Genomes and Genes
Affiliation: Memorial Sloan-Kettering Cancer Center
- Xue X, Choi K, Bonner J, Szakal B, Chen Y, Papusha A, et al. Selective modulation of the functions of a conserved DNA motor by a histone fold complex. Genes Dev. 2015;29:1000-5 pubmed publisher..Thus, scMHF is a function-specific enhancer of Mph1 that enables flexible response to different genome repair situations. ..
- Hang L, Peng J, Tan W, Szakal B, Menolfi D, Sheng Z, et al. Rtt107 Is a Multi-functional Scaffold Supporting Replication Progression with Partner SUMO and Ubiquitin Ligases. Mol Cell. 2015;60:268-79 pubmed publisher..These findings suggest that Rtt107 functions as a multi-functional platform to support replication progression with its partner E3 enzymes. ..
- Bonner J, Choi K, Xue X, Torres N, Szakal B, Wei L, et al. Smc5/6 Mediated Sumoylation of the Sgs1-Top3-Rmi1 Complex Promotes Removal of Recombination Intermediates. Cell Rep. 2016;16:368-378 pubmed publisher..These findings expand the roles of sumoylation and Smc5/6 in genome maintenance by demonstrating that they foster STR functions in the removal of recombination intermediates. ..
- Dhingra N, Zhao X. SUMO Teams Up with a Translocase to Save TOPO. Mol Cell. 2017;66:577-578 pubmed publisher..2017) report how a DNA translocase uses SUMO as a cue to save Top2 from ubiquitin-mediated degradation and to minimize DNA breaks, thus providing insights into the SUMO and ubiquitin interplay in genome maintenance. ..