V D Ding
Affiliation: Merck Research Laboratories
- Sex hormone-binding globulin mediates prostate androgen receptor action via a novel signaling pathwayV D Ding
Department of Biochemistry and Physiology, Merck Research Laboratories, Rahway, New Jersey 07065, USA
Endocrinology 139:213-8. 1998....
- Regulation of insulin signal transduction pathway by a small-molecule insulin receptor activatorVictor D H Ding
Department of Molecular Endocrinology, Merck Research Laboratories, PO Box 2000, 126 East Lincoln Avenue, Rahway, NJ 07065, U S A
Biochem J 367:301-6. 2002..These results demonstrate that IR activators have implications for the future development of new therapeutic approaches to Type I and Type II diabetes...
- Discovery and investigation of a novel class of thiophene-derived antagonists of the human glucagon receptorJoseph L Duffy
Department of Basic Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA
Bioorg Med Chem Lett 15:1401-5. 2005..This SAR exploration resulted in the synthesis of 13, which exhibited good potency as an hGCGR functional antagonist (IC50 = 34 nM) and moderate bioavailability (36% in mice)...
- Direct observation (NMR) of the efficacy of glucagon receptor antagonists in murine liver expressing the human glucagon receptorSheila M Cohen
Department of Research Imaging, Merck Research Laboratories, Rahway, NJ 07065, USA
Bioorg Med Chem 14:1506-17. 2006..This technique does not provide adequate quantitative precision for the comparative ranking of active compounds, but does afford physiological evidence of efficacy in the early development of a chemical series of antagonists...