V D Ding

Summary

Affiliation: Merck Research Laboratories
Country: USA

Publications

  1. ncbi request reprint Sex hormone-binding globulin mediates prostate androgen receptor action via a novel signaling pathway
    V D Ding
    Department of Biochemistry and Physiology, Merck Research Laboratories, Rahway, New Jersey 07065, USA
    Endocrinology 139:213-8. 1998
  2. pmc Regulation of insulin signal transduction pathway by a small-molecule insulin receptor activator
    Victor D H Ding
    Department of Molecular Endocrinology, Merck Research Laboratories, PO Box 2000, 126 East Lincoln Avenue, Rahway, NJ 07065, U S A
    Biochem J 367:301-6. 2002
  3. ncbi request reprint Discovery and investigation of a novel class of thiophene-derived antagonists of the human glucagon receptor
    Joseph L Duffy
    Department of Basic Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA
    Bioorg Med Chem Lett 15:1401-5. 2005
  4. ncbi request reprint Direct observation (NMR) of the efficacy of glucagon receptor antagonists in murine liver expressing the human glucagon receptor
    Sheila M Cohen
    Department of Research Imaging, Merck Research Laboratories, Rahway, NJ 07065, USA
    Bioorg Med Chem 14:1506-17. 2006

Collaborators

Detail Information

Publications4

  1. ncbi request reprint Sex hormone-binding globulin mediates prostate androgen receptor action via a novel signaling pathway
    V D Ding
    Department of Biochemistry and Physiology, Merck Research Laboratories, Rahway, New Jersey 07065, USA
    Endocrinology 139:213-8. 1998
    ....
  2. pmc Regulation of insulin signal transduction pathway by a small-molecule insulin receptor activator
    Victor D H Ding
    Department of Molecular Endocrinology, Merck Research Laboratories, PO Box 2000, 126 East Lincoln Avenue, Rahway, NJ 07065, U S A
    Biochem J 367:301-6. 2002
    ..These results demonstrate that IR activators have implications for the future development of new therapeutic approaches to Type I and Type II diabetes...
  3. ncbi request reprint Discovery and investigation of a novel class of thiophene-derived antagonists of the human glucagon receptor
    Joseph L Duffy
    Department of Basic Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA
    Bioorg Med Chem Lett 15:1401-5. 2005
    ..This SAR exploration resulted in the synthesis of 13, which exhibited good potency as an hGCGR functional antagonist (IC50 = 34 nM) and moderate bioavailability (36% in mice)...
  4. ncbi request reprint Direct observation (NMR) of the efficacy of glucagon receptor antagonists in murine liver expressing the human glucagon receptor
    Sheila M Cohen
    Department of Research Imaging, Merck Research Laboratories, Rahway, NJ 07065, USA
    Bioorg Med Chem 14:1506-17. 2006
    ..This technique does not provide adequate quantitative precision for the comparative ranking of active compounds, but does afford physiological evidence of efficacy in the early development of a chemical series of antagonists...