Max Ciarlet

Summary

Affiliation: Merck Research Laboratories
Country: USA

Publications

  1. ncbi Vaccines: the pentavalent rotavirus vaccine: discovery to licensure and beyond
    Penny M Heaton
    Merck Research Laboratories, West Point, Pennsylvania, USA
    Clin Infect Dis 45:1618-24. 2007
  2. ncbi Concomitant use of the oral pentavalent human-bovine reassortant rotavirus vaccine and oral poliovirus vaccine
    Max Ciarlet
    Vaccine Biologics Clinical Research, Merck Research Laboratories, North Wales, PA 19454, USA
    Pediatr Infect Dis J 27:874-80. 2008
  3. ncbi Genomic characterization of a novel group A lamb rotavirus isolated in Zaragoza, Spain
    Max Ciarlet
    Vaccine and Biologics Clinical Research, Merck Research Laboratories, Mailstop UG3CD 28, P O Box 1000, North Wales, PA 19454 1099, USA
    Virus Genes 37:250-65. 2008
  4. ncbi Concomitant use of the 3-dose oral pentavalent rotavirus vaccine with a 3-dose primary vaccination course of a diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated polio-Haemophilus influenzae type b vaccine: immunogenicity and reactogenicity
    Max Ciarlet
    Vaccine Biologics Clinical Research, Merck Research Laboratories, North Wales, PA 19454, USA
    Pediatr Infect Dis J 28:177-81. 2009
  5. ncbi Development of a rotavirus vaccine: clinical safety, immunogenicity, and efficacy of the pentavalent rotavirus vaccine, RotaTeq
    Max Ciarlet
    Infectious Diseases and Vaccines Clinical Research Department, Merck Research Laboratories, North Wales, PA, USA
    Vaccine 27:G72-81. 2009
  6. ncbi Separation of rotavirus double-layered particles and triple-layered particles by capillary zone electrophoresis
    Pamela K Mathis
    Bioprocess and Bioanalytical Research, Merck Research Laboratories, West Point, PA 19486, USA
    J Virol Methods 169:13-21. 2010
  7. ncbi RotaTeq: Progress toward developing world access
    Michelle G Goveia
    Merck and Co, West Point, Pennsylvania 19486, USA
    J Infect Dis 202:S87-92. 2010
  8. ncbi A novel type of VP4 carried by a porcine rotavirus strain
    Ferdinando Liprandi
    Centro de Microbiologia y Biologia Celular, Instituto Venezolano de Investigaciones Cientificas, 21827 Caracas 1020 A, Venezuela
    Virology 315:373-80. 2003
  9. ncbi Detection of a porcine-like rotavirus in a child with enteritis in Italy
    Vito Martella
    Department of Public Health and Animal Sciences, University of Bari, Valenzano, Bari, Italy
    J Clin Microbiol 46:3501-7. 2008
  10. ncbi Initial interaction of rotavirus strains with N-acetylneuraminic (sialic) acid residues on the cell surface correlates with VP4 genotype, not species of origin
    Max Ciarlet
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Virol 76:4087-95. 2002

Detail Information

Publications22

  1. ncbi Vaccines: the pentavalent rotavirus vaccine: discovery to licensure and beyond
    Penny M Heaton
    Merck Research Laboratories, West Point, Pennsylvania, USA
    Clin Infect Dis 45:1618-24. 2007
    ..This report focuses on the safety and efficacy data from the late-phase studies of PRV and discusses plans for providing this vaccine to the developing world...
  2. ncbi Concomitant use of the oral pentavalent human-bovine reassortant rotavirus vaccine and oral poliovirus vaccine
    Max Ciarlet
    Vaccine Biologics Clinical Research, Merck Research Laboratories, North Wales, PA 19454, USA
    Pediatr Infect Dis J 27:874-80. 2008
    ..This open-label, multicenter study evaluated the immunogenicity and safety of coadministering oral poliovirus vaccine (OPV) with PRV...
  3. ncbi Genomic characterization of a novel group A lamb rotavirus isolated in Zaragoza, Spain
    Max Ciarlet
    Vaccine and Biologics Clinical Research, Merck Research Laboratories, Mailstop UG3CD 28, P O Box 1000, North Wales, PA 19454 1099, USA
    Virus Genes 37:250-65. 2008
    ..This is the first report of a lamb rotavirus with P[14] and G8 specificities, providing additional evidence for the wide genetic and antigenic diversity of group A rotaviruses...
  4. ncbi Concomitant use of the 3-dose oral pentavalent rotavirus vaccine with a 3-dose primary vaccination course of a diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated polio-Haemophilus influenzae type b vaccine: immunogenicity and reactogenicity
    Max Ciarlet
    Vaccine Biologics Clinical Research, Merck Research Laboratories, North Wales, PA 19454, USA
    Pediatr Infect Dis J 28:177-81. 2009
    ....
  5. ncbi Development of a rotavirus vaccine: clinical safety, immunogenicity, and efficacy of the pentavalent rotavirus vaccine, RotaTeq
    Max Ciarlet
    Infectious Diseases and Vaccines Clinical Research Department, Merck Research Laboratories, North Wales, PA, USA
    Vaccine 27:G72-81. 2009
    ..Additional studies in 8 different locations in the US have shown 85-95% reduction in rotavirus-associated hospitalizations and/or ED visits in the first 2-2.5 years of routine use...
  6. ncbi Separation of rotavirus double-layered particles and triple-layered particles by capillary zone electrophoresis
    Pamela K Mathis
    Bioprocess and Bioanalytical Research, Merck Research Laboratories, West Point, PA 19486, USA
    J Virol Methods 169:13-21. 2010
    ....
  7. ncbi RotaTeq: Progress toward developing world access
    Michelle G Goveia
    Merck and Co, West Point, Pennsylvania 19486, USA
    J Infect Dis 202:S87-92. 2010
    ..The RotaTeq Partnership with the Nicaraguan Ministry of Health provides an example of the successful introduction of this vaccine into a developing world country...
  8. ncbi A novel type of VP4 carried by a porcine rotavirus strain
    Ferdinando Liprandi
    Centro de Microbiologia y Biologia Celular, Instituto Venezolano de Investigaciones Cientificas, 21827 Caracas 1020 A, Venezuela
    Virology 315:373-80. 2003
    ..These results indicate that strain A34 should be considered as prototype of a new P genotype and serotype (P14[23]) and provide further evidence for the vast genetic and antigenic diversity of group A rotaviruses...
  9. ncbi Detection of a porcine-like rotavirus in a child with enteritis in Italy
    Vito Martella
    Department of Public Health and Animal Sciences, University of Bari, Valenzano, Bari, Italy
    J Clin Microbiol 46:3501-7. 2008
    ..The reassortant nature of the virus rules out a direct zoonotic event...
  10. ncbi Initial interaction of rotavirus strains with N-acetylneuraminic (sialic) acid residues on the cell surface correlates with VP4 genotype, not species of origin
    Max Ciarlet
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Virol 76:4087-95. 2002
    ....
  11. ncbi Full genome-based classification of rotaviruses reveals a common origin between human Wa-Like and porcine rotavirus strains and human DS-1-like and bovine rotavirus strains
    Jelle Matthijnssens
    Laboratory of Clinical and Epidemiological Virology, Department of Microbiology and Immunology, Rega Institute for Medical Research, Minderbroedersstraat 10, B 3000 Leuven, Belgium
    J Virol 82:3204-19. 2008
    ..These close evolutionary links between human and animal rotaviruses emphasize the need for close simultaneous monitoring of rotaviruses in animals and humans...
  12. ncbi Sequence analysis of the VP4, VP6, VP7, and NSP4 gene products of the bovine rotavirus WC3
    Max Ciarlet
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA
    Virus Genes 24:107-18. 2002
    ..In addition, the VP6 and VP7 of BRV WC3 were very similar to the VP6 and VP7 of both SG I and G6 BRV NCDV and UK strains. However, the NSP4 of BRV WC3 was more closely related to that BRV NCDV, the P6 prototype, than to that of BRV UK...
  13. ncbi Genetic heterogeneity in the VP7 of group C rotaviruses
    Vito Martella
    Department of Animal Health and Wellbeing, Faculty of Veterinary Medicine of Bari, Valenzano, Bari, Italy
    Virology 367:358-66. 2007
    ..These findings provide the need for future epidemiological surveys and warrant studies to investigate the pathogenic potential of these novel GCRVs in pigs...
  14. ncbi Immunogenicity and protective efficacy of rotavirus 2/6-virus-like particles produced by a dual baculovirus expression vector and administered intramuscularly, intranasally, or orally to mice
    Andrea Bertolotti-Ciarlet
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, BCM-385, Houston, TX 77030, USA
    Vaccine 21:3885-900. 2003
    ..The use of 2/6-VLPs expressed from a single recombinant baculovirus simplifies production and would reduce the cost of a VLP-based vaccine...
  15. ncbi Full genomic analysis of human rotavirus strain B4106 and lapine rotavirus strain 30/96 provides evidence for interspecies transmission
    Jelle Matthijnssens
    Laboratory of Clinical and Epidemiological Virology, Department of Microbiology and Immunology, Rega Institute for Medical Research, University of Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium
    J Virol 80:3801-10. 2006
    ..Altogether, these findings confirm that a rotavirus strain with an entirely lapine genome complement was able to infect and cause severe disease in a human child...
  16. ncbi Molecular characterization of the VP4, VP6, VP7, and NSP4 genes of lapine rotaviruses identified in italy: emergence of a novel VP4 genotype
    Vito Martella
    Department of Animal Health and Well Being, Faculty of Veterinary Medicine of Bari, Italy
    Virology 314:358-70. 2003
    ..This report confirms the worldwide genetic constellations of LRVs and identifies a novel VP4 genotype in rabbits, tentatively proposed as genotype P[22]...
  17. ncbi Relationships among porcine and human P[6] rotaviruses: evidence that the different human P[6] lineages have originated from multiple interspecies transmission events
    Vito Martella
    , , S.p. per Casamassima km 3, 70010 Valenzano, Bari, Italy
    Virology 344:509-19. 2006
    ....
  18. ncbi Evaluation of serum antibody responses against the rotavirus nonstructural protein NSP4 in children after rhesus rotavirus tetravalent vaccination or natural infection
    Esmeralda Vizzi
    Laboratorio de Biología de Virus, Centro de Microbiologia y Biologia Celular, Instituto Venezolano de Investigaciones Cientificas IVIC, Carretera Panamericana Km 11, Caracas, 1020 A, Edo Miranda, Venezuela
    Clin Diagn Lab Immunol 12:1157-63. 2005
    ..In addition, previous exposures to rotavirus did not affect the NSP4 seroconversion rate...
  19. ncbi Rotavirus viremia and extraintestinal viral infection in the neonatal rat model
    Sue E Crawford
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA
    J Virol 80:4820-32. 2006
    ....
  20. ncbi Rotavirus antigenaemia and viraemia: a common event?
    Sarah E Blutt
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA
    Lancet 362:1445-9. 2003
    ..We assessed whether rotavirus antigen, RNA, or both, were present in serum samples from immunocompetent rotavirus-infected children and animals...
  21. ncbi VLA-2 (alpha2beta1) integrin promotes rotavirus entry into cells but is not necessary for rotavirus attachment
    Max Ciarlet
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Virol 76:1109-23. 2002
    ..Therefore, VLA-2 is not involved in the initial attachment of rotavirus to cells but may play a role at a postattachment level...
  22. ncbi Group A rotavirus infection and age-dependent diarrheal disease in rats: a new animal model to study the pathophysiology of rotavirus infection
    Max Ciarlet
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Virol 76:41-57. 2002
    ....