Xiaolan Zhao

Summary

Affiliation: Memorial Sloan-Kettering Cancer Center
Country: USA

Publications

  1. Dhingra N, Wei L, Zhao X. Replication protein A (RPA) sumoylation positively influences the DNA damage checkpoint response in yeast. J Biol Chem. 2019;294:2690-2699 pubmed publisher
    ..Our results suggest that SUMO-based modulation of a DNA damage sensor positively influences the checkpoint response. ..
  2. Zhao X. SUMO-Mediated Regulation of Nuclear Functions and Signaling Processes. Mol Cell. 2018;71:409-418 pubmed publisher
  3. Sarangi P, Zhao X. SUMO-mediated regulation of DNA damage repair and responses. Trends Biochem Sci. 2015;40:233-42 pubmed publisher
    ..These emerging themes and models will stimulate our thinking and research in sumoylation and genome maintenance. ..
  4. Wei L, Zhao X. Roles of SUMO in Replication Initiation, Progression, and Termination. Adv Exp Med Biol. 2017;1042:371-393 pubmed publisher
    ..As this area of research is still at its infancy, many outstanding questions remain to be explored, and we discuss these issues in light of the new advances. ..
  5. Bonner J, Zhao X. Replication-Associated Recombinational Repair: Lessons from Budding Yeast. Genes (Basel). 2016;7: pubmed publisher
    ..As many of the protein factors and biological principles uncovered in budding yeast are conserved in higher eukaryotes, these findings are crucial for stimulating studies in more complex organisms. ..
  6. Sarangi P, Bartosova Z, Altmannova V, Holland C, Chavdarova M, Lee S, et al. Sumoylation of the Rad1 nuclease promotes DNA repair and regulates its DNA association. Nucleic Acids Res. 2014;42:6393-404 pubmed publisher
    ..These findings suggest a model whereby sumoylation of Rad1 promotes its disengagement from DNA after nuclease cleavage, allowing it to efficiently attend to large numbers of DNA lesions. ..
  7. Sarangi P, Altmannova V, Holland C, Bartosova Z, Hao F, Anrather D, et al. A versatile scaffold contributes to damage survival via sumoylation and nuclease interactions. Cell Rep. 2014;9:143-52 pubmed publisher
    ..These effects of Saw1 and its sumoylation suggest that Saw1 is a multifunctional scaffold that can facilitate diverse types of DNA repair through its modification and nuclease interactions. ..
  8. Xue X, Choi K, Bonner J, Chiba T, Kwon Y, Xu Y, et al. Restriction of replication fork regression activities by a conserved SMC complex. Mol Cell. 2014;56:436-45 pubmed publisher
    ..Our findings provide molecular insights into replication fork repair regulation and uncover a role of Smc5-Smc6 in directing Mph1 activity toward a specific biochemical outcome. ..
  9. Choi K, Batke S, Szakal B, Lowther J, Hao F, Sarangi P, et al. Concerted and differential actions of two enzymatic domains underlie Rad5 contributions to DNA damage tolerance. Nucleic Acids Res. 2015;43:2666-77 pubmed publisher
    ..These findings delineate how two Rad5 enzymatic domains concertedly influence PCNA modification, and unveil their discrete contributions to stress tolerance. ..

More Information

Publications13

  1. Xue X, Choi K, Bonner J, Szakal B, Chen Y, Papusha A, et al. Selective modulation of the functions of a conserved DNA motor by a histone fold complex. Genes Dev. 2015;29:1000-5 pubmed publisher
    ..Thus, scMHF is a function-specific enhancer of Mph1 that enables flexible response to different genome repair situations. ..
  2. Hang L, Peng J, Tan W, Szakal B, Menolfi D, Sheng Z, et al. Rtt107 Is a Multi-functional Scaffold Supporting Replication Progression with Partner SUMO and Ubiquitin Ligases. Mol Cell. 2015;60:268-79 pubmed publisher
    ..These findings suggest that Rtt107 functions as a multi-functional platform to support replication progression with its partner E3 enzymes. ..
  3. Bonner J, Choi K, Xue X, Torres N, Szakal B, Wei L, et al. Smc5/6 Mediated Sumoylation of the Sgs1-Top3-Rmi1 Complex Promotes Removal of Recombination Intermediates. Cell Rep. 2016;16:368-378 pubmed publisher
    ..These findings expand the roles of sumoylation and Smc5/6 in genome maintenance by demonstrating that they foster STR functions in the removal of recombination intermediates. ..
  4. Dhingra N, Zhao X. SUMO Teams Up with a Translocase to Save TOPO. Mol Cell. 2017;66:577-578 pubmed publisher
    ..2017) report how a DNA translocase uses SUMO as a cue to save Top2 from ubiquitin-mediated degradation and to minimize DNA breaks, thus providing insights into the SUMO and ubiquitin interplay in genome maintenance. ..