Sriram Venneti

Summary

Affiliation: Memorial Sloan-Kettering Cancer Center
Country: USA

Publications

  1. pmc A sensitive and specific histopathologic prognostic marker for H3F3A K27M mutant pediatric glioblastomas
    Sriram Venneti
    Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center MSKCC, New York, NY, 10065, USA
    Acta Neuropathol 128:743-53. 2014
  2. doi request reprint MiRNA-9 and MiRNA-200a distinguish hemangioblastomas from metastatic clear cell renal cell carcinomas in the CNS
    Sriram Venneti
    Division of Neuropathology, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA
    Brain Pathol 22:522-9. 2012
  3. pmc Molecular imaging of microglia/macrophages in the brain
    Sriram Venneti
    Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Glia 61:10-23. 2013
  4. doi request reprint Malignant rhabdoid tumors express stem cell factors, which relate to the expression of EZH2 and Id proteins
    Sriram Venneti
    Division of Neuropathology, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Am J Surg Pathol 35:1463-72. 2011
  5. pmc Evaluation of histone 3 lysine 27 trimethylation (H3K27me3) and enhancer of Zest 2 (EZH2) in pediatric glial and glioneuronal tumors shows decreased H3K27me3 in H3F3A K27M mutant glioblastomas
    Sriram Venneti
    Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Brain Pathol 23:558-64. 2013
  6. pmc Histone 3 lysine 9 trimethylation is differentially associated with isocitrate dehydrogenase mutations in oligodendrogliomas and high-grade astrocytomas
    Sriram Venneti
    Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    J Neuropathol Exp Neurol 72:298-306. 2013
  7. pmc Serine catabolism regulates mitochondrial redox control during hypoxia
    Jiangbin Ye
    Cancer Biology and Genetics Program and Immunology Program, Memorial Sloan Kettering Cancer Center, New York, New York
    Cancer Discov 4:1406-17. 2014
  8. doi request reprint Feedback circuitry between miR-218 repression and RTK activation in glioblastoma
    Lijoy K Mathew
    Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA Howard Hughes Medical Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    Sci Signal 8:ra42. 2015
  9. pmc miR-218 opposes a critical RTK-HIF pathway in mesenchymal glioblastoma
    Lijoy K Mathew
    Abramson Family Cancer Research Institute, Howard Hughes Medical Institute, Penn Molecular Profiling Facility Bioinformatics Group, and Departments of Cell and Developmental Biology, Pathology and Laboratory Medicine, Cancer Biology, and Radiation Oncology, University of Pennsylvania, Philadelphia, PA 19104
    Proc Natl Acad Sci U S A 111:291-6. 2014
  10. pmc Induction of sarcomas by mutant IDH2
    Chao Lu
    Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Genes Dev 27:1986-98. 2013

Collaborators

Detail Information

Publications19

  1. pmc A sensitive and specific histopathologic prognostic marker for H3F3A K27M mutant pediatric glioblastomas
    Sriram Venneti
    Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center MSKCC, New York, NY, 10065, USA
    Acta Neuropathol 128:743-53. 2014
    ..These results suggest that immunohistochemical detection of H3.3 K27M is a sensitive and specific surrogate for the H3F3A K27M mutation and defines a prognostically poor subset of pediatric GBM. ..
  2. doi request reprint MiRNA-9 and MiRNA-200a distinguish hemangioblastomas from metastatic clear cell renal cell carcinomas in the CNS
    Sriram Venneti
    Division of Neuropathology, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA
    Brain Pathol 22:522-9. 2012
    ..Our data suggest that miR-9 and miR-200a can distinguish between hemangioblastomas and Met CCRCC. Further, these results may also provide insight in understanding the biology of hemangioblastomas...
  3. pmc Molecular imaging of microglia/macrophages in the brain
    Sriram Venneti
    Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Glia 61:10-23. 2013
    ..Despite many technical advances, more sensitive agents are required to be useful indicators of neuroinflammation in brain...
  4. doi request reprint Malignant rhabdoid tumors express stem cell factors, which relate to the expression of EZH2 and Id proteins
    Sriram Venneti
    Division of Neuropathology, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Am J Surg Pathol 35:1463-72. 2011
    ..This study underscores similarities between MRTs and stem cells and may help elucidate common biologic pathways that could serve in advancing more effective therapeutic strategies to treat MRTs...
  5. pmc Evaluation of histone 3 lysine 27 trimethylation (H3K27me3) and enhancer of Zest 2 (EZH2) in pediatric glial and glioneuronal tumors shows decreased H3K27me3 in H3F3A K27M mutant glioblastomas
    Sriram Venneti
    Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Brain Pathol 23:558-64. 2013
    ..Our results indicate that H3F3A K27M mutant GBMs show decreased H3K27me3 that may be of both diagnostic and biological relevance. ..
  6. pmc Histone 3 lysine 9 trimethylation is differentially associated with isocitrate dehydrogenase mutations in oligodendrogliomas and high-grade astrocytomas
    Sriram Venneti
    Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    J Neuropathol Exp Neurol 72:298-306. 2013
    ..Furthermore, H3K9me3 may define a subset of grade II oligodendrogliomas with better overall survival. Our results suggest variable roles for IDH mutations in the pathogenesis of oligodendrogliomas versus astrocytic tumors...
  7. pmc Serine catabolism regulates mitochondrial redox control during hypoxia
    Jiangbin Ye
    Cancer Biology and Genetics Program and Immunology Program, Memorial Sloan Kettering Cancer Center, New York, New York
    Cancer Discov 4:1406-17. 2014
    ..Together, these data demonstrate that mitochondrial serine catabolism supports tumor growth by maintaining mitochondrial redox balance and cell survival...
  8. doi request reprint Feedback circuitry between miR-218 repression and RTK activation in glioblastoma
    Lijoy K Mathew
    Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA Howard Hughes Medical Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    Sci Signal 8:ra42. 2015
    ..These data identify previously unknown feedback loops by which miR-218 repression promotes increased RTK signaling in high-grade gliomas. ..
  9. pmc miR-218 opposes a critical RTK-HIF pathway in mesenchymal glioblastoma
    Lijoy K Mathew
    Abramson Family Cancer Research Institute, Howard Hughes Medical Institute, Penn Molecular Profiling Facility Bioinformatics Group, and Departments of Cell and Developmental Biology, Pathology and Laboratory Medicine, Cancer Biology, and Radiation Oncology, University of Pennsylvania, Philadelphia, PA 19104
    Proc Natl Acad Sci U S A 111:291-6. 2014
    ..Collectively, our results identify an miR-218-RTK-HIF2α signaling axis that promotes GBM cell survival and tumor angiogenesis, particularly in necrotic mesenchymal tumors. ..
  10. pmc Induction of sarcomas by mutant IDH2
    Chao Lu
    Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Genes Dev 27:1986-98. 2013
    ..The oncogenic potential of mutant IDH2 correlated with the ability to produce 2-hydroxyglutarate. Together, these data demonstrate that neomorphic IDH2 mutations can be oncogenic in mesenchymal cells. ..
  11. doi request reprint Immunohistochemical expression of glypican-3 in pediatric tumors: an analysis of 414 cases
    Elaine S Chan
    Department of Pathology and Laboratory Medicine, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Pediatr Dev Pathol 16:272-7. 2013
    ..0001) in addition to negative INI1/BAF47/SMARCB1 staining to differentiate atypical teratoid rhabdoid tumors from other high-grade pediatric brain tumors...
  12. pmc Simulated brain biopsy for diagnosing neurodegeneration using autopsy-confirmed cases
    Sriram Venneti
    Division of Neuropathology, Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 4283, USA
    Acta Neuropathol 122:737-45. 2011
    ....
  13. pmc Metabolic modulation of epigenetics in gliomas
    Sriram Venneti
    Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Brain Pathol 23:217-21. 2013
    ..Modification of the epigenetic state by alterations in metabolic enzymes is a novel phenomenon that contributes to the pathogenesis of gliomas and may help in the identification of new therapeutic targets...
  14. pmc p16INK4A and p14ARF tumor suppressor pathways are deregulated in malignant rhabdoid tumors
    Sriram Venneti
    Division of Neuropathology, Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, USA
    J Neuropathol Exp Neurol 70:596-609. 2011
    ..These results provide insights into cell cycle deregulation in the pathogenesis of human MRT and may aid in the design and evaluation of potential therapies for these tumors...
  15. doi request reprint Ganglioglioma arising from dysplastic cortex
    Xilma R Ortiz-Gonzalez
    Department of Pediatrics and Neurology, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Epilepsia 52:e106-8. 2011
    ..The lesion and surrounding dysplastic cortex were resected. Palmini grade IIA dysplasia and a ganglioglioma were diagnosed. These findings suggest that cellular components of cortical dysplasias have oncogenic potential...
  16. pmc Asparagine plays a critical role in regulating cellular adaptation to glutamine depletion
    Ji Zhang
    Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Mol Cell 56:205-18. 2014
    ..Coupled with the success of L-asparaginase as a therapy for childhood leukemia, the data suggest that intracellular asparagine is a critical suppressor of apoptosis in many human tumors...
  17. doi request reprint The evolving molecular genetics of low-grade glioma
    Sriram Venneti
    Department of Pathology, Division of Neuropathology, University of Michigan Medical School, Ann Arbor, MI Department of Pathology and Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY
    Adv Anat Pathol 22:94-101. 2015
    ..These findings have considerably refined approaches to classifying these tumors. Moreover, many of the molecular alterations identified in LGG directly impact on prognosis, tumor biology, and the development of novel therapies. ..
  18. doi request reprint Asymmetric bilateral demyelinating optic neuropathy from tacrolimus toxicity
    Sriram Venneti
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Neurol Sci 301:112-5. 2011
    ....
  19. pmc Imaging microglial activation during neuroinflammation and Alzheimer's disease
    Sriram Venneti
    Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
    J Neuroimmune Pharmacol 4:227-43. 2009
    ....