X M Guan

Summary

Affiliation: Merck Research Laboratories
Country: USA

Publications

  1. ncbi Regulation of energy homeostasis by bombesin receptor subtype-3: selective receptor agonists for the treatment of obesity
    Xiao Ming Guan
    Merck Research Laboratories, Rahway, NJ 07065, USA
    Cell Metab 11:101-12. 2010
  2. ncbi Evidence of altered hypothalamic pro-opiomelanocortin/ neuropeptide Y mRNA expression in tubby mice
    X M Guan
    Department of Genetics and Molecular Biology, Merck Research Laboratories, P O Box 2000, Rahway, NJ 07065, USA
    Brain Res Mol Brain Res 59:273-9. 1998
  3. ncbi Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass
    A S Chen
    Department of Obesity Research, Merck Research Laboratories, Rahway, New Jersey, USA
    Nat Genet 26:97-102. 2000
  4. ncbi Orexigenic action of peripheral ghrelin is mediated by neuropeptide Y and agouti-related protein
    H Y Chen
    Department of Metabolic Disorders, Merck Research Laboratories, P O Box 2000, RY80T 150, Rahway, New Jersey 07065, USA
    Endocrinology 145:2607-12. 2004
  5. ncbi Role of the melanocortin-4 receptor in metabolic rate and food intake in mice
    A S Chen
    Department of Metabolic Disorders, Merck Research Laboratories, NJ, USA
    Transgenic Res 9:145-54. 2000
  6. ncbi A selective human beta3 adrenergic receptor agonist increases metabolic rate in rhesus monkeys
    M H Fisher
    Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, New Jersey 07065, USA
    J Clin Invest 101:2387-93. 1998
  7. ncbi Identification and characterization of novel mammalian neuropeptide FF-like peptides that attenuate morphine-induced antinociception
    Q Liu
    Department of Pharmacology, Merck Research Laboratories, West Point, Pennsylvania 19486, USA
    J Biol Chem 276:36961-9. 2001
  8. ncbi Identification of receptors for neuromedin U and its role in feeding
    A D Howard
    Department of Metabolic Disorders, Merck Research Laboratories, Rahway, New Jersey 07065, USA
    Nature 406:70-4. 2000
  9. ncbi Potent and selective human beta(3)-adrenergic receptor antagonists
    M R Candelore
    Department of Molecular Pharmacology Immunology and Rheumatology, Merck and Co, Rahway, New Jersey, USA
    J Pharmacol Exp Ther 290:649-55. 1999
  10. ncbi Mutant human presenilin 1 protects presenilin 1 null mouse against embryonic lethality and elevates Abeta1-42/43 expression
    S Qian
    Department of Biochemistry and Physiology, Merck Research Laboratories, Rahway, New Jersey 07065, USA
    Neuron 20:611-7. 1998

Detail Information

Publications12

  1. ncbi Regulation of energy homeostasis by bombesin receptor subtype-3: selective receptor agonists for the treatment of obesity
    Xiao Ming Guan
    Merck Research Laboratories, Rahway, NJ 07065, USA
    Cell Metab 11:101-12. 2010
    ..These results demonstrate that BRS-3 has a role in energy homeostasis that complements several well-known pathways and that BRS-3 agonists represent a potential approach to the treatment of obesity...
  2. ncbi Evidence of altered hypothalamic pro-opiomelanocortin/ neuropeptide Y mRNA expression in tubby mice
    X M Guan
    Department of Genetics and Molecular Biology, Merck Research Laboratories, P O Box 2000, Rahway, NJ 07065, USA
    Brain Res Mol Brain Res 59:273-9. 1998
    ..These results suggest that the altered hypothalamic POMC and/or NPY functions may be important contributing factors for the development of obesity in this animal model...
  3. ncbi Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass
    A S Chen
    Department of Obesity Research, Merck Research Laboratories, Rahway, New Jersey, USA
    Nat Genet 26:97-102. 2000
    ..Mice lacking both Mc3r and Mc4r become significantly heavier than Mc4r(-/-) mice. We conclude that Mc3r and Mc4r serve non-redundant roles in the regulation of energy homeostasis...
  4. ncbi Orexigenic action of peripheral ghrelin is mediated by neuropeptide Y and agouti-related protein
    H Y Chen
    Department of Metabolic Disorders, Merck Research Laboratories, P O Box 2000, RY80T 150, Rahway, New Jersey 07065, USA
    Endocrinology 145:2607-12. 2004
    ..Our results establish an in vivo orexigenic function for NPY and AgRP, mediating the effect of ghrelin...
  5. ncbi Role of the melanocortin-4 receptor in metabolic rate and food intake in mice
    A S Chen
    Department of Metabolic Disorders, Merck Research Laboratories, NJ, USA
    Transgenic Res 9:145-54. 2000
    ..We conclude that MC-4R can mediate control of both metabolic rate and food intake in mice. We infer that a role for MC-3R in mediating the acute effects of MT-II on basal metabolic rate and food intake in wildtype mice seems limited...
  6. ncbi A selective human beta3 adrenergic receptor agonist increases metabolic rate in rhesus monkeys
    M H Fisher
    Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, New Jersey 07065, USA
    J Clin Invest 101:2387-93. 1998
    ..These data suggest a role for beta3 agonists in the treatment of human obesity...
  7. ncbi Identification and characterization of novel mammalian neuropeptide FF-like peptides that attenuate morphine-induced antinociception
    Q Liu
    Department of Pharmacology, Merck Research Laboratories, West Point, Pennsylvania 19486, USA
    J Biol Chem 276:36961-9. 2001
    ..These results indicate that the endogenous ligands for FF1 and FF2 are NPVF- and NPFF-derived peptides, respectively, and suggest that the NPVF/FF1 system may be an important part of endogenous anti-opioid mechanism...
  8. ncbi Identification of receptors for neuromedin U and its role in feeding
    A D Howard
    Department of Metabolic Disorders, Merck Research Laboratories, Rahway, New Jersey 07065, USA
    Nature 406:70-4. 2000
    ..These findings provide a molecular basis for the biochemical activities of NMU and may indicate that NMU is involved in the central control of feeding...
  9. ncbi Potent and selective human beta(3)-adrenergic receptor antagonists
    M R Candelore
    Department of Molecular Pharmacology Immunology and Rheumatology, Merck and Co, Rahway, New Jersey, USA
    J Pharmacol Exp Ther 290:649-55. 1999
    ..In addition, we describe specific 3'-phenoxy substitutions that transform these compounds from potent agonists into selective antagonists...
  10. ncbi Mutant human presenilin 1 protects presenilin 1 null mouse against embryonic lethality and elevates Abeta1-42/43 expression
    S Qian
    Department of Biochemistry and Physiology, Merck Research Laboratories, Rahway, New Jersey 07065, USA
    Neuron 20:611-7. 1998
    ....
  11. ncbi Characteristic dysfunction of stunned myocardium induced by 2,3-butanedione monoxime without ischaemia
    X Wang
    Department of Physiology and Biophysics, UMDNJ-Robert Wood Johnson Medical School, Piscataway, New Jersey 08854-5635, USA
    Clin Exp Pharmacol Physiol 32:968-74. 2005
    ..Because contractility was not impaired, dysfunction was apparently caused by disrupting the association between contractile force and muscle motion...
  12. ncbi Cloning, sequencing, and expression of the rhesus monkey beta 2 adrenergic receptor
    A M Amend
    Department of Molecular Pharmacology and Biochemistry, Merck Research Laboratories, Rahway, NJ 07065, USA
    DNA Cell Biol 14:753-7. 1995
    ..Therefore, the rhesus monkey represents a valid animal model for developing therapeutic agents targeted at the corresponding human beta 2 receptor...