C C Bridges

Summary

Affiliation: Mercer University
Country: USA

Publications

  1. pmc System b0,+ and the transport of thiol-s-conjugates of methylmercury
    Christy C Bridges
    Mercer University School of Medicine, 1550 College Street, Macon, GA 31207, USA
    J Pharmacol Exp Ther 319:948-56. 2006
  2. pmc Glutathione status and the renal elimination of inorganic mercury in the Mrp2(-/-) mouse
    Christy C Bridges
    Mercer University School of Medicine, Division of Basic Medical Sciences, Macon, Georgia, United States of America
    PLoS ONE 8:e73559. 2013
  3. pmc Aging and the disposition and toxicity of mercury in rats
    Christy C Bridges
    Mercer University School of Medicine, Division of Basic Medical Sciences, Macon, GA 31207, United States Electronic address
    Exp Gerontol 53:31-9. 2014
  4. pmc Placental and fetal disposition of mercuric ions in rats exposed to methylmercury: role of Mrp2
    Christy C Bridges
    Mercer University School of Medicine, Division of Basic Medical Sciences, Macon, GA 31207, United States
    Reprod Toxicol 34:628-34. 2012
  5. pmc Transport of thiol-conjugates of inorganic mercury in human retinal pigment epithelial cells
    Christy C Bridges
    Division of Basic Medical Sciences, Mercer University School of Medicine, Macon, GA 31207, USA
    Toxicol Appl Pharmacol 221:251-60. 2007
  6. pmc Multidrug resistance proteins and the renal elimination of inorganic mercury mediated by 2,3-dimercaptopropane-1-sulfonic acid and meso-2,3-dimercaptosuccinic acid
    Christy C Bridges
    Mercer University School of Medicine, Division of Basic Medical Sciences, 1550 College Street, Macon, GA 31207, USA
    J Pharmacol Exp Ther 324:383-90. 2008
  7. pmc MRP2 and the DMPS- and DMSA-mediated elimination of mercury in TR(-) and control rats exposed to thiol S-conjugates of inorganic mercury
    Christy C Bridges
    Mercer University School of Medicine, Division of Basic Medical Sciences, Macon, Georgia 31207, USA
    Toxicol Sci 105:211-20. 2008
  8. pmc Effect of DMPS and DMSA on the placental and fetal disposition of methylmercury
    C C Bridges
    Division of Basic Medical Sciences, Mercer University School of Medicine, 1550 College Street, Macon, GA 31207, USA
    Placenta 30:800-5. 2009
  9. doi request reprint Transport of inorganic mercury and methylmercury in target tissues and organs
    Christy C Bridges
    Division of Basic Medical Sciences, Mercer University School of Medicine, Macon, Georgia 31207, USA
    J Toxicol Environ Health B Crit Rev 13:385-410. 2010
  10. pmc MRP2 and the handling of mercuric ions in rats exposed acutely to inorganic and organic species of mercury
    Christy C Bridges
    Mercer University School of Medicine, Division of Basic Medical Sciences, 1550 College St, Macon, GA 31207, USA
    Toxicol Appl Pharmacol 251:50-8. 2011

Research Grants

Collaborators

  • RUDOLFS ZALUPS
  • Francois Verrey
  • Fatima Martel
  • Sylvia B Smith
  • Takahiro Hatanaka
  • Vadivel Ganapathy
  • Elisa Keating
  • Seiji Miyauchi
  • Malliga E Ganapathy
  • Huankai Hu
  • Wei Huang
  • Hany Naggar
  • Pedro Goncalves
  • Fernanda Costa
  • Isabel Campos
  • Clara Lemos
  • Masayuki Haramura
  • You Jun Fei
  • Preethi S Ganapathy
  • Pamela Moore
  • Puttur D Prasad
  • M Shamsul Ola
  • Takeo Nakanishi

Detail Information

Publications24

  1. pmc System b0,+ and the transport of thiol-s-conjugates of methylmercury
    Christy C Bridges
    Mercer University School of Medicine, 1550 College Street, Macon, GA 31207, USA
    J Pharmacol Exp Ther 319:948-56. 2006
    ..g., methionine) that are normally transported by system B(0,+). To our knowledge, this is the first report implicating system B(0,+) in the transport of any mercuric species...
  2. pmc Glutathione status and the renal elimination of inorganic mercury in the Mrp2(-/-) mouse
    Christy C Bridges
    Mercer University School of Medicine, Division of Basic Medical Sciences, Macon, Georgia, United States of America
    PLoS ONE 8:e73559. 2013
    ..Expression of GCL was also altered in Mrp2(-/-) mice under normal conditions and following exposure to HgCl2. This study provides important novel data regarding the transport of Hg(2+) and the effect of Hg(2+) exposure on GSH levels. ..
  3. pmc Aging and the disposition and toxicity of mercury in rats
    Christy C Bridges
    Mercer University School of Medicine, Division of Basic Medical Sciences, Macon, GA 31207, United States Electronic address
    Exp Gerontol 53:31-9. 2014
    ..Our findings indicate 1) that overall renal function is significantly impaired in aged rats, resulting in chronic renal insufficiency and 2) the disposition of HgCl2 in aging rats is significantly altered compared to that of young rats. ..
  4. pmc Placental and fetal disposition of mercuric ions in rats exposed to methylmercury: role of Mrp2
    Christy C Bridges
    Mercer University School of Medicine, Division of Basic Medical Sciences, Macon, GA 31207, United States
    Reprod Toxicol 34:628-34. 2012
    ..Thus, our findings suggest that Mrp2 may be involved in the export of mercuric ions from maternal and fetal organs following exposure to methylmercury...
  5. pmc Transport of thiol-conjugates of inorganic mercury in human retinal pigment epithelial cells
    Christy C Bridges
    Division of Basic Medical Sciences, Mercer University School of Medicine, Macon, GA 31207, USA
    Toxicol Appl Pharmacol 221:251-60. 2007
    ..These amino acid transporters may play a role in the retinal toxicity observed following exposure to mercury...
  6. pmc Multidrug resistance proteins and the renal elimination of inorganic mercury mediated by 2,3-dimercaptopropane-1-sulfonic acid and meso-2,3-dimercaptosuccinic acid
    Christy C Bridges
    Mercer University School of Medicine, Division of Basic Medical Sciences, 1550 College Street, Macon, GA 31207, USA
    J Pharmacol Exp Ther 324:383-90. 2008
    ..Collectively, these data support a role for Mrp2 in the DMPS- and DMSA-mediated elimination of Hg(2+) from the kidney...
  7. pmc MRP2 and the DMPS- and DMSA-mediated elimination of mercury in TR(-) and control rats exposed to thiol S-conjugates of inorganic mercury
    Christy C Bridges
    Mercer University School of Medicine, Division of Basic Medical Sciences, Macon, Georgia 31207, USA
    Toxicol Sci 105:211-20. 2008
    ..Overall, these data support our hypothesis that Mrp2 is involved in the DMPS and DMSA-mediated extraction of the body burden of Hg2+...
  8. pmc Effect of DMPS and DMSA on the placental and fetal disposition of methylmercury
    C C Bridges
    Division of Basic Medical Sciences, Mercer University School of Medicine, 1550 College Street, Macon, GA 31207, USA
    Placenta 30:800-5. 2009
    ..The results of the current study are the first to show that DMPS and DMSA are capable of extracting mercuric ions, not only from maternal tissues, but also from placental and fetal tissues following maternal exposure to CH3Hg+...
  9. doi request reprint Transport of inorganic mercury and methylmercury in target tissues and organs
    Christy C Bridges
    Division of Basic Medical Sciences, Mercer University School of Medicine, Macon, Georgia 31207, USA
    J Toxicol Environ Health B Crit Rev 13:385-410. 2010
    ..This review identifies known mechanisms of mercury transport and provides information on additional mechanisms that may potentially play a role in the transport of mercuric ions into target cells...
  10. pmc MRP2 and the handling of mercuric ions in rats exposed acutely to inorganic and organic species of mercury
    Christy C Bridges
    Mercer University School of Medicine, Division of Basic Medical Sciences, 1550 College St, Macon, GA 31207, USA
    Toxicol Appl Pharmacol 251:50-8. 2011
    ..Collectively, these data indicate that MRP2 plays a role in the physiological handling and elimination of mercuric ions from the kidney...
  11. pmc Molecular and ionic mimicry and the transport of toxic metals
    Christy C Bridges
    Division of Basic Medical Sciences, Mercer University School of Medicine, Macon, GA 31207, USA
    Toxicol Appl Pharmacol 204:274-308. 2005
    ..This review will present the established and putative roles of molecular and ionic mimicry in the transport of mercury, cadmium, lead, arsenic, selenium, and selected oxyanions in target organs and tissues...
  12. pmc Homocysteine, system b0,+ and the renal epithelial transport and toxicity of inorganic mercury
    Christy C Bridges
    Mercer University School of Medicine, Division of Basic Medical Sciences, 1550 College St, Macon, GA 31207, USA
    Am J Pathol 165:1385-94. 2004
    ..These data are the first to implicate a specific, luminal membrane transporter in the uptake and toxicity of mercuric conjugates of Hcy in any epithelial cell...
  13. pmc Seventy-five percent nephrectomy and the disposition of inorganic mercury in 2,3-dimercaptopropanesulfonic acid-treated rats lacking functional multidrug-resistance protein 2
    Rudolfs K Zalups
    Division of Basic Medical Sciences, Mercer University School of Medicine, 1550 College Street, Macon, GA 31207, USA
    J Pharmacol Exp Ther 332:866-75. 2010
    ..We conclude that MRP2 plays a significant role in the renal and corporal disposition of Hg(2+) after a 75% reduction of renal mass...
  14. doi request reprint MRP2 involvement in renal proximal tubular elimination of methylmercury mediated by DMPS or DMSA
    Rudolfs K Zalups
    Division of Basic Medical Sciences, Mercer University School of Medicine, 1550 College St, Macon, GA 31207, USA
    Toxicol Appl Pharmacol 235:10-7. 2009
    ..Overall, these dispositional findings indicate that MRP2 does play a role in DMPS- and DMSA-mediated elimination of mercury from the kidney...
  15. pmc Mercuric conjugates of cysteine are transported by the amino acid transporter system b(0,+): implications of molecular mimicry
    Christy C Bridges
    Division of Basic Medical Sciences, Mercer University School of Medicine, Macon, GA 31207, USA
    J Am Soc Nephrol 15:663-73. 2004
    ..These data represent the first direct molecular evidence for the participation of a specific transporter in the luminal uptake of a large divalent metal cation in proximal tubular cells...
  16. pmc Cystine and glutamate transport in renal epithelial cells transfected with human system x(-) (c)
    Christy C Bridges
    Division of Basic Medical Sciences, Mercer University School of Medicine, Macon, Georgia 31207, USA
    Kidney Int 68:653-64. 2005
    ..In the current study we tested the hypothesis that stable transfection of Madin-Darby canine kidney (MDCK) cells with human xCT and 4F2hc results in the expression of functional system x(-) (c)...
  17. ncbi request reprint Molecular mimicry as a mechanism for the uptake of cysteine S-conjugates of methylmercury and inorganic mercury
    Christy C Bridges
    Chem Res Toxicol 19:1117-8; author reply 1118-20. 2006
  18. ncbi request reprint Transport of amino acid-based prodrugs by the Na+- and Cl(-) -coupled amino acid transporter ATB0,+ and expression of the transporter in tissues amenable for drug delivery
    Takahiro Hatanaka
    Department of Medicine, Medical College of Georgia, Augusta, GA 30912, USA
    J Pharmacol Exp Ther 308:1138-47. 2004
    ..The ability of ATB(0,+) to transport valacyclovir was comparable with that of the peptide transporter PEPT1. These findings suggest that ATB(0,+) has significant potential as a delivery system for amino acid-based drugs and prodrugs...
  19. pmc Induction of cystine-glutamate transporter xc- by human immunodeficiency virus type 1 transactivator protein tat in retinal pigment epithelium
    Christy C Bridges
    Department of Biochemistry, Medical College of Georgia, Augusta 30912 9947, USA
    Invest Ophthalmol Vis Sci 45:2906-14. 2004
    ....
  20. ncbi request reprint Progesterone inhibits folic acid transport in human trophoblasts
    Elisa Keating
    Department of Biochemistry U38 FCT, Faculty of Medicine of Porto, University of Porto, Porto 4200 319, Portugal
    J Membr Biol 216:143-52. 2007
    ..These results suggest that progesterone inhibits RFC. In conclusion, our results show that progesterone, a sterol produced by the placenta, inhibits both FA uptake and efflux in BeWo cells and primary cultured human trophoblasts...
  21. pmc Identification of a novel Na+- and Cl--coupled transport system for endogenous opioid peptides in retinal pigment epithelium and induction of the transport system by HIV-1 Tat
    Huankai Hu
    Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, GA 30912, USA
    Biochem J 375:17-22. 2003
    ....
  22. ncbi request reprint Transcellular transfer of folate across the retinal pigment epithelium
    Christy C Bridges
    Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta, Georgia 30912 2000, USA
    Curr Eye Res 24:129-38. 2002
    ....
  23. ncbi request reprint Transport of D-serine via the amino acid transporter ATB(0,+) expressed in the colon
    Takahiro Hatanaka
    Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, Georgia 30912, USA
    Biochem Biophys Res Commun 291:291-5. 2002
    ..Expression is most predominant in the colon where the transporter is localized to the luminal membrane of colonocytes, making this transporter uniquely suitable for absorption of bacteria-derived D-serine...
  24. ncbi request reprint Downregulation of reduced-folate transporter by glucose in cultured RPE cells and in RPE of diabetic mice
    Hany Naggar
    Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta, Georgia 30912 2000, USA
    Invest Ophthalmol Vis Sci 43:556-63. 2002
    ..NO is elevated in diabetes, and therefore in the present study the alteration of RFT-1 activity in RPE under conditions of high glucose was investigated...

Research Grants3

  1. MECHANISMS FOR RENAL UPTAKE OF MERCURY
    CHRISTY BRIDGES; Fiscal Year: 2005
    ..These studies are important in that they will determine the exact mechanisms that participate in the transport of mercury across the plasma membranes of the proximal tubular cells. ..
  2. Role of Multidrug Resistance Proteins 2 and/or 4, and DMPS and DMSA in the Renal
    CHRISTY BRIDGES; Fiscal Year: 2007
    ..These data will serve as the basis for the development of additional treatments for mercury poisoning. ..