Jörg Habermann

Summary

Affiliation: Merck Research Laboratories
Country: USA

Publications

  1. doi request reprint Discovery of pentacyclic compounds as potent inhibitors of hepatitis C virus NS5B RNA polymerase
    Jörg Habermann
    Department of Medicinal Chemistry, IRBM P Angeletti S p A, Merck Research Laboratories Rome, Via Pontina Km 30, 600, I 00040 Pomezia, Rome, Italy
    Bioorg Med Chem Lett 19:633-8. 2009
  2. doi request reprint Discovery of (7R)-14-cyclohexyl-7-{[2-(dimethylamino)ethyl](methyl) amino}-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylic acid (MK-3281), a potent and orally bioavailable finger-loop inhibitor of the hepatitis C virus NS5B polymerase
    Frank Narjes
    Istituto di Ricerche di Biologia Molecolare, P Angeletti SpA Merck Research Laboratories, Rome, Pomezia, Italy
    J Med Chem 54:289-301. 2011
  3. doi request reprint Optimization of thienopyrrole-based finger-loop inhibitors of the hepatitis C virus NS5B polymerase
    Jose Ignacio Martin Hernando
    Department of Medicinal Chemistry, Istituto di Ricerche di Biologia Molecolare P Angeletti S p A Merck Sharp and Dohme Research Laboratories Rome, Via Pontina Km 30, 600, 00040 Pomezia Italy
    ChemMedChem 4:1695-713. 2009

Collaborators

Detail Information

Publications3

  1. doi request reprint Discovery of pentacyclic compounds as potent inhibitors of hepatitis C virus NS5B RNA polymerase
    Jörg Habermann
    Department of Medicinal Chemistry, IRBM P Angeletti S p A, Merck Research Laboratories Rome, Via Pontina Km 30, 600, I 00040 Pomezia, Rome, Italy
    Bioorg Med Chem Lett 19:633-8. 2009
    ..The compounds displayed a high activity in the enzyme assay and displayed good activity in the cell-based (replicon) assay in the presence of serum proteins...
  2. doi request reprint Discovery of (7R)-14-cyclohexyl-7-{[2-(dimethylamino)ethyl](methyl) amino}-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylic acid (MK-3281), a potent and orally bioavailable finger-loop inhibitor of the hepatitis C virus NS5B polymerase
    Frank Narjes
    Istituto di Ricerche di Biologia Molecolare, P Angeletti SpA Merck Research Laboratories, Rome, Pomezia, Italy
    J Med Chem 54:289-301. 2011
    ..The compound caused a consistent decrease in viremia in vivo using the chimeric mouse model of HCV infection...
  3. doi request reprint Optimization of thienopyrrole-based finger-loop inhibitors of the hepatitis C virus NS5B polymerase
    Jose Ignacio Martin Hernando
    Department of Medicinal Chemistry, Istituto di Ricerche di Biologia Molecolare P Angeletti S p A Merck Sharp and Dohme Research Laboratories Rome, Via Pontina Km 30, 600, 00040 Pomezia Italy
    ChemMedChem 4:1695-713. 2009
    ....