Matt S Anderson

Summary

Affiliation: Merck Research Laboratories
Country: USA

Publications

  1. ncbi request reprint Conserved cytoplasmic motifs that distinguish sub-groups of the polyprenol phosphate:N-acetylhexosamine-1-phosphate transferase family
    M S Anderson
    Department of Chemistry, State University of New York College of Environmental Science and Forestry, Syracuse, NY 13210, USA
    FEMS Microbiol Lett 191:169-75. 2000
  2. pmc Minimal pharmacokinetic interaction between the human immunodeficiency virus nonnucleoside reverse transcriptase inhibitor etravirine and the integrase inhibitor raltegravir in healthy subjects
    Matt S Anderson
    Department of Clinical Pharmacology, Merck and Co, Inc, RY34A 500, P O Box 2000, Rahway, NJ 07065, USA
    Antimicrob Agents Chemother 52:4228-32. 2008
  3. ncbi request reprint Kinetic mechanism of the Escherichia coli UDPMurNAc-tripeptide D-alanyl-D-alanine-adding enzyme: use of a glutathione S-transferase fusion
    M S Anderson
    Department of Enzymology, Merck Research Laboratories, Rahway, New Jersey 07065, USA
    Biochemistry 35:16264-9. 1996
  4. pmc Effect of raltegravir on estradiol and norgestimate plasma pharmacokinetics following oral contraceptive administration in healthy women
    Matt S Anderson
    Merck Research Labs, Merck and Co, Inc, Whitehouse Station, NJ 07065 0900, USA
    Br J Clin Pharmacol 71:616-20. 2011
  5. doi request reprint Effect of raltegravir on the pharmacokinetics of methadone
    Matt S Anderson
    Merck and Co, Inc, Whitehouse Station, NJ, USA
    J Clin Pharmacol 50:1461-6. 2010
  6. ncbi request reprint A high-throughput solid-phase extraction assay capable of measuring diverse polyprenyl phosphate: sugar-1-phosphate transferases as exemplified by the WecA, MraY, and MurG proteins
    Sheryl A Hyland
    Department of Atherosclerosis and Endocrinology, Merck Research Laboratories, P O Box 2000, Rahway, NJ 07065, USA
    Anal Biochem 317:156-65. 2003
  7. doi request reprint 2-Arylbenzoxazoles as CETP inhibitors: Substitution of the benzoxazole moiety
    Cameron J Smith
    Department of Medicinal Chemistry, Merck Research Laboratories, Rahway NJ 07065, United States
    Bioorg Med Chem Lett 20:346-9. 2010
  8. doi request reprint Design of a novel class of biphenyl CETP inhibitors
    Zhijian Lu
    Department of Medicinal Chemistry, Merck Sharp and Dohme Corp, Rahway, NJ 07065, USA
    Bioorg Med Chem Lett 20:7469-72. 2010
  9. doi request reprint 2-(4-carbonylphenyl)benzoxazole inhibitors of CETP: scaffold design and advancement in HDLc-raising efficacy
    Ramzi F Sweis
    Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA
    Bioorg Med Chem Lett 21:1890-5. 2011
  10. ncbi request reprint An ex vivo angiogenesis assay utilizing commercial porcine carotid artery: modification of the rat aortic ring assay
    J Stiffey-Wilusz
    Department of Endocrinology and Chemical Biology, Merck Research Laboratories, Rahway, New Jersey 07065, USA
    Angiogenesis 4:3-9. 2001

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Conserved cytoplasmic motifs that distinguish sub-groups of the polyprenol phosphate:N-acetylhexosamine-1-phosphate transferase family
    M S Anderson
    Department of Chemistry, State University of New York College of Environmental Science and Forestry, Syracuse, NY 13210, USA
    FEMS Microbiol Lett 191:169-75. 2000
    ..Four diverse loops are apparent, for MraY, WecA, WbcO and RgpG, that uniquely characterize these sub-groups of the transferase family, and a correlation is evident with the known or implied UDP-sugar specificity...
  2. pmc Minimal pharmacokinetic interaction between the human immunodeficiency virus nonnucleoside reverse transcriptase inhibitor etravirine and the integrase inhibitor raltegravir in healthy subjects
    Matt S Anderson
    Department of Clinical Pharmacology, Merck and Co, Inc, RY34A 500, P O Box 2000, Rahway, NJ 07065, USA
    Antimicrob Agents Chemother 52:4228-32. 2008
    ..Coadministration of etravirine and raltegravir was generally well tolerated; the data suggest that no dose adjustment for either drug is necessary...
  3. ncbi request reprint Kinetic mechanism of the Escherichia coli UDPMurNAc-tripeptide D-alanyl-D-alanine-adding enzyme: use of a glutathione S-transferase fusion
    M S Anderson
    Department of Enzymology, Merck Research Laboratories, Rahway, New Jersey 07065, USA
    Biochemistry 35:16264-9. 1996
    ..1990) J. Gen. Appl. Microbiol. 36, 179-187], raise the prospect that all of these enzymes will be found to proceed via this mechanism...
  4. pmc Effect of raltegravir on estradiol and norgestimate plasma pharmacokinetics following oral contraceptive administration in healthy women
    Matt S Anderson
    Merck Research Labs, Merck and Co, Inc, Whitehouse Station, NJ 07065 0900, USA
    Br J Clin Pharmacol 71:616-20. 2011
    ....
  5. doi request reprint Effect of raltegravir on the pharmacokinetics of methadone
    Matt S Anderson
    Merck and Co, Inc, Whitehouse Station, NJ, USA
    J Clin Pharmacol 50:1461-6. 2010
    ..Coadministration of raltegravir and methadone is generally well tolerated. Raltegravir has no clinically meaningful effect on methadone pharmacokinetics. No dose adjustment is required for methadone when coadministered with raltegravir...
  6. ncbi request reprint A high-throughput solid-phase extraction assay capable of measuring diverse polyprenyl phosphate: sugar-1-phosphate transferases as exemplified by the WecA, MraY, and MurG proteins
    Sheryl A Hyland
    Department of Atherosclerosis and Endocrinology, Merck Research Laboratories, P O Box 2000, Rahway, NJ 07065, USA
    Anal Biochem 317:156-65. 2003
    ..Thus, the use of this flexible assay tool will allow a critical biochemical and enzymologic analysis of many such membrane-bound transferases in a similar setting...
  7. doi request reprint 2-Arylbenzoxazoles as CETP inhibitors: Substitution of the benzoxazole moiety
    Cameron J Smith
    Department of Medicinal Chemistry, Merck Research Laboratories, Rahway NJ 07065, United States
    Bioorg Med Chem Lett 20:346-9. 2010
    ..Substitution at the 5- and 7-positions of the benzoxazole moiety was found to be beneficial for CETP inhibition. Compound 47 was found to be the most potent inhibitor in this series and inhibited CETP with an IC(50) of 28nM...
  8. doi request reprint Design of a novel class of biphenyl CETP inhibitors
    Zhijian Lu
    Department of Medicinal Chemistry, Merck Sharp and Dohme Corp, Rahway, NJ 07065, USA
    Bioorg Med Chem Lett 20:7469-72. 2010
    ..A new class of CETP inhibitors was designed and prepared. These compounds are potent both in vitro and in vivo. The most active compound (12d) has shown an ability to raise HDL significantly in transgenic mouse PD model...
  9. doi request reprint 2-(4-carbonylphenyl)benzoxazole inhibitors of CETP: scaffold design and advancement in HDLc-raising efficacy
    Ramzi F Sweis
    Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA
    Bioorg Med Chem Lett 21:1890-5. 2011
    ..These efforts lead to the discovery of benzoxazole 11v, which raised HDLc by 24 mg/dl in our transgenic mouse PD model...
  10. ncbi request reprint An ex vivo angiogenesis assay utilizing commercial porcine carotid artery: modification of the rat aortic ring assay
    J Stiffey-Wilusz
    Department of Endocrinology and Chemical Biology, Merck Research Laboratories, Rahway, New Jersey 07065, USA
    Angiogenesis 4:3-9. 2001
    ..The system should prove adaptable to other forms of angiogenic stimulation, ultimately making a variety of assays for angiogenesis available to laboratories of limited resources...
  11. ncbi request reprint Crystal structure of Escherichia coli UDPMurNAc-tripeptide d-alanyl-d-alanine-adding enzyme (MurF) at 2.3 A resolution
    Y Yan
    Department of Structural Biology, West Point, PA, 19486, USA
    J Mol Biol 304:435-45. 2000
    ..As such, catalysis is not feasible and significant domain closure is expected upon substrate binding...
  12. ncbi request reprint Conditionally lethal Escherichia coli murein mutants contain point defects that map to regions conserved among murein and folyl poly-gamma-glutamate ligases: identification of a ligase superfamily
    S S Eveland
    Department of Enzymology, Merck Research Laboratories, Rahway, New Jersey 07065, USA
    Biochemistry 36:6223-9. 1997
    ..These data argue that these proteins comprise a superfamily of three substrate amide ligases that share significant structural and catalytic homologies...
  13. ncbi request reprint The envA permeability/cell division gene of Escherichia coli encodes the second enzyme of lipid A biosynthesis. UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase
    K Young
    Department of Antibiotic Discovery and Development, Merck Research Laboratories, Rahway, New Jersey 07065, USA
    J Biol Chem 270:30384-91. 1995
    ..Thus, envA is the structural gene for UDP-3-O-acyl-GlcNAc deacetylase. Based on its function in lipid A biosynthesis, we propose the new designation lpxC for this gene...
  14. ncbi request reprint The firA gene of Escherichia coli encodes UDP-3-O-(R-3-hydroxymyristoyl)-glucosamine N-acyltransferase. The third step of endotoxin biosynthesis
    T M Kelly
    Department of Biochemistry, Merck Research Laboratories, Rahway, New Jersey 07065
    J Biol Chem 268:19866-74. 1993
    ..The N-acyltransferase displays absolute specificity for the R-3-OH moiety of R-3-hydroxymyristoyl-ACP, as does the O-acyltransferase, consistent with the placement of R-3-hydroxymyristate in E. coli lipid A...
  15. doi request reprint SAR studies on the central phenyl ring of substituted biphenyl oxazolidinone-potent CETP inhibitors
    Zhijian Lu
    Department of Medicinal Chemistry, Merck Sharp and Dohme Corp, PO Box 2000, Rahway, NJ 07065, USA
    Bioorg Med Chem Lett 22:199-203. 2012
    ..Five of these new analogs raised HDL-C significantly (>20mg/dL). None of them however was better than anacetrapib in vivo. The synthesis and biological evaluation of these CETP inhibitors are described...
  16. ncbi request reprint The cell wall and cell division gene cluster in the Mra operon of Pseudomonas aeruginosa: cloning, production, and purification of active enzymes
    B A Azzolina
    Department of Biochemistry, Merck Research Laboratories, Rahway, New Jersey 07065, USA
    Protein Expr Purif 21:393-400. 2001
    ..The four recombinant P. aeruginosa Mur ligases, MurC, MurD, MurE, and MurF were overproduced in E. coli and purified as active enzymes...
  17. ncbi request reprint The effects of simvastatin on the pharmacokinectics of sitagliptin
    Michael Cerra
    Merck Sharp and Dohme Corp, Whitehouse Station, NJ, UDA
    J Popul Ther Clin Pharmacol 19:e356-60. 2012
    ....
  18. ncbi request reprint UDP-N-acetylglucosamine acyltransferase of Escherichia coli. The first step of endotoxin biosynthesis is thermodynamically unfavorable
    M S Anderson
    Department of Biochemistry, Merck Research Laboratories, Rahway, New Jersey 07065
    J Biol Chem 268:19858-65. 1993
    ..The specific activity of the deacetylase is elevated approximately 5-fold when lipid A synthesis is inhibited...
  19. ncbi request reprint An Escherichia coli gene (FabZ) encoding (3R)-hydroxymyristoyl acyl carrier protein dehydrase. Relation to fabA and suppression of mutations in lipid A biosynthesis
    S Mohan
    Department of Biochemistry, Merck Research Laboratories, Rahway, New Jersey 07065
    J Biol Chem 269:32896-903. 1994
    ..The orf17 gene (which we now designate fabZ) is not regulated by fadR. However, orf17 may be related to sefA, a suppressor of certain lesions in the cell division/lipid A biosynthesis gene, envA...
  20. doi request reprint Effects of Rifampin, a potent inducer of drug-metabolizing enzymes and an inhibitor of OATP1B1/3 transport, on the single dose pharmacokinetics of anacetrapib
    Matt S Anderson
    Merck Sharp and Dohme Corp, Whitehouse Station, NJ 07065, USA
    J Clin Pharmacol 53:746-52. 2013
    ....
  21. doi request reprint Biphenyl-substituted oxazolidinones as cholesteryl ester transfer protein inhibitors: modifications of the oxazolidinone ring leading to the discovery of anacetrapib
    Cameron J Smith
    Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, New Jersey 07065, United States
    J Med Chem 54:4880-95. 2011
    ....
  22. ncbi request reprint Effect of the cholesteryl ester transfer protein inhibitor, anacetrapib, on lipoproteins in patients with dyslipidaemia and on 24-h ambulatory blood pressure in healthy individuals: two double-blind, randomised placebo-controlled phase I studies
    Rajesh Krishna
    Merck and Co, Whitehouse Station, NJ, USA
    Lancet 370:1907-14. 2007
    ..We aimed to assess anacetrapib's effects as monotherapy on low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) and on 24-h ambulatory blood pressure...
  23. ncbi request reprint Antibacterial agents that inhibit lipid A biosynthesis
    H R Onishi
    Department of Microbiology, Merck Research Laboratories, Rahway, NJ 07065, USA
    Science 274:980-2. 1996
    ..coli...
  24. pmc Cloning, expression, and purification of UDP-3-O-acyl-GlcNAc deacetylase from Pseudomonas aeruginosa: a metalloamidase of the lipid A biosynthesis pathway
    S A Hyland
    Department of Enzymology, Merck Research Laboratories, Rahway, New Jersey 07065, USA
    J Bacteriol 179:2029-37. 1997
    ..The lpxC gene has no significant homology with amidase signature sequences. Therefore, we assign this protein to the metalloamidase family as a member with a novel structure...
  25. doi request reprint 2-Arylbenzoxazoles as CETP inhibitors: substitution and modification of the alpha-alkoxyamide moiety
    Julianne A Hunt
    Merck Research Laboratories, Rahway, NJ 07065, United States
    Bioorg Med Chem Lett 20:1019-22. 2010
    ....
  26. ncbi request reprint Regulation of UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase in Escherichia coli. The second enzymatic step of lipid a biosynthesis
    P G Sorensen
    Department of Biochemistry, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 271:25898-905. 1996
    ..The underacylated lipid A-like disaccharide precursors that accumulate during inhibition of Kdo formation may be sufficient to exert normal feedback control...
  27. pmc Cloning of human basic A1, a distinct 59-kDa dystrophin-associated protein encoded on chromosome 8q23-24
    A H Ahn
    Program in Neuroscience, Harvard Medical School, Boston, MA 02115
    Proc Natl Acad Sci U S A 91:4446-50. 1994
    ..We have mapped the human basic component of A1 and EST25263 genes to chromosomes 8q23-24 and 16, respectively...
  28. ncbi request reprint Farnesyl diphosphate synthetase. Molecular cloning, sequence, and expression of an essential gene from Saccharomyces cerevisiae
    M S Anderson
    Department of Chemistry, University of Utah, Salt Lake City 84112
    J Biol Chem 264:19176-84. 1989
    ..The gene for FPP synthetase resides on chromosome XI as judged from Southern blots of separated yeast chromosomes...
  29. ncbi request reprint Biosynthesis of lipid A in Escherichia coli: identification of UDP-3-O-[(R)-3-hydroxymyristoyl]-alpha-D-glucosamine as a precursor of UDP-N2,O3-bis[(R)-3-hydroxymyristoyl]-alpha-D-glucosamine
    M S Anderson
    Department of Biochemistry, College of Agricultural and Life Sciences, University of Wisconsin, Madison 53706
    Biochemistry 27:1908-17. 1988
    ..Our observations provide strong evidence that UDP-3-O-[(R)-3-hydroxymyristoyl]glucosamine is a true intermediate in the biosynthesis of UDP-2,3-diacyl-GlcN and lipid A...
  30. pmc Molecular cloning of the genes for lipid A disaccharide synthase and UDP-N-acetylglucosamine acyltransferase in Escherichia coli
    D N Crowell
    J Bacteriol 168:152-9. 1986
    ..Our data prove that lpxB and lpxA are transcribed in the clockwise direction and suggest that they may be cotranscribed...
  31. ncbi request reprint Biosynthesis of lipid A precursors in Escherichia coli. A cytoplasmic acyltransferase that converts UDP-N-acetylglucosamine to UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine
    M S Anderson
    J Biol Chem 262:5159-69. 1987
    ..coli leading either to lipid A or to peptidoglycan...
  32. ncbi request reprint The biosynthesis of gram-negative endotoxin. Formation of lipid A precursors from UDP-GlcNAc in extracts of Escherichia coli
    M S Anderson
    J Biol Chem 260:15536-41. 1985
    ..No reaction is detected with fatty acyl-CoA or free fatty acid. The fatty acylation of sugar nucleotides has not been reported previously in E. coli or any other organism...
  33. ncbi request reprint Isopentenyl diphosphate:dimethylallyl diphosphate isomerase. An improved purification of the enzyme and isolation of the gene from Saccharomyces cerevisiae
    M S Anderson
    Department of Chemistry, University of Utah, Salt Lake City 84112
    J Biol Chem 264:19169-75. 1989
    ..This is the first reported isolation of the gene for IPP isomerase...