Jin Xu

Summary

Affiliation: Memorial Sloan-Kettering Cancer Center
Country: USA

Publications

  1. pmc Characterizing exons 11 and 1 promoters of the mu opioid receptor (Oprm) gene in transgenic mice
    Jin Xu
    Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY 10021 USA
    BMC Mol Biol 7:41. 2006
  2. ncbi request reprint DJ-1 transcriptionally up-regulates the human tyrosine hydroxylase by inhibiting the sumoylation of pyrimidine tract-binding protein-associated splicing factor
    Nan Zhong
    Department of Neurology, Caritas St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02135, USA
    J Biol Chem 281:20940-8. 2006
  3. pmc Stabilization of the μ-opioid receptor by truncated single transmembrane splice variants through a chaperone-like action
    Jin Xu
    Department of Neurology and The Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    J Biol Chem 288:21211-27. 2013
  4. pmc Isolation and characterization of new exon 11-associated N-terminal splice variants of the human mu opioid receptor gene
    Jin Xu
    Department of Neurology and The Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    J Neurochem 108:962-72. 2009
  5. pmc Identification and characterization of seven new exon 11-associated splice variants of the rat μ opioid receptor gene, OPRM1
    Jin Xu
    Department of Neurology and Program in Molecular Pharmacology and Chemistry, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Mol Pain 7:9. 2011
  6. ncbi request reprint Identification of three new alternatively spliced variants of the rat mu opioid receptor gene: dissociation of affinity and efficacy
    David A Pasternak
    Laboratory of Molecular Neuropharmacology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Neurochem 91:881-90. 2004
  7. pmc Involvement of exon 11-associated variants of the mu opioid receptor MOR-1 in heroin, but not morphine, actions
    Ying Xian Pan
    Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 106:4917-22. 2009
  8. doi request reprint Synergistic activation of the human MnSOD promoter by DJ-1 and PGC-1alpha: regulation by SUMOylation and oxidation
    Nan Zhong
    Department of Neurology, Caritas St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA 02135, USA
    Hum Mol Genet 17:3357-67. 2008
  9. ncbi request reprint Identification of four novel exon 5 splice variants of the mouse mu-opioid receptor gene: functional consequences of C-terminal splicing
    Ying Xian Pan
    Laboratory of Molecular Neuropharmacology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
    Mol Pharmacol 68:866-75. 2005
  10. ncbi request reprint Isolating and characterizing three alternatively spliced mu opioid receptor variants: mMOR-1A, mMOR-1O, and mMOR-1P
    Jin Xu
    Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, New York, New York, 10065
    Synapse 68:144-52. 2014

Collaborators

Detail Information

Publications17

  1. pmc Characterizing exons 11 and 1 promoters of the mu opioid receptor (Oprm) gene in transgenic mice
    Jin Xu
    Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY 10021 USA
    BMC Mol Biol 7:41. 2006
    ..The aim of this study is to further characterize the E11 and E1 promoters in vivo using a transgenic mouse model...
  2. ncbi request reprint DJ-1 transcriptionally up-regulates the human tyrosine hydroxylase by inhibiting the sumoylation of pyrimidine tract-binding protein-associated splicing factor
    Nan Zhong
    Department of Neurology, Caritas St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02135, USA
    J Biol Chem 281:20940-8. 2006
    ..Therefore, our results suggest DJ-1 as a regulator of protein sumoylation and directly link the loss of DJ-1 expression and transcriptional dysfunction to impaired dopamine synthesis...
  3. pmc Stabilization of the μ-opioid receptor by truncated single transmembrane splice variants through a chaperone-like action
    Jin Xu
    Department of Neurology and The Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    J Biol Chem 288:21211-27. 2013
    ..Our studies suggest the functional roles of truncated receptors in other G protein-coupled receptor families. ..
  4. pmc Isolation and characterization of new exon 11-associated N-terminal splice variants of the human mu opioid receptor gene
    Jin Xu
    Department of Neurology and The Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    J Neurochem 108:962-72. 2009
    ..The presence of exon 11-associated variants in humans raises questions regarding their potential role in heroin and morphine-6beta-glucuronide actions in people as they do in mice...
  5. pmc Identification and characterization of seven new exon 11-associated splice variants of the rat μ opioid receptor gene, OPRM1
    Jin Xu
    Department of Neurology and Program in Molecular Pharmacology and Chemistry, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Mol Pain 7:9. 2011
    ..We now have examined 5' splicing in the rat...
  6. ncbi request reprint Identification of three new alternatively spliced variants of the rat mu opioid receptor gene: dissociation of affinity and efficacy
    David A Pasternak
    Laboratory of Molecular Neuropharmacology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Neurochem 91:881-90. 2004
    ..Thus, selectivity of opioid action might be achieved by designing compounds with varying efficacies at different MOR-1 variants...
  7. pmc Involvement of exon 11-associated variants of the mu opioid receptor MOR-1 in heroin, but not morphine, actions
    Ying Xian Pan
    Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 106:4917-22. 2009
    ....
  8. doi request reprint Synergistic activation of the human MnSOD promoter by DJ-1 and PGC-1alpha: regulation by SUMOylation and oxidation
    Nan Zhong
    Department of Neurology, Caritas St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA 02135, USA
    Hum Mol Genet 17:3357-67. 2008
    ..Consequent abnormal mitochondrial gene expression may contribute to the development of sporadic PD...
  9. ncbi request reprint Identification of four novel exon 5 splice variants of the mouse mu-opioid receptor gene: functional consequences of C-terminal splicing
    Ying Xian Pan
    Laboratory of Molecular Neuropharmacology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
    Mol Pharmacol 68:866-75. 2005
    ..In conclusion, alterations in the amino acid sequence of the C terminus do not alter the mu-specificity of the receptor but they can influence the binding characteristics, efficacy, and potency of mu-opioids...
  10. ncbi request reprint Isolating and characterizing three alternatively spliced mu opioid receptor variants: mMOR-1A, mMOR-1O, and mMOR-1P
    Jin Xu
    Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, New York, New York, 10065
    Synapse 68:144-52. 2014
    ....
  11. ncbi request reprint Morphine regulates expression of μ-opioid receptor MOR-1A, an intron-retention carboxyl terminal splice variant of the μ-opioid receptor (OPRM1) gene via miR-103/miR-107
    Zhigang Lu
    Department of Neurology and The Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, New York, New York
    Mol Pharmacol 85:368-80. 2014
    ....
  12. pmc Altered Ca2+ homeostasis in the skeletal muscle of DJ-1 null mice
    Alexander Shtifman
    Department of Neurology, Caritas St Elizabeth s Medical Center, Tufts University School of Medicine, 736 Cambridge St, CBR 406, Boston, MA 02135, USA
    Neurobiol Aging 32:125-32. 2011
    ..These results provide evidence of DJ-1's association with Ca(2+) regulatory pathways in mouse skeletal muscle, and suggest the potential benefit of resveratrol to functionally compensate for the loss of DJ-1...
  13. ncbi request reprint Identification and characterization of two new human mu opioid receptor splice variants, hMOR-1O and hMOR-1X
    Ying Xian Pan
    Department of Neurology, Laboratory of Molecular Neuropharmacology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
    Biochem Biophys Res Commun 301:1057-61. 2003
    ..These two new human mu opioid receptors are the first human MOR-1 variants containing new exons and suggest that the complex splicing present in mice may extend to humans...
  14. doi request reprint Deletion of podocyte STAT3 mitigates the entire spectrum of HIV-1-associated nephropathy
    Leyi Gu
    Division of Nephrology, Mount Sinai School of Medicine, New York, New York 10029, USA
    AIDS 27:1091-8. 2013
    ..We confirm here that deletion of podocyte STAT3 is sufficient to mitigate the glomerular as well as tubulointerstitial findings of HIVAN...
  15. pmc HIV-1 Nef disrupts the podocyte actin cytoskeleton by interacting with diaphanous interacting protein
    Ting Chi Lu
    Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Biol Chem 283:8173-82. 2008
    ..We conclude that in HIV-infected podocytes, Nef, through the recruitment of DIP and p190RhoAGAP to Nef-Src complex, activates p190RhoAGAP and down-regulates RhoA activity...
  16. ncbi request reprint The Parkinson's disease-associated DJ-1 protein is a transcriptional co-activator that protects against neuronal apoptosis
    Jin Xu
    Department of Neurology, Caritas St Elizabeth s Center, Tufts University School of Medicine, Boston, MA 02135, USA
    Hum Mol Genet 14:1231-41. 2005
    ..Mutations that impair the transcriptional co-activator function of DJ-1 render dopaminergic neurons vulnerable to apoptosis and may contribute to the pathogenesis of PD...
  17. pmc Cooperativity of TMPRSS2-ERG with PI3-kinase pathway activation in prostate oncogenesis
    Jennifer C King
    Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Nat Genet 41:524-6. 2009
    ..TMPRSS2-ERG-positive human tumors are also enriched for PTEN loss, suggesting cooperation in prostate tumorigenesis...