Aimee L Jackson

Summary

Affiliation: Merck Research Laboratories
Country: USA

Publications

  1. ncbi request reprint Expression profiling reveals off-target gene regulation by RNAi
    Aimee L Jackson
    Rosetta Inpharmatics LLC, 12040 115th Avenue NE, Kirkland, Washington 98034, USA
    Nat Biotechnol 21:635-7. 2003
  2. ncbi request reprint Noise amidst the silence: off-target effects of siRNAs?
    Aimee L Jackson
    Rosetta Inpharmatics LLC, 401 Terry Avenue N, Seattle, WA 98109, USA
    Trends Genet 20:521-4. 2004
  3. pmc Widespread siRNA "off-target" transcript silencing mediated by seed region sequence complementarity
    Aimee L Jackson
    Rosetta Inpharmatics, LLC, Seattle, WA 98109, USA
    RNA 12:1179-87. 2006
  4. pmc Position-specific chemical modification of siRNAs reduces "off-target" transcript silencing
    Aimee L Jackson
    Rosetta Inpharmatics, LLC, Seattle, WA 98109, USA
    RNA 12:1197-205. 2006
  5. pmc MicroRNA-like off-target transcript regulation by siRNAs is species specific
    Julja Burchard
    Rosetta Inpharmatics LLC, Seattle, Washington 98109, USA
    RNA 15:308-15. 2009
  6. doi request reprint Coordinated regulation of cell cycle transcripts by p53-Inducible microRNAs, miR-192 and miR-215
    Sara A Georges
    Rosetta Inpharmatics LLC, Seattle, Washington WA 98109, USA
    Cancer Res 68:10105-12. 2008
  7. pmc MicroRNAs in the miR-106b family regulate p21/CDKN1A and promote cell cycle progression
    Irena Ivanovska
    Rosetta Inpharmatics LLC, 401 Terry Ave N, Seattle, WA 98109, USA
    Mol Cell Biol 28:2167-74. 2008
  8. pmc Transcripts targeted by the microRNA-16 family cooperatively regulate cell cycle progression
    Peter S Linsley
    Rosetta Inpharmatics, LLC, 401 Terry Ave N, Seattle, WA 98109, USA
    Mol Cell Biol 27:2240-52. 2007
  9. pmc Small interfering RNA screens reveal enhanced cisplatin cytotoxicity in tumor cells having both BRCA network and TP53 disruptions
    Steven R Bartz
    Rosetta Inpharmatics, LLC, Seattle, WA 98109, USA
    Mol Cell Biol 26:9377-86. 2006
  10. pmc Myc-regulated microRNAs attenuate embryonic stem cell differentiation
    Chin Hsing Lin
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 4417, USA
    EMBO J 28:3157-70. 2009

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Expression profiling reveals off-target gene regulation by RNAi
    Aimee L Jackson
    Rosetta Inpharmatics LLC, 12040 115th Avenue NE, Kirkland, Washington 98034, USA
    Nat Biotechnol 21:635-7. 2003
    ..These results demonstrate that siRNAs may cross-react with targets of limited sequence similarity...
  2. ncbi request reprint Noise amidst the silence: off-target effects of siRNAs?
    Aimee L Jackson
    Rosetta Inpharmatics LLC, 401 Terry Avenue N, Seattle, WA 98109, USA
    Trends Genet 20:521-4. 2004
    ..In the meantime, caution is warranted in interpreting gene function and phenotypes resulting from RNAi experiments...
  3. pmc Widespread siRNA "off-target" transcript silencing mediated by seed region sequence complementarity
    Aimee L Jackson
    Rosetta Inpharmatics, LLC, Seattle, WA 98109, USA
    RNA 12:1179-87. 2006
    ..Thus, short stretches of sequence complementarity to the siRNA or shRNA seed region are key to the silencing of unintended transcripts...
  4. pmc Position-specific chemical modification of siRNAs reduces "off-target" transcript silencing
    Aimee L Jackson
    Rosetta Inpharmatics, LLC, Seattle, WA 98109, USA
    RNA 12:1197-205. 2006
    ....
  5. pmc MicroRNA-like off-target transcript regulation by siRNAs is species specific
    Julja Burchard
    Rosetta Inpharmatics LLC, Seattle, Washington 98109, USA
    RNA 15:308-15. 2009
    ..Therefore, siRNA therapeutics may trigger microRNA-like silencing of many unintended targets in vivo, and the potential toxicities caused by these off-target gene regulations cannot be accurately assessed in rodent models...
  6. doi request reprint Coordinated regulation of cell cycle transcripts by p53-Inducible microRNAs, miR-192 and miR-215
    Sara A Georges
    Rosetta Inpharmatics LLC, Seattle, Washington WA 98109, USA
    Cancer Res 68:10105-12. 2008
    ..Our results showing a role for miR-192/215 in cell proliferation combined with recent observations that these miRNAs are underexpressed in primary cancers support the idea that miR-192 and miR-215 function as tumor suppressors...
  7. pmc MicroRNAs in the miR-106b family regulate p21/CDKN1A and promote cell cycle progression
    Irena Ivanovska
    Rosetta Inpharmatics LLC, 401 Terry Ave N, Seattle, WA 98109, USA
    Mol Cell Biol 28:2167-74. 2008
    ..We also show that miR-106b overrides a doxorubicin-induced DNA damage checkpoint. Thus, miR-106b family members contribute to tumor cell proliferation in part by regulating cell cycle progression and by modulating checkpoint functions...
  8. pmc Transcripts targeted by the microRNA-16 family cooperatively regulate cell cycle progression
    Peter S Linsley
    Rosetta Inpharmatics, LLC, 401 Terry Ave N, Seattle, WA 98109, USA
    Mol Cell Biol 27:2240-52. 2007
    ..Simultaneous silencing of these genes was more effective at blocking cell cycle progression than disruption of the individual genes. Thus, miR-16 coordinately regulates targets that may act in concert to control cell cycle progression...
  9. pmc Small interfering RNA screens reveal enhanced cisplatin cytotoxicity in tumor cells having both BRCA network and TP53 disruptions
    Steven R Bartz
    Rosetta Inpharmatics, LLC, Seattle, WA 98109, USA
    Mol Cell Biol 26:9377-86. 2006
    ..Thus, tumor cells having disruptions in BRCA1/2 network genes and TP53 together are more sensitive to cisplatin than cells with either disruption alone...
  10. pmc Myc-regulated microRNAs attenuate embryonic stem cell differentiation
    Chin Hsing Lin
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 4417, USA
    EMBO J 28:3157-70. 2009
    ..In contrast, knockdown of the endogenous miRNAs accelerate differentiation. Our data show that in ES cells c-Myc acts, in part, through a subset of miRNAs to attenuate differentiation...
  11. ncbi request reprint How will RNAi facilitate drug development?
    Steven Bartz
    Rosetta Inpharmatics, LLC, a wholly owned subsidiary of Merck and Co, Inc, 401 Terry Avenue North, Seattle, WA 98109, USA
    Sci STKE 2005:pe39. 2005
    ..Here, we discuss the potential impact of RNAi screens on target identification and validation and consider issues that warrant caution when interpreting RNAi screening results...
  12. ncbi request reprint Genome-wide resources of endoribonuclease-prepared short interfering RNAs for specific loss-of-function studies
    Ralf Kittler
    Max Planck Institute for Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, D 01307 Dresden, Germany
    Nat Methods 4:337-44. 2007
    ..Hence, the presented esiRNA libraries offer an efficient, cost-effective and specific alternative to presently available mammalian RNAi resources...
  13. ncbi request reprint A microRNA component of the p53 tumour suppressor network
    Lin He
    Watson School of Biological Sciences, Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
    Nature 447:1130-4. 2007
    ..The p53 network suppresses tumour formation through the coordinated activation of multiple transcriptional targets, and miR-34 may act in concert with other effectors to inhibit inappropriate cell proliferation...
  14. ncbi request reprint Genome-scale RNAi profiling of cell division in human tissue culture cells
    Ralf Kittler
    Max Planck Institute for Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, D 01307 Dresden, Germany
    Nat Cell Biol 9:1401-12. 2007
    ..Our work provides an experimental framework from which the systematic analysis of novel genes necessary for cell division in human cells can begin...
  15. ncbi request reprint Minimizing the risk of reporting false positives in large-scale RNAi screens
    Christophe J Echeverri
    Cenix BioScience GmbH, Tatzberg 47, Dresden, 10307, Germany
    Nat Methods 3:777-9. 2006
    ....