F F Zheng

Summary

Affiliation: Memorial Sloan-Kettering Cancer Center
Country: USA

Publications

  1. ncbi Identification of a geldanamycin dimer that induces the selective degradation of HER-family tyrosine kinases
    F F Zheng
    Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Cancer Res 60:2090-4. 2000
  2. ncbi A small molecule designed to bind to the adenine nucleotide pocket of Hsp90 causes Her2 degradation and the growth arrest and differentiation of breast cancer cells
    G Chiosis
    Program in Cell Biology and Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
    Chem Biol 8:289-99. 2001

Detail Information

Publications2

  1. ncbi Identification of a geldanamycin dimer that induces the selective degradation of HER-family tyrosine kinases
    F F Zheng
    Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Cancer Res 60:2090-4. 2000
    ..GMD-4c could be useful in the treatment of carcinomas dependent on HER-kinases...
  2. ncbi A small molecule designed to bind to the adenine nucleotide pocket of Hsp90 causes Her2 degradation and the growth arrest and differentiation of breast cancer cells
    G Chiosis
    Program in Cell Biology and Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
    Chem Biol 8:289-99. 2001
    ..e. steroid receptors, Her2, Raf). We have used the structural features of this pocket to design a small molecule inhibitor of Hsp90...