Research Topics
| M W JannSummaryAffiliation: Mercer University Country: USA Publications
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Detail Information
Publications
Influence of ritonavir on olanzapine pharmacokinetics in healthy volunteersScott R Penzak
Department of Pharmacy Practice, Mercer University, Southern School of Pharmacy, Atlanta, Georgia, USA
J Clin Psychopharmacol 22:366-70. 2002..001) after ritonavir. Ritonavir significantly reduced the systemic exposure of olanzapine in volunteers. Patients receiving this combination may ultimately require higher olanzapine doses to achieve desired therapeutic effects...
Lack of pharmacokinetic interaction between lamotrigine and olanzapine in healthy volunteersMichael W Jann
Department of Clinical and Administrative Sciences, Mercer University, Southern School of Pharmacy, Atlanta, Georgia 30341, USA
Pharmacotherapy 26:627-33. 2006..When prescribing high doses of olanzapine and lamotrigine for bipolar disorder, patients must be carefully monitored...
Lack of a pharmacokinetic drug-drug interaction with venlafaxine extended-release/indinavir and desvenlafaxine extended-release/indinavirMichael W Jann
Mercer University College of Pharmacy and Health Sciences, 3001 Mercer University Dr, Atlanta, GA 30341, USA
Eur J Clin Pharmacol 68:715-21. 2012..To assess the effects of venlafaxine extended-release (XR) capsules and desvenlafaxine extended-release (XR) tablets upon indinavir pharmacokinetic properties when co-administrated to healthy volunteers...
Advanced strategies for treatment of Parkinson's disease: the role of early treatmentMichael W Jann
Department of Pharmacy Practice, College of Pharmacy and Health Sciences, Mercer University, Atlanta, GA, USA
Am J Manag Care 17:S315-21. 2011..It appears that early treatment with the MAO-B inhibitor rasagiline (1 mg), as compared with late treatment, delays the onset of worsened UPDRS score, especially the nonmotor activities of daily living subscore...
Antidepressant agents for the treatment of chronic pain and depressionMichael W Jann
Department of Pharmacy Practice, Mercer University College of Pharmacy and Health Sciences, 3001 Mercer University Drive, Atlanta, GA 30341, USA
Pharmacotherapy 27:1571-87. 2007..Their extended use into chronic pain, depression with physical pain, physical pain with or without depression, and other potential medical conditions should be recognized...
Implications for atypical antipsychotics in the treatment of schizophrenia: neurocognition effects and a neuroprotective hypothesisMichael W Jann
Department of Clinical and Administrative Sciences, Southern School of Pharmacy, Mercer University, Atlanta, Georgia 30341, USA
Pharmacotherapy 24:1759-83. 2004..A neurodevelopmental model of cognitive impairment in schizophrenia aids in understanding why atypical antipsychotics improve cognitive symptoms...
Clinical significance of drug binding, protein binding, and binding displacement drug interactionsMichael W Jann
Departments of Clinical and Administratives Sciences, Mercer University, Atlanta, Georgia, USA
Psychopharmacol Bull 36:22-41. 2002..Additional studies are needed to examine the optimal methods for switching patients from one atypical agent to another atypical antipsychotic...
Pharmacology and clinical efficacy of cholinesterase inhibitorsM W Jann
Pharmacy Practice and Pharmaceutical Sciences, Mercer University Southern School of Pharmacy, Atlanta, GA 30341, USA
Am J Health Syst Pharm 55:S22-5. 1998..Although ChEIs generally improve cognition in patients with AD, differences among these medications are substantial in some cases and should be thoroughly considered by clinicians...
Clinical pharmacokinetics and pharmacodynamics of cholinesterase inhibitorsMichael W Jann
Department of Clinical and Administrative Sciences, Southern School of Pharmacy, Mercer University, Atlanta, Georgia 30341, USA
Clin Pharmacokinet 41:719-39. 2002..The increased information available to clinicians can optimise the use of these agents in the management of patients with Alzheimer's disease...
Pharmacokinetics of fluvoxamine in relation to CYP2C19 phenotype and genotypeMichael W Jan
Department of Pharmacy Practice and Pharmaceutical Sciences, Mercer University, Southern School of Pharmacy, Atlanta, GA 30341, USA
Drug Metabol Drug Interact 19:1-11. 2002..To evaluate the pharmacokinetics of fluvoxamine (FLV) in poor metabolizers (PMs) versus extensive metabolizers (EMs) of cytochrome P450 (CYP)2C19...
Effect of thioridazine on gap junction intercellular communication in connexin 43-expressing cellsD F Matesic
Southern School of Pharmacy, Mercer University, Atlanta, Georgia, USA
Cell Biol Toxicol 22:257-68. 2006....
Altered methylprednisolone pharmacodynamics in healthy subjects with histamine N-methyltransferase C314T genetic polymorphismYuen Yi Hon
Department of Clinical and Administrative Sciences, Mercer University Southern School of Pharmacy, Atlanta, Georgia, USA
J Clin Pharmacol 46:408-17. 2006..031 and .033, respectively, Wilcoxon rank sum test). Subjects who are heterozygous for the T314 variant allele thus appeared less sensitive to the suppressive effects of methylprednisolone on cortisol secretion...
Disposition of D-serine in healthy adultsGuochuan E Tsai
Department of Psychiatry, Harbor-UCLA Medical Center, F9, 1000 W. Carson Street, Torrance, CA 90509, USA
J Clin Pharmacol 48:524-7. 2008
Dosing strategies of clozapine-fluvoxamine cotreatmentMong-Liang Lu
J Clin Psychopharmacol 22:626-8. 2002
Dose-dependent alternations in the pharmacokinetics of olanzapine during coadministration of fluvoxamine in patients with schizophreniaChih-Chiang Chiu
Laboratory of Biological Psychiatry, Taipei City Psychiatric Center, Taipei, Taiwan
J Clin Pharmacol 44:1385-90. 2004..Presumably, altered olanzapine pharmacokinetics are attributed to the inhibition of CYP1A2. Patients treated with the combination of olanzapine and fluvoxamine should be monitored carefully...
Correlation of cytochrome P450 (CYP) 1A2 activity using caffeine phenotyping and olanzapine disposition in healthy volunteersKara Lee Shirley
Albany College of Pharmacy, Albany, NY, USA
Neuropsychopharmacology 28:961-6. 2003..Interpatient variability in CYP1A2 activity may explain the wide interpatient variability in olanzapine disposition. Compounds that modulate CYP1A2 activity may be expected to alter olanzapine pharmacokinetics accordingly...
Endogenous histamine and cortisol levels in subjects with different histamine N-methyltransferase C314T genotypes : a pilot studyYuen Yi Hon
Department of Clinical and Administrative Sciences, Mercer University Southern School of Pharmacy, Atlanta, Georgia, USA
Mol Diagn Ther 10:109-14. 2006....
