Research Topics
| C J GirmanSummaryAffiliation: Merck Research Laboratories Country: USA Publications
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Publications
Association of health-related quality of life and benign prostatic enlargementC J Girman
Department of Epidemiology, Merck Research Laboratories, West Point, PA, USA
Eur Urol 35:277-84. 1999..To investigate the association of benign prostatic enlargement and health-related quality of life (HRQoL) assessed by validated questionnaires...
Prediction of fracture in nursing home residentsCynthia J Girman
Department of Epidemiology, Merck Research Laboratories, Blue Bell, Pennsylvania 19422, USA
J Am Geriatr Soc 50:1341-7. 2002..To investigate cross-validated methods of identifying patients at increased risk of fracture in nursing homes using readily available data...
Measurement of distal forearm bone mineral density: can different forearm segments be used interchangeably ?A R Martin
Merck Research Laboratories, West Point, PA 19486, USA
J Clin Densitom 2:381-7. 1999..Thus, different forearm sites may be used interchangeably for diagnostic purposes; however, the prognostic value of each site remains unknown...
The effects of hair loss in European men: a survey in four countriesD Budd
Department of Epidemiology, Merck Research Laboratories, BL 1 7, 10 Sentry Parkway, Blue Bell, PA 19422, USA
Eur J Dermatol 10:122-7. 2000..The degree that hair loss is perceived as noticeable to others appears to be a significant contributor to these negative effects...
Low bone mineral density and risk of fracture in white female nursing home residentsJ M Chandler
Department of Epidemiology, BL1 7, Merck Research Laboratories, PO Box 4, West Point, PA 19486 0004, USA
JAMA 284:972-7. 2000..Low bone mineral density (BMD) is a strong risk factor for fracture in community-dwelling white women, but the relationship in white female nursing home residents, for whom fracture rates are highest, is less clear...
Patients with type 2 diabetes mellitus have higher risk for acute pancreatitis compared with those without diabetesC J Girman
Global Clinical Development and Regulatory Affairs, Merck Research Laboratories, North Wales, PA 19454, USA
Diabetes Obes Metab 12:766-71. 2010..The aetiology of acute pancreatitis (AP) is complex, and many risk factors for AP are shared by patients with type 2 diabetes mellitus (T2DM). However, few have assessed risk factors for AP specifically in T2DM patients...
The Finnish Diabetes Risk Score is associated with insulin resistance but not reduced β-cell function, by classical and model-based estimatesK G Brodovicz
Epidemiology, Merck Research Laboratories, Merck Sharp and Dohme Corp, North Wales, PA 19454, USA
Diabet Med 28:1078-81. 2011..The aim of this analysis was to evaluate FINDRISC as a tool to characterize reduced β-cell function in individuals without known diabetes...
Characteristics of patients prescribed sitagliptin and other oral antihyperglycaemic agents in a large US claims databaseB Cai
Department of Epidemiology, Clinical Research, Merck Sharp and Dohme Corp, Whitehouse Station, NJ, USA
Int J Clin Pract 64:1601-8. 2010..Characteristics of patients with type 2 diabetes mellitus (T2DM) taking sitagliptin were compared with patients taking other oral antihyperglycaemic agents (OAHA) in a large US insurance claims database...
Health-related quality of life among patients with facial acne -- assessment of a new acne-specific questionnaireA R Martin
Department of Epidemiology, Merck Research Laboratories, West Point, Pennsylvania 19486, USA
Clin Exp Dermatol 26:380-5. 2001..The use of the Acne-QoL should aid physicians in understanding the impact of facial acne on young adults, and may be useful in assessing therapeutic effects in acne clinical trials...
Initial monotherapy with either metformin or sulphonylureas often fails to achieve or maintain current glycaemic goals in patients with Type 2 diabetes in UK primary careM N Cook
Department of Epidemiology, Merck Research Laboratories, West Point, PA 19486 0004, USA
Diabet Med 24:350-8. 2007..To describe initial achievement of glycaemic targets and subsequent hyperglycaemia in patients with Type 2 diabetes managed with oral agent monotherapy in UK primary care from 1998 to 2004...
The impact of osteoporosis on quality-of-life: the OFELY cohortA R Martin
Merck Research Laboratories, West Point, PA, USA
Bone 31:32-6. 2002..Recognition of the impact of Op-related factors on QoL may help health-care providers more fully appreciate the importance of prevention and treatment...
Development of a health-related quality of life questionnaire for women with androgenetic alopeciaK S Dolte
Department of Epidemiology, Merck Research Laboratories, Blue Bell, Pennsylvania, USA
Clin Exp Dermatol 25:637-42. 2000....
Non-high-density lipoprotein cholesterol and apolipoprotein B in the prediction of coronary heart disease in menTobias Pischon
Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
Circulation 112:3375-83. 2005....
Treatment escalation and rise in HbA1c following successful initial metformin therapyGregory A Nichols
Kaiser Permanente Center for Health Research, 3800 N Interstate Avenue, Portland, OR 97227 1098, USA
Diabetes Care 29:504-9. 2006..To describe secondary failure of initial metformin therapy in patients who achieved initial HbA(1c) (A1C) <8% and to identify predictors of failure...
Metabolic syndrome and cardiovascular disease in older people: The cardiovascular health studyAnn Marie McNeill
Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina 27514, USA
J Am Geriatr Soc 54:1317-24. 2006....
The metabolic syndrome and 11-year risk of incident cardiovascular disease in the atherosclerosis risk in communities studyAnn Marie McNeill
University of North Carolina, Chapel Hill, 137 E Franklin St, Chapel Hill, NC 28514, USA
Diabetes Care 28:385-90. 2005..To assess the magnitude of the association between the National Cholesterol Education Program's Third Adult Treatment Panel Report (ATP III) definition of the metabolic syndrome and cardiovascular disease (CVD)...
Contemporary analysis of secondary failure of successful sulfonylurea therapyGregory A Nichols
Kaiser Permanente Center for Health Research, Portland, Oregon 97227 1098, USA
Endocr Pract 13:37-44. 2007..To revise older estimates of secondary failure that may no longer describe the contemporary pattern of sulfonylurea (SU) monotherapy and to identify predictors of such failure...
Inflammation, the metabolic syndrome, and risk of coronary heart disease in women and menTobias Pischon
Department of Epidemiology, German Institute of Human Nutrition, Potsdam Rehbruecke, Arthur Scheunert Allee 114 116, 14558 Nuthetal, Germany
Atherosclerosis 197:392-9. 2008..This study examined whether inflammation adds to the prediction of coronary heart disease (CHD) beyond metabolic syndrome (MetS), and whether these associations differ between sexes...
An exploratory analysis of criteria for the metabolic syndrome and its prediction of long-term cardiovascular outcomes: the Hoorn studyCynthia J Girman
Department of Epidemiology, Merck Research Laboratories, West Point, PA 19486, USA
Am J Epidemiol 162:438-47. 2005....
Glycemic control continues to deteriorate after sulfonylureas are added to metformin among patients with type 2 diabetesMichael N Cook
Department of Epidemiology, Merck Research Laboratories, Merck, BL 1 7, P O Box 4, West Point, PA 19486 0004, USA
Diabetes Care 28:995-1000. 2005..To describe the course and predictors of glycemic control among patients with type 2 diabetes after sulfonylureas (SUs) are added to metformin (MF)...
Prevalence of coronary heart disease and carotid arterial thickening in patients with the metabolic syndrome (The ARIC Study)Ann Marie McNeill
Department of Epidemiology, University of North Carolina at Chapel Hill, 27514, USA
Am J Cardiol 94:1249-54. 2004..0001). Thus, MS was significantly associated with the presence of CHD and carotid intimal medial wall thickness. Identification of patients who have MS may provide opportunities to initiate CHD prevention strategies...
The metabolic syndrome and risk of major coronary events in the Scandinavian Simvastatin Survival Study (4S) and the Air Force/Texas Coronary Atherosclerosis Prevention Study (AFCAPS/TexCAPS)Cynthia J Girman
Departments of Epidemiology, Merck Research Laboratories, West Point, Pennsylvania 19486, USA
Am J Cardiol 93:136-41. 2004..It appears that the metabolic syndrome is associated with risk that is not entirely accounted for by traditional risk scoring paradigms...
Limitations of using outcomes in the placebo arm of a clinical trial of benign prostatic hyperplasia to quantify those in the communityRosebud O Roberts
Department of Health Sciences Research and Division of Epidemiology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Mayo Clin Proc 80:759-64. 2005..Extrapolation of findings from the placebo arm of clinical trials to describe the natural history of disease in community-dwelling men should be done with caution and appropriate recognition of limitations...
A population-based study of daily nonsteroidal anti-inflammatory drug use and prostate cancerRosebud O Roberts
Department of Health Sciences Research, Mayo Clinic, Rochester, Minn 55905, USA
Mayo Clin Proc 77:219-25. 2002..The stronger effect among older men suggests that NSAIDs may prevent the progression of prostate cancer from latent to clinical disease...
Concomitant longitudinal changes in frequency of and bother from lower urinary tract symptoms in community dwelling menAruna V Sarma
Department of Urology and Epidemiology, University of Michigan, Ann Abor, USA
J Urol 168:1446-52. 2002..However, there remain some men with increases in frequency who do not report similar increases in bother, possibly representing some component of adaptation or acceptance of worsening symptom severity with age...
Associations between diabetes and clinical markers of benign prostatic hyperplasia among community-dwelling Black and White menAruna V Sarma
Department of Urology, University of Michigan, Ann Arbor, Michigan, USA
Diabetes Care 31:476-82. 2008..The aim of this study was to examine associations between diabetes and clinical markers of benign prostatic hyperplasia (BPH) in community-dwelling white and black men aged 40-79 years...
Prevalence of prostatitis-like symptoms in a community based cohort of older menRosebud O Roberts
Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA
J Urol 168:2467-71. 2002..While pain measures may be useful in distinguishing between men with and without prostatitis-like symptoms, the urinary symptom and quality of life impact scores could partly reflect benign prostatic hyperplasia...
Frequency of sexual activity and prostatic health: fact or fairy tale?Steven J Jacobsen
Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic, Rochester, Minnesota 55905, USA
Urology 61:348-53. 2003....
Insulin-like growth factor I, insulin-like growth factor binding protein 3, and urologic measures of benign prostatic hyperplasiaRosebud O Roberts
Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic, Rochester, MN 55905, USA
Am J Epidemiol 157:784-91. 2003..72, 95% CI: 1.05, 2.82), after simultaneous adjustment for IGF-I and age, but not with other urologic measures. These data do not provide evidence for an association between benign prostatic hyperplasia and serum IGF-I...
Dropout in a longitudinal, cohort study of urologic disease in community menNaomi M Gades
Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
BMC Med Res Methodol 6:58. 2006..Factors associated with dropout were evaluated in a twelve-year community-based, prospective cohort study of urologic disease in men...
Association of anthropometric measures with the presence and progression of benign prostatic hyperplasiaJames P Burke
Division of Epidemiology, Mayo Clinic, Rochester, MN, USA
Am J Epidemiol 164:41-6. 2006..These data provide no evidence of a consistent significant relation between anthropometric measures and BPH...
Inverse association between prostate cancer and the use of calcium channel blockersJose D Debes
Department of Urology, Mayo Clinic, Rochester, Minnesota 55905, USA
Cancer Epidemiol Biomarkers Prev 13:255-9. 2004..64 (0.82-8.47) in men with a family history of prostate cancer (P = 0.006). These findings suggest an association between prostate cancer and daily use of calcium channel blockers that varies by family history of prostate cancer...
Correlations between longitudinal changes in transitional zone volume and measures of benign prostatic hyperplasia in a population-based cohortJennifer L St Sauver
Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
Eur Urol 50:105-11. 2006..CONCLUSION: Tracking changes in TZV over time may be unlikely to provide a good surrogate measure for the development of benign prostatic hyperplasia...
Association between dietary factors and plasma adiponectin concentrations in menTobias Pischon
Departments of Nutrition and Epidemiology, Harvard School of Public Health, Boston, MA, USA
Am J Clin Nutr 81:780-6. 2005..However, little is known about dietary predictors of plasma adiponectin concentrations in humans...
Effect of fracture on the health care use of nursing home residentsSheryl Zimmerman
Cecil G. Sheps Center for Health Services Research, The School of Social Work, University of North Carolina at Chapel Hill, 27599-3386, USA
Arch Intern Med 162:1502-8. 2002..For patients who fractured a hip, higher use decreased after 6 months, similar to community cohorts. Nursing home residents who visit the emergency department may warrant special screening for a fracture...
