Terence G Hamill

Summary

Affiliation: Merck Research Laboratories
Country: USA

Publications

  1. doi request reprint The synthesis and preclinical evaluation in rhesus monkey of [¹⁸F]MK-6577 and [¹¹C]CMPyPB glycine transporter 1 positron emission tomography radiotracers
    Terence G Hamill
    Discovery Imaging, Merck Research Laboratories, West Point, Pennsylvania 19486, USA
    Synapse 65:261-70. 2011
  2. ncbi request reprint Synthesis, characterization, and first successful monkey imaging studies of metabotropic glutamate receptor subtype 5 (mGluR5) PET radiotracers
    Terence G Hamill
    Merck Research Laboratories, Imaging Research Department, West Point, PA 19486, USA
    Synapse 56:205-16. 2005
  3. doi request reprint PET imaging studies in rhesus monkey with the cannabinoid-1 (CB1) receptor ligand [11C]CB-119
    Terence G Hamill
    Merck Research Laboratories, Imaging Research Department, WP44C 2, West Point, PA 19486, USA
    Mol Imaging Biol 11:246-52. 2009
  4. doi request reprint Inverse agonist histamine H3 receptor PET tracers labelled with carbon-11 or fluorine-18
    Terence G Hamill
    Merck Research Laboratories, Discovery Imaging Department, West Point, Pennsylvania 19486, USA
    Synapse 63:1122-32. 2009
  5. doi request reprint Biodistribution and radiation dosimetry of [18F]F-PEB in nonhuman primates
    Marie Jose Belanger
    Imaging Department, Merck Research Laboratories, West Point, Pennsylvania 19486 004, USA
    Nucl Med Commun 29:915-9. 2008
  6. ncbi request reprint Species differences in mGluR5 binding sites in mammalian central nervous system determined using in vitro binding with [18F]F-PEB
    Shil Patel
    Department of Research Imaging, Merck Research Laboratories, West Point, PA 19486, USA
    Nucl Med Biol 34:1009-17. 2007
  7. pmc [18F]MK-9470, a positron emission tomography (PET) tracer for in vivo human PET brain imaging of the cannabinoid-1 receptor
    H Donald Burns
    Imaging Research, Merck Research Laboratories, West Point, PA 19486, USA
    Proc Natl Acad Sci U S A 104:9800-5. 2007
  8. doi request reprint Kinetic analysis of the cannabinoid-1 receptor PET tracer [(18)F]MK-9470 in human brain
    Sandra Marina Sanabria-Bohórquez
    Imaging, Merck Research Laboratories, Sumneytown Pike WP44D 2, West Point, PA 19486, USA
    Eur J Nucl Med Mol Imaging 37:920-33. 2010
  9. doi request reprint Quantification of the glycine transporter 1 in rhesus monkey brain using [18F]MK-6577 and a model-based input function
    Sandra M Sanabria-Bohórquez
    Imaging, Merck Research Laboratories, West Point, PA 19486, USA
    Neuroimage 59:2589-99. 2012

Detail Information

Publications9

  1. doi request reprint The synthesis and preclinical evaluation in rhesus monkey of [¹⁸F]MK-6577 and [¹¹C]CMPyPB glycine transporter 1 positron emission tomography radiotracers
    Terence G Hamill
    Discovery Imaging, Merck Research Laboratories, West Point, Pennsylvania 19486, USA
    Synapse 65:261-70. 2011
    ..Of these two tracers, [¹⁸F]MK-6577 was more extensively characterized and is a promising clinical positron emission tomography tracer for imaging GlyT1 and for measuring GlyT1 occupancy of therapeutic compounds...
  2. ncbi request reprint Synthesis, characterization, and first successful monkey imaging studies of metabotropic glutamate receptor subtype 5 (mGluR5) PET radiotracers
    Terence G Hamill
    Merck Research Laboratories, Imaging Research Department, West Point, PA 19486, USA
    Synapse 56:205-16. 2005
    ..In vivo metabolism studies showed 3b to be long-lived in rhesus plasma with only one other more polar metabolite observed...
  3. doi request reprint PET imaging studies in rhesus monkey with the cannabinoid-1 (CB1) receptor ligand [11C]CB-119
    Terence G Hamill
    Merck Research Laboratories, Imaging Research Department, WP44C 2, West Point, PA 19486, USA
    Mol Imaging Biol 11:246-52. 2009
    ..The in vitro and in vivo evaluation of the selective, high affinity (human CB1 IC(50) 0.49 nM) inverse agonist CB1R tracer [(11)C]CB-119, a close analog of the previously disclosed [(18)F]MK-9470, was undertaken...
  4. doi request reprint Inverse agonist histamine H3 receptor PET tracers labelled with carbon-11 or fluorine-18
    Terence G Hamill
    Merck Research Laboratories, Discovery Imaging Department, West Point, Pennsylvania 19486, USA
    Synapse 63:1122-32. 2009
    ..These tracers are very promising candidates as clinical PET tracers to both study the histamine H3R system and measure receptor occupancy of H3R therapeutic compounds...
  5. doi request reprint Biodistribution and radiation dosimetry of [18F]F-PEB in nonhuman primates
    Marie Jose Belanger
    Imaging Department, Merck Research Laboratories, West Point, Pennsylvania 19486 004, USA
    Nucl Med Commun 29:915-9. 2008
    ..We report here on the rhesus monkey biodistribution and radiation dosimetry of [18F]3-fluoro-5-[(pyridine-3-yl)ethynyl]benzonitrile, [18F]F-PEB, a mGluR5 positron emission tomography (PET) radiotracer...
  6. ncbi request reprint Species differences in mGluR5 binding sites in mammalian central nervous system determined using in vitro binding with [18F]F-PEB
    Shil Patel
    Department of Research Imaging, Merck Research Laboratories, West Point, PA 19486, USA
    Nucl Med Biol 34:1009-17. 2007
    ....
  7. pmc [18F]MK-9470, a positron emission tomography (PET) tracer for in vivo human PET brain imaging of the cannabinoid-1 receptor
    H Donald Burns
    Imaging Research, Merck Research Laboratories, West Point, PA 19486, USA
    Proc Natl Acad Sci U S A 104:9800-5. 2007
    ..In addition, it allows demonstration of target engagement and noninvasive dose-occupancy studies to aid in dose selection for clinical trials of CB1R inverse agonists...
  8. doi request reprint Kinetic analysis of the cannabinoid-1 receptor PET tracer [(18)F]MK-9470 in human brain
    Sandra Marina Sanabria-Bohórquez
    Imaging, Merck Research Laboratories, Sumneytown Pike WP44D 2, West Point, PA 19486, USA
    Eur J Nucl Med Mol Imaging 37:920-33. 2010
    ..Quantitative imaging of the type 1 cannabinoid receptor (CB1R) opens perspectives for many neurological and psychiatric disorders. We characterized the kinetics and reproducibility of the CB1R tracer [(18)F]MK-9470 in human brain...
  9. doi request reprint Quantification of the glycine transporter 1 in rhesus monkey brain using [18F]MK-6577 and a model-based input function
    Sandra M Sanabria-Bohórquez
    Imaging, Merck Research Laboratories, West Point, PA 19486, USA
    Neuroimage 59:2589-99. 2012
    ..This technique was applied for determination of the dose-occupancy relationship of a GlyT1 inhibitor in monkey brain...