Elena Fattori

Summary

Affiliation: Merck Research Laboratories
Country: USA

Publications

  1. ncbi Electro-gene-transfer: a new approach for muscle gene delivery
    Elena Fattori
    Dipartimento di Biologia Molecolare e Cellulare, Instituto di Ricerche di Biologia Molecolare, I R B M P Angeletti, Via Pontina Km 30, 600 00040 Pomezia, Roma, Italia
    Somat Cell Mol Genet 27:75-83. 2002
  2. doi ErbB2 genetic cancer vaccine in nonhuman primates: relevance of single nucleotide polymorphisms
    Elena Fattori
    Istituto di Ricerca di Biologia Molecolare, Via Pontina, Pomezia, Italy
    Hum Gene Ther 20:253-65. 2009
  3. ncbi Gene electro-transfer of an improved erythropoietin plasmid in mice and non-human primates
    Elena Fattori
    Istituto di Ricerche di Biologia Molecolare IRBM, Via Pontina Km 30 600, 00040 Pomezia Rome, Italy
    J Gene Med 7:228-36. 2005
  4. ncbi Efficient immunization of rhesus macaques with an HCV candidate vaccine by heterologous priming-boosting with novel adenoviral vectors based on different serotypes
    E Fattori
    Department of Molecular and Cellular Biololgy, Istituto di Ricerche di Biologia Molecolare P Angeletti, Pomezia, Rome, Italy
    Gene Ther 13:1088-96. 2006
  5. ncbi Modulation of the immune response induced by gene electrotransfer of a hepatitis C virus DNA vaccine in nonhuman primates
    Stefania Capone
    Istituto di Ricerche di Biologia Molecolare, P Angeletti, Rome, Italy
    J Immunol 177:7462-71. 2006
  6. doi Synergistic effect of gene-electro transfer and adjuvant cytokines in increasing the potency of hepatitis C virus genetic vaccination
    Mirko Arcuri
    Istituto di Ricerche di Biologia Molecolare P Angeletti IRBM, Pomezia, Rome, Italy
    J Gene Med 10:1048-54. 2008
  7. ncbi A T-cell HCV vaccine eliciting effective immunity against heterologous virus challenge in chimpanzees
    Antonella Folgori
    Istituto di Ricerche di Biologia Molecolare P Angeletti, via Pontina km30, 600, 00040 Pomezia, Rome, Italy
    Nat Med 12:190-7. 2006
  8. pmc Immunization against proprotein convertase subtilisin-like/kexin type 9 lowers plasma LDL-cholesterol levels in mice
    Elena Fattori
    Biotechnology Department, Istituto di Ricerche di Biologia Molecolare P Angeletti, I 00040 Pomezia Roma, Italy
    J Lipid Res 53:1654-61. 2012
  9. ncbi In vivo DNA gene electro-transfer: a systematic analysis of different electrical parameters
    Immacolata Zampaglione
    Istituto di Ricerche di Biologia Molecolare IRBM, Via Pontina Km 30 600, 00040 Pomezia Rome, Italy
    J Gene Med 7:1475-81. 2005
  10. ncbi Gene electro-transfer improves transduction by modifying the fate of intramuscular DNA
    Manuela Cappelletti
    Istituto di Ricerche di Biologia Molecolare P Angeletti, 00040 Pomezia Rome, Italy
    J Gene Med 5:324-32. 2003

Collaborators

  • Luigi Aurisicchio
  • Barbara Cipriani
  • Tong Ming Fu
  • John W Shiver
  • Yan G Ni
  • Immacolata Zampaglione
  • Gennaro Ciliberto
  • Mirko Arcuri
  • Manuela Cappelletti
  • Alfredo Nicosia
  • Stefania Capone
  • Antonella Folgori
  • Riccardo Cortese
  • Stefano Colloca
  • Nicola La Monica
  • Rosalba Tafi
  • Alessandra Vitelli
  • Monica Pezzanera
  • Lionello Ruggeri
  • Annalisa Meola
  • Bruno Bruni Ercole
  • Alessandra Luzzago
  • Stefania Lamartina
  • Gabriella Rizzuto
  • Carmela Mennuni
  • Claudia Santini
  • Armin Lahm
  • Elisabetta Sporeno
  • Lisa Kierstead
  • Janine Burns
  • Gemma Perretta
  • Odalys Gonzalez Paz
  • Giuseppe Roscilli
  • Adam J Simon
  • Ralph Laufer
  • Luisa Silvi
  • Danilo Casimiro
  • Cira Daniela Rinaudo
  • Carlo Toniatti
  • Hermann Bujard
  • Mary Ellen Davies
  • Francesco Calvaruso
  • Daniela Rinaudo
  • Ernesta Dammassa

Detail Information

Publications12

  1. ncbi Electro-gene-transfer: a new approach for muscle gene delivery
    Elena Fattori
    Dipartimento di Biologia Molecolare e Cellulare, Instituto di Ricerche di Biologia Molecolare, I R B M P Angeletti, Via Pontina Km 30, 600 00040 Pomezia, Roma, Italia
    Somat Cell Mol Genet 27:75-83. 2002
    ..We also summarize the results obtained with electro-gene-transfer in animal models to date and the technical issues that must be solved before its use for human therapy can be considered...
  2. doi ErbB2 genetic cancer vaccine in nonhuman primates: relevance of single nucleotide polymorphisms
    Elena Fattori
    Istituto di Ricerca di Biologia Molecolare, Via Pontina, Pomezia, Italy
    Hum Gene Ther 20:253-65. 2009
    ..Our findings are particularly relevant in the investigation of the impact of TAA polymorphisms on the efficacy of a cancer vaccine strategy...
  3. ncbi Gene electro-transfer of an improved erythropoietin plasmid in mice and non-human primates
    Elena Fattori
    Istituto di Ricerche di Biologia Molecolare IRBM, Via Pontina Km 30 600, 00040 Pomezia Rome, Italy
    J Gene Med 7:228-36. 2005
    ..Transduction can be improved in several animal models by application of electric pulses after DNA injection...
  4. ncbi Efficient immunization of rhesus macaques with an HCV candidate vaccine by heterologous priming-boosting with novel adenoviral vectors based on different serotypes
    E Fattori
    Department of Molecular and Cellular Biololgy, Istituto di Ricerche di Biologia Molecolare P Angeletti, Pomezia, Rome, Italy
    Gene Ther 13:1088-96. 2006
    ..The induced responses are broad and show significant cross-strain reactivity. Boosting can be delayed for over 2 years after priming, indicating that there is long-term maintenance of resting memory cells...
  5. ncbi Modulation of the immune response induced by gene electrotransfer of a hepatitis C virus DNA vaccine in nonhuman primates
    Stefania Capone
    Istituto di Ricerche di Biologia Molecolare, P Angeletti, Rome, Italy
    J Immunol 177:7462-71. 2006
    ..These data support the hypothesis that T cell responses elicited by the present strategy could be beneficial in prophylactic vaccine approaches against HCV...
  6. doi Synergistic effect of gene-electro transfer and adjuvant cytokines in increasing the potency of hepatitis C virus genetic vaccination
    Mirko Arcuri
    Istituto di Ricerche di Biologia Molecolare P Angeletti IRBM, Pomezia, Rome, Italy
    J Gene Med 10:1048-54. 2008
    ..This technology has been used to increase the production of therapeutic proteins, such as cytokines and growth factors, and to improve immunization efficiency following the injection of antigen-encoding plasmids...
  7. ncbi A T-cell HCV vaccine eliciting effective immunity against heterologous virus challenge in chimpanzees
    Antonella Folgori
    Istituto di Ricerche di Biologia Molecolare P Angeletti, via Pontina km30, 600, 00040 Pomezia, Rome, Italy
    Nat Med 12:190-7. 2006
    ....
  8. pmc Immunization against proprotein convertase subtilisin-like/kexin type 9 lowers plasma LDL-cholesterol levels in mice
    Elena Fattori
    Biotechnology Department, Istituto di Ricerche di Biologia Molecolare P Angeletti, I 00040 Pomezia Roma, Italy
    J Lipid Res 53:1654-61. 2012
    ..Our data support the IKD approach as an effective method to the rapid validation of new target proteins...
  9. ncbi In vivo DNA gene electro-transfer: a systematic analysis of different electrical parameters
    Immacolata Zampaglione
    Istituto di Ricerche di Biologia Molecolare IRBM, Via Pontina Km 30 600, 00040 Pomezia Rome, Italy
    J Gene Med 7:1475-81. 2005
    ..Intramuscular plasmid injection followed by electroporation is an efficient method for gene therapy or vaccination. Several protocols have been described that give good transduction levels with several reporter genes...
  10. ncbi Gene electro-transfer improves transduction by modifying the fate of intramuscular DNA
    Manuela Cappelletti
    Istituto di Ricerche di Biologia Molecolare P Angeletti, 00040 Pomezia Rome, Italy
    J Gene Med 5:324-32. 2003
    ..The molecular mechanisms underlying this increment in transduction efficiency are, however, still unclear...
  11. ncbi Construction of an rtTA2(s)-m2/tts(kid)-based transcription regulatory switch that displays no basal activity, good inducibility, and high responsiveness to doxycycline in mice and non-human primates
    Stefania Lamartina
    IRBM P Angeletti, Via Pontina Km 30, 600, 00040 Pomezia Rome, Italy
    Mol Ther 7:271-80. 2003
    ..Tight regulation of the gene encoding SEAP was demonstrated also in non-human primates. Notably, the system was induced in animals by Dox-dosing regimens comparable to those used in humans...
  12. ncbi Hyaluronidase increases electrogene transfer efficiency in skeletal muscle
    Carmela Mennuni
    Istituto di Ricerche di Biologia Molecolare P Angeletti, 00040 Pomezia, Italy
    Hum Gene Ther 13:355-65. 2002
    ..HYAse is used in a variety of clinical applications, and thus the combination of HYAse pretreatment and muscle EGT may constitute an efficient gene transfer method to achieve therapeutic levels of gene expression...