Marcelo Bigal

Summary

Affiliation: Merck Research Laboratories
Country: USA

Publications

  1. doi request reprint Barriers to satisfactory migraine outcomes. What have we learned, where do we stand?
    Marcelo Bigal
    The Merck Research Laboratories, 1 Merck Drive, office WHS 3C26, Whitehouse Station, NJ 08889, USA
    Headache 49:1028-41. 2009
  2. pmc Migraine attacks the Basal Ganglia
    Nasim Maleki
    Department of Radiology, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Mol Pain 7:71. 2011
  3. ncbi request reprint Overuse of acute migraine medications and migraine chronification
    Marcelo E Bigal
    Merck Research Laboratories, Whitehouse Station, NJ 08889, USA
    Curr Pain Headache Rep 13:301-7. 2009
  4. ncbi request reprint Putative mechanisms of the relationship between obesity and migraine progression
    Marcelo E Bigal
    Global Director for Scientific Affairs, Merck Research Laboratories, Whitehouse Station, NJ 08889, USA
    Curr Pain Headache Rep 12:207-12. 2008
  5. ncbi request reprint Migraine in the triptan era: progresses achieved, lessons learned and future developments
    Marcelo E Bigal
    Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA
    Arq Neuropsiquiatr 67:559-69. 2009
  6. doi request reprint Excessive acute migraine medication use and migraine progression
    Marcelo E Bigal
    Merck Research Laboratories, Whitehouse Station, NJ 08889, USA
    Neurology 71:1821-8. 2008
  7. doi request reprint Weight change and clinical markers of cardiovascular disease risk during preventive treatment of migraine
    M E Bigal
    Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA
    Cephalalgia 29:1188-96. 2009
  8. pmc Migraine and cardiovascular disease: possible mechanisms of interaction
    M E Bigal
    Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA
    Neurology 72:1864-71. 2009
  9. doi request reprint The acute treatment of episodic and chronic migraine in the USA
    M E Bigal
    Merck Research Laboratories, Whitehouse Station, NJ 08889, USA
    Cephalalgia 29:891-7. 2009
  10. doi request reprint The epidemiology, burden, and comorbidities of migraine
    Marcelo E Bigal
    Merck Research Laboratories, 1 Merck Drive, Whitehouse Station, NJ 08889, USA
    Neurol Clin 27:321-34. 2009

Detail Information

Publications100

  1. doi request reprint Barriers to satisfactory migraine outcomes. What have we learned, where do we stand?
    Marcelo Bigal
    The Merck Research Laboratories, 1 Merck Drive, office WHS 3C26, Whitehouse Station, NJ 08889, USA
    Headache 49:1028-41. 2009
    ..We follow by addressing new barriers to migraine care that have emerged as a function of the knowledge gained in this process...
  2. pmc Migraine attacks the Basal Ganglia
    Nasim Maleki
    Department of Radiology, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Mol Pain 7:71. 2011
    ....
  3. ncbi request reprint Overuse of acute migraine medications and migraine chronification
    Marcelo E Bigal
    Merck Research Laboratories, Whitehouse Station, NJ 08889, USA
    Curr Pain Headache Rep 13:301-7. 2009
    ..While we await randomized trials, these findings should inform the choice of acute migraine treatments with the goal of reducing the risk of migraine progression to chronic migraine...
  4. ncbi request reprint Putative mechanisms of the relationship between obesity and migraine progression
    Marcelo E Bigal
    Global Director for Scientific Affairs, Merck Research Laboratories, Whitehouse Station, NJ 08889, USA
    Curr Pain Headache Rep 12:207-12. 2008
    ..In addition, we discuss the importance of metabolic syndrome and autonomic dysfunction in modulating the obesity/migraine progression relationship...
  5. ncbi request reprint Migraine in the triptan era: progresses achieved, lessons learned and future developments
    Marcelo E Bigal
    Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA
    Arq Neuropsiquiatr 67:559-69. 2009
    ..We then review the class of the triptans--mechanism of action and clinical evidence. We close by briefly discussing the class of CGRP receptor antagonists, which is currently being developed for the acute treatment of migraine...
  6. doi request reprint Excessive acute migraine medication use and migraine progression
    Marcelo E Bigal
    Merck Research Laboratories, Whitehouse Station, NJ 08889, USA
    Neurology 71:1821-8. 2008
    ..Accordingly, specific classes of medications are associated with migraine progression, and high frequency of headaches seems to be a risk factor for chronic migraine regardless of medication exposure...
  7. doi request reprint Weight change and clinical markers of cardiovascular disease risk during preventive treatment of migraine
    M E Bigal
    Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA
    Cephalalgia 29:1188-96. 2009
    ..0 vs. -1.3 mmHg) and high-density lipoprotein cholesterol (-3.7 vs. -0.8 mg/dl). Increased weight during migraine treatment is not associated with poor headache treatment outcomes, but is associated with deterioration of CVD risk markers...
  8. pmc Migraine and cardiovascular disease: possible mechanisms of interaction
    M E Bigal
    Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA
    Neurology 72:1864-71. 2009
    ..Ultimately, it will be important to determine whether MA is a modifiable risk factor for CVD and if preventive medications for migraine or antiplatelet therapy might reduce the risk of CVD in patients with MA...
  9. doi request reprint The acute treatment of episodic and chronic migraine in the USA
    M E Bigal
    Merck Research Laboratories, Whitehouse Station, NJ 08889, USA
    Cephalalgia 29:891-7. 2009
    ..For CM, > 34% use opiates or barbiturates. Accordingly, a sizable proportion use medications that are not firstline according to the US Headache Consortium Guidelines...
  10. doi request reprint The epidemiology, burden, and comorbidities of migraine
    Marcelo E Bigal
    Merck Research Laboratories, 1 Merck Drive, Whitehouse Station, NJ 08889, USA
    Neurol Clin 27:321-34. 2009
    ..For some such as depression, the association has been well described, but for others, the relationship has been recently suggested, such as in the case of clinical and subclinical vascular brain lesions and coronary heart disease...
  11. doi request reprint The triptans
    Marcelo E Bigal
    Merck Research Laboratories, Whitehouse Station, NJ 08889, USA
    Expert Rev Neurother 9:649-59. 2009
    ..We close with our view of the future and hopes for the next generation of antimigraine therapies...
  12. ncbi request reprint Malformations of cortical development
    Marilisa M Guerreiro
    Departamento de Neurologia, Faculdade de Ciencias Medicas, Universidade Estadual de Campinas, Campinas, SP, Brasil
    Arq Neuropsiquiatr 67:570-4. 2009
    ..The second part of this presentation will address the most important MCD. Finally, the last part of this presentation will address the correlation between MCD and epilepsy...
  13. doi request reprint Clinical course in migraine: conceptualizing migraine transformation
    Marcelo E Bigal
    Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA
    Neurology 71:848-55. 2008
    ..Herein we discuss the evidence that migraine may transform and then consider potential mechanisms as well as risk factors. We close with a brief discussion of clinical strategies that arise based on this perspective on migraine...
  14. doi request reprint What predicts the change from episodic to chronic migraine?
    Marcelo E Bigal
    Merck Research Laboratories, Merck, Inc, Whitehouse Station, New Jersey, USA
    Curr Opin Neurol 22:269-76. 2009
    ..Because migraine worsens in a sizeable subgroup of sufferers, but not in most, identifying factors that predict the change from episodic into chronic migraine is of extreme interest and should be seen as a priority in headache research...
  15. pmc Prevalence and characteristics of allodynia in headache sufferers: a population study
    M E Bigal
    Departments of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA
    Neurology 70:1525-33. 2008
    ..The authors estimated the prevalence and severity of cutaneous allodynia (CA) in individuals with primary headaches from the general population...
  16. pmc Occipital levels of GABA are related to severe headaches in migraine
    M E Bigal
    Departments of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA
    Neurology 70:2078-80. 2008
  17. ncbi request reprint The metabolic headaches
    Marcelo E Bigal
    Global Director for Scientific Affairs, Neuroscience, Merck Research Laboratories, One Merck Drive, PO Box 100, Whitehouse Station, NJ 08889, USA
    Curr Pain Headache Rep 12:292-5. 2008
    ..For each headache type, we discuss the clinical features and diagnosis, as well as therapeutic strategies...
  18. ncbi request reprint The paradoxical effects of analgesics and the development of chronic migraine
    Marcelo E Bigal
    Office of the Chief Medical Officer, Merck and Co, Inc, North Wales, PA 19454, USA
    Arq Neuropsiquiatr 69:544-51. 2011
    ..The concept of critical dose of exposure for different classes is presented and biological plausibility and putative mechanisms are reviewed...
  19. ncbi request reprint Migraine and cardiovascular disease
    Marcelo E Bigal
    Head of the Merck Investigator Studies Program, Scientific Education Group, Office of the Chief Medical Officer, Merck Inc, Upper Gwynedd, PA, USA
    Arq Neuropsiquiatr 69:122-9. 2011
    ..We follow by summarizing the evidence on the topic. We then briefly present the results of a recent meta-analysis. We close by highlighting results of a large epidemiological study conducted after the publication of the meta-analysis...
  20. doi request reprint Migraine chronification
    Marcelo E Bigal
    Head of the Merck Investigator Study Program and Scientific Education Group, Office of the Chief Medical Officer, Merck and Co, Inc, 351 North Sumneytown Pike, North Wales, PA 19454, USA
    Curr Neurol Neurosci Rep 11:139-48. 2011
    ....
  21. doi request reprint Chronic migraine in the population: burden, diagnosis, and satisfaction with treatment
    Marcelo E Bigal
    Merck Research Laboratories, 1 Merck Drive, Whitehouse Station, NJ 08889, USA
    Neurology 71:559-66. 2008
    ..To evaluate the disability profile and patterns of treatment and health care use for chronic migraine (CM) in the general population, in contrast to episodic migraine...
  22. ncbi request reprint Advances in the pharmacologic treatment of tension-type headache
    Marcelo E Bigal
    Global Director for Scientific Affairs, Merck Research Laboratories, Whitehouse Station, NJ 08889, USA
    Curr Pain Headache Rep 12:442-6. 2008
    ..We close by discussing potential future therapies, including calcitonin gene-related peptide receptor antagonism, as well as substance P and the nitric oxide pathways...
  23. pmc Migraine and cardiovascular disease: a population-based study
    M E Bigal
    1 Merck Dr, PO Box 100, Whitehouse Station, NJ 08889 0100, USA
    Neurology 74:628-35. 2010
    ..Herein we contrast the rate of diagnosed CVD as well as of risk factors for CVD in individuals with migraine with and without aura (MA and MO) and in controls...
  24. ncbi request reprint A randomized double-blind study comparing rizatriptan, dexamethasone, and the combination of both in the acute treatment of menstrually related migraine
    Marcelo Bigal
    Merck Research Laboratories, Whitehouse Station, NJ, USA
    Headache 48:1286-93. 2008
    ..To assess the efficacy and tolerability of rizatriptan (RI), dexamethasone (DE), and RI combined with DE (RI+DE) in the acute treatment of menstrually related migraine (MRM)...
  25. doi request reprint Topiramate treatment of chronic migraine: a randomized, placebo-controlled trial of quality of life and other efficacy measures
    Stephen Silberstein
    Thomas Jefferson University, Department of Neurology, Philadelphia, PA 19107, USA
    Headache 49:1153-62. 2009
    ..To define yet more clearly the utility of topiramate in the treatment of chronic migraine, we evaluated prespecified secondary endpoints from a recent randomized, double-blind, placebo-controlled, multicenter clinical trial...
  26. doi request reprint Key concepts of migraine postdrome: a qualitative study to develop a post-migraine questionnaire
    Daisy S Ng-Mak
    Epidemiology Department, Merck Sharp and Dohme Corp, North Wales, PA 19454, USA
    Headache 51:105-17. 2011
    ..To understand migraine postdrome by directly interviewing migraine patients with postdrome symptoms. To document these symptoms, as well as impacts, as a prelude to developing a postdrome migraine questionnaire...
  27. doi request reprint Migraine treatment with rizatriptan and almotriptan: a crossover study
    Daisy S Ng-Mak
    Epidemiology Department, Merck Research Laboratories, 351 North Sumneytown Pike, North Wales, PA, USA
    Headache 49:655-62. 2009
    ..Rizatriptan and almotriptan are effective and well-tolerated triptans that have not been compared directly...
  28. ncbi request reprint Memantine in the preventive treatment of refractory migraine
    Marcelo Bigal
    Merck Research Laboratories and the Albert Einstein College of Medicine Neurology, Bronx, New York, NY, USA
    Headache 48:1337-42. 2008
    ..To assess the efficacy and tolerability of memantine(MEM)in the preventive treatment of refractory migraine...
  29. ncbi request reprint Acetaminophen in the treatment of headaches associated with dipyridamole-aspirin combination
    R B Lipton
    Department of Neurology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Neurology 63:1099-101. 2004
    ..The headaches were self-limited (69.4% placebo efficacy in 2 hours) and the incidence markedly declined over time. Acetaminophen was no more effective than placebo in the acute and preemptive treatment of these headaches...
  30. ncbi request reprint Satisfaction with current migraine therapy: experience from 3 centers in US and Sweden
    Marcelo Bigal
    Albert Einstein College of Medicine Neurology, Bronx, NY 10461, USA
    Headache 47:475-9. 2007
    ..To assess the level of satisfaction and determinants of satisfaction or dissatisfaction of patients presenting in tertiary care, in regard to their usual care (UC) for the acute treatment of migraine...
  31. ncbi request reprint Migraine in adolescents: association with socioeconomic status and family history
    M E Bigal
    Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Neurology 69:16-25. 2007
    ..The influence of socioeconomic status on the prevalence of migraine is unknown in adolescents. Accordingly, we investigated the prevalence of migraine in a large sample of adolescents by sociodemographic features...
  32. ncbi request reprint Prevalence and impact of migraine and probable migraine in a health plan
    N V Patel
    AdvancePCS, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Neurology 63:1432-8. 2004
    ..A large number of headache sufferers with features of migraine fail to meet criteria for strict migraine (SM; migraine with or without aura) but do meet criteria for probable migraine (PM)...
  33. ncbi request reprint Patterns of medical diagnosis and treatment of migraine and probable migraine in a health plan
    M E Bigal
    Department of Neurology, Albert Einstein College of Medicine, Bronx, New York, NY, USA
    Cephalalgia 26:43-9. 2006
    ..Educational strategies should focus on physician education addressing diagnosing the full spectrum of migraine and physician management of migraine with specific migraine therapy in appropriate patients...
  34. ncbi request reprint Why headache treatment fails
    R B Lipton
    Department of Neurology, Albert Einstein College of Medicine, Bronx, NY10461, USA
    Neurology 60:1064-70. 2003
    ..Persistence in treating these patients can be very rewarding. The authors provide a checklist intended to facilitate the management of refractory patients...
  35. ncbi request reprint Clinical trials of acute treatments for migraine including multiple attack studies of pain, disability, and health-related quality of life
    R B Lipton
    Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Neurology 65:S50-8. 2005
    ..We consider clinical trials strategies designed to address the more complex clinical and policy requirements for meeting the needs of those with migraine...
  36. ncbi request reprint Intravenous dipyrone for the acute treatment of episodic tension-type headache: a randomized, placebo-controlled, double-blind study
    M E Bigal
    Departmet of Neurology, Albert Einstein School of Medicine, Bronx, NY, USA
    Braz J Med Biol Res 35:1139-45. 2002
    ..6%) for the dipyrone group. Intravenous dipyrone is an effective drug for the relief of pain in tension-type headache and its use is justified in the emergency room setting...
  37. ncbi request reprint Intravenous magnesium sulphate in the acute treatment of migraine without aura and migraine with aura. A randomized, double-blind, placebo-controlled study
    M E Bigal
    Department of Neurology, Sao Paulo University, School of Medicine at Ribeirao Preto, 3900, 14049 900 Ribeirao Preto, SP, Brazil
    Cephalalgia 22:345-53. 2002
    ..Our data support the idea that magnesium sulphate can be used for the treatment of all symptoms in migraine with aura, or as an adjuvant therapy for associated symptoms in patients with migraine without aura...
  38. ncbi request reprint Etiology and distribution of headaches in two Brazilian primary care units
    M E Bigal
    Department of Neurology, , , , SP, Brazil
    Headache 40:241-7. 2000
    ....
  39. ncbi request reprint Headache prevention outcome and body mass index
    M E Bigal
    Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA
    Cephalalgia 26:445-50. 2006
    ..Contrary to what we hypothesized, obesity at baseline does not seem to be related to follow-up refractoriness to preventive treatment...
  40. ncbi request reprint Chronic migraine is an earlier stage of transformed migraine in adults
    M E Bigal
    Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA
    Neurology 65:1556-61. 2005
    ..They are often classified as transformed migraine (TM), a disorder not addressed in the International Headache Society classification...
  41. ncbi request reprint Epilepsy and migraine
    M E Bigal
    Department of Neurology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Epilepsy Behav 4:S13-24. 2003
    ..We summarize the epidemiologic evidence that migraine and epilepsy are associated and discuss specific interrelationships between migraine and epilepsy...
  42. ncbi request reprint Probable migraine in the United States: results of the American Migraine Prevalence and Prevention (AMPP) study
    S Silberstein
    Jefferson Headache Center, Philadelphia, PA, USA
    Cephalalgia 27:220-34. 2007
    ..In contrast to migraine, which is less prevalent in African-Americans than in Whites, PM is more prevalent in African-Americans than in Whites. In the USA, many with PM do not receive adequate treatment...
  43. ncbi request reprint [Evaluation of placebo use in migraine without aura, migraine with aura and episodic tension-type headache acute attacks]
    M E Bigal
    Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, SP, Brasil
    Arq Neuropsiquiatr 59:552-8. 2001
    ..The mean of this relief, evaluated by the numerical pain scale, was 41.6%, 23.1% and 36%, respectively. Use of placebo is essential in evaluating the therapeutic role of drugs used in the treatment of acute headache...
  44. ncbi request reprint Zolmitriptan nasal spray in the acute treatment of cluster headache: a double-blind study
    A M Rapoport
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Neurology 69:821-6. 2007
    ..To evaluate the efficacy and tolerability of zolmitriptan 5 mg and 10 mg nasal spray (ZNS) vs placebo in the acute treatment of cluster headache. Design/..
  45. ncbi request reprint Migraine prevalence, disease burden, and the need for preventive therapy
    R B Lipton
    Department of Neurology, The Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Neurology 68:343-9. 2007
    ....
  46. ncbi request reprint Field testing alternative criteria for chronic migraine
    M E Bigal
    Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA
    Cephalalgia 26:477-82. 2006
    ..Consistently, criteria for CM and CM+ should be revised to require at least 8 days of migraine or probable migraine per month, in individuals with 15 or more days of headache per month...
  47. ncbi request reprint Double-blind clinical trials of oral triptans vs other classes of acute migraine medication - a review
    R B Lipton
    Department of Neurology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Cephalalgia 24:321-32. 2004
    ....
  48. ncbi request reprint Migraine practice patterns among neurologists
    R B Lipton
    Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Neurology 62:1926-31. 2004
    ..To assess the attitudes, knowledge, and practice patterns of US neurologists regarding migraine management relative to the US Headache Consortium Guidelines (the Guidelines)...
  49. ncbi request reprint MMPI personality profiles in patients with primary chronic daily headache: a case-control study
    M E Bigal
    Department of Neurology, Albert Einstein College of Medicine, Rousso Building, 1165 Morris Park Avenue, Bronx, NY 10461, USA
    Neurol Sci 24:103-10. 2003
    ....
  50. ncbi request reprint Classification of primary headaches
    R B Lipton
    Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461 1926, USA
    Neurology 63:427-35. 2004
    ..They conclude by presenting an approach to headache diagnosis based upon these criteria...
  51. ncbi request reprint Primary chronic daily headache and its subtypes in adolescents and adults
    M E Bigal
    Department of Neurology, Albert Einstein College of Medicine, 1165 Morris Park Avenue, Bronx, NY 10461, USA
    Neurology 63:843-7. 2004
    ..To determine the relative frequency of chronic daily headache (CDH) subtypes in adolescents and to compare the distribution of CDH subtypes in adolescents and adults of various ages...
  52. ncbi request reprint Preventive migraine therapy: what is new
    A M Rapoport
    Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Neurol Sci 25:S177-85. 2004
    ....
  53. ncbi request reprint Migraine headache disability and health-related quality-of-life: a population-based case-control study from England
    R B Lipton
    Department of Neurology, Albert Einstein College of Medicine, Bronx, New York, NY 10461, USA
    Cephalalgia 23:441-50. 2003
    ..Specifically, individuals classified with moderate to severe work-related disability had lower HRQoL scores than those classified with low disability...
  54. ncbi request reprint Patterns of health care utilization for migraine in England and in the United States
    R B Lipton
    Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Neurology 60:441-8. 2003
    ..To assess patterns of medical consultation, diagnosis, and medication use in representative samples of adults with migraine in England and the United States...
  55. doi request reprint New daily persistent headache in the paediatric population
    E Kung
    Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA
    Cephalalgia 29:17-22. 2009
    ..On most days, they had migraine-associated symptoms (one of nausea, photophobia or phonophobia)). NDPH is common in children and adolescents with CDH. Most subjects do not overuse medication. Migraine features are common...
  56. ncbi request reprint Opioid therapy and headache: a cause and a cure
    Richard B Lipton
    Neurology 62:1662-3. 2004
  57. pmc Cutaneous allodynia in the migraine population
    Richard B Lipton
    Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Ann Neurol 63:148-58. 2008
    ..To develop and validate a questionnaire for assessing cutaneous allodynia (CA), and to estimate the prevalence and severity of CA in the migraine population...
  58. ncbi request reprint Tension-type headache: classification and diagnosis
    Marcelo E Bigal
    Department of Neurology, Albert Einstein College of Medicine, 1165 Morris Park Avenue, Bronx, NY 10461, USA
    Curr Pain Headache Rep 9:423-9. 2005
    ..A structured approach to the patient and a better comprehension of this variability of presentation should translate into better quality of care and a more specific diagnosis for TTH sufferers...
  59. ncbi request reprint When migraine progresses: transformed or chronic migraine
    Marcelo E Bigal
    Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Expert Rev Neurother 6:297-306. 2006
    ..The risk factors for migraine progression and the mechanisms for progression will be discussed. This review concludes with the prospects for treating transformed migraine and avoiding migraine progression...
  60. doi request reprint Looking to the future: research designs for study of headache disease progression
    Richard B Lipton
    Department of Neurology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Headache 48:58-66. 2008
    ....
  61. doi request reprint Concepts and mechanisms of migraine chronification
    Marcelo E Bigal
    Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA
    Headache 48:7-15. 2008
    ..Research on this issue is in its infancy and cautions are necessary before extrapolating this information into clinical practice...
  62. ncbi request reprint Assessment of migraine disability using the migraine disability assessment (MIDAS) questionnaire: a comparison of chronic migraine with episodic migraine
    Marcelo E Bigal
    Department of Neurology, Albert Einstein College of Medicine, Office 334 A, Rousso Building, 1165 Morris Park Avenue, Bronx, NY 10461, USA
    Headache 43:336-42. 2003
    ..Chronic migraine is the most common type of chronic daily headache seen in headache tertiary care centers. Most patients with chronic migraine report their ability to function and feeling of well-being as severely impaired...
  63. doi request reprint Toward an epidemiology of refractory migraine: current knowledge and issues for future research
    Richard B Lipton
    Departments of Neurology and Epidemiology and Population Health, Albert Einstein College of Medicine, and The Montefiore Headache Center, Bronx, NY, USA
    Headache 48:791-8. 2008
    ..The epidemiology of these modifiers is discussed...
  64. doi request reprint Headache as a real disease
    Richard B Lipton
    Albert Einstein College of Medicine, Bronx, New York, USA
    Headache 48:707-10. 2008
    ..Drs. Lipton and Bigal examine the path to acceptance and the impediments that had to be overcome...
  65. ncbi request reprint Obesity and chronic daily headache
    Marcelo E Bigal
    Department of Neurology, Albert Einstein College of Medicine, 1165 Morris Park Avenue, Bronx, NY 10461, USA
    Curr Pain Headache Rep 12:56-61. 2008
    ..We then review the potential pathophysiologic mechanisms to support this relationship. We close by briefly discussing clinical interventions related to obesity and migraine...
  66. ncbi request reprint Obesity, migraine, and chronic migraine: possible mechanisms of interaction
    Marcelo E Bigal
    Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Neurology 68:1851-61. 2007
    ..Dysfunction in the orexins pathways seems to be a risk factor for both conditions. Finally, conditions that are comorbid to both states (e.g., depression, sleep apnea) may also make the relationship between both diseases more complex...
  67. ncbi request reprint Tools for diagnosing migraine and measuring its severity
    Richard B Lipton
    Department of Neurology, The Albert Einstein College of Medicine, Bronx, NY, USA
    Headache 44:387-98. 2004
    ..Migraine is assessed to determine how well it meets criteria for screening and the steps that are necessary before firm public policy recommendations for screening for migraine are possible...
  68. ncbi request reprint The medical management of migraine
    Marcelo E Bigal
    Department of Neurology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Am J Ther 11:130-40. 2004
    ..The clinicians have in their armamentariums an ever-expanding variety of medications. With experience, clinicians can match individual patient needs with the specific characteristics of a drug to optimize therapeutic benefit...
  69. ncbi request reprint The epidemiology and impact of migraine
    Marcelo E Bigal
    Department of Neurology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Curr Neurol Neurosci Rep 4:98-104. 2004
    ..Probable migraine is a prevalent form of migraine, and like migraine with and without aura it produces decrements in health-related quality of life and increments in disability relative to control subjects...
  70. ncbi request reprint [Menstrual headache: semiological study in 100 cases]
    Lineu Miziara
    Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, SP, Brasil
    Arq Neuropsiquiatr 61:596-600. 2003
    ..Nauseas and/or vomiting were the most frequent associated symptoms. Finally, we found, among the menstrual headaches, 9 cases of tension type headache, 2 cases of cervicogenic headache and 1 case of stabbing headache...
  71. ncbi request reprint Chronic daily headache: is analgesic overuse a cause or a consequence?
    Richard B Lipton
    Neurology 61:154-5. 2003
  72. ncbi request reprint The triptan formulations: a critical evaluation
    Marcelo E Bigal
    Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA
    Arq Neuropsiquiatr 61:313-20. 2003
    ....
  73. ncbi request reprint Naratriptan in the preventive treatment of refractory chronic migraine: a review of 27 cases
    Alan M Rapoport
    Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Headache 43:482-9. 2003
    ..To review the efficacy of naratriptan as preventive treatment in 27 patients with chronic migraine refractory to other commonly used preventive therapies...
  74. ncbi request reprint The clinical spectrum of migraine
    Alan M Rapoport
    Columbia University College of Physicians and Surgeons, New York, NY, USA
    Compr Ther 29:35-42. 2003
    ..A structured approach to the patient and a better comprehension of this variability of presentation, should translate into better quality of care for migraineurs...
  75. ncbi request reprint New developments in migraine prophylaxis
    Marcelo E Bigal
    Department of Neurology, Albert Einstein College of Medicine, New York, USA
    Expert Opin Pharmacother 4:433-43. 2003
    ..The aim of this review is to present and discuss the new options for migraine prevention...
  76. ncbi request reprint New migraine preventive options: an update with pathophysiological considerations
    Marcelo E Bigal
    New England Center for Headache, Stamfor, CT, USA
    Rev Hosp Clin Fac Med Sao Paulo 57:293-8. 2002
    ..The better knowledge about migraine pathophisiology led us to discuss new treatment options...
  77. ncbi request reprint Headache and hemodialysis: a prospective study
    Ana L Antoniazzi
    Department of Neurology, School of Medicine at Ribeirao Preto, Sao Paulo University, Brazil
    Headache 43:99-102. 2003
    ..To determine the prevalence and clinical characteristics of headache in patients undergoing hemodialysis and to compare the prevalence of headache prior to and following the beginning of a hemodialysis program...
  78. ncbi request reprint Chronic daily headache: identification of factors associated with induction and transformation
    Marcelo E Bigal
    Department of Neurology and Epidemiology, Albert Einstein College of Medicine, Bronx, New York, USA
    Headache 42:575-81. 2002
    ..The analysis of factors related to the transformation from episodic to chronic migraine (CM) and to the de novo development of new daily persistent headache (NDPH) remain poorly understood...
  79. ncbi request reprint Migraine with aura versus migraine without aura: pain intensity and associated symptom intensities after placebo
    Marcelo E Bigal
    Department of Neurology, Albert Einstein College of Medicine, Bronx, New York, USA
    Headache 42:872-7. 2002
    ..To compare the intensity of pain and associated symptoms after placebo administration in patients with migraine with aura and migraine without aura...
  80. ncbi request reprint Intravenous dipyrone in the acute treatment of migraine without aura and migraine with aura: a randomized, double blind, placebo controlled study
    Marcelo E Bigal
    Department of Neurology, Albert Einstein College of Medicine, Bronx, New York, USA
    Headache 42:862-71. 2002
    ..Dipyrone (Metamizol) has been used in the acute treatment of migraines in Brazil. Some investigators have found it to be a highly effective medication for migraine pain and associated symptoms...
  81. ncbi request reprint [Headache and hemodialysis: evaluation of the possible triggering factors and of the treatment]
    Ana L Antoniazzi
    Departamento de Neurologia, Hospital das Clinicas, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, SP, Brasil
    Arq Neuropsiquiatr 60:614-8. 2002
    ..The identification of possible triggering factors and further evaluations of the treatment might increase our knowledge and contribute to reduce the burden of the headaches in patients with chronic renal failure...
  82. ncbi request reprint Patterns of use of triptans and reasons for switching them in a tertiary care migraine population
    Fred D Sheftell
    Department of Psychiatry, New York Medical College, NY, USA
    Headache 44:661-8. 2004
    ..To assess the reasons for switching triptans within migraine patients presenting to a specialty clinic...
  83. ncbi request reprint Intranasal medications for the treatment of migraine and cluster headache
    Alan M Rapoport
    Columbia University College of Physicians and Surgeons, New York, NY, USA
    CNS Drugs 18:671-85. 2004
    ..Nevertheless, it is our opinion that nasal preparations increase therapeutic options and may result in faster response times and better efficacy than oral formulations and better patient satisfaction than injectable preparations...
  84. ncbi request reprint Botulinum neurotoxin type A in the preventive treatment of refractory headache: a review of 100 consecutive cases
    Stewart J Tepper
    The New England Center for Headache, Stamford, CT 06902, USA
    Headache 44:794-800. 2004
    ..To review the efficacy of botulinum neurotoxin type A (BoNT-A) in the preventive treatment of refractory headache...
  85. ncbi request reprint Ten lessons on the epidemiology of migraine
    Richard B Lipton
    Montefiore Headache Unit, Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Headache 47:S2-9. 2007
    ....
  86. ncbi request reprint Modifiable risk factors for migraine progression (or for chronic daily headaches)--clinical lessons
    Marcelo E Bigal
    Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Headache 46:S144-6. 2006
    ..These recommendations have not been demonstrated to improve outcomes in longitudinal studies...
  87. ncbi request reprint Obesity is a risk factor for transformed migraine but not chronic tension-type headache
    Marcelo E Bigal
    Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA
    Neurology 67:252-7. 2006
    ..To assess the influence of the body mass index (BMI) on the prevalence and severity of chronic daily headache (CDH) and its most frequent subtypes, transformed migraine (TM) and chronic tension-type headache (CTTH)...
  88. ncbi request reprint Medications associated with probable medication overuse headache reported in a tertiary care headache center over a 15-year period
    Chelsea A Meskunas
    Princeton University, Molecular Biology, NJ, USA
    Headache 46:766-72. 2006
    ..To evaluate the substances associated with medication overuse headache (MOH) in a headache center, over the course of the past 15 years...
  89. ncbi request reprint Side-locked headache as the chief complaint of inflammatory orbital pseudotumor (myositic form): a case report
    Abouch V Krymchantowski
    Headache Center of Rio, Rio de Janeiro, Brazil
    Headache 46:683-6. 2006
    ..After 5 months she developed orbital and eyelid edema, with painful restrictions to eye movement. Orbital MRI and pathological exam demonstrated inflammatory orbital pseudotumor (myositic form)...
  90. pmc Chronic disorders with episodic manifestations: focus on epilepsy and migraine
    Sheryl R Haut
    Comprehensive Epilepsy Management Center, Montefiore Medical Center and the Albert Einstein College of Medicine, Bronx, NY 10467 2490, USA
    Lancet Neurol 5:148-57. 2006
    ..This investigation draws attention to unique aspects of both epilepsy and migraine, while identifying areas of crossover in which each specialty could benefit from the experience of the other...
  91. ncbi request reprint Obesity and migraine: a population study
    Marcelo E Bigal
    Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA
    Neurology 66:545-50. 2006
    ..To assess the influence of body mass index (BMI) on the prevalence, attack frequency, and clinical features of migraine...
  92. ncbi request reprint Naratriptan in the preventive treatment of refractory transformed migraine: a prospective pilot study
    Fred D Sheftell
    The New England Center for Headache, College of Medicine, Stanford, CT, USA
    Headache 45:1400-6. 2005
    ..To assess the efficacy, safety, and tolerability of daily naratriptan in the preventive treatment of transformed migraine (TM) refractory to previous first line therapies...
  93. ncbi request reprint Comorbidity of migraine
    Ann I Scher
    Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    Curr Opin Neurol 18:305-10. 2005
    ..Thus, estimates of the burden of migraine often include the costs of conditions comorbid with it...
  94. ncbi request reprint Zolmitriptan (Zomig)
    Alan M Rapoport
    College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Expert Rev Neurother 4:33-41. 2004
    ..5-mg dose at early time points. The physician can now choose the optimum route of delivery of zolmitriptan to stop the headache, increase the likelihood of reducing disability and restore the patient to complete functionality...
  95. ncbi request reprint The epidemiology of migraine
    Richard B Lipton
    Department of Neurology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Am J Med 118:3S-10S. 2005
    ..However, prevalence is high in groups other than these high-risk groups. In a subgroup of patients, migraine may be a progressive disorder...
  96. ncbi request reprint New onset headache in a woman with recurrent ear infections
    Brian M Grosberg
    Montefiore Headache Unit, Albert Einstein College of Medicine, Bronx, NY, USA
    Headache 45:240-1. 2005
  97. ncbi request reprint Migraine: epidemiology, impact, and risk factors for progression
    Richard B Lipton
    Department of Neurology, Albert Einstein College of Medicine and Montefiore Headache Unit, Bronx, NY 10461, USA
    Headache 45:S3-S13. 2005
    ..Future epidemiologic studies should focus on identifying patients who are at higher risk for progression and on assessing the impact of intervention strategies on disease progression...
  98. ncbi request reprint Headache: triumphs in translational research
    Richard B Lipton
    Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA
    Lancet Neurol 4:11-2. 2005
  99. ncbi request reprint Multiple cranial neuropathies, headache, and facial pain in a septuagenarian
    Brian M Grosberg
    Albert Einstein College of Medicine, The Montefiore Headache Unit, Bronx, NY, USA
    Headache 44:1038-9. 2004
  100. ncbi request reprint [Efficacy of three drugs in the treatment of migrainous aura: a randomized placebo-controlled study]
    Marcelo E Bigal
    Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, SP, Brasil
    Arq Neuropsiquiatr 60:406-9. 2002
    ..Our findings make possible some speculations about the pathophysiology of migraine, as well as about the therapeutic approach of patients presenting migrainous aura...