Research Topics
| P B ZanzonicoSummaryAffiliation: Memorial Sloan-Kettering Cancer Center Country: USA Publications
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Detail Information
Publications
Principles of nuclear medicine imaging: planar, SPECT, PET, multi-modality, and autoradiography systemsPat Zanzonico
Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Radiat Res 177:349-64. 2012..These include gamma cameras, single-photon emission computed tomography (SPECT) scanners, and positron emission tomography (PET) scanners. The technical basis of autoradiography is reviewed as well...
Insertion of the human sodium iodide symporter to facilitate deep tissue imaging does not alter oncolytic or replication capability of a novel vaccinia virusDana Haddad
Department of Biochemistry, University of Wuerzburg, Wuerzburg D 97074, Germany
J Transl Med 9:36. 2011..This study aimed to determine if insertion of the human sodium iodide symporter (hNIS) cDNA as a marker for non-invasive imaging of virotherapy alters the replication and oncolytic capability of a novel vaccinia virus, GLV-1h153...
PET-based biological imaging for radiation therapy treatment planningPat Zanzonico
Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Crit Rev Eukaryot Gene Expr 16:61-101. 2006..It remains unclear, however, whether PET is currently capable of delineating the true extent of viable tumor with sufficient accuracy and precision to reliably guide therapy on a routine basis...
[131I]FIAU labeling of genetically transduced, tumor-reactive lymphocytes: cell-level dosimetry and dose-dependent toxicityPat Zanzonico
Department of Medical Physics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, USA
Eur J Nucl Med Mol Imaging 33:988-97. 2006....
Routine quality control of clinical nuclear medicine instrumentation: a brief reviewPat Zanzonico
Departments of Medical Physics and Radiology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
J Nucl Med 49:1114-31. 2008..It should be particularly useful for residents, fellows, and other trainees in nuclear medicine, nuclear cardiology, and radiology. The procedures described and their respective frequencies are presented only as general guidelines...
Introduction to clinical and laboratory (small-animal) image registration and fusionPat B Zanzonico
Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Conf Proc IEEE Eng Med Biol Soc 1:1580-3. 2006..g. PET-CT, devices which provide registered and fused three-dimensional image sets. This paper briefly reviews the basics of image registration and fusion and available clinical and small-animal multi-modality instrumentation...
Broad-spectrum multi-modality image registration: from PET, CT, and MRI to autoradiography, microscopy, and beyondP B Zanzonico
Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Conf Proc IEEE Eng Med Biol Soc 1:1584-8. 2006....
Patient-specific radiation dosimetry for radionuclide therapy of liver tumors with intrahepatic artery rhenium-188 lipiodolPat B Zanzonico
Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Semin Nucl Med 38:S30-9. 2008..Although not required for treatment planning, tumor absorbed dose may also be estimated. This algorithm has been automated using an Excel (Microsoft, Redmond, WA) spreadsheet...
Operational radiation safety for PET-CT, SPECT-CT, and cyclotron facilitiesPat Zanzonico
Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Health Phys 95:554-70. 2008..The radiation burden accrued by the patients undergoing PET-CT or SPECT-CT exams will be considered as well...
Animal-specific positioning molds for registration of repeat imaging studies: comparative microPET imaging of F18-labeled fluoro-deoxyglucose and fluoro-misonidazole in rodent tumorsPat Zanzonico
Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Nucl Med Biol 33:65-70. 2006....
Effects of time of administration and dietary iodine levels on potassium iodide (KI) blockade of thyroid irradiation by 131I from radioactive falloutP B Zanzonico
Nuclear Medicine Service, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Health Phys 78:660-7. 2000....
A generalized algorithm for determining the time of release and the duration of post-release radiation precautions following radionuclide therapyP B Zanzonico
Nuclear Medicine Service, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Health Phys 78:648-59. 2000..Even so, dose-based release criteria should prove more cost-effective overall than hospitalization of patients commonly imposed by activity-based and dose rate-based release criteria...
Model-based versus patient-specific dosimetry: blurring the linesPat B Zanzonico
Memorial Sloan-Kettering Cancer Center New York, New York 10021, USA
J Nucl Med 43:1665-6. 2002
Enhancement of radioiodine treatment of small-pool hyperthyroidism with antithyroid drugs: kinetics and dosimetryPat B Zanzonico
Division of Nuclear Medicine, New York Presbyterian Hospital, New York, USA
J Nucl Med 45:2102-8. 2004....
Age-dependent thyroid absorbed doses for radiobiologically significant radioisotopes of iodineP B Zanzonico
Nuclear Medicine Service, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Health Phys 78:60-7. 2000..Although the thyroid absorbed dose for inhalation is substantially (30 to 70%) less than that for injection for all radioiodines and at all ages, it is markedly (25%) less for ingestion only for short-lived 132I...
Pretargeted radioimmunotherapy with a single-chain antibody/streptavidin construct and radiolabeled DOTA-biotin: strategies for reduction of the renal doseGregor J Förster
Nuclear Medicine Research Laboratory, Memorial Sloan Kettering Cancer Center, New York, New York, USA
J Nucl Med 47:140-9. 2006..The objective of the current study, therefore, was to evaluate the reduction of kidney uptake of radiolabeled DOTA-biotin achieved by each of 4 different methods...
Imaging a Genetically Engineered Oncolytic Vaccinia Virus (GLV-1h99) Using a Human Norepinephrine Transporter Reporter GenePeter Brader
Departments of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York, USA
Clin Cancer Res 15:3791-801. 2009....
A preclinical model for noninvasive imaging of hypoxia-induced gene expression; comparison with an exogenous marker of tumor hypoxiaBixiu Wen
Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, NY, New York 10021, USA
Eur J Nucl Med Mol Imaging 31:1530-8. 2004....
Serial in vivo imaging of the targeted migration of human HSV-TK-transduced antigen-specific lymphocytesGuenther Koehne
Allogeneic Bone Marrow Transplantation Service, Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
Nat Biotechnol 21:405-13. 2003..This technique for imaging the migration of ex vivo-transduced antigen-specific T cells in vivo is informative, nontoxic, and potentially applicable to humans...
Visualization of experimental lung and bone metastases in live nude mice by X-ray micro-computed tomographyXiao Feng Li
Department of Medical Physics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
Technol Cancer Res Treat 5:147-55. 2006..Micro-CT may be used as an accurate, noninvasive tool to detect and monitor experimental bone and lung metastases in intact live nude mice...
Bisphosphonate delivery to tubular bone allograftsGene R DiResta
Department of Surgery Orthopaedic Surgical Service, Memorial Sloan Kettering Cancer Center, Weill Medical College of Cornell University, 1275 York Ave, Suite A342, New York, NY 10065 6004, USA
Clin Orthop Relat Res 466:1871-9. 2008..Flow resistance was reduced with octylphenoxy polyethoxy ethanol but unaffected with beractant. Pumped allografts displayed a more homogeneous indicator distribution in less time than soaking while surfactants enhanced fluid movement...
Compartmental intrathecal radioimmunotherapy: results for treatment for metastatic CNS neuroblastomaKim Kramer
Department of Pediatrics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 429, New York, NY 10065, USA
J Neurooncol 97:409-18. 2010..The cRIT-salvage regimen for CNS metastases was well tolerated by young patients, despite their prior history of intensive cytotoxic therapies. It has the potential to increase survival with better than expected quality of life...
Assessment of regional tumor hypoxia using 18F-fluoromisonidazole and 64Cu(II)-diacetyl-bis(N4-methylthiosemicarbazone) positron emission tomography: Comparative study featuring microPET imaging, Po2 probe measurement, autoradiography, and fluorescent micJoseph A O'Donoghue
Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, USA
Int J Radiat Oncol Biol Phys 61:1493-502. 2005..To compare two potential positron emission tomography (PET) tracers of tumor hypoxia in an animal model...
Improved tumor imaging and therapy via i.v. IgG-mediated time-sequential modulation of neonatal Fc receptorJaspreet Singh Jaggi
Molecular Pharmacology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
J Clin Invest 117:2422-30. 2007..The ability to reduce the serum persistence of conjugated IgG antibodies after their infusion can enhance their therapeutic index, resulting in improved therapeutic and diagnostic efficacy...
A robotic system for 18F-FMISO PET-guided intratumoral pO2 measurementsJenghwa Chang
Department of Medical Physics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA
Med Phys 36:5301-9. 2009....
Whole-body clearance kinetics and external dosimetry of 131I-3F8 monoclonal antibody for radioimmunotherapy of neuroblastomaLawrence T Dauer
Department of Medical Physics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
Health Phys 92:33-9. 2007....
Optimizing tumor targeting of the lipophilic EGFR-binding radiotracer SKI 243 using a liposomal nanoparticle delivery systemOula Penate Medina
Molecular Pharmacology and Chemistry Department, Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue 10021 New York, New York, United States
J Control Release 149:292-8. 2011..SKI 243 and liposomal SKI 243 are both taken up by tumor xenografts but liposomal SKI 243 remained in the blood longer and consequently exhibited a 3- to 6-fold increase in uptake in the tumor among several other organs...
Single-chain Fv-streptavidin substantially improved therapeutic index in multistep targeting directed at disialoganglioside GD2Nai Kong V Cheung
Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
J Nucl Med 45:867-77. 2004..Neuroblastoma is uniquely suited for such investigations because of its abundance of surface ganglioside GD2...
Iodine-124-labeled iodo-azomycin-galactoside imaging of tumor hypoxia in mice with serial microPET scanningPat Zanzonico
Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
Eur J Nucl Med Mol Imaging 31:117-28. 2004....
Escherichia coli Nissle 1917 facilitates tumor detection by positron emission tomography and optical imagingPeter Brader
Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Clin Cancer Res 14:2295-302. 2008..Imaging bacteria specifically targeting and replicating within tumors using radiotracer techniques and optical imaging can provide confirmation of successful colonization of malignant tissue...
Tumor hypoxia imaging in orthotopic liver tumors and peritoneal metastasis: a comparative study featuring dynamic 18F-MISO and 124I-IAZG PET in the same study cohortChristopher C Riedl
Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Eur J Nucl Med Mol Imaging 35:39-46. 2008....
In vivo imaging and quantitation of adoptively transferred human antigen-specific T cells transduced to express a human norepinephrine transporter geneMikhail M Doubrovin
Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Cancer Res 67:11959-69. 2007..The hNET-based system described may thus have significant potential as a nonimmunogenic reporter for extended repeated quantitative in vivo imaging of transduced cells in man...
Pharmacokinetic assessment of the uptake of 16beta-18F-fluoro-5alpha-dihydrotestosterone (FDHT) in prostate tumors as measured by PETBradley J Beattie
Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
J Nucl Med 51:183-92. 2010....
Ga-66 labeled somatostatin analogue DOTA-DPhe1-Tyr3-octreotide as a potential agent for positron emission tomography imaging and receptor mediated internal radiotherapy of somatostatin receptor positive tumorsOmer Ugur
Nuclear Medicine Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
Nucl Med Biol 29:147-57. 2002..66Ga-DOTATOC may also be used in higher doses for ablation of these tumors. However, kidney is the critical organ for toxicity (tumor/kidney ratio = 1.64), and high kidney uptake must be eliminated before devising a therapy protocol...
Optical bioluminescence imaging of human ES cell progeny in the rodent CNSMichelle S Bradbury
Department of Radiology, Sloan Kettering Institute for Cancer Research, New York City, New York, USA
J Neurochem 102:2029-39. 2007..In conclusion, our data suggest that optical bioluminescence imaging can serve as an essential tool for the development of hESC-based grafting strategies in the CNS...
Measurements of tumor tissue oxygen tension using a time-resolved luminescence-based optical oxylite probe: comparison with a paired survival assayMuneyasu Urano
Department of Medical Physics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA
Radiat Res 158:167-73. 2002..For comparison, the tumor cell survivals were assayed after a dose of 20 Gy given in air at 5, 20 and 60 min after anesthesia. The result showed a decrease in cell survival only in tumors irradiated 20 min after an injection of Nembutal...
Different strategies for reducing intestinal background radioactivity associated with imaging HSV1-tk expression using established radionucleoside probesAlessandro Ruggiero
Department of Radiology, Cyclotron and Radiochemistry Core Facility, and Research Animal Resource Center, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Mol Imaging 9:47-58. 2010..The combination of Peptamen and Nulytely increased radiotracer elimination by increasing bowel motility without inducing dehydration...
hNIS-IRES-eGFP dual reporter gene imagingJiantu Che
Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA
Mol Imaging 4:128-36. 2005..These studies indicate the potential for a wider application of hNIS reporter imaging and translation into patient studies using radioisotopes that are currently available for human use for both SPECT and PET imaging...
Endogenous expression of Hras(G12V) induces developmental defects and neoplasms with copy number imbalances of the oncogeneXu Chen
Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
Proc Natl Acad Sci U S A 106:7979-84. 2009....
Radiation exposure of computed tomography and direct intracoronary angiography: risk has its rewardPat Zanzonico
Department of Medical Physics, Nuclear Medicine Section, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
J Am Coll Cardiol 47:1846-9. 2006..When weighing the relative risks of alternative medical procedures, therefore, it is imperative that one consider the overall risk of the respective procedures...
Image deconvolution in digital autoradiography: a preliminary studyMutian Zhang
Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
Med Phys 35:522-30. 2008..Digital autoradiograms following deconvolution show improved sharpness and contrast relative to the unprocessed autoradiograms...
Imaging hNET reporter gene expression with 124I-MIBGMaxim A Moroz
Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
J Nucl Med 48:827-36. 2007..We have extended this effort by constructing an internal ribosomal entry site (IRES)-linked hNET-green fluorescent protein (GFP) hybrid reporter gene for both nuclear and optical imaging...
Imaging of hypoxia-driven gene expression in an orthotopic liver tumor modelPeter Brader
Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Mol Cancer Ther 6:2900-8. 2007..However, the severity of tumor ischemia after permanent ligation of the hepatic artery limits our ability to image severe hypoxia in this animal model...
Imaging hypoxia in orthotopic rat liver tumors with iodine 124-labeled iodoazomycin galactopyranoside PETChristopher C Riedl
Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, Room C 278, New York, NY 10021, USA
Radiology 248:561-70. 2008....
Multimodality registration without a dedicated multimodality scannerBradley J Beattie
Momorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Mol Imaging 6:108-20. 2007....
Pharmacokinetics and Biodistribution of (86)Y-Trastuzumab for (90)Y dosimetry in an ovarian carcinoma model: correlative MicroPET and MRIStig Palm
Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
J Nucl Med 44:1148-55. 2003..MicroPET and MRI-based preclinical biodistribution and localization data were obtained and used to assess the therapeutic potential of (90)Y-trastuzumab monoclonal antibody (mAb) (anti-HER2/neu) against ovarian carcinoma...
Phase I study of targeted radioimmunotherapy for leptomeningeal cancers using intra-Ommaya 131-I-3F8Kim Kramer
Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
J Clin Oncol 25:5465-70. 2007..We tested the toxicity, pharmacokinetics, and dosimetry of intraventricular iodine-131-labeled monoclonal antibody 3F8 (131I-3F8) targeting GD2-positive CNS/LM disease in a phase I clinical trial...
Reproducibility of intratumor distribution of (18)F-fluoromisonidazole in head and neck cancerSadek A Nehmeh
Department of Medical Physics, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
Int J Radiat Oncol Biol Phys 70:235-42. 2008..The aim of this study was to evaluate the reproducibility of (18)F-FMISO intratumor distribution using two pretreatment PET scans...
Noninvasive molecular imaging of hypoxia in human xenografts: comparing hypoxia-induced gene expression with endogenous and exogenous hypoxia markersFuqiu He
Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Cancer Res 68:8597-606. 2008....
Dynamic small-animal PET imaging of tumor proliferation with 3'-deoxy-3'-18F-fluorothymidine in a genetically engineered mouse model of high-grade gliomasMichelle S Bradbury
Department of Radiology, Sloan Kettering Institute for Cancer Research, New York, New York 10021, USA
J Nucl Med 49:422-9. 2008..Our goal was to develop a robust and reproducible method of kinetic analysis for the quantitative evaluation of tumor proliferation...
PET-based radiation dosimetry in man of 18F-fluorodihydrotestosterone, a new radiotracer for imaging prostate cancerPat B Zanzonico
Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA
J Nucl Med 45:1966-71. 2004..0151 cGy/MBq]) is recommended for (18)F-FDHT...
Organ and fetal absorbed dose estimates from 99mTc-sulfur colloid lymphoscintigraphy and sentinel node localization in breast cancer patientsNeeta Pandit-Taskar
Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA
J Nucl Med 47:1202-8. 2006..Calculations using actual patient population characteristics resulted in lower organ dose estimates than more conservative reference models...
Tumor-specific in vivo transfection with HSV-1 thymidine kinase gene using a Sindbis viral vector as a basis for prodrug ganciclovir activation and PETJen-Chieh Tseng
NYU Cancer Institute, Rita J. and Stanley H. Kaplan Comprehensive Cancer Center, NYU Gene Therapy Center, NYU School of Medicine, New York, New York 10016, USA
J Nucl Med 47:1136-43. 2006....
Radioiodine fallout and breast-feedingRobert W Miller
Clinical Genetics Branch, National Cancer Institute, Bethesda, MD 20892-7132, USA
Radiat Res 164:339-40. 2005..The rationale for suspension of breast-feeding after exposure to radioiodine in fallout is presented...
