Research Topics
| Matt S AndersonSummaryAffiliation: Merck Research Laboratories Country: USA Publications
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Publications
Conserved cytoplasmic motifs that distinguish sub-groups of the polyprenol phosphate:N-acetylhexosamine-1-phosphate transferase familyM S Anderson
Department of Chemistry, State University of New York College of Environmental Science and Forestry, Syracuse, NY 13210, USA
FEMS Microbiol Lett 191:169-75. 2000..Four diverse loops are apparent, for MraY, WecA, WbcO and RgpG, that uniquely characterize these sub-groups of the transferase family, and a correlation is evident with the known or implied UDP-sugar specificity...- Kinetic mechanism of the Escherichia coli UDPMurNAc-tripeptide D-alanyl-D-alanine-adding enzyme: use of a glutathione S-transferase fusionM S Anderson
Department of Enzymology, Merck Research Laboratories, Rahway, New Jersey 07065, USA
Biochemistry 35:16264-9. 1996..1990) J. Gen. Appl. Microbiol. 36, 179-187], raise the prospect that all of these enzymes will be found to proceed via this mechanism... 
Effect of raltegravir on the pharmacokinetics of methadoneMatt S Anderson
Merck and Co, Inc, Whitehouse Station, NJ, USA
J Clin Pharmacol 50:1461-6. 2010..Coadministration of raltegravir and methadone is generally well tolerated. Raltegravir has no clinically meaningful effect on methadone pharmacokinetics. No dose adjustment is required for methadone when coadministered with raltegravir...
Effect of raltegravir on estradiol and norgestimate plasma pharmacokinetics following oral contraceptive administration in healthy womenMatt S Anderson
Merck Research Labs, Merck and Co, Inc, Whitehouse Station, NJ 07065 0900, USA
Br J Clin Pharmacol 71:616-20. 2011....- Minimal pharmacokinetic interaction between the human immunodeficiency virus nonnucleoside reverse transcriptase inhibitor etravirine and the integrase inhibitor raltegravir in healthy subjectsMatt S Anderson
Department of Clinical Pharmacology, Merck and Co, Inc, RY34A 500, P O Box 2000, Rahway, NJ 07065, USA
Antimicrob Agents Chemother 52:4228-32. 2008..Coadministration of etravirine and raltegravir was generally well tolerated; the data suggest that no dose adjustment for either drug is necessary... - A high-throughput solid-phase extraction assay capable of measuring diverse polyprenyl phosphate: sugar-1-phosphate transferases as exemplified by the WecA, MraY, and MurG proteinsSheryl A Hyland
Department of Atherosclerosis and Endocrinology, Merck Research Laboratories, P O Box 2000, Rahway, NJ 07065, USA
Anal Biochem 317:156-65. 2003..Thus, the use of this flexible assay tool will allow a critical biochemical and enzymologic analysis of many such membrane-bound transferases in a similar setting... - 2-(4-carbonylphenyl)benzoxazole inhibitors of CETP: scaffold design and advancement in HDLc-raising efficacyRamzi F Sweis
Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA
Bioorg Med Chem Lett 21:1890-5. 2011..These efforts lead to the discovery of benzoxazole 11v, which raised HDLc by 24 mg/dl in our transgenic mouse PD model... - Design of a novel class of biphenyl CETP inhibitorsZhijian Lu
Department of Medicinal Chemistry, Merck Sharp and Dohme Corp, Rahway, NJ 07065, USA
Bioorg Med Chem Lett 20:7469-72. 2010..A new class of CETP inhibitors was designed and prepared. These compounds are potent both in vitro and in vivo. The most active compound (12d) has shown an ability to raise HDL significantly in transgenic mouse PD model... - 2-Arylbenzoxazoles as CETP inhibitors: Substitution of the benzoxazole moietyCameron J Smith
Department of Medicinal Chemistry, Merck Research Laboratories, Rahway NJ 07065, United States
Bioorg Med Chem Lett 20:346-9. 2010..Substitution at the 5- and 7-positions of the benzoxazole moiety was found to be beneficial for CETP inhibition. Compound 47 was found to be the most potent inhibitor in this series and inhibited CETP with an IC(50) of 28nM... - An ex vivo angiogenesis assay utilizing commercial porcine carotid artery: modification of the rat aortic ring assayJ Stiffey-Wilusz
Department of Endocrinology and Chemical Biology, Merck Research Laboratories, Rahway, New Jersey 07065, USA
Angiogenesis 4:3-9. 2001..The system should prove adaptable to other forms of angiogenic stimulation, ultimately making a variety of assays for angiogenesis available to laboratories of limited resources... - Conditionally lethal Escherichia coli murein mutants contain point defects that map to regions conserved among murein and folyl poly-gamma-glutamate ligases: identification of a ligase superfamilyS S Eveland
Department of Enzymology, Merck Research Laboratories, Rahway, New Jersey 07065, USA
Biochemistry 36:6223-9. 1997..These data argue that these proteins comprise a superfamily of three substrate amide ligases that share significant structural and catalytic homologies... - The envA permeability/cell division gene of Escherichia coli encodes the second enzyme of lipid A biosynthesis. UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylaseK Young
Department of Antibiotic Discovery and Development, Merck Research Laboratories, Rahway, New Jersey 07065, USA
J Biol Chem 270:30384-91. 1995..Thus, envA is the structural gene for UDP-3-O-acyl-GlcNAc deacetylase. Based on its function in lipid A biosynthesis, we propose the new designation lpxC for this gene... - The firA gene of Escherichia coli encodes UDP-3-O-(R-3-hydroxymyristoyl)-glucosamine N-acyltransferase. The third step of endotoxin biosynthesisT M Kelly
Department of Biochemistry, Merck Research Laboratories, Rahway, New Jersey 07065
J Biol Chem 268:19866-74. 1993..The N-acyltransferase displays absolute specificity for the R-3-OH moiety of R-3-hydroxymyristoyl-ACP, as does the O-acyltransferase, consistent with the placement of R-3-hydroxymyristate in E. coli lipid A... - Crystal structure of Escherichia coli UDPMurNAc-tripeptide d-alanyl-d-alanine-adding enzyme (MurF) at 2.3 A resolutionY Yan
Department of Structural Biology, West Point, PA, 19486, USA
J Mol Biol 304:435-45. 2000..As such, catalysis is not feasible and significant domain closure is expected upon substrate binding... - SAR studies on the central phenyl ring of substituted biphenyl oxazolidinone-potent CETP inhibitorsZhijian Lu
Department of Medicinal Chemistry, Merck Sharp and Dohme Corp, PO Box 2000, Rahway, NJ 07065, USA
Bioorg Med Chem Lett 22:199-203. 2012..Five of these new analogs raised HDL-C significantly (>20mg/dL). None of them however was better than anacetrapib in vivo. The synthesis and biological evaluation of these CETP inhibitors are described... - The cell wall and cell division gene cluster in the Mra operon of Pseudomonas aeruginosa: cloning, production, and purification of active enzymesB A Azzolina
Department of Biochemistry, Merck Research Laboratories, Rahway, New Jersey 07065, USA
Protein Expr Purif 21:393-400. 2001..The four recombinant P. aeruginosa Mur ligases, MurC, MurD, MurE, and MurF were overproduced in E. coli and purified as active enzymes... - UDP-N-acetylglucosamine acyltransferase of Escherichia coli. The first step of endotoxin biosynthesis is thermodynamically unfavorableM S Anderson
Department of Biochemistry, Merck Research Laboratories, Rahway, New Jersey 07065
J Biol Chem 268:19858-65. 1993..The specific activity of the deacetylase is elevated approximately 5-fold when lipid A synthesis is inhibited... - An Escherichia coli gene (FabZ) encoding (3R)-hydroxymyristoyl acyl carrier protein dehydrase. Relation to fabA and suppression of mutations in lipid A biosynthesisS Mohan
Department of Biochemistry, Merck Research Laboratories, Rahway, New Jersey 07065
J Biol Chem 269:32896-903. 1994..The orf17 gene (which we now designate fabZ) is not regulated by fadR. However, orf17 may be related to sefA, a suppressor of certain lesions in the cell division/lipid A biosynthesis gene, envA... - The effects of simvastatin on the pharmacokinectics of sitagliptinMichael Cerra
Merck Sharp and Dohme Corp, Whitehouse Station, NJ, UDA
J Popul Ther Clin Pharmacol 19:e356-60. 2012.... - Effect of the cholesteryl ester transfer protein inhibitor, anacetrapib, on lipoproteins in patients with dyslipidaemia and on 24-h ambulatory blood pressure in healthy individuals: two double-blind, randomised placebo-controlled phase I studiesRajesh Krishna
Merck and Co, Whitehouse Station, NJ, USA
Lancet 370:1907-14. 2007..We aimed to assess anacetrapib's effects as monotherapy on low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) and on 24-h ambulatory blood pressure... - Biphenyl-substituted oxazolidinones as cholesteryl ester transfer protein inhibitors: modifications of the oxazolidinone ring leading to the discovery of anacetrapibCameron J Smith
Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, New Jersey 07065, United States
J Med Chem 54:4880-95. 2011.... - Cloning, expression, and purification of UDP-3-O-acyl-GlcNAc deacetylase from Pseudomonas aeruginosa: a metalloamidase of the lipid A biosynthesis pathwayS A Hyland
Department of Enzymology, Merck Research Laboratories, Rahway, New Jersey 07065, USA
J Bacteriol 179:2029-37. 1997..The lpxC gene has no significant homology with amidase signature sequences. Therefore, we assign this protein to the metalloamidase family as a member with a novel structure... - Antibacterial agents that inhibit lipid A biosynthesisH R Onishi
Department of Microbiology, Merck Research Laboratories, Rahway, NJ 07065, USA
Science 274:980-2. 1996..coli... - 2-Arylbenzoxazoles as CETP inhibitors: substitution and modification of the alpha-alkoxyamide moietyJulianne A Hunt
Merck Research Laboratories, Rahway, NJ 07065, United States
Bioorg Med Chem Lett 20:1019-22. 2010.... - Farnesyl diphosphate synthetase. Molecular cloning, sequence, and expression of an essential gene from Saccharomyces cerevisiaeM S Anderson
Department of Chemistry, University of Utah, Salt Lake City 84112
J Biol Chem 264:19176-84. 1989..The gene for FPP synthetase resides on chromosome XI as judged from Southern blots of separated yeast chromosomes... - Cloning of human basic A1, a distinct 59-kDa dystrophin-associated protein encoded on chromosome 8q23-24A H Ahn
Program in Neuroscience, Harvard Medical School, Boston, MA 02115
Proc Natl Acad Sci U S A 91:4446-50. 1994..We have mapped the human basic component of A1 and EST25263 genes to chromosomes 8q23-24 and 16, respectively... - Regulation of UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase in Escherichia coli. The second enzymatic step of lipid a biosynthesisP G Sorensen
Department of Biochemistry, Duke University Medical Center, Durham, North Carolina 27710, USA
J Biol Chem 271:25898-905. 1996..The underacylated lipid A-like disaccharide precursors that accumulate during inhibition of Kdo formation may be sufficient to exert normal feedback control... - Biosynthesis of lipid A in Escherichia coli: identification of UDP-3-O-[(R)-3-hydroxymyristoyl]-alpha-D-glucosamine as a precursor of UDP-N2,O3-bis[(R)-3-hydroxymyristoyl]-alpha-D-glucosamineM S Anderson
Department of Biochemistry, College of Agricultural and Life Sciences, University of Wisconsin, Madison 53706
Biochemistry 27:1908-17. 1988..Our observations provide strong evidence that UDP-3-O-[(R)-3-hydroxymyristoyl]glucosamine is a true intermediate in the biosynthesis of UDP-2,3-diacyl-GlcN and lipid A... - Molecular cloning of the genes for lipid A disaccharide synthase and UDP-N-acetylglucosamine acyltransferase in Escherichia coliD N Crowell
J Bacteriol 168:152-9. 1986..Our data prove that lpxB and lpxA are transcribed in the clockwise direction and suggest that they may be cotranscribed... - Biosynthesis of lipid A precursors in Escherichia coli. A cytoplasmic acyltransferase that converts UDP-N-acetylglucosamine to UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamineM S Anderson
J Biol Chem 262:5159-69. 1987..coli leading either to lipid A or to peptidoglycan... - The biosynthesis of gram-negative endotoxin. Formation of lipid A precursors from UDP-GlcNAc in extracts of Escherichia coliM S Anderson
J Biol Chem 260:15536-41. 1985..No reaction is detected with fatty acyl-CoA or free fatty acid. The fatty acylation of sugar nucleotides has not been reported previously in E. coli or any other organism... - Isopentenyl diphosphate:dimethylallyl diphosphate isomerase. An improved purification of the enzyme and isolation of the gene from Saccharomyces cerevisiaeM S Anderson
Department of Chemistry, University of Utah, Salt Lake City 84112
J Biol Chem 264:19169-75. 1989..This is the first reported isolation of the gene for IPP isomerase...