S B Heymsfield

Summary

Affiliation: Merck Research Laboratories
Country: USA

Publications

  1. pmc Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: a randomized trial
    Ralf Nass
    University of Virginia, Charlottesville, Virginia 22908, USA
    Ann Intern Med 149:601-11. 2008
  2. pmc New fat free mass - fat mass model for use in physiological energy balance equations
    Diana Thomas
    Department of Mathematical Sciences, Montclair State University, Montclair, NJ, USA
    Nutr Metab (Lond) 7:39. 2010
  3. pmc Accuracy of DXA in estimating body composition changes in elite athletes using a four compartment model as the reference method
    Diana A Santos
    Exercise and Health Laboratory, Faculty of Human Movement Technical University of Lisbon, Portugal
    Nutr Metab (Lond) 7:22. 2010
  4. pmc Physiological models of body composition and human obesity
    David G Levitt
    Department of Integrative Biology and Physiology, University of Minnesota, 321 Church St, S, E, Minneapolis, MN 55455, USA
    Nutr Metab (Lond) 4:19. 2007
  5. pmc Physiological models of body composition and human obesity
    David G Levitt
    Department of Integrative Biology and Physiology, University of Minnesota, 321 Church Street SE, Minneapolis, MN 55455, USA
    Nutr Metab (Lond) 6:7. 2009
  6. pmc Sexual dimorphism of adipose tissue distribution across the lifespan: a cross-sectional whole-body magnetic resonance imaging study
    Wei Shen
    Obesity Research Center, St, Luke s Roosevelt Hospital and Institute of Human Nutrition, Columbia University, College of Physicians and Surgeons, New York, NY, USA
    Nutr Metab (Lond) 6:17. 2009
  7. pmc Greater lean tissue and skeletal muscle mass are associated with higher bone mineral content in children
    Karen B Dorsey
    Department of Pediatrics, Yale University School of Medicine, New Haven, CT, USA
    Nutr Metab (Lond) 7:41. 2010
  8. pmc One-year health-related quality of life outcomes in weight loss trial participants: comparison of three measures
    Ronette L Kolotkin
    Obesity and Quality of Life Consulting, 762 Ninth Street 563, Durham, North Carolina 27705, USA
    Health Qual Life Outcomes 7:53. 2009
  9. doi Development of imaging methods to assess adiposity and metabolism
    S B Heymsfield
    Global Center for Scientific Affairs, Merck and Co, Rahway, NJ, USA
    Int J Obes (Lond) 32:S76-82. 2008
  10. doi Differences between brain mass and body weight scaling to height: potential mechanism of reduced mass-specific resting energy expenditure of taller adults
    Steven B Heymsfield
    Merck Research Laboratories, Rahway, NJ 07065 0900, USA
    J Appl Physiol (1985) 106:40-8. 2009

Detail Information

Publications79

  1. pmc Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: a randomized trial
    Ralf Nass
    University of Virginia, Charlottesville, Virginia 22908, USA
    Ann Intern Med 149:601-11. 2008
    ..The decline of growth hormone in the development of sarcopenia is one of many factors, and its etiologic role needs to be demonstrated...
  2. pmc New fat free mass - fat mass model for use in physiological energy balance equations
    Diana Thomas
    Department of Mathematical Sciences, Montclair State University, Montclair, NJ, USA
    Nutr Metab (Lond) 7:39. 2010
    ..Comparison of translates to a representative sample of the US population indicate that this parameter is a reflection of age, height, race and gender effects...
  3. pmc Accuracy of DXA in estimating body composition changes in elite athletes using a four compartment model as the reference method
    Diana A Santos
    Exercise and Health Laboratory, Faculty of Human Movement Technical University of Lisbon, Portugal
    Nutr Metab (Lond) 7:22. 2010
    ....
  4. pmc Physiological models of body composition and human obesity
    David G Levitt
    Department of Integrative Biology and Physiology, University of Minnesota, 321 Church St, S, E, Minneapolis, MN 55455, USA
    Nutr Metab (Lond) 4:19. 2007
    ..We attempt to develop regression relations that are based on realistic models of body composition changes in obesity. These models, if valid, can then be extrapolated to the high fat fraction of the morbidly obese...
  5. pmc Physiological models of body composition and human obesity
    David G Levitt
    Department of Integrative Biology and Physiology, University of Minnesota, 321 Church Street SE, Minneapolis, MN 55455, USA
    Nutr Metab (Lond) 6:7. 2009
    ..ABSTRACT: Correction to Levitt DG, Heymsfield SB, Pierson Jr RN, Shapses SA, Kral JG: Physiological models of body composition and human obesity. Nutrition & Metabolism 2007, 4:19...
  6. pmc Sexual dimorphism of adipose tissue distribution across the lifespan: a cross-sectional whole-body magnetic resonance imaging study
    Wei Shen
    Obesity Research Center, St, Luke s Roosevelt Hospital and Institute of Human Nutrition, Columbia University, College of Physicians and Surgeons, New York, NY, USA
    Nutr Metab (Lond) 6:17. 2009
    ..abstract:..
  7. pmc Greater lean tissue and skeletal muscle mass are associated with higher bone mineral content in children
    Karen B Dorsey
    Department of Pediatrics, Yale University School of Medicine, New Haven, CT, USA
    Nutr Metab (Lond) 7:41. 2010
    ..To compare the relationship of skeletal muscle mass with bone mineral content in an ethnically diverse group of 6 to 18 year old boys and girls...
  8. pmc One-year health-related quality of life outcomes in weight loss trial participants: comparison of three measures
    Ronette L Kolotkin
    Obesity and Quality of Life Consulting, 762 Ninth Street 563, Durham, North Carolina 27705, USA
    Health Qual Life Outcomes 7:53. 2009
    ....
  9. doi Development of imaging methods to assess adiposity and metabolism
    S B Heymsfield
    Global Center for Scientific Affairs, Merck and Co, Rahway, NJ, USA
    Int J Obes (Lond) 32:S76-82. 2008
    ..The scientific advances made possible by these new and innovative methods continue to unfold today and hold enormous promise for the future of obesity research...
  10. doi Differences between brain mass and body weight scaling to height: potential mechanism of reduced mass-specific resting energy expenditure of taller adults
    Steven B Heymsfield
    Merck Research Laboratories, Rahway, NJ 07065 0900, USA
    J Appl Physiol (1985) 106:40-8. 2009
    ....
  11. pmc Body circumferences: clinical implications emerging from a new geometric model
    Steven B Heymsfield
    Merck and Company, Rahway, NJ, USA
    Nutr Metab (Lond) 5:24. 2008
    ..Concepts emerging from the developed model were then used to examine the relations between the evaluated clinical measures and body composition...
  12. ncbi How much may I eat? Calorie estimates based upon energy expenditure prediction equations
    S B Heymsfield
    Merck and Company, Metabolism and Epidemiology, Rahway, New Jersey 07065 0900, USA
    Obes Rev 7:361-70. 2006
    ..This information should provide healthcare professionals with the tools and understanding to appropriately answer the question, 'How much may I eat?'..
  13. ncbi Fat and energy partitioning: longitudinal observations in leptin-treated adults homozygous for a Lep mutation
    Steven B Heymsfield
    Department of Clinical Research and Metabolism, Merck Research Laboratories, Rahway, New Jersey 07065 0900, USA
    Obesity (Silver Spring) 14:258-65. 2006
    ..The objective of this study was to evaluate body composition in three leptin-treated Turkish adults homozygous for a missense mutation (C-->T substitution at codon 105 resulting in Arg-->Trp) of Lep...
  14. pmc Scaling of human body composition to stature: new insights into body mass index
    Steven B Heymsfield
    From Merck and Company, Rahway, NJ 07065 0900, USA
    Am J Clin Nutr 86:82-91. 2007
    ..Although Quetelet first reported in 1835 that adult weight scales to the square of stature, limited or no information is available on how anatomical body compartments, including adipose tissue (AT), scale to height...
  15. ncbi Body size and human energy requirements: reduced mass-specific resting energy expenditure in tall adults
    Steven B Heymsfield
    Merck and Company, Rahway, New Jersey, USA
    J Appl Physiol (1985) 103:1543-50. 2007
    ..These observations have implications for the modeling of adult human energy requirements and associate with anthropological concepts founded on body size...
  16. doi Body size and human energy requirements: Reduced mass-specific total energy expenditure in tall adults
    Steven B Heymsfield
    Global Center for Scientific Affairs, Merck and Co, Rahway, New Jersey, SUA
    Am J Hum Biol 22:301-9. 2010
    ..These observations reveal previously unforeseen associations between human stature and energy requirements that have implications for modeling efforts and provide new links to mammalian biology as a whole...
  17. ncbi Why do obese patients not lose more weight when treated with low-calorie diets? A mechanistic perspective
    Steven B Heymsfield
    Merck and Company, Rahway, NJ, USA
    Am J Clin Nutr 85:346-54. 2007
    ....
  18. pmc Body mass index as a phenotypic expression of adiposity: quantitative contribution of muscularity in a population-based sample
    S B Heymsfield
    Global Center for Scientific Affairs, Merck and Co, Rahway, NJ, USA
    Int J Obes (Lond) 33:1363-73. 2009
    ..The current study aimed to fill this important gap by applying advanced imaging methods to test the hypothesis that, after controlling first for adiposity, SM mass is also a significant determinant of BMI in a population-based sample...
  19. ncbi Neuropeptide Y5 receptor antagonism does not induce clinically meaningful weight loss in overweight and obese adults
    Ngozi Erondu
    Merck and Co, Inc, 126 E Lincoln Avenue, Rahway, New Jersey 07065
    Cell Metab 4:275-82. 2006
    ..These observations provide the first clinical insight into the human NPY-energy homeostatic pathway and suggest that solely targeting the NPY5R in future drug development programs is unlikely to produce therapeutic efficacy...
  20. pmc Evolving concepts on adjusting human resting energy expenditure measurements for body size
    S B Heymsfield
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Obes Rev 13:1001-14. 2012
    ....
  21. doi Voluntary weight loss: systematic review of early phase body composition changes
    S B Heymsfield
    Merck Research Laboratories, Merck and Co, Inc, Rahway, NJ, USA
    Obes Rev 12:e348-61. 2011
    ..Our in depth review collectively characterizes phase I as a distinct weight loss period while revealing important knowledge gaps that can be filled with appropriately designed future studies...
  22. ncbi Efficacy and safety of intranasal peptide YY3-36 for weight reduction in obese adults
    Ira Gantz
    Clinical Research, Metabolism, Merck Research Laboratories, 126 East Lincoln Avenue, P O Box 2000, RY34A A202, Rahway, NJ 07065 0900, USA
    J Clin Endocrinol Metab 92:1754-7. 2007
    ..The gastrointestinal peptide hormone, peptide YY(3-36) (PYY(3-36)), is implicated to be a postprandial satiety factor...
  23. ncbi NPY5R antagonism does not augment the weight loss efficacy of orlistat or sibutramine
    Ngozi Erondu
    Merck Research Laboratories, 126 E Lincoln Avenue, PO Box 2000, RY34A Rahway, NJ 07065 0900, USA
    Obesity (Silver Spring) 15:2027-42. 2007
    ..This study evaluated whether blockade of the NPY Y5 receptor (NPY5R) with the selective antagonist MK-0557 potentiates sibutramine and orlistat weight loss effects...
  24. ncbi Effect of NPY5R antagonist MK-0557 on weight regain after very-low-calorie diet-induced weight loss
    Ngozi Erondu
    Department of Clinical Research, Metabolism, Merck Research Laboratories, 126 E Lincoln Avenue, PO Box 2000, RY34A A238, Rahway, NJ 07065 0900, USA
    Obesity (Silver Spring) 15:895-905. 2007
    ..To evaluate whether MK-0557, a highly selective, orally administered neuropeptide Y Y5 receptor antagonist, could limit weight regain after very-low-calorie diet (VLCD)-induced weight loss...
  25. pmc A computational model to determine energy intake during weight loss
    Diana M Thomas
    Department of Mathematical Sciences, Montclair State University, Montclair, NJ, USA
    Am J Clin Nutr 92:1326-31. 2010
    ..Energy intake (EI) during weight loss is difficult and costly to measure accurately...
  26. doi The acyclic CB1R inverse agonist taranabant mediates weight loss by increasing energy expenditure and decreasing caloric intake
    Carol Addy
    Merck Research Laboratories, Boston, MA 02115, USA
    Cell Metab 7:68-78. 2008
    ..Mechanism-of-action studies suggest that engagement of the CB1R by taranabant leads to weight loss by reducing food intake and increasing energy expenditure and fat oxidation...
  27. doi Potent and selective agonism of the melanocortin receptor 4 with MK-0493 does not induce weight loss in obese human subjects: energy intake predicts lack of weight loss efficacy
    R Krishna
    Merck and Co, Inc, Whitehouse Station, New Jersey, USA
    Clin Pharmacol Ther 86:659-66. 2009
    ..We conclude that agonism of MC4R is not likely to represent a viable approach to the development of antiobesity therapeutics...
  28. doi Cannabinoid-1 receptor inverse agonists: current understanding of mechanism of action and unanswered questions
    T M Fong
    Merck Research Laboratories, Department of Metabolic Disorders, Rahway, NJ, USA
    Int J Obes (Lond) 33:947-55. 2009
    ..This review will carefully examine the published literature and provide a perspective on what new tools and studies are required to address the peripheral site of action hypothesis...
  29. pmc Total-body skeletal muscle mass: estimation by dual-energy X-ray absorptiometry in children and adolescents
    Jaehee Kim
    Obesity Research Center, St Luke s Roosevelt Hospital, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Am J Clin Nutr 84:1014-20. 2006
    ..Skeletal muscle (SM) is an important compartment but is difficult to quantify in children and adolescents...
  30. pmc Evaluation of between-methods agreement of extracellular water measurements in adults and children
    Analiza M Silva
    New York Obesity Research Center, St Luke s Roosevelt Hospital, Columbia University Institute of Human Nutrition, College of Physicians and Surgeons, New York, NY, USA
    Am J Clin Nutr 88:315-23. 2008
    ..Extracellular water (ECW), a relevant molecular level component for clinical assessment, is commonly obtained by 2 methods that rely on assumptions that may not be possible to test at the time the measurements are made...
  31. ncbi Supplementation with soy-protein-rich foods does not enhance weight loss
    Marie Pierre St-Onge
    New York Obesity Research Center, St Luke s Roosevelt Hospital, New York, NY 10026, USA
    J Am Diet Assoc 107:500-5. 2007
    ..Our results do not lend support to the emerging notion that soy-protein-rich foods could be considered potential functional foods for weight management, in the quantities consumed in this study...
  32. pmc Metabolically active portion of fat-free mass: a cellular body composition level modeling analysis
    ZiMian Wang
    Obesity Research Center, 1090 Amsterdam Ave, 14th Floor, New York, NY 10025, USA
    Am J Physiol Endocrinol Metab 292:E49-53. 2007
    ..584 +/- 0.041 and 0.529 +/- 0.041 for adult men and women (P < 0.001), respectively. A multiple linear regression model showed that there are independent significant associations of sex, age, and fat mass with BCM/FFM...
  33. ncbi Assessment of body composition in long-term hemodialysis patients: rationale and methodology
    Shubho R Sarkar
    Renal Research Institute, New York, NY 10128, USA
    J Ren Nutr 15:152-8. 2005
    ..Preliminary results based on up to 40 hemodialysis patients are reported...
  34. ncbi Waist circumference and cardiometabolic risk: a consensus statement from Shaping America's Health: Association for Weight Management and Obesity Prevention; NAASO, The Obesity Society; the American Society for Nutrition; and the American Diabetes Associat
    Samuel Klein
    Center for Human Nutrition and the Division of Geriatrics and Nutritional Science, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Clin Nutr 85:1197-202. 2007
  35. pmc Does percent body fat predict outcome in anorexia nervosa?
    Laurel E S Mayer
    Eating Disorders Research Unit, New York State Psychiatric Institute, Columbia College of Physicians and Surgeons, Columbia University, and New York Obesity Research Center, St Luke s Roosevelt Hospital Center, New York, NY 10032, USA
    Am J Psychiatry 164:970-2. 2007
    ..The goal of this study was to investigate the relationship of body composition and neuroendocrine levels with clinical outcome in women with anorexia nervosa in a relapse-prevention trial...
  36. ncbi Comparison of weight-loss diets
    Steven B Heymsfield
    JAMA 298:173-4; author reply 174-5. 2007
  37. pmc A new total body potassium method to estimate total body skeletal muscle mass in children
    ZiMian Wang
    Obesity Research Center, St Luke s Roosevelt Hospital, Columbia University College of Physicians and Surgeons, New York, NY 10025, USA
    J Nutr 137:1988-91. 2007
    ..Because the adult TBK SM prediction model is not applicable for pediatric use, this study provides new empirical TBK SM prediction equations that should prove useful for studies on nutrition, growth, and development in children...
  38. pmc Simple anthropometric measures correlate with metabolic risk indicators as strongly as magnetic resonance imaging-measured adipose tissue depots in both HIV-infected and control subjects
    Rebecca Scherzer
    Northern California Institute for Research and Education, San Francisco, CA, USA
    Am J Clin Nutr 87:1809-17. 2008
    ..Studies in persons without HIV infection have compared percentage body fat (%BF) and waist circumference as markers of risk for the complications of excess adiposity, but only limited study has been conducted in HIV-infected subjects...
  39. ncbi Dual-energy X-ray absorptiometry is a valid tool for assessing skeletal muscle mass in older women
    Zhao Chen
    College of Public Health, University of Arizona, Tucson, AZ 85724, USA
    J Nutr 137:2775-80. 2007
    ..We conclude that DXA is a reliable method for cross-sectional assessments of SMM in older women...
  40. pmc Comparison of dual-energy X-ray absorptiometry and magnetic resonance imaging-measured adipose tissue depots in HIV-infected and control subjects
    Rebecca Scherzer
    University of California, San Francisco, CA 94121, USA
    Am J Clin Nutr 88:1088-96. 2008
    ....
  41. ncbi Is percentage body fat differentially related to body mass index in Hispanic Americans, African Americans, and European Americans?
    Jose R Fernandez
    Obesity Research Center, St Luke s Roosevelt Hospital and the Institute of Human Nutrition, Columbia University College of Physicians and Surgeons, New York, USA
    Am J Clin Nutr 77:71-5. 2003
    ....
  42. ncbi Total body protein mass: validation of total body potassium prediction model in children and adolescents
    ZiMian Wang
    Obesity Research Center, St Luke s Roosevelt Hospital, Columbia University College of Physicians and Surgeons, New York, NY, USA
    J Nutr 136:1032-6. 2006
    ..032, P > 0.05). The TBK-Mo model can thus be used to estimate TBPro in healthy adults, adolescents, and children > 5 y old...
  43. ncbi Percentage body fat ranges associated with metabolic syndrome risk: results based on the third National Health and Nutrition Examination Survey (1988-1994)
    Shankuan Zhu
    New York Obesity Research Center, St Luke s Roosevelt Hospital, Institute of Human Nutrition, College of Physicians and Surgeons, Columbia University, New York, USA
    Am J Clin Nutr 78:228-35. 2003
    ..Increasing attention has focused on the association between body fatness and related metabolic risk factors. The quantitative link between percentage body fat (%BF) and the risk of metabolic syndrome is unknown...
  44. ncbi Dubious assumptions underlying the adjustment of metabolic rates for changes in fat-free mass
    Dympna Gallagher
    J Clin Endocrinol Metab 88:3454; author reply 3454-5. 2003
  45. ncbi Recombinant variant of ciliary neurotrophic factor for weight loss in obese adults: a randomized, dose-ranging study
    Mark P Ettinger
    Radiant Research, Stuart, Fla, USA
    JAMA 289:1826-32. 2003
    ..A genetically engineered recombinant human variant ciliary neurotrophic factor (rhvCNTF) that signals through leptinlike pathways in the hypothalamus has been shown to bypass leptin resistance in animal models of obesity...
  46. ncbi Bioimpedance analysis: a useful technique for assessing appendicular lean soft tissue mass and distribution
    Serenella Salinari
    Dipartimento di Informatica e Sistemistica, Universita di Roma La Sapienza, 00184 Roma, Italy
    J Appl Physiol (1985) 94:1552-6. 2003
    ..4 and 5.9 +/- 3.4% in the two groups, respectively. Similar results were obtained by using five resistance values for the analysis. In conclusion, the proposed BIA model provides an adequate means of evaluating appendicular SM mass...
  47. ncbi Comparisons of waist circumferences measured at 4 sites
    Jack Wang
    Body Composition Unit and New York Obesity Research Center, St Luke s Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, New York 10025, USA
    Am J Clin Nutr 77:379-84. 2003
    ....
  48. ncbi Development of bioelectrical impedance analysis prediction equations for body composition with the use of a multicomponent model for use in epidemiologic surveys
    Shumei S Sun
    Lifespan Research Center, Department of Community Health, Wright State University School of Medicine, Dayton, OH 45420, USA
    Am J Clin Nutr 77:331-40. 2003
    ..Previous studies to develop and validate bioelectrical impedance analysis (BIA) equations to predict body composition were limited by small sample sizes, sex specificity, and reliance on reference methods that use a 2-component model...
  49. ncbi Project Grow-2-Gether: a study of the genetic and environmental influences on child eating and obesity
    Myles S Faith
    Weight and Eating Disorders Program, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Twin Res 5:472-5. 2002
    ..Future directions may involve longitudinal assessment of child growth and molecular analyses for specific genes that influence child eating behavior...
  50. ncbi Magnitude and variation of fat-free mass density: a cellular-level body composition modeling study
    ZiMian Wang
    Obesity Research Center, St Luke s Roosevelt Hospital, College of Physicians and Surgeons, Columbia University, New York 10025, USA
    Am J Physiol Endocrinol Metab 284:E267-73. 2003
    ..The difference in FFM density across sex, race, and age groups was examined with the developed model. The present study thus provides a conceptual framework for the systematic study of FFM density in humans...
  51. ncbi Whole-body skeletal muscle mass: development and validation of total-body potassium prediction models
    ZiMian Wang
    Obesity Research Center, St Luke s Roosevelt Hospital, Columbia University College of Physicians and Surgeons, New York, USA
    Am J Clin Nutr 77:76-82. 2003
    ..There are now > 30 whole-body counters worldwide that have large cross-sectional and longitudinal TBK databases...
  52. ncbi Application of simple anthropometry in the assessment of health risk: implications for the Canadian Physical Activity, Fitness and Lifestyle Appraisal
    Ian Janssen
    School of Physical and Health Education, Queen s University, Kingston, ON
    Can J Appl Physiol 27:396-414. 2002
    ..Consistent with this objective, when necessary we present original data to reinforce important concepts not suitably addressed in the literature...
  53. ncbi DXA: potential for creating a metabolic map of organ-tissue resting energy expenditure components
    Matthew Hayes
    Department of Medicine, Obesity Research Center, St Luke s Roosevelt Hospital, Columbia University, College of Physicians and Surgeons, New York, New York 10025, USA
    Obes Res 10:969-77. 2002
    ....
  54. ncbi Total-body skeletal muscle mass: estimation by a new dual-energy X-ray absorptiometry method
    Jaehee Kim
    Obesity Research Center, St Luke s Roosevelt Hospital and the Institute of Human Nutrition, Columbia University, College of Physicians and Surgeons, New York, NY 10025, USA
    Am J Clin Nutr 76:378-83. 2002
    ..A large proportion of total-body SM is found in the extremities, and a large proportion of extremity lean soft tissue is SM. A strong link should thus exist between appendicular lean soft tissue (ALST) mass and total-body SM mass...
  55. ncbi Effect of recombinant human growth hormone in the treatment of visceral fat accumulation in HIV infection
    Ellen S Engelson
    Gastrointestinal Division, Obesity Research Center, New York 10025, USA
    J Acquir Immune Defic Syndr 30:379-91. 2002
    ..However, frequent adverse effects warrant controlled studies and careful patient monitoring, especially regarding glucose tolerance...
  56. ncbi Low relative skeletal muscle mass (sarcopenia) in older persons is associated with functional impairment and physical disability
    Ian Janssen
    School of Physical and Health Education, Queen s University, Kingston, Ontario, Canada
    J Am Geriatr Soc 50:889-96. 2002
    ..To establish the prevalence of sarcopenia in older Americans and to test the hypothesis that sarcopenia is related to functional impairment and physical disability in older persons...
  57. ncbi Low dose leptin administration reverses effects of sustained weight-reduction on energy expenditure and circulating concentrations of thyroid hormones
    Michael Rosenbaum
    Columbia University, New York, New York, USA
    J Clin Endocrinol Metab 87:2391-4. 2002
    ..These data indicate that decrease leptin concentrations resulting from loss of fat mass account for some aspects of the endocrine/metabolic phenotype associated with the weight-reduced state...
  58. ncbi Use of a Durnin-Womersley formula to estimate change in subcutaneous fat content in HIV-infected subjects
    Shireen Andrade
    Gastrointestinal Division, the Weight Control Unit, The Department of Medicine, St Luke s Roosevelt Hospital Center, Columbia University of Physicians and Surgeons, New York, USA
    Am J Clin Nutr 75:587-92. 2002
    ..HIV-infected individuals may develop malnutrition or lipodystrophy, leading to losses of subcutaneous adipose tissue (SAT)...
  59. ncbi Association of lean tissue and fat mass with bone mineral content in children and adolescents
    Angelo Pietrobelli
    Obesity Research Center, St Luke s Roosevelt Hospital, Columbia University, College of Physicians and Surgeons, New York, New York, USA
    Obes Res 10:56-60. 2002
    ..Based on suggested skeletal muscle-bone relationships, this study tested the hypothesis that in children and adolescents lean tissue mass (LTM) is a better predictor of total bone mineral content (TBMC) than is FM...
  60. ncbi Transgenic complementation of leptin receptor deficiency. II. Increased leptin receptor transgene dose effects on obesity/diabetes and fertility/lactation in lepr-db/db mice
    Streamson C Chua
    Department of Pediatrics, Columbia University, New York, New York 10032, USA
    Am J Physiol Endocrinol Metab 286:E384-92. 2004
    ..Finally, the slightly increased adiposity and mild insulin resistance of transgenic db/db dams were not a contributory factor to the increased fat content of transgenic db/db male progeny...
  61. ncbi Effect of calcium supplementation on weight and fat loss in women
    Sue A Shapses
    Department of Nutritional Sciences, Rutgers University, New Brunswick, New Jersey 08901, USA
    J Clin Endocrinol Metab 89:632-7. 2004
    ..Nevertheless, the magnitude and direction of the differences for group means are consistent with a hypothesized small effect...
  62. ncbi Inadequate sleep as a risk factor for obesity: analyses of the NHANES I
    James E Gangwisch
    Mailman School of Public Health, Department of Epidemiology, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    Sleep 28:1289-96. 2005
    ..This study examines cross-sectional and longitudinal data from a large United States sample to determine whether sleep duration is associated with obesity and weight gain...
  63. pmc Pediatric obesity phenotyping by magnetic resonance methods
    Wei Shen
    New York Obesity Research Center, St Luke s Roosevelt Hospital, Institute of Human Nutrition, College of Physicians and Surgeons, Columbia University, New York, NY 10025, USA
    Curr Opin Clin Nutr Metab Care 8:595-601. 2005
    ..The aim is to provide an investigator-focused overview of magnetic resonance methods for use in the study of pediatric body composition and metabolism...
  64. ncbi Air displacement plethysmography: validation in overweight and obese subjects
    Samir R Ginde
    Weight Control Unit, 1090 Amsterdam Avenue, 14th Floor, New York, NY 10025, USA
    Obes Res 13:1232-7. 2005
    ..The purpose of this study was to compare D(b) measured by ADP to D(b) measured by underwater weighing (UWW) in subjects ranging from normal weight to severely obese...
  65. ncbi Bioelectrical impedance analysis: population reference values for phase angle by age and sex
    Maria Cristina G Barbosa-Silva
    Programa de Pós Graduação em Epidemiologia, Universidade Federal de Pelotas, Brasil
    Am J Clin Nutr 82:49-52. 2005
    ..Phase angle is an indicator based on reactance and resistance obtained from bioelectrical impedance analysis (BIA). Although its biological meaning is still not clear, phase angle appears to have an important prognostic role...
  66. ncbi Waist circumference and abdominal adipose tissue distribution: influence of age and sex
    Jennifer L Kuk
    School of Physical and Health Education and the Department of Medicine, Division of Endocrinology and Metabolism, Queen s University, Kingston, Canada
    Am J Clin Nutr 81:1330-4. 2005
    ..The influence of age and sex on the distribution of abdominal adipose tissue for a given waist circumference (WC) is unclear...
  67. ncbi QDR 4500A dual-energy X-ray absorptiometer underestimates fat mass in comparison with criterion methods in adults
    Dale A Schoeller
    Nutritional Sciences, University of Wisconsin Madison
    Am J Clin Nutr 81:1018-25. 2005
    ....
  68. ncbi A cellular-level approach to predicting resting energy expenditure across the adult years
    ZiMian Wang
    Obesity Research Center, St Luke s Roosevelt Hospital, Columbia University College of Physicians and Surgeons, New York, USA
    Am J Clin Nutr 81:799-806. 2005
    ..Although the model predicted REE well in young persons, it overpredicted REE by approximately 11% in elderly adults. This overprediction may occur because of a decline in the fraction of organs and tissues as cell mass with aging...
  69. ncbi Comparison of visceral adipose tissue mass in adult African Americans and whites
    Daniel J Hoffman
    Department of Nutritional Sciences, Rutgers University, Room 230 Davison Hall, 26 Nichol Avenue, Room 228B, New Brunswick, NJ 08901, USA
    Obes Res 13:66-74. 2005
    ..This study was designed to measure the extent to which race is associated with VAT, controlling for total adipose tissue (TAT) mass and testosterone...
  70. ncbi Relation between whole-body and regional measures of human skeletal muscle
    So Jung Lee
    School of Physical and Health Education, Queen s University, Kingston, Ontario, Canada
    Am J Clin Nutr 80:1215-21. 2004
    ..It is unknown whether regional measures of skeletal muscle (SM) in the thigh and abdomen accurately reflect whole-body SM mass...
  71. ncbi Dual-energy x-ray absorptiometry-measured lean soft tissue mass: differing relation to body cell mass across the adult life span
    Marie Pierre St-Onge
    St Luke s Roosevelt Hospital, Columbia University College of Physicians and Surgeons, New York, NY, USA
    J Gerontol A Biol Sci Med Sci 59:796-800. 2004
    ..001) than women; quadratic and cubic age terms were also significant or approached significance. Thus, the fraction of LST as BCM is smaller in older adults, a finding that has implications for the interpretation of DEXA results...
  72. ncbi Metabolic syndrome in normal-weight Americans: new definition of the metabolically obese, normal-weight individual
    Marie Pierre St-Onge
    Institute of Human Nutrition, Obesity Research Center, Columbia University, New York, New York, USA
    Diabetes Care 27:2222-8. 2004
    ..To determine the prevalence rates and likelihood of the metabolic syndrome and its individual components in normal-weight and slightly overweight individuals (BMI 18.5-26.9 kg/m(2))...
  73. ncbi Total body skeletal muscle and adipose tissue volumes: estimation from a single abdominal cross-sectional image
    Wei Shen
    Obesity Research Center, St Luke s Roosevelt Hospital, Columbia University, New York, NY, USA
    J Appl Physiol (1985) 97:2333-8. 2004
    ..Measurement of a single abdominal image can thus provide estimates of total body SM and AT for group studies of healthy adults...
  74. ncbi Dual-energy X-ray absorptiometry lean soft tissue hydration: independent contributions of intra- and extracellular water
    Marie Pierre St-Onge
    St Luke s Roosevelt Hospital, Columbia University College of Physicians and Surgeons, New Youk, NY 10025, USA
    Am J Physiol Endocrinol Metab 287:E842-7. 2004
    ..This observation has implications for the accuracy of body fat measurements by DEXA and the use of TBW as a means of checking DEXA system calibration...
  75. ncbi Measurement of percentage of body fat in 411 children and adolescents: a comparison of dual-energy X-ray absorptiometry with a four-compartment model
    Aviva B Sopher
    Institute of Human Nutrition, Columbia University, New York, New York, USA
    Pediatrics 113:1285-90. 2004
    ....
  76. ncbi The weight debate: balancing food composition and physical activity. Preface
    Steven B Heymsfield
    Am J Clin Nutr 79:897S-898S. 2004
  77. ncbi Body-composition differences between African American and white women: relation to resting energy requirements
    Alfredo Jones
    Department of Medicine, Obesity Research Center, St Luke s Roosevelt Hospital, Columbia University College of Physicians and Surgeons, Weight Control Unit, 1090 Amsterdam Avenue, 14th Floor, New York, NY 10025, USA
    Am J Clin Nutr 79:780-6. 2004
    ..Body composition differs between African American (AA) and white women, and the resting metabolic rate (RMR) is likely to be lower in AA women than in white women...
  78. ncbi Intermuscular adipose tissue-free skeletal muscle mass: estimation by dual-energy X-ray absorptiometry in adults
    Jaehee Kim
    Obesity Research Center, College of Physicians and Surgeons, Columbia University, New York, NY 10025, USA
    J Appl Physiol 97:655-60. 2004
    ..The DXA-based models are accurate for predicting IMAT-free SM in selected populations and thus provide a new opportunity for quantifying SM in physiological and epidemiological investigations...
  79. ncbi Body-size dependence of resting energy expenditure can be attributed to nonenergetic homogeneity of fat-free mass
    Steven B Heymsfield
    New York Obesity Research Center, St Luke s Roosevelt Hospital, New York, NY 10025, USA
    Am J Physiol Endocrinol Metab 282:E132-8. 2002
    ..These observations have important implications for the interpretation of between-individual differences in REE expressed relative to metabolically active tissue mass...