Anima Ghosal

Summary

Affiliation: Merck Research Laboratories
Country: USA

Publications

  1. doi Characterization of human liver enzymes involved in the biotransformation of boceprevir, a hepatitis C virus protease inhibitor
    Anima Ghosal
    Drug Metabolism and Pharmacokinetics, Merck Research Laboratories, 2015 Galloping Hill Road, K 15 1945, Kenilworth, NJ 07033, USA
    Drug Metab Dispos 39:510-21. 2011
  2. ncbi Metabolism of loratadine and further characterization of its in vitro metabolites
    Anima Ghosal
    Pharmaceutical Sciences and Drug Metabolism, Schering Plough Research Institute, Kenilworth, New Jersey 07033, USA
    Drug Metab Lett 3:162-70. 2009
  3. ncbi Identification of human liver cytochrome P450 enzymes involved in biotransformation of vicriviroc, a CCR5 receptor antagonist
    Anima Ghosal
    Drug Metabolism and Pharmacokinetics, Schering Plough Research Institute, Kenilworth, NJ 07033, USA
    Drug Metab Dispos 35:2186-95. 2007
  4. ncbi Identification of human UDP-glucuronosyltransferase enzyme(s) responsible for the glucuronidation of ezetimibe (Zetia)
    Anima Ghosal
    Drug Metabolism and Pharmacokinetics, Schering Plough Research Institute, Kenilworth, New Jersey 07033, USA
    Drug Metab Dispos 32:314-20. 2004
  5. ncbi Identification of human UDP-glucuronosyltransferase enzyme(s) responsible for the glucuronidation of 3-hydroxydesloratadine
    Anima Ghosal
    Drug Metabolism and Pharmacokinetics, Schering Plough Research Institute, Kenilworth, New Jersey 07033, USA
    Biopharm Drug Dispos 25:243-52. 2004
  6. ncbi Identification of human liver cytochrome P450 enzymes responsible for the metabolism of lonafarnib (Sarasar)
    Anima Ghosal
    Drug Metabolism and Pharmacokinetics, Schering Plough Research Institute, 2015 Galloping Hill Rd, K 15 1945, Kenilworth, NJ 07033, USA
    Drug Metab Dispos 34:628-35. 2006
  7. ncbi Identification of unstable metabolites of Lonafarnib using liquid chromatography-quadrupole time-of-flight mass spectrometry, stable isotope incorporation and ion source temperature alteration
    Wei Tong
    Department of Drug Metabolism and Pharmacokinetics, Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA
    J Mass Spectrom 41:1430-41. 2006
  8. doi Identification of human liver cytochrome P450 enzymes involved in the metabolism of SCH 530348 (Vorapaxar), a potent oral thrombin protease-activated receptor 1 antagonist
    Anima Ghosal
    Drug Metabolism and Pharmacokinetics, Merck Research Laboratories, Kenilworth, New Jersey 07033, USA
    Drug Metab Dispos 39:30-8. 2011
  9. ncbi Identification of human UDP-glucuronosyltransferase enzyme(s) responsible for the glucuronidation of posaconazole (Noxafil)
    Anima Ghosal
    Drug Metabolism and Pharmacokinetics, Schering Plough Research Institute, Kenilworth, NJ 07033, USA
    Drug Metab Dispos 32:267-71. 2004
  10. doi A retention-time-shift-tolerant background subtraction and noise reduction algorithm (BgS-NoRA) for extraction of drug metabolites in liquid chromatography/mass spectrometry data from biological matrices
    Peijuan Zhu
    Drug Disposition, Pharmaceutical Sciences, Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033 1300, USA
    Rapid Commun Mass Spectrom 23:1563-72. 2009

Detail Information

Publications11

  1. doi Characterization of human liver enzymes involved in the biotransformation of boceprevir, a hepatitis C virus protease inhibitor
    Anima Ghosal
    Drug Metabolism and Pharmacokinetics, Merck Research Laboratories, 2015 Galloping Hill Road, K 15 1945, Kenilworth, NJ 07033, USA
    Drug Metab Dispos 39:510-21. 2011
    ....
  2. ncbi Metabolism of loratadine and further characterization of its in vitro metabolites
    Anima Ghosal
    Pharmaceutical Sciences and Drug Metabolism, Schering Plough Research Institute, Kenilworth, New Jersey 07033, USA
    Drug Metab Lett 3:162-70. 2009
    ..The relative abundance of CYP3A4 in the human liver exceeds that of CYP2C19 and CYP2D6 and therefore the contribution of CYP3A4 in the metabolism of loratadine should be major (approximately 70%)...
  3. ncbi Identification of human liver cytochrome P450 enzymes involved in biotransformation of vicriviroc, a CCR5 receptor antagonist
    Anima Ghosal
    Drug Metabolism and Pharmacokinetics, Schering Plough Research Institute, Kenilworth, NJ 07033, USA
    Drug Metab Dispos 35:2186-95. 2007
    ..CYP2C9 and CYP3A5 most likely play a minor role in the biotransformation of this compound. These enzymology data will provide guidance to design clinical studies to address any potential drug-drug interactions...
  4. ncbi Identification of human UDP-glucuronosyltransferase enzyme(s) responsible for the glucuronidation of ezetimibe (Zetia)
    Anima Ghosal
    Drug Metabolism and Pharmacokinetics, Schering Plough Research Institute, Kenilworth, New Jersey 07033, USA
    Drug Metab Dispos 32:314-20. 2004
    ..In conclusion, the formation of SCH 60663 is mediated via UGT1A1, UGT1A3, and UGT2B15, and the formation SCH 488128 is mediated via UGT2B7...
  5. ncbi Identification of human UDP-glucuronosyltransferase enzyme(s) responsible for the glucuronidation of 3-hydroxydesloratadine
    Anima Ghosal
    Drug Metabolism and Pharmacokinetics, Schering Plough Research Institute, Kenilworth, New Jersey 07033, USA
    Biopharm Drug Dispos 25:243-52. 2004
    ..The results from this study demonstrated that the in vitro formation of 3-hydroxydesloratadine-glucuronide from 3-hydroxydesloratadine was mediated via UGT1A1, UGT1A3 and UGT2B15 in human liver...
  6. ncbi Identification of human liver cytochrome P450 enzymes responsible for the metabolism of lonafarnib (Sarasar)
    Anima Ghosal
    Drug Metabolism and Pharmacokinetics, Schering Plough Research Institute, 2015 Galloping Hill Rd, K 15 1945, Kenilworth, NJ 07033, USA
    Drug Metab Dispos 34:628-35. 2006
    ..In conclusion, the formation of metabolites M1, M2, and M3 from lonafarnib was mediated via CYP3A4 and CYP3A5...
  7. ncbi Identification of unstable metabolites of Lonafarnib using liquid chromatography-quadrupole time-of-flight mass spectrometry, stable isotope incorporation and ion source temperature alteration
    Wei Tong
    Department of Drug Metabolism and Pharmacokinetics, Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA
    J Mass Spectrom 41:1430-41. 2006
    ..A and C readily interconvert through hydration/dehydration, and B and C through addition/elimination of methanol present in the sample-processing solvents. Finally, NMR experiments were performed to confirm the structures of A and C...
  8. doi Identification of human liver cytochrome P450 enzymes involved in the metabolism of SCH 530348 (Vorapaxar), a potent oral thrombin protease-activated receptor 1 antagonist
    Anima Ghosal
    Drug Metabolism and Pharmacokinetics, Merck Research Laboratories, Kenilworth, New Jersey 07033, USA
    Drug Metab Dispos 39:30-8. 2011
    ..These results suggest that CYP3A4 and CYP2J2 are both involved in the formation of M20 metabolite...
  9. ncbi Identification of human UDP-glucuronosyltransferase enzyme(s) responsible for the glucuronidation of posaconazole (Noxafil)
    Anima Ghosal
    Drug Metabolism and Pharmacokinetics, Schering Plough Research Institute, Kenilworth, NJ 07033, USA
    Drug Metab Dispos 32:267-71. 2004
    ..These results confirmed that the formation of major posaconazole-glucuronide produced from human liver microsomes was mediated via UGT1A4...
  10. doi A retention-time-shift-tolerant background subtraction and noise reduction algorithm (BgS-NoRA) for extraction of drug metabolites in liquid chromatography/mass spectrometry data from biological matrices
    Peijuan Zhu
    Drug Disposition, Pharmaceutical Sciences, Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033 1300, USA
    Rapid Commun Mass Spectrom 23:1563-72. 2009
    ..Data from these types of studies are critical to meet the latest FDA guidance on Metabolite in Safety Testing (MIST)...
  11. ncbi Rapid determination of enzyme activities of recombinant human cytochromes P450, human liver microsomes and hepatocytes
    Anima Ghosal
    Drug Metabolism and Pharmacokinetics, Schering Plough Research Institute, Kenilworth, New Jersey 07033, USA
    Biopharm Drug Dispos 24:375-84. 2003
    ..82), AMMC for CYP2D6 (r=0.83) and DBF for CYP3A4 (r=0.92). The fluorescent plate reader was found to be useful for the rapid assessment of CYP activities (positive control) in both intact cells and subcellular fractions...