Joao B Xavier
Affiliation: Memorial Sloan-Kettering Cancer Center
- A molecular mechanism that stabilizes cooperative secretions in Pseudomonas aeruginosaJoao B Xavier
Center for Systems Biology, Harvard University, 52 Oxford St, Cambridge, MA 02138, USA
Mol Microbiol 79:166-79. 2011..More generally, prudent regulation is a mechanism to stabilize cooperation...
- Social interaction in synthetic and natural microbial communitiesJoao B Xavier
Program in Computational Biology, Memorial Sloan Kettering Cancer Center, New York City, NY 10065, USA
Mol Syst Biol 7:483. 2011..Finding similar patterns in such diverse systems suggests that the same 'social interaction motifs' may be general to many cell populations...
- Intestinal microbiota containing Barnesiella species cures vancomycin-resistant Enterococcus faecium colonizationCarles Ubeda
Infectious Diseases Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA
Infect Immun 81:965-73. 2013..Our studies indicate that obligate anaerobic bacteria belonging to the Barnesiella genus enable clearance of intestinal VRE colonization and may provide novel approaches to prevent the spread of highly antibiotic-resistant bacteria...
- Convergent evolution of hyperswarming leads to impaired biofilm formation in pathogenic bacteriaDave van Ditmarsch
Program in Computational Biology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
Cell Rep 4:697-708. 2013..The finding that evolution in swarming colonies reliably produces evolution of poor biofilm formers supports the existence of an evolutionary trade-off between motility and biofilm formation. ..
- A quantitative test of population genetics using spatiogenetic patterns in bacterial coloniesKirill S Korolev
Department of Physics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Am Nat 178:538-52. 2011..While our experimental system is a simplification of natural microbial community, we argue that it constitutes proof of principle that the spatial models of population genetics can quantitatively capture organismal evolution...
- Social interaction, noise and antibiotic-mediated switches in the intestinal microbiotaVanni Bucci
Program in Computational Biology, Memorial Sloan Kettering Cancer Center, New York, New York, USA
PLoS Comput Biol 8:e1002497. 2012..Our methodology can be extended to multiple bacterial groups and thus it provides an ecological formalism to help interpret the present surge in microbiome data...
- The evolution of bacteriocin production in bacterial biofilmsVanni Bucci
Program in Computational Biology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
Am Nat 178:E162-73. 2011..However, under conditions of high nutrient penetration leading to well-mixed biofilms, biodiversity rapidly decreases and becomes sensitive to the critical bacteriocin range...
- High-resolution time series of Pseudomonas aeruginosa gene expression and rhamnolipid secretion through growth curve synchronizationDave van Ditmarsch
Computational Biology Program, Memorial Sloan Kettering Cancer Center, 408 East 69th Street, New York NY, 10021 5604, USA
BMC Microbiol 11:140. 2011..However, measuring the secreted rhamnolipid biosurfactants requires laborious sample processing, which makes this an offline measurement...
- Multilevel selection analysis of a microbial social traitLaura De Vargas Roditi
Program in Computational Biology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
Mol Syst Biol 9:684. 2013..Our analysis supports the key prediction that strong group selection does not necessarily mean that microbial cooperation will always emerge. ..
- Exploiting social evolution in biofilmsKerry E Boyle
Program in Computational Biology, Memorial Sloan Kettering Cancer Center, New York, NY, United States
Curr Opin Microbiol 16:207-12. 2013..This exciting new research can ultimately lead to new therapies against biofilm infections that exploit evolutionary cheating or the trade-off between biofilm formation and dispersal...
- Intestinal domination and the risk of bacteremia in patients undergoing allogeneic hematopoietic stem cell transplantationYing Taur
Infectious Disease Service, Department of Medicine, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA
Clin Infect Dis 55:905-14. 2012..We examined the microbiota of patients undergoing allo-HSCT, and correlated microbial shifts with the risk of bacteremia...
- Social evolution of spatial patterns in bacterial biofilms: when conflict drives disorderJoao B Xavier
Center for Systems Biology, Harvard University, Cambridge, Massachusetts 02138, USA
Am Nat 174:1-12. 2009..Moreover, and contrary to previous theory, our analysis predicts an antagonistic relationship between evolutionary conflict and pattern formation: conflict drives disorder...