Rowena Cube

Summary

Affiliation: Merck Research Laboratories
Country: USA

Publications

  1. doi request reprint Discovery and expanded SAR of 4,4-disubstituted quinazolin-2-ones as potent T-type calcium channel antagonists
    Kelly Ann S Schlegel
    Department of Medicinal Chemistry, Merck and Co, Inc, West Point, PA 19486, USA
    Bioorg Med Chem Lett 20:5147-52. 2010
  2. doi request reprint Pyridyl amides as potent inhibitors of T-type calcium channels
    Thomas S Reger
    Department of Medicinal Chemistry, Merck Research Laboratories, West Point, PA 19486, USA
    Bioorg Med Chem Lett 21:1692-6. 2011

Collaborators

Detail Information

Publications2

  1. doi request reprint Discovery and expanded SAR of 4,4-disubstituted quinazolin-2-ones as potent T-type calcium channel antagonists
    Kelly Ann S Schlegel
    Department of Medicinal Chemistry, Merck and Co, Inc, West Point, PA 19486, USA
    Bioorg Med Chem Lett 20:5147-52. 2010
    ..In vivo, 45 suppressed seizure frequency in a rat model of absence epilepsy and showed significant alterations of sleep architecture after oral dosing to rats as measured by EEG...
  2. doi request reprint Pyridyl amides as potent inhibitors of T-type calcium channels
    Thomas S Reger
    Department of Medicinal Chemistry, Merck Research Laboratories, West Point, PA 19486, USA
    Bioorg Med Chem Lett 21:1692-6. 2011
    ..Optimization of the screening hit 3 led to identification of the potent and selective T-type antagonist 37 that displayed in vivo efficacy in rodent models of epilepsy and sleep...