Martin R Weiser

Summary

Affiliation: Memorial Sloan-Kettering Cancer Center
Country: USA

Publications

  1. ncbi request reprint Clinical examination following preoperative chemoradiation for rectal cancer is not a reliable surrogate end point
    Jose G Guillem
    Colorectal Service, Memorial Sloan Kettering Cancer Center, 1275 York Ave, Room C 1077, New York, NY 10021, USA
    J Clin Oncol 23:3475-9. 2005
  2. ncbi request reprint Predictive clinicopathologic factors for limited response of T3 rectal cancer to combined modality therapy
    Anne Y Lin
    Colorectal Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Int J Colorectal Dis 23:243-9. 2008
  3. doi request reprint Pathologic stage is most prognostic of disease-free survival in locally advanced rectal cancer patients after preoperative chemoradiation
    Hak Mien Quah
    Department of Colorectal Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Cancer 113:57-64. 2008
  4. doi request reprint Effects of obesity in rectal cancer surgery
    Hueylan Chern
    Colorectal Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    J Am Coll Surg 211:55-60. 2010
  5. doi request reprint Immunohistochemical staining for DNA mismatch repair proteins in intestinal tract carcinoma: how reliable are biopsy samples?
    Jinru Shia
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Am J Surg Pathol 35:447-54. 2011
  6. ncbi request reprint Colorectal cancer patients with oligometastatic liver disease: what is the optimal approach?
    Martin R Weiser
    Colorectal Service Dept of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Oncology (Williston Park) 27:1074-8. 2013
  7. ncbi request reprint Management of complete response after chemoradiation in rectal cancer
    Martin R Weiser
    Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA Electronic address
    Surg Oncol Clin N Am 23:113-25. 2014
  8. doi request reprint Sphincter preservation in low rectal cancer is facilitated by preoperative chemoradiation and intersphincteric dissection
    Martin R Weiser
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Ann Surg 249:236-42. 2009
  9. pmc Predicting survival after curative colectomy for cancer: individualizing colon cancer staging
    Martin R Weiser
    Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    J Clin Oncol 29:4796-802. 2011
  10. doi request reprint Individualized prediction of colon cancer recurrence using a nomogram
    Martin R Weiser
    Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
    J Clin Oncol 26:380-5. 2008

Detail Information

Publications84

  1. ncbi request reprint Clinical examination following preoperative chemoradiation for rectal cancer is not a reliable surrogate end point
    Jose G Guillem
    Colorectal Service, Memorial Sloan Kettering Cancer Center, 1275 York Ave, Room C 1077, New York, NY 10021, USA
    J Clin Oncol 23:3475-9. 2005
    ..However, because the accuracy of this approach has not been established, we conducted a prospective analysis to determine the operating surgeon's ability to assess response using DRE...
  2. ncbi request reprint Predictive clinicopathologic factors for limited response of T3 rectal cancer to combined modality therapy
    Anne Y Lin
    Colorectal Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Int J Colorectal Dis 23:243-9. 2008
    ..The aim of this study was to identify pretreatment factors associated with poor tumor response to neoadjuvant chemoradiation...
  3. doi request reprint Pathologic stage is most prognostic of disease-free survival in locally advanced rectal cancer patients after preoperative chemoradiation
    Hak Mien Quah
    Department of Colorectal Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Cancer 113:57-64. 2008
    ....
  4. doi request reprint Effects of obesity in rectal cancer surgery
    Hueylan Chern
    Colorectal Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    J Am Coll Surg 211:55-60. 2010
    ..In this study, we evaluate whether higher body mass index (BMI) compromises surgical resection in patients with locally advanced, mid-to-low rectal cancer after neoadjuvant therapy, adversely affecting long-term oncologic outcomes...
  5. doi request reprint Immunohistochemical staining for DNA mismatch repair proteins in intestinal tract carcinoma: how reliable are biopsy samples?
    Jinru Shia
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Am J Surg Pathol 35:447-54. 2011
    ..However, whether biopsy samples can be reliably used for mismatch repair protein detection remains to be determined...
  6. ncbi request reprint Colorectal cancer patients with oligometastatic liver disease: what is the optimal approach?
    Martin R Weiser
    Colorectal Service Dept of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Oncology (Williston Park) 27:1074-8. 2013
    ..Here we present the insights we have arrived at through our own considerable experience with this patient population, and we reflect on the relevant studies that are available...
  7. ncbi request reprint Management of complete response after chemoradiation in rectal cancer
    Martin R Weiser
    Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA Electronic address
    Surg Oncol Clin N Am 23:113-25. 2014
    ..This review discusses the current literature, and describes treatment strategies for patients who have a complete clinical response on follow-up endoscopy after chemoradiotherapy. ..
  8. doi request reprint Sphincter preservation in low rectal cancer is facilitated by preoperative chemoradiation and intersphincteric dissection
    Martin R Weiser
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Ann Surg 249:236-42. 2009
    ....
  9. pmc Predicting survival after curative colectomy for cancer: individualizing colon cancer staging
    Martin R Weiser
    Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    J Clin Oncol 29:4796-802. 2011
    ..The purpose of this study was to extend the seventh edition of the AJCC staging system for colon cancer to incorporate additional information available from tumor registries, thereby improving prognostic accuracy...
  10. doi request reprint Individualized prediction of colon cancer recurrence using a nomogram
    Martin R Weiser
    Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
    J Clin Oncol 26:380-5. 2008
    ..Although easy to implement, there remains significant heterogeneity within each stage grouping. In the era of multimodality treatment, a more refined tool is needed to predict recurrence...
  11. ncbi request reprint Surgical salvage of recurrent rectal cancer after transanal excision
    Martin R Weiser
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Dis Colon Rectum 48:1169-75. 2005
    ..This study examines surgical salvage of locally recurrent rectal cancer following transanal excision of early tumors...
  12. doi request reprint Identification of patients with high-risk stage II colon cancer for adjuvant therapy
    Hak Mien Quah
    Colorectal Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Dis Colon Rectum 51:503-7. 2008
    ..The purpose of this study was to assess the prognostic significance of commonly reported clinicopathologic features of Stage II colon cancer to identify high-risk patients...
  13. doi request reprint Response to neoadjuvant therapy in patients with early age-of-onset rectal cancer
    Emily Steinhagen
    Department of Surgery, Colorectal Service, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Dis Colon Rectum 56:58-63. 2013
    ..The response to neoadjuvant treatment in patients ≤ 50 years of age is not known. Factors affecting the response to neoadjuvant therapy in this age group have not been evaluated...
  14. doi request reprint Squamous-cell carcinoma of the anal canal: predictors of treatment outcome
    Ramin Roohipour
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Dis Colon Rectum 51:147-53. 2008
    ..The incidence of anal canal squamous-cell carcinoma is increasing. Limited data exist on predictors of treatment failure. This study was designed to identify predictors for relapse/persistence after first-line therapy...
  15. doi request reprint Evaluation of ¹⁸F-FDG-PET for early detection of suboptimal response of rectal cancer to preoperative chemoradiotherapy: a prospective analysis
    Tobias Leibold
    Department of Surgery Colorectal Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Ann Surg Oncol 18:2783-9. 2011
    ..We prospectively evaluated tumor response with (18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET) early in the course of preoperative CRT...
  16. doi request reprint Locoregional lymphadenectomy in the surgical management of anorectal melanoma
    Daniel R Perez
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Ann Surg Oncol 20:2339-44. 2013
    ..Understanding the significance of lymphatic dissemination might assist in stratifying patients for either organ preservation or radical surgery...
  17. pmc What is the significance of the circumferential margin in locally advanced rectal cancer after neoadjuvant chemoradiotherapy?
    Atthaphorn Trakarnsanga
    Colorectal Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Ann Surg Oncol 20:1179-84. 2013
    ..However, its significance in the setting of long-course neoadjuvant chemoradiotherapy (nCRT) is not well defined...
  18. doi request reprint Detailed pathologic characteristics of the primary colorectal tumor independently predict outcome after hepatectomy for metastases
    Kenneth Cardona
    Department of Surgery, Division of Hepatopancreatobiliary Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Ann Surg Oncol 20:148-54. 2013
    ..This study analyzes the prognostic relevance of pathologic details of the primary colorectal tumor in patients undergoing hepatic resection for CRLM...
  19. ncbi request reprint Squamous-cell carcinoma of the rectum: a rare but curable tumor
    Caio S R Nahas
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Dis Colon Rectum 50:1393-400. 2007
    ..This study was designed to evaluate one institution's experience with treatment outcomes for rectal squamous-cell carcinoma...
  20. ncbi request reprint Carcinoid of the rectum risk stratification (CaRRs): a strategy for preoperative outcome assessment
    Bridget N Fahy
    Department of Surgery, Division of Colorectal Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Ann Surg Oncol 14:1735-43. 2007
    ..Predicting rectal carcinoid behavior based exclusively on tumor size is imprecise. We sought to identify factors associated with outcome and incorporate them into a pre-operative risk stratification scheme...
  21. doi request reprint Synchronous hepatic metastases from colon cancer: changing treatment strategies and results of surgical intervention
    Bridget N Fahy
    Department of Surgery, The Methodist Hospital, Houston, TX 77030, USA
    Ann Surg Oncol 16:361-70. 2009
    ..A multidisciplinary treatment approach which combines both medical and surgical modalities may be associated with improved survival...
  22. doi request reprint Anastomotic leak following low anterior resection in stage IV rectal cancer is associated with poor survival
    James D Smith
    Colorectal Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Ann Surg Oncol 20:2641-6. 2013
    ..We measured the incidence of anastomotic leak and its association with clinical outcome...
  23. doi request reprint Neither FDG-PET Nor CT can distinguish between a pathological complete response and an incomplete response after neoadjuvant chemoradiation in locally advanced rectal cancer: a prospective study
    Jose G Guillem
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Ann Surg 258:289-95. 2013
    ..To prospectively compare the ability of flourodeoxyglucose-positron emission tomography (FDG-PET) and computed tomography (CT) to identify a pathological complete response (pCR) in patients with rectal cancer treated by chemoradiation...
  24. doi request reprint Rate of residual disease after complete endoscopic resection of malignant colonic polyp
    Jean M Butte
    Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    Dis Colon Rectum 55:122-7. 2012
    ..Following polypectomy, colectomy is performed selectively to ensure complete clearance of neoplasia...
  25. doi request reprint A predictive model for lymph node yield in colon cancer resection specimens
    Garrett M Nash
    Department of Surgery, Colorectal Service, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    Ann Surg 253:318-22. 2011
    ..To develop a predictive model of lymph node yield in a series of colon cancer resection specimens with detailed anatomic and surgical technique data...
  26. doi request reprint Pathologic classification and clinical behavior of the spectrum of goblet cell carcinoid tumors of the appendix
    Laura H Tang
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Am J Surg Pathol 32:1429-43. 2008
    ..Surgical management with right hemicolectomy is recommended after appendectomy for most cases, particularly those with an adenocarcinoma component (groups B and C)...
  27. pmc Challenging the feasibility and clinical significance of current guidelines on lymph node examination in rectal cancer in the era of neoadjuvant therapy
    Anand Govindarajan
    Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    J Clin Oncol 29:4568-73. 2011
    ..We sought to examine the feasibility and clinical significance of current guidelines on nodal assessment in patients with rectal cancer (RC) treated with neoadjuvant radiation...
  28. ncbi request reprint Complications after preoperative combined modality therapy and radical resection of locally advanced rectal cancer: a 14-year experience from a specialty service
    David B Chessin
    Colorectal Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Am Coll Surg 200:876-82; discussion 882-4. 2005
    ..But its impact on postoperative complications has not been adequately evaluated. Our aims were to evaluate our comprehensive experience and identify factors predictive of complications in this patient population...
  29. ncbi request reprint Can differences in bowel function after surgery for rectal cancer be identified by the European Organization for Research and Treatment of Cancer quality of life instrument?
    Heather B Neuman
    Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, New York 10021, USA
    Ann Surg Oncol 14:1727-34. 2007
    ....
  30. ncbi request reprint Management and outcome of perianal Paget's disease: a 6-decade institutional experience
    Daniel R Perez
    1Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 2Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York
    Dis Colon Rectum 57:747-51. 2014
    ..It is often noninvasive but frequently recurs locally. Invasive disease can metastasize to distant sites...
  31. doi request reprint MET activation mediates resistance to lapatinib inhibition of HER2-amplified gastric cancer cells
    Chin Tung Chen
    Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    Mol Cancer Ther 11:660-9. 2012
    ..Development of inhibitors targeting multiple receptors or common downstream signaling proteins merits further investigation...
  32. doi request reprint Pulmonary recurrence predominates after combined modality therapy for rectal cancer: an original retrospective study
    Peirong Ding
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Ann Surg 256:111-6. 2012
    ..To characterize patterns of recurrence in locally advanced rectal cancer treated with combined modality therapy (CMT): neoadjuvant chemoradiation + total mesorectal excision + adjuvant chemotherapy...
  33. doi request reprint Recurrence rates and prognostic factors in ypN0 rectal cancer after neoadjuvant chemoradiation and total mesorectal excision
    Anand Govindarajan
    Department of Colorectal Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Ann Surg Oncol 18:3666-72. 2011
    ..Patients with pathologically node-negative tumors have an improved prognosis, but recurrence patterns and independent prognostic factors in these patients have been incompletely characterized...
  34. doi request reprint Significance of acellular mucin pools in rectal carcinoma after neoadjuvant chemoradiotherapy
    Jinru Shia
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Am J Surg Pathol 35:127-34. 2011
    ....
  35. pmc Clinical and pathologic factors that predict lymph node yield from surgical specimens in colorectal cancer: a population-based study
    Joanne F Chou
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Cancer 116:2560-70. 2010
    ..However, heterogeneity in LN harvest exists. The objective of this study was to investigate the clinicopathologic factors that influence LN yield...
  36. ncbi request reprint Feasibility of ex vivo FDG PET of the colon
    Marc J Gollub
    Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10023, USA
    Radiology 252:232-9. 2009
    ....
  37. pmc Long-term oncologic outcome following preoperative combined modality therapy and total mesorectal excision of locally advanced rectal cancer
    Jose G Guillem
    Department of Surgery Colorectal Service, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Ann Surg 241:829-36; discussion 836-8. 2005
    ....
  38. doi request reprint Long-term survival after transanal excision of T1 rectal cancer
    Garrett M Nash
    Department of Surgery, Colorectal Service, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Dis Colon Rectum 52:577-82. 2009
    ..However, the impact of transanal excision on cancer mortality has not been adequately studied. The purpose of this study was to compare oncologic outcomes of transanal excision with those of radical resection...
  39. ncbi request reprint Limitations of early rectal cancer nodal staging may explain failure after local excision
    Ron G Landmann
    Colorectal Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Dis Colon Rectum 50:1520-5. 2007
    ..The limitations of endorectal ultrasound in accurately staging nodal disease in early rectal lesions may, in part, explain the relatively high recurrence rates seen after local excision...
  40. doi request reprint Is nonsmall cell type high-grade neuroendocrine carcinoma of the tubular gastrointestinal tract a distinct disease entity?
    Jinru Shia
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Am J Surg Pathol 32:719-31. 2008
    ..These tumors are clinically aggressive. Prospective studies using defined diagnostic criteria are needed to determine their biologic characteristics and optimal management...
  41. doi request reprint Patterns of failure in patients with early onset (synchronous) resectable liver metastases from rectal cancer
    Jean M Butte
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Cancer 118:5414-23. 2012
    ..In this study, the authors examined recurrence patterns and survival after resection of SLMRC...
  42. doi request reprint Treatment for patients with rectal cancer and a clinical complete response to neoadjuvant therapy: a decision analysis
    Heather B Neuman
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Dis Colon Rectum 52:863-71. 2009
    ..Therefore, the objective was to develop a decision-analytic model to evaluate the relative benefits of surgery vs. observation in rectal cancer patients who achieve clinical complete response after neoadjuvant chemoradiation...
  43. pmc T1 adenocarcinoma of the rectum: transanal excision or radical surgery?
    David J Bentrem
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Ann Surg 242:472-7; discussion 477-9. 2005
    ..We performed a retrospective evaluation of patients with T1 rectal cancers treated by either transanal excision or radical resection at our institution to assess patient selection, cancer recurrence, and survival...
  44. ncbi request reprint Operative salvage for locoregional recurrent colon cancer after curative resection: an analysis of 100 cases
    Wilbur B Bowne
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Dis Colon Rectum 48:897-909. 2005
    ..This investigation was undertaken to review our experience with surgical resection for patients with locoregional recurrence colon cancer, determine predictors of respectability, and define prognostic factors associated with survival...
  45. ncbi request reprint Sacral resection for recurrent rectal cancer: analysis of morbidity and treatment results
    Genevieve B Melton
    Division of Colorectal Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Dis Colon Rectum 49:1099-107. 2006
    ..Composite sacropelvic resection for locally advanced recurrent rectal cancer is a high-risk procedure that benefits select patients. We reviewed our recent institutional experience to evaluate case selection, morbidity, and outcomes...
  46. doi request reprint Nonoperative management of rectal cancer with complete clinical response after neoadjuvant therapy
    James D Smith
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Ann Surg 256:965-72. 2012
    ....
  47. doi request reprint Whole-mount pathologic analysis of rectal cancer following neoadjuvant therapy: implications of margin status on long-term oncologic outcome
    James J Mezhir
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Ann Surg 256:274-9. 2012
    ..We set out to determine the long-term oncologic impact of resection margins in patients with locally advanced rectal cancer using a comprehensive pathologic whole-mount section analysis...
  48. pmc Antitumor activity of SNX-2112, a synthetic heat shock protein-90 inhibitor, in MET-amplified tumor cells with or without resistance to selective MET Inhibition
    Thomas Bachleitner-Hofmann
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Clin Cancer Res 17:122-33. 2011
    ..MET, a tyrosine kinase that is constitutively active in tumor cells with MET oncogene amplification, has recently been identified as another HSP-90 client...
  49. doi request reprint Folate receptor-α expression in resectable hepatic colorectal cancer metastases: patterns and significance
    Michael D'Angelica
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Mod Pathol 24:1221-8. 2011
    ..The prognostic value of FRα expression and the utility of FRα-targeted therapies in stage-IV colorectal cancer patients deserve further exploration...
  50. ncbi request reprint Positron emission tomography detection of distant metastatic or synchronous disease in patients with locally advanced rectal cancer receiving preoperative chemoradiation
    Caio S R Nahas
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Ann Surg Oncol 15:704-11. 2008
    ....
  51. pmc MET expression and amplification in patients with localized gastric cancer
    Yelena Y Janjigian
    Gastrointestinal Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, Weill Medical College of Cornell University, New York, NY 10065, USA
    Cancer Epidemiol Biomarkers Prev 20:1021-7. 2011
    ..MET, the receptor for hepatocyte growth factor, has been proposed as a therapeutic target in gastric cancer. This study assessed the incidence of MET expression and gene amplification in tumors of Western patients with gastric cancer...
  52. ncbi request reprint Oncologic outcomes of salvage surgery for epidermoid carcinoma of the anus initially managed with combined modality therapy
    Robert P Akbari
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Dis Colon Rectum 47:1136-44. 2004
    ..Primary chemoradiation failure for epidermoid carcinoma of the anus is treated by surgical resection. This study evaluates the outcome of salvage surgery at one institution...
  53. pmc The role of abdominoperineal resection as surgical therapy for anorectal melanoma
    Jen Jen Yeh
    Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Ann Surg 244:1012-7. 2006
    ..1) Characterize changes in the surgical treatment of anorectal melanoma over time. 2) Determine if the extent of surgical resection is associated with outcome. 3) Identify prognostic factors correlating with survival...
  54. doi request reprint Immunohistochemistry as first-line screening for detecting colorectal cancer patients at risk for hereditary nonpolyposis colorectal cancer syndrome: a 2-antibody panel may be as predictive as a 4-antibody panel
    Jinru Shia
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Am J Surg Pathol 33:1639-45. 2009
    ..Such a cost-effective approach carries significant implication, as immunohistochemistry is being widely used as first-line screening for HNPCC...
  55. doi request reprint Evaluation of an endorectal electrode for performing focused irreversible electroporation ablations in the Swine rectum
    Govindarajan Srimathveeravalli
    Radiochemistry and Imaging Science Service and Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    J Vasc Interv Radiol 24:1249-56. 2013
    ..To study the feasibility of a novel endorectal electrode for the creation of focal ablations of the rectal wall with the use of irreversible electroporation (IRE)...
  56. ncbi request reprint Patterns of morphologic alteration in residual rectal carcinoma following preoperative chemoradiation and their association with long-term outcome
    Jinru Shia
    Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Am J Surg Pathol 28:215-23. 2004
    ..Our results demonstrate distinct morphologic features in treated rectal carcinomas that are prognostically relevant...
  57. doi request reprint HER kinase activation confers resistance to MET tyrosine kinase inhibition in MET oncogene-addicted gastric cancer cells
    Thomas Bachleitner-Hofmann
    Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Mol Cancer Ther 7:3499-508. 2008
    ....
  58. pmc Nodal staging score: a tool to assess adequate staging of node-negative colon cancer
    Mithat Gonen
    Memorial Sloan Kettering Cancer Center, Department of Epidemiology and Biostatistics, 1275 York Ave, Box 44, New York, NY 10065, USA
    J Clin Oncol 27:6166-71. 2009
    ..We sought to refine this definition by quantifying the likelihood that a pathologically node-negative patient has, indeed, no positive nodes...
  59. doi request reprint Quality of life and symptom control after stent placement or surgical palliation of malignant colorectal obstruction
    Satish Nagula
    Department of Medicine, Gastroenterology, and Nutrition Service, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    J Am Coll Surg 210:45-53. 2010
    ..Self-expanding metal stents have emerged as an alternative for palliation of malignant LBO. However, there are few long-term studies documenting the effect of surgical palliation or colonic stents on symptoms or quality of life (QoL)...
  60. doi request reprint c-Met gene amplification is associated with advanced stage colorectal cancer and liver metastases
    Zhao Shi Zeng
    Department of Surgery, Colorectal Service, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Cancer Lett 265:258-69. 2008
    ..c-Met gene amplification is linked to metastatic progression, and is a viable target for a significant subset of advanced CRC...
  61. ncbi request reprint Novel xenograft model expressing human hepatocyte growth factor shows ligand-dependent growth of c-Met-expressing tumors
    Todd D Francone
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Mol Cancer Ther 6:1460-6. 2007
    ..This novel xenograft model is ideal for investigating c-Met/HGF-dependent human tumor progression and for evaluating c-Met targeted therapy...
  62. doi request reprint Early postoperative intraperitoneal chemotherapy following cytoreductive surgery for appendiceal mucinous neoplasms with isolated peritoneal metastasis
    Patrick L Wagner
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Dis Colon Rectum 55:407-15. 2012
    ..At our institution, patients undergoing complete cytoreduction in this setting typically receive multiple cycles of early postoperative intraperitoneal chemotherapy...
  63. pmc HGF rescues colorectal cancer cells from EGFR inhibition via MET activation
    David Liska
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Clin Cancer Res 17:472-82. 2011
    ..Here, we investigate hepatocyte growth factor (HGF)-dependent mesenchymal-epithelial transition factor (MET) activation as a mediator of cetuximab resistance through signal diversification in CRC cell lines...
  64. doi request reprint Anastomotic leak is not associated with oncologic outcome in patients undergoing low anterior resection for rectal cancer
    James D Smith
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Ann Surg 256:1034-8. 2012
    ..To examine the association between anastomotic leak and oncologic outcome after anterior resection, stratifying for defunctioning stoma...
  65. ncbi request reprint Carcinoid of the rectum risk stratification (CaRRS): a strategy for preoperative outcome assessment
    Bridget N Fahy
    Department of Surgery, Division of Colorectal Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Ann Surg Oncol 14:396-404. 2007
    ..Predicting rectal carcinoid behavior exclusively on the basis of tumor size is imprecise. We sought to identify factors associated with outcome and incorporate them into a preoperative risk stratification scheme...
  66. ncbi request reprint The development of a validated instrument to evaluate bowel function after sphincter-preserving surgery for rectal cancer
    Larissa K Temple
    Department of Surgery, Division of Colorectal Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Dis Colon Rectum 48:1353-65. 2005
    ..Therefore, the purpose of this study was to develop an instrument to evaluate bowel function after sphincter-preserving surgery...
  67. ncbi request reprint Differential expression of alpha-methylacyl-coenzyme A racemase in colorectal carcinoma bears clinical and pathologic significance
    Anne Lin
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Hum Pathol 38:850-6. 2007
    ..Further investigation on interaction between AMACR and other known colorectal cancer development pathways may provide new insights on colorectal carcinogenesis...
  68. doi request reprint Prospective immunohistochemical analysis of primary colorectal cancers for loss of mismatch repair protein expression
    Steven A Lee-Kong
    Department of Surgery, Colorectal Service, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Clin Colorectal Cancer 9:255-9. 2010
    ..We examined the value of routine immunohistochemistry (IHC) for MMR proteins in patients with colorectal cancer (CRC) undergoing resection at a single institution...
  69. ncbi request reprint Factors associated with sphincter-preserving surgery for rectal cancer at national comprehensive cancer network centers
    Larissa K Temple
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Ann Surg 250:260-7. 2009
    ..To determine rate and predictors of sphincter-preserving surgery (SPS) for rectal cancer patients treated at specialty institutions...
  70. doi request reprint Randomized clinical trials in rectal and anal cancers
    Jason Park
    Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    Surg Oncol Clin N Am 19:205-23. 2010
    ..The article discusses the major RCTs and relevant findings that have impacted clinical management most and includes most but not all RCTs on therapy for rectal cancer published during this period...
  71. ncbi request reprint Contemporary imaging for colorectal cancer
    Carl R Schmidt
    Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Surg Oncol Clin N Am 16:369-88. 2007
    ..Postoperative imaging enhances identification of recurrent disease that might be amenable to salvage surgery...
  72. doi request reprint Immunohistochemical expression of folate receptor alpha in colorectal carcinoma: patterns and biological significance
    Jinru Shia
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Hum Pathol 39:498-505. 2008
    ..The significance of such an association as well as the prognostic value of FRalpha expression deserves further exploration...
  73. ncbi request reprint Increased endocrine cells in treated rectal adenocarcinomas: a possible reflection of endocrine differentiation in tumor cells induced by chemotherapy and radiotherapy
    Jinru Shia
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Am J Surg Pathol 26:863-72. 2002
    ..The possible mechanism for the increased endocrine cells in treated rectal adenocarcinomas may be related to induction of endocrine differentiation in tumor cells by cytotoxic insult...
  74. doi request reprint Accuracy of endorectal ultrasound for measurement of the closest predicted radial mesorectal margin for rectal cancer
    P Terry Phang
    St Paul s Hospital, University of British Columbia, Vancouver, British Columbia, Canada
    Dis Colon Rectum 55:59-64. 2012
    ..Endorectal ultrasound is also used to assess the clinical stage of the cancer that will determine the recommendation for neoadjuvant chemoradiation, but it has not been used to assess the closest predicted radial margin...
  75. doi request reprint Whither TNM?
    Mithat Gonen
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Semin Oncol 37:27-30. 2010
    ..We recommend that parsimony should be considered to counterbalance the instinct to increase the number of categories in future revisions of staging systems such as TNM...
  76. ncbi request reprint Prevalence of perianal intraepithelial neoplasia in HIV-infected patients referred for high-resolution anoscopy
    Caio S R Nahas
    Colorectal Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Dis Colon Rectum 49:1581-6. 2006
    ..This study was designed to describe perianal disease in a cohort of HIV-infected patients referred for high-resolution anoscopy...
  77. ncbi request reprint Response of stage IV anal mucosal melanoma to chemotherapy
    Jen Jen Yeh
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Lancet Oncol 6:438-9. 2005
  78. ncbi request reprint Immunoblot analysis of c-Met expression in human colorectal cancer: overexpression is associated with advanced stage cancer
    Zhaoshi Zeng
    Colorectal Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Clin Exp Metastasis 21:409-17. 2004
    ..C-Met protein is expressed at levels significantly higher than adjacent mucosa in most primary adenocarcinomas of the colon. Our results support an important role for c-Met in human CRC progression and metastasis...
  79. ncbi request reprint Combined CT colonography and 18F-FDG PET of colon polyps: potential technique for selective detection of cancer and precancerous lesions
    Marc J Gollub
    Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, Rm C276F, New York, NY 10021, USA
    AJR Am J Roentgenol 188:130-8. 2007
    ..The purpose of this study was to determine the feasibility of imaging the colon with fused CT colonography (CTC) and 18F-FDG PET and to correlate the findings with the histologic features of polyps...
  80. ncbi request reprint L576P KIT mutation in anal melanomas correlates with KIT protein expression and is sensitive to specific kinase inhibition
    Cristina R Antonescu
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Int J Cancer 121:257-64. 2007
    ..These results suggest that a subset of anal melanomas show activating KIT mutations, which are susceptible for therapy with specific kinase inhibitors...
  81. ncbi request reprint An update on laparoscopic resection for rectal cancer
    David Row
    Colorectal Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Cancer Control 17:16-24. 2010
    ..The available literature focusing on laparoscopic resection for rectal cancer has been predominantly retrospective in nature, with a limited number of prospective studies...
  82. doi request reprint Randomized clinical trials in colon cancer
    Heather B Neuman
    Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, H1206, New York, NY 10065, USA
    Surg Oncol Clin N Am 19:183-204. 2010
    ..We review those randomized controlled trials that have most impacted the clinical management of patients with colon cancer in 2009...
  83. ncbi request reprint Lymph node metastasis in T1 adenocarcinoma of the colon and rectum
    Satoshi Okabe
    Department of Surgery, Tokyo Medical and Dental University, Tokyo, Japan
    J Gastrointest Surg 8:1032-9; discussion 1039-40. 2004
    ..In early colorectal cancers, tumor morphology is the strongest clinical predictor of metastatic behavior...
  84. ncbi request reprint Molecular co-expression of the c-Met oncogene and hepatocyte growth factor in primary colon cancer predicts tumor stage and clinical outcome
    Udai S Kammula
    Surgery Branch, National Cancer Institute, Bethesda, MD, USA
    Cancer Lett 248:219-28. 2007
    ..We hypothesize that over-expression of the c-Met receptor and its ligand, hepatocyte growth factor (HGF) in the tumor microenvironment is associated with tumor progression and metastases...