City, IA 52242, USA
    Drug Metab Dispos 26:507-12. 1998
  3. ncbi Cloning and stable expression of a cDNA encoding a rat liver UDP-glucuronosyltransferase (UDP-glucuronosyltransferase 1.1) that catalyzes the glucuronidation of opioids and bilirubin
    B L Coffman
    Department of Pharmacology, University of Iowa, Iowa City 52242, USA
    Mol Pharmacol 47:1101-5. 1995
  4. ncbi Expression of UDP-glucuronosyltransferases (UGTs) 2B7 and 1A6 in the human brain and identification of 5-hydroxytryptamine as a substrate
    C D King
    Department of Pharmacology, College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    Arch Biochem Biophys 365:156-62. 1999

Collaborators

Detail Information

Publications4

  1. ncbi UDP-glucuronosyltransferases
    C D King
    Department of Drug Metabolism, Merck Research Laboratories, Rahway, New Jersey 07605, USA
    Curr Drug Metab 1:143-61. 2000
    ..This review discusses the two UGT gene families, substrate specificities, and the recent discoveries of UGTs in extrahepatic tissues...
  2. ncbi Glucuronidation of amines and other xenobiotics catalyzed by expressed human UDP-glucuronosyltransferase 1A3
    M D Green
    Department of Pharmacology, The University of Iowa, Iwo City, IA 52242, USA
    Drug Metab Dispos 26:507-12. 1998
    ..g. menthol and borneol), and androgens, were not conjugated by expressed human UGT1A3. Of the compounds tested, scopoletin, naringenin, and norbuprenorphine appeared to be the best xenobiotic substrates for human UGT1A3...
  3. ncbi Cloning and stable expression of a cDNA encoding a rat liver UDP-glucuronosyltransferase (UDP-glucuronosyltransferase 1.1) that catalyzes the glucuronidation of opioids and bilirubin
    B L Coffman
    Department of Pharmacology, University of Iowa, Iowa City 52242, USA
    Mol Pharmacol 47:1101-5. 1995
    ..Other opioids, such as nalorphine and morphine, were also substrates for the expressed UGT1.1r protein. These results show that bilirubin and opioids can be conjugated by the same rat liver UGT...
  4. ncbi Expression of UDP-glucuronosyltransferases (UGTs) 2B7 and 1A6 in the human brain and identification of 5-hydroxytryptamine as a substrate
    C D King
    Department of Pharmacology, College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    Arch Biochem Biophys 365:156-62. 1999
    ..UGT1A6 could play an important role in the glucuronidation of 5-hydroxytryptamine in vivo, therefore terminating the actions of the neurotransmitter...