F F Zheng
Affiliation: Memorial Sloan-Kettering Cancer Center
- Identification of a geldanamycin dimer that induces the selective degradation of HER-family tyrosine kinasesF F Zheng
Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Cancer Res 60:2090-4. 2000..GMD-4c could be useful in the treatment of carcinomas dependent on HER-kinases...
- A small molecule designed to bind to the adenine nucleotide pocket of Hsp90 causes Her2 degradation and the growth arrest and differentiation of breast cancer cellsG Chiosis
Program in Cell Biology and Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
Chem Biol 8:289-99. 2001..e. steroid receptors, Her2, Raf). We have used the structural features of this pocket to design a small molecule inhibitor of Hsp90...