Kristen L Zakian

Summary

Affiliation: Memorial Sloan-Kettering Cancer Center
Country: USA

Publications

  1. ncbi request reprint A dual-tuned resonator for proton-decoupled phosphorus-31 chemical shift imaging of the brain
    K L Zakian
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Magn Reson Med 41:809-15. 1999
  2. ncbi request reprint 1H magnetic resonance spectroscopy of prostate cancer: biomarkers for tumor characterization
    Kristen L Zakian
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, NY, USA
    Cancer Biomark 4:263-76. 2008
  3. ncbi request reprint Liver regeneration in humans is characterized by significant changes in cellular phosphorus metabolism: assessment using proton-decoupled 31P-magnetic resonance spectroscopic imaging
    Kristen L Zakian
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Magn Reson Med 54:264-71. 2005
  4. ncbi request reprint Correlation of proton MR spectroscopic imaging with gleason score based on step-section pathologic analysis after radical prostatectomy
    Kristen L Zakian
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
    Radiology 234:804-14. 2005
  5. ncbi request reprint Identification of prognostic markers in bone sarcomas using proton-decoupled phosphorus magnetic resonance spectroscopy
    Kristen L Zakian
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Cancer Res 63:9042-7. 2003
  6. ncbi request reprint Transition zone prostate cancer: metabolic characteristics at 1H MR spectroscopic imaging--initial results
    Kristen L Zakian
    Departments of Medical Physics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Radiology 229:241-7. 2003
  7. pmc An exploratory study of endorectal magnetic resonance imaging and spectroscopy of the prostate as preoperative predictive biomarkers of biochemical relapse after radical prostatectomy
    Kristen L Zakian
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    J Urol 184:2320-7. 2010
  8. ncbi request reprint A quantitative assessment of liver metabolites during jaundice using three dimensional phosphorus chemical shift imaging
    K L Zakian
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, USA
    Magn Reson Imaging 18:181-7. 2000
  9. ncbi request reprint The utility of magnetic resonance imaging and spectroscopy for predicting insignificant prostate cancer: an initial analysis
    Amita Shukla-Dave
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    BJU Int 99:786-93. 2007
  10. pmc Correlation of MR imaging and MR spectroscopic imaging findings with Ki-67, phospho-Akt, and androgen receptor expression in prostate cancer
    Amita Shukla-Dave
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
    Radiology 250:803-12. 2009

Detail Information

Publications33

  1. ncbi request reprint A dual-tuned resonator for proton-decoupled phosphorus-31 chemical shift imaging of the brain
    K L Zakian
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Magn Reson Med 41:809-15. 1999
    ..Acquisition of good quality 31P spectra over this volume is due to the dome structure as well as quadrature operation at both proton and phosphorus frequencies...
  2. ncbi request reprint 1H magnetic resonance spectroscopy of prostate cancer: biomarkers for tumor characterization
    Kristen L Zakian
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, NY, USA
    Cancer Biomark 4:263-76. 2008
    ..This article reviews the assessment of choline-containing compounds, citrate, and polyamines as markers for prostate tumor detection and aggressiveness...
  3. ncbi request reprint Liver regeneration in humans is characterized by significant changes in cellular phosphorus metabolism: assessment using proton-decoupled 31P-magnetic resonance spectroscopic imaging
    Kristen L Zakian
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Magn Reson Med 54:264-71. 2005
    ..This study demonstrates that 31P MRSI can be used to assess metabolic changes in humans during liver regeneration, and may be useful for assessing derangement of the regenerative process or guiding adjuvant chemotherapies...
  4. ncbi request reprint Correlation of proton MR spectroscopic imaging with gleason score based on step-section pathologic analysis after radical prostatectomy
    Kristen L Zakian
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
    Radiology 234:804-14. 2005
    ..To determine whether hydrogen 1 magnetic resonance (MR) spectroscopic imaging can be used to predict aggressiveness of prostate cancer...
  5. ncbi request reprint Identification of prognostic markers in bone sarcomas using proton-decoupled phosphorus magnetic resonance spectroscopy
    Kristen L Zakian
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Cancer Res 63:9042-7. 2003
    ..The results are promising, although a prospective study is necessary for confirmation. (31)P MRSI appears to be a useful tool for the prediction of survival before therapy in bone sarcomas...
  6. ncbi request reprint Transition zone prostate cancer: metabolic characteristics at 1H MR spectroscopic imaging--initial results
    Kristen L Zakian
    Departments of Medical Physics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Radiology 229:241-7. 2003
    ..To determine whether cancers of the prostate transition zone (TZ) possess a unique metabolic pattern by which they may be identified at proton magnetic resonance (MR) spectroscopic imaging...
  7. pmc An exploratory study of endorectal magnetic resonance imaging and spectroscopy of the prostate as preoperative predictive biomarkers of biochemical relapse after radical prostatectomy
    Kristen L Zakian
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    J Urol 184:2320-7. 2010
    ..We determined whether pretreatment endorectal magnetic resonance imaging/magnetic resonance spectroscopic imaging predicts biochemical recurrence after radical prostatectomy...
  8. ncbi request reprint A quantitative assessment of liver metabolites during jaundice using three dimensional phosphorus chemical shift imaging
    K L Zakian
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, USA
    Magn Reson Imaging 18:181-7. 2000
    ..However, absolute quantitation requires careful attention to many factors including point spread function, correct T(1) values, and adequate signal-to-noise ratio...
  9. ncbi request reprint The utility of magnetic resonance imaging and spectroscopy for predicting insignificant prostate cancer: an initial analysis
    Amita Shukla-Dave
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    BJU Int 99:786-93. 2007
    ..To design new models that combine clinical variables and biopsy data with magnetic resonance imaging (MRI) and MR spectroscopic imaging (MRSI) data, and assess their value in predicting the probability of insignificant prostate cancer...
  10. pmc Correlation of MR imaging and MR spectroscopic imaging findings with Ki-67, phospho-Akt, and androgen receptor expression in prostate cancer
    Amita Shukla-Dave
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
    Radiology 250:803-12. 2009
    ....
  11. pmc Prediction of prostate cancer recurrence using magnetic resonance imaging and molecular profiles
    Amita Shukla-Dave
    Departments of Medical Physics, Memorial Sloan Kettering Cancer Center New York, New York, USA
    Clin Cancer Res 15:3842-9. 2009
    ....
  12. pmc Prostate tumor volume measurement with combined T2-weighted imaging and diffusion-weighted MR: correlation with pathologic tumor volume
    Yousef Mazaheri
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, 1275 York Ave, Room C 278, New York, NY 10065, USA
    Radiology 252:449-57. 2009
    ....
  13. ncbi request reprint Detection of prostate cancer with MR spectroscopic imaging: an expanded paradigm incorporating polyamines
    Amita Shukla-Dave
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY 10021 USA
    Radiology 245:499-506. 2007
    ....
  14. ncbi request reprint Preliminary assessment of magnetic resonance spectroscopic imaging in predicting treatment outcome in patients with prostate cancer at high risk for relapse
    Darko Pucar
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Clin Prostate Cancer 3:174-81. 2004
    ..Although MRSI did not provide added prognostic value to MRI in this small number of patients, MRSI might increase the confidence of the clinician in assessing risk on MRI by contributing supporting metabolic data...
  15. pmc Prostate cancer: correlation of MR imaging and MR spectroscopy with pathologic findings after radiation therapy-initial experience
    Darko Pucar
    Department of Radiology, Medical Physics, Epidemiology and Biostatistics, Urology, Pathology, and Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
    Radiology 236:545-53. 2005
    ..To prospectively evaluate magnetic resonance (MR) imaging and MR spectroscopy for depiction of local prostate cancer recurrence after external-beam radiation therapy, with step-section pathologic findings as the standard of reference...
  16. pmc Serial measurement of hepatic lipids during chemotherapy in patients with colorectal cancer: a 1 H MRS study
    Jing Qi
    Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    NMR Biomed 26:204-12. 2013
    ..Six of 26 patients developed steatosis during chemotherapy. Lipid changes were observable at 6 weeks...
  17. pmc 31P MR spectroscopic imaging detects regenerative changes in human liver stimulated by portal vein embolization
    Jing Qi
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Magn Reson Imaging 34:336-44. 2011
    ..Second, to compare the biophysiologic differences between hepatic regeneration stimulated by PVE and by partial hepatectomy (PH)...
  18. doi request reprint Prostate cancer: identification with combined diffusion-weighted MR imaging and 3D 1H MR spectroscopic imaging--correlation with pathologic findings
    Yousef Mazaheri
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, 1275 York Ave, Room C 278, New York, NY 10021, USA
    Radiology 246:480-8. 2008
    ....
  19. pmc Imaging transgene activity in vivo
    Terence P F Gade
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Cancer Res 68:2878-84. 2008
    ..This study presents a translational imaging paradigm for precise, in vivo measurements of transgene activity with potential applications in both preclinical and clinical settings...
  20. ncbi request reprint Chronic prostatitis: MR imaging and 1H MR spectroscopic imaging findings--initial observations
    Amita Shukla-Dave
    Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Radiology 231:717-24. 2004
    ..To determine whether chronic prostatitis affects three-dimensional proton magnetic resonance (MR) spectroscopic imaging in evaluation of disease in the peripheral zone...
  21. pmc Performance characteristics of MR imaging in the evaluation of clinically low-risk prostate cancer: a prospective study
    Hebert Alberto Vargas
    Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, Room C 278, New York, NY 10065, USA
    Radiology 265:478-87. 2012
    ....
  22. pmc Preoperative nomograms incorporating magnetic resonance imaging and spectroscopy for prediction of insignificant prostate cancer
    Amita Shukla-Dave
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    BJU Int 109:1315-22. 2012
    ..Upon initial testing, the new MR models performed significantly better than a clinical model lacking detailed biopsy data...
  23. pmc Preclinical study of treatment response in HCT-116 cells and xenografts with (1) H-decoupled (31) P MRS
    Moses M Darpolor
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    NMR Biomed 24:1159-68. 2011
    ..The decrease in phosphocholine may be a potential indicator of early tumor response to the sequential treatment of irinotecan followed by flavopiridol in noninvasive and/or longitudinal studies...
  24. ncbi request reprint Metabolic response of the CWR22 prostate tumor xenograft after 20 Gy of radiation studied by 1H spectroscopic imaging
    Jonathan P Dyke
    Citigroup Biomedical Imaging Center, Department of Radiology, Weill Cornell Medical College, New York, New York 10021, USA
    Clin Cancer Res 9:4529-36. 2003
    ..Current markers of tumor progression such as prostate-specific antigen (PSA) do not provide spatial information about tumor extent or regions of high metabolic activity...
  25. pmc J-difference lactate editing at 3.0 Tesla in the presence of strong lipids
    Mari A Smith
    Department of Medical Physics, Mail Box 84, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    J Magn Reson Imaging 28:1492-8. 2008
    ..To implement in vivo detection of lactate in the presence of lipids by proton magnetic resonance spectroscopy at a 3 Tesla (T) field strength for potential applications in human tumors outside of the brain...
  26. ncbi request reprint Treatment planning for prostate implants using magnetic-resonance spectroscopy imaging
    M Zaider
    Departments of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Int J Radiat Oncol Biol Phys 47:1085-96. 2000
    ..A method is described that registers MRSI to intraoperative-obtained ultrasound images and incorporates this information into a treatment-planning system to achieve dose escalation to intraprostatic tumor deposits...
  27. ncbi request reprint In vivo 5-fluorouracil and fluoronucleotide T1 relaxation time measurements using the variable nutation angle method
    Terence P F Gade
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Magn Reson Med 52:169-73. 2004
    ..The determined T1's for 5FU and FNuc (2.3 +/- 0.1 s and 1.3 +/- 0.1 s, respectively) represent the first reported in vivo measurements for these metabolites in tumor...
  28. pmc Relationships between LDH-A, lactate, and metastases in 4T1 breast tumors
    Asif Rizwan
    Authors Affiliations Departments of Medical Physics, Neurology, Radiology, and Medicine, Bioinformatics Core, Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center and Department of Physiology and Biophysics, Weill Cornell Graduate School of Medical Sciences, New York, New York
    Clin Cancer Res 19:5158-69. 2013
    ..To investigate the relationship between lactate dehydrogenase A (LDH-A) expression, lactate concentration, cell metabolism, and metastases in murine 4T1 breast tumors...
  29. ncbi request reprint In vivo 31P MR spectral patterns and reproducibility in cancer patients studied in a multi-institutional trial
    F Arias-Mendoza
    Hatch Center for MR Research, Radiology Department, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    NMR Biomed 19:504-12. 2006
    ....
  30. ncbi request reprint A photothrombotic model of small early ischemic infarcts in the rat brain with histologic and MRI correlation
    P H Pevsner
    Department of Pharmacology, New York University School of Medicine, NYU Medical Center, 550 First Ave, New York, New York 10016, USA
    J Pharmacol Toxicol Methods 45:227-33. 2001
    ..As demonstrated by a comparison with the histologic features of such infarcts in surgical and autopsy brain specimens, the model is relevant to acute human ischemic infarcts...
  31. ncbi request reprint Developments in nuclear magnetic resonance imaging and spectroscopy: application to radiation oncology
    K L Zakian
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Semin Radiat Oncol 11:3-15. 2001
    ..This article provides a brief review of magnetic resonance techniques for imaging of tissue physiological function and addresses possible applications in the realm of radiation oncology...
  32. ncbi request reprint Magnetic resonance spectroscopy and clinical cancer prognosis
    Kristen L Zakian
    Acad Radiol 11:365-7. 2004
  33. ncbi request reprint Prediction of treatment response of head and neck cancers with P-31 MR spectroscopy from pretreatment relative phosphomonoester levels
    Amita Shukla-Dave
    Dept of Radiology, University of Pennsylvania Medical Center, Philadelphia, USA
    Acad Radiol 9:688-94. 2002
    ..Frequent regional node involvement facilitates surface coil investigation with phosphorus-31 magnetic resonance spectroscopy...