Affiliation: Merck Research Laboratories
- Discovery and expanded SAR of 4,4-disubstituted quinazolin-2-ones as potent T-type calcium channel antagonistsKelly Ann S Schlegel
Department of Medicinal Chemistry, Merck and Co, Inc, West Point, PA 19486, USA
Bioorg Med Chem Lett 20:5147-52. 2010..In vivo, 45 suppressed seizure frequency in a rat model of absence epilepsy and showed significant alterations of sleep architecture after oral dosing to rats as measured by EEG...
- Pyridyl amides as potent inhibitors of T-type calcium channelsThomas S Reger
Department of Medicinal Chemistry, Merck Research Laboratories, West Point, PA 19486, USA
Bioorg Med Chem Lett 21:1692-6. 2011..Optimization of the screening hit 3 led to identification of the potent and selective T-type antagonist 37 that displayed in vivo efficacy in rodent models of epilepsy and sleep...