Zhanxin Wang

Summary

Affiliation: Memorial Sloan-Kettering Cancer Center
Country: USA

Publications

  1. pmc Combinatorial readout of dual histone modifications by paired chromatin-associated modules
    Zhanxin Wang
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    J Biol Chem 286:18363-8. 2011
  2. doi Pro isomerization in MLL1 PHD3-bromo cassette connects H3K4me readout to CyP33 and HDAC-mediated repression
    Zhanxin Wang
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Cell 141:1183-94. 2010
  3. pmc An alpha motif at Tas3 C terminus mediates RITS cis spreading and promotes heterochromatic gene silencing
    Haitao Li
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Mol Cell 34:155-67. 2009
  4. pmc A stable transcription factor complex nucleated by oligomeric AML1-ETO controls leukaemogenesis
    Xiao Jian Sun
    Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, New York 10065, USA
    Nature 500:93-7. 2013
  5. pmc A poised chromatin platform for TGF-β access to master regulators
    Qiaoran Xi
    Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Cell 147:1511-24. 2011
  6. pmc Multiple interactions recruit MLL1 and MLL1 fusion proteins to the HOXA9 locus in leukemogenesis
    Thomas A Milne
    Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University, New York, NY 10065, USA
    Mol Cell 38:853-63. 2010
  7. pmc Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger
    Gang G Wang
    Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University, New York, New York 10065, USA
    Nature 459:847-51. 2009
  8. doi Readout of epigenetic modifications
    Dinshaw J Patel
    Structural Biology Department, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Annu Rev Biochem 82:81-118. 2013

Collaborators

Detail Information

Publications8

  1. pmc Combinatorial readout of dual histone modifications by paired chromatin-associated modules
    Zhanxin Wang
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    J Biol Chem 286:18363-8. 2011
    ..Structure/function-based studies on paired module-mediated histone cross-talk have greatly enhanced our understanding of the plasticity of the "histone code" hypothesis...
  2. doi Pro isomerization in MLL1 PHD3-bromo cassette connects H3K4me readout to CyP33 and HDAC-mediated repression
    Zhanxin Wang
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Cell 141:1183-94. 2010
    ..Our results highlight the role of PHD3-Bromo cassette as a regulatory platform, orchestrating MLL1 binding of H3K4me3/2 marks and cyclophilin-mediated repression through HDAC recruitment...
  3. pmc An alpha motif at Tas3 C terminus mediates RITS cis spreading and promotes heterochromatic gene silencing
    Haitao Li
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Mol Cell 34:155-67. 2009
    ..These results demonstrate that, in addition to the chromodomain of Chp1 and siRNA-loaded Ago1, Tas3 self-association is required for RITS spreading and efficient heterochromatic gene silencing at centromeric repeat regions...
  4. pmc A stable transcription factor complex nucleated by oligomeric AML1-ETO controls leukaemogenesis
    Xiao Jian Sun
    Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, New York 10065, USA
    Nature 500:93-7. 2013
    ..These results reveal new mechanisms of action of AML1-ETO, and provide a potential therapeutic target in t(8;21)-positive acute myeloid leukaemia. ..
  5. pmc A poised chromatin platform for TGF-β access to master regulators
    Qiaoran Xi
    Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Cell 147:1511-24. 2011
    ..In turn, Smad4 increases K18 acetylation to augment TRIM33-Smad2/3 binding. Thus, nodal effectors use the H3K9me3 mark as a platform to switch master regulators of stem cell differentiation from the poised to the active state...
  6. pmc Multiple interactions recruit MLL1 and MLL1 fusion proteins to the HOXA9 locus in leukemogenesis
    Thomas A Milne
    Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University, New York, NY 10065, USA
    Mol Cell 38:853-63. 2010
    ..Since wild-type MLL1 and oncogenic MLL1 fusion proteins have overlapping yet distinct recruitment mechanisms, this creates a window of opportunity that could be exploited for the development of targeted therapies...
  7. pmc Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger
    Gang G Wang
    Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University, New York, New York 10065, USA
    Nature 459:847-51. 2009
    ....
  8. doi Readout of epigenetic modifications
    Dinshaw J Patel
    Structural Biology Department, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Annu Rev Biochem 82:81-118. 2013
    ..The review ends by highlighting new initiatives and advances, as well as future challenges, toward the promise of enhancing our structural and mechanistic understanding of the readout of histone PTMs at the nucleosomal level...