K P Keenan

Summary

Affiliation: Merck Research Laboratories
Country: USA

Publications

  1. ncbi request reprint Diet, caloric restriction, and the rodent bioassay
    K P Keenan
    Department of Safety Assessment, Merck Research Laboratories, West Point, Pennsylvania 19486, USA
    Toxicol Sci 52:24-34. 1999
  2. ncbi request reprint Chronic nephropathy in ad libitum overfed Sprague-Dawley rats and its early attenuation by increasing degrees of dietary (caloric) restriction to control growth
    K P Keenan
    Department of Safety Assessment and Biometrics, Merck Research Laboratories, West Point, Pennsylvania 19486, USA
    Toxicol Pathol 28:788-98. 2000
  3. ncbi request reprint Diet, overfeeding, and moderate dietary restriction in control Sprague-Dawley rats: II. Effects on age-related proliferative and degenerative lesions
    K P Keenan
    Department of Safety Assessment, Merck Research Laboratories, West Point, Pennsylvania 19486, USA
    Toxicol Pathol 23:287-302. 1995
  4. ncbi request reprint The effects of diet, ad libitum overfeeding, and moderate dietary restriction on the rodent bioassay: the uncontrolled variable in safety assessment
    K P Keenan
    Department of Safety Assessment, Merck Research Laboratories, West Point, Pennsylvania 19480, USA
    Toxicol Pathol 24:757-68. 1996
  5. ncbi request reprint Diet, overfeeding, and moderate dietary restriction in control Sprague-Dawley rats: I. Effects on spontaneous neoplasms
    K P Keenan
    Department of Safety Assessment, Merck Research Laboratories, West Point, Pennsylvania 19486, USA
    Toxicol Pathol 23:269-86. 1995
  6. ncbi request reprint The effects of diet, ad Libitum feeding, and moderate and severe dietary restriction on body weight, survival, clinical pathology parameters, and cause of death in control Sprague-Dawley rats
    M F Hubert
    Department of Safety Assessment, Merck Research Laboratories, 63963 Clermont Ferrand Cedex 9, France West Point, Pennsylvania 19486, USA
    Toxicol Sci 58:195-207. 2000
  7. ncbi request reprint The effects of overfeeding and dietary restriction on Sprague-Dawley rat survival and early pathology biomarkers of aging
    K P Keenan
    Department of Safety Assessment, Merck Research Laboratories, West Point, Pennsylvania 19486
    Toxicol Pathol 22:300-15. 1994
  8. ncbi request reprint Morphological and hormonal changes in the ventral and dorsolateral prostatic lobes of rats treated with finasteride, a 5-alpha reductase inhibitor
    S Prahalada
    Department of Safety Assessment, Merck Research Laboratory, West Point, Pennsylvania 19486, USA
    Prostate 35:157-64. 1998

Detail Information

Publications8

  1. ncbi request reprint Diet, caloric restriction, and the rodent bioassay
    K P Keenan
    Department of Safety Assessment, Merck Research Laboratories, West Point, Pennsylvania 19486, USA
    Toxicol Sci 52:24-34. 1999
    ..Feeding a balanced diet by a moderate DR regimen of 70-75% of the maximum, unrestricted adult AL food intake is recommended for conducting well-controlled toxicity and carcinogenicity studies...
  2. ncbi request reprint Chronic nephropathy in ad libitum overfed Sprague-Dawley rats and its early attenuation by increasing degrees of dietary (caloric) restriction to control growth
    K P Keenan
    Department of Safety Assessment and Biometrics, Merck Research Laboratories, West Point, Pennsylvania 19486, USA
    Toxicol Pathol 28:788-98. 2000
    ..These results indicate that control of body and renal growth by DR may be essential to prevent the development and progression of glomerulosclerosis in spontaneous nephropathy of laboratory rats...
  3. ncbi request reprint Diet, overfeeding, and moderate dietary restriction in control Sprague-Dawley rats: II. Effects on age-related proliferative and degenerative lesions
    K P Keenan
    Department of Safety Assessment, Merck Research Laboratories, West Point, Pennsylvania 19486, USA
    Toxicol Pathol 23:287-302. 1995
    ....
  4. ncbi request reprint The effects of diet, ad libitum overfeeding, and moderate dietary restriction on the rodent bioassay: the uncontrolled variable in safety assessment
    K P Keenan
    Department of Safety Assessment, Merck Research Laboratories, West Point, Pennsylvania 19480, USA
    Toxicol Pathol 24:757-68. 1996
    ..These and other data indicate that moderate DR is the most appropriate method of dietary control for the rodent bioassay when used to assess pharmaceuticals for human safety and compounds for risk assessment...
  5. ncbi request reprint Diet, overfeeding, and moderate dietary restriction in control Sprague-Dawley rats: I. Effects on spontaneous neoplasms
    K P Keenan
    Department of Safety Assessment, Merck Research Laboratories, West Point, Pennsylvania 19486, USA
    Toxicol Pathol 23:269-86. 1995
    ..The conclusion from this study is that moderate DR delays death due to fatal cardiovascular or renal degenerative disease and spontaneous tumors, particularly those of the pituitary and mammary gland.(ABSTRACT TRUNCATED AT 400 WORDS)..
  6. ncbi request reprint The effects of diet, ad Libitum feeding, and moderate and severe dietary restriction on body weight, survival, clinical pathology parameters, and cause of death in control Sprague-Dawley rats
    M F Hubert
    Department of Safety Assessment, Merck Research Laboratories, 63963 Clermont Ferrand Cedex 9, France West Point, Pennsylvania 19486, USA
    Toxicol Sci 58:195-207. 2000
    ..In conclusion, a DR rate of approximately 25% appears to be appropriate for Sprague-Dawley rats in toxicity and carcinogenicity assays to improve survival without impairing growth and routine clinical pathology parameters...
  7. ncbi request reprint The effects of overfeeding and dietary restriction on Sprague-Dawley rat survival and early pathology biomarkers of aging
    K P Keenan
    Department of Safety Assessment, Merck Research Laboratories, West Point, Pennsylvania 19486
    Toxicol Pathol 22:300-15. 1994
    ....
  8. ncbi request reprint Morphological and hormonal changes in the ventral and dorsolateral prostatic lobes of rats treated with finasteride, a 5-alpha reductase inhibitor
    S Prahalada
    Department of Safety Assessment, Merck Research Laboratory, West Point, Pennsylvania 19486, USA
    Prostate 35:157-64. 1998
    ..Therefore, studies were designed to determine the differences in intraprostatic hormonal levels, morphology, and 5alphaR activity in different lobes of the rat prostate...