H E Young
Affiliation: Mercer University
Young H, Duplaa C, Romero Ramos M, Chesselet M, Vourc H P, Yost M, et al
. Adult reserve stem cells and their potential for tissue engineering. Cell Biochem Biophys. 2004;40:1-80 pubmed
..Several model systems are currently being investigated to determine the possibilities of using these adult quiescent reserve precursor cells for tissue engineering. ..
Young H, Black A. Adult stem cells. Anat Rec A Discov Mol Cell Evol Biol. 2004;276:75-102 pubmed
..These reserve precursor cells provide for the continual maintenance and repair of the organism after birth. ..
Young H, Steele T, Bray R, Detmer K, Blake L, Lucas P, et al
. Human pluripotent and progenitor cells display cell surface cluster differentiation markers CD10, CD13, CD56, and MHC class-I. Proc Soc Exp Biol Med. 1999;221:63-71 pubmed
..Northern analysis revealed that CD13 and CD56 were actively transcribed at time of cell harvest. We report the first identification of CD10, CD13, CD56, and MHC Class-I cell surface antigens on these human cells. ..
Young H, Duplaa C, Young T, Floyd J, Reeves M, Davis K, et al
. Clonogenic analysis reveals reserve stem cells in postnatal mammals: I. Pluripotent mesenchymal stem cells. Anat Rec. 2001;263:350-60 pubmed
..This report demonstrates that clonal populations of reserve stem cells are present in mammals after birth. Potential roles for such cells in the maintenance, repair, and regeneration of mesodermal tissues are discussed. ..
Young H, Steele T, Bray R, Hudson J, Floyd J, Hawkins K, et al
. Human reserve pluripotent mesenchymal stem cells are present in the connective tissues of skeletal muscle and dermis derived from fetal, adult, and geriatric donors. Anat Rec. 2001;264:51-62 pubmed
..Flow cytometric analysis of adult stem cell populations revealed positive staining for CD34 and CD90 and negative staining for CD3, CD4, CD8, CD11c, CD33, CD36, CD38, CD45, CD117, Glycophorin-A, and HLA DR-II. ..
Young H. Existence of reserve quiescent stem cells in adults, from amphibians to humans. Curr Top Microbiol Immunol. 2004;280:71-109 pubmed
..e., lineage-committed progenitor stem cells and lineage-uncommitted pluripotent stem cells, resident within the connective tissues could provide for the continual maintenance and repair of the postnatal organism after birth. ..
Young H, Duplaa C, Yost M, Henson N, Floyd J, Detmer K, et al
. Clonogenic analysis reveals reserve stem cells in postnatal mammals. II. Pluripotent epiblastic-like stem cells. Anat Rec A Discov Mol Cell Evol Biol. 2004;277:178-203 pubmed
..This study suggests that embryonic-like stem cells are retained within postnatal mammals and have the potential for use in gene therapy and tissue engineering. ..