Marcel van den Brink

Summary

Affiliation: Memorial Sloan-Kettering Cancer Center
Country: USA

Publications

  1. ncbi request reprint Cytolytic pathways in haematopoietic stem-cell transplantation
    Marcel R m van den Brink
    Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Nat Rev Immunol 2:273-81. 2002
  2. pmc Repertoire enhancement with adoptively transferred female lymphocytes controls the growth of pre-implanted murine prostate cancer
    Robert R Jenq
    Department of Immunology and Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America
    PLoS ONE 7:e35222. 2012
  3. pmc Ceacam1 separates graft-versus-host-disease from graft-versus-tumor activity after experimental allogeneic bone marrow transplantation
    Sydney X Lu
    Department of Immunology and Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America
    PLoS ONE 6:e21611. 2011
  4. pmc The central nervous system is a target of acute graft versus host disease in mice
    Steffen Hartrampf
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Blood 121:1906-10. 2013
  5. ncbi request reprint Strategies to enhance T-cell reconstitution in immunocompromised patients
    Marcel R m van den Brink
    Departments of Medicine and Immunology, Box 111 Kettering 406D, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA
    Nat Rev Immunol 4:856-67. 2004
  6. doi request reprint Transplantation in remission improves the disease-free survival of patients with advanced myelodysplastic syndromes treated with myeloablative T cell-depleted stem cell transplants from HLA-identical siblings
    Hugo Castro-Malaspina
    The Allogeneic Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Biol Blood Marrow Transplant 14:458-68. 2008
  7. ncbi request reprint Molecular imaging reveals skeletal engraftment sites of transplanted bone marrow cells
    Philipp Mayer-Kuckuk
    In Vivo Cellular Molecular Imaging Center, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Cell Transplant 15:75-82. 2006
  8. pmc Early Clostridium difficile infection during allogeneic hematopoietic stem cell transplantation
    Melissa A Kinnebrew
    Immunology Program, Sloan Kettering Institute, New York, New York, United States of America Weill Cornell Medical College, New York, New York, United States of America
    PLoS ONE 9:e90158. 2014
  9. ncbi request reprint TLR1 and TLR6 polymorphisms are associated with susceptibility to invasive aspergillosis after allogeneic stem cell transplantation
    Sandra Kesh
    Department of Medicine, Infectious Diseases Service, Memorial Sloan Kettering Cancer Center, 1275 York Ave, Box 9, New York, NY 10021, USA
    Ann N Y Acad Sci 1062:95-103. 2005
  10. pmc Absence of donor T-cell-derived soluble TNF decreases graft-versus-host disease without impairing graft-versus-tumor activity
    Chiara Borsotti
    Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Blood 110:783-6. 2007

Research Grants

  1. Strategies to enhance immune reconstitution after BMT
    Marcel van den Brink; Fiscal Year: 2002
  2. T cell homing in intestinal graft-versus-host disease
    Marcel van den Brink; Fiscal Year: 2009
  3. CEACAM-1a regulates graft-versus-host-disease after allogeneic HSCT
    Marcel van den Brink; Fiscal Year: 2009
  4. Strategies to enhance immune reconstitution after BMT
    Marcel van den Brink; Fiscal Year: 2009
  5. Strategies to Enhance Lymphoid Recovery After Radiation-Induced Injury
    Marcel van den Brink; Fiscal Year: 2009
  6. Strategies to Enhance Lymphoid Recovery After Radiation-Induced Injury
    Marcel R m van den Brink; Fiscal Year: 2010
  7. CEACAM-1a regulates graft-versus-host-disease after allogeneic HSCT
    Marcel R m van den Brink; Fiscal Year: 2010
  8. Strategies to enhance immune reconstitution after BMT
    Marcel R m van den Brink; Fiscal Year: 2010
  9. Strategies to enhance immune reconstitution after BMT
    Marcel van den Brink; Fiscal Year: 2007
  10. T cell homing in intestinal graft-versus-host disease
    Marcel van den Brink; Fiscal Year: 2007

Collaborators

Detail Information

Publications39

  1. ncbi request reprint Cytolytic pathways in haematopoietic stem-cell transplantation
    Marcel R m van den Brink
    Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Nat Rev Immunol 2:273-81. 2002
    ..Therefore, the selective blockade or enhancement of cytolytic pathways provides an intriguing therapeutic opportunity to separate the desired GVT effect from the potentially devastating GVHD...
  2. pmc Repertoire enhancement with adoptively transferred female lymphocytes controls the growth of pre-implanted murine prostate cancer
    Robert R Jenq
    Department of Immunology and Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America
    PLoS ONE 7:e35222. 2012
    ..In contrast, the female mature T-cell repertoire should contain abundant precursors capable of recognizing these classes of prostate cancer antigens and mediating effective anti-tumor immune responses...
  3. pmc Ceacam1 separates graft-versus-host-disease from graft-versus-tumor activity after experimental allogeneic bone marrow transplantation
    Sydney X Lu
    Department of Immunology and Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America
    PLoS ONE 6:e21611. 2011
    ..Previous studies suggest that Ceacam1 negatively regulates inflammation in inflammatory bowel disease models...
  4. pmc The central nervous system is a target of acute graft versus host disease in mice
    Steffen Hartrampf
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Blood 121:1906-10. 2013
    ..Therefore, these clinically relevant studies offer a novel and rational explanation for the well-described neurological symptoms observed after allo-HSCT...
  5. ncbi request reprint Strategies to enhance T-cell reconstitution in immunocompromised patients
    Marcel R m van den Brink
    Departments of Medicine and Immunology, Box 111 Kettering 406D, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA
    Nat Rev Immunol 4:856-67. 2004
    ....
  6. doi request reprint Transplantation in remission improves the disease-free survival of patients with advanced myelodysplastic syndromes treated with myeloablative T cell-depleted stem cell transplants from HLA-identical siblings
    Hugo Castro-Malaspina
    The Allogeneic Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Biol Blood Marrow Transplant 14:458-68. 2008
    ....
  7. ncbi request reprint Molecular imaging reveals skeletal engraftment sites of transplanted bone marrow cells
    Philipp Mayer-Kuckuk
    In Vivo Cellular Molecular Imaging Center, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Cell Transplant 15:75-82. 2006
    ..Multiple, discrete BM cell engraftment sites were observed. Taken together, this multimodality approach may be useful for further in vivo characterization of various therapeutic cell types...
  8. pmc Early Clostridium difficile infection during allogeneic hematopoietic stem cell transplantation
    Melissa A Kinnebrew
    Immunology Program, Sloan Kettering Institute, New York, New York, United States of America Weill Cornell Medical College, New York, New York, United States of America
    PLoS ONE 9:e90158. 2014
    ..Further study of this unique population with more discriminating CDI diagnostic tests are warranted. ..
  9. ncbi request reprint TLR1 and TLR6 polymorphisms are associated with susceptibility to invasive aspergillosis after allogeneic stem cell transplantation
    Sandra Kesh
    Department of Medicine, Infectious Diseases Service, Memorial Sloan Kettering Cancer Center, 1275 York Ave, Box 9, New York, NY 10021, USA
    Ann N Y Acad Sci 1062:95-103. 2005
    ..13 to 1.50; P < .001). Further analyses using a prospective cohort may enable us to identify TLR polymorphisms associated with the susceptibility to IA within a defined interval among immunocompromised patients...
  10. pmc Absence of donor T-cell-derived soluble TNF decreases graft-versus-host disease without impairing graft-versus-tumor activity
    Chiara Borsotti
    Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Blood 110:783-6. 2007
    ..These data suggest that suppressing the secretion of solTNF by donor T cells significantly decreases GVHD without impairing GVT activity...
  11. pmc Regulation of B versus T lymphoid lineage fate decision by the proto-oncogene LRF
    Takahiro Maeda
    Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Science 316:860-6. 2007
    ..We propose a new model for lymphoid lineage commitment, in which LRF acts as a master regulator of the cell's determination of B versus T lineage...
  12. ncbi request reprint Enhanced immune reconstitution by sex steroid ablation following allogeneic hemopoietic stem cell transplantation
    Gabrielle L Goldberg
    Department of Pathology and Immunology, Central and Eastern Clinical School, Monash University, Melbourne, Australia
    J Immunol 178:7473-84. 2007
    ..These results indicate that sex steroid ablation can profoundly enhance thymic and hemopoietic recovery following allogeneic HSCT without increasing GVHD and maintaining GVT...
  13. ncbi request reprint IFN-gamma and Fas ligand are required for graft-versus-tumor activity against renal cell carcinoma in the absence of lethal graft-versus-host disease
    Teresa Ramirez-Montagut
    Department of Immunology, Laboratory of the Immunology of Bone Marrow Transplantation, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Immunol 179:1669-80. 2007
    ....
  14. pmc T cell depleted stem-cell transplantation for adults with hematologic malignancies: sustained engraftment of HLA-matched related donor grafts without the use of antithymocyte globulin
    Ann A Jakubowski
    Adult Allogeneic Bone Marrow Transplant Service, Division of Hematologic Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, Weill Medical College of Cornell University, New York, NY 10065, USA
    Blood 110:4552-9. 2007
    ..Life-threatening OIs occurred in 3 of 52 patients and was fatal in 1. This study demonstrates durable engraftment with a low incidence of GvHD despite the lack of ATG, as well as the curative potential of this regimen...
  15. pmc Enhancing T cell reconstitution after hematopoietic stem cell transplantation: a brief update of the latest trends
    Johannes L Zakrzewski
    Department of Medicine and Immunology, Memorial Sloan Kettering Cancer Center, Zuckerman Research Center, New York, NY 10021, USA
    Blood Cells Mol Dis 40:44-7. 2008
    ..The translation of most of these strategies into clinical trials is likely and in some cases Phase I/II studies are already underway...
  16. ncbi request reprint Fludarabine-based conditioning secures engraftment of second hematopoietic stem cell allografts (HSCT) in the treatment of initial graft failure
    Joseph H Chewning
    Bone Marrow Transplant Service, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Biol Blood Marrow Transplant 13:1313-23. 2007
    ....
  17. pmc Organ-derived dendritic cells have differential effects on alloreactive T cells
    Theo D Kim
    Department of Medicine and Immunology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Blood 111:2929-40. 2008
    ..A gut-homing phenotype correlates with increased GVHD mortality and morbidity after murine BMT, underlining the importance of the gut in the pathophysiology of GVHD...
  18. pmc Tumor immunotherapy across MHC barriers using allogeneic T-cell precursors
    Johannes L Zakrzewski
    Department Immunology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA
    Nat Biotechnol 26:453-61. 2008
    ..We conclude that ex vivo generated MHC-disparate T-cell precursors from any donor can be used universally for 'off-the-shelf' immunotherapy, and can be further enhanced by genetic engineering for targeted immunotherapy...
  19. ncbi request reprint T cells require TRAIL for optimal graft-versus-tumor activity
    Cornelius Schmaltz
    Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Nat Med 8:1433-7. 2002
    ..These data suggest that strategies to enhance TRAIL-mediated GVT activity could decrease relapse rates of malignancies after hematopoietic cell transplantation without exacerbation of graft-versus-host disease...
  20. ncbi request reprint Donor T cell-derived TNF is required for graft-versus-host disease and graft-versus-tumor activity after bone marrow transplantation
    Cornelius Schmaltz
    Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Blood 101:2440-5. 2003
    ..We could not detect TNF in the serum of our transplant recipients, suggesting that T cells contribute to GVHD and GVL via membrane-bound or locally released TNF...
  21. ncbi request reprint Direct evidence for new T-cell generation by patients after either T-cell-depleted or unmodified allogeneic hematopoietic stem cell transplantations
    Sharon R Lewin
    Aaron Diamond AIDS Research Center, The Rockefeller University, New York, NY
    Blood 100:2235-42. 2002
    ..T-cell neogenesis, appropriate to age but delayed in adult recipients of T-cell-depleted allografts, justifies interventions to hasten this process and to stimulate desirable cellular immune responses...
  22. ncbi request reprint DNA immunization against tissue-restricted antigens enhances tumor immunity after allogeneic hemopoietic stem cell transplantation
    Miguel Angel Perales
    Swim Across America Laboratory of Tumor Immunology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Immunol 177:4159-67. 2006
    ..These results demonstrate that DNA immunization against tissue-restricted Ags after allogeneic T cell-depleted HSCT can induce potent antitumor effects without causing GVHD...
  23. ncbi request reprint Adoptive transfer of T-cell precursors enhances T-cell reconstitution after allogeneic hematopoietic stem cell transplantation
    Johannes L Zakrzewski
    Department of Medicine, Zuckerman Research Center 1404, Mailbox 111, New York, New York 10021, USA
    Nat Med 12:1039-47. 2006
    ..We conclude that the adoptive transfer of OP9-DL1-derived T-cell precursors markedly enhances T-cell reconstitution after transplantation, resulting in GVT activity without GVHD...
  24. ncbi request reprint Glucocorticoid-induced TNF receptor family related gene activation overcomes tolerance/ignorance to melanoma differentiation antigens and enhances antitumor immunity
    Teresa Ramirez-Montagut
    Department of Medicine and Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Immunol 176:6434-42. 2006
    ..Thus, we conclude that overall, GITR stimulation overcomes self-tolerance/ignorance and enhances T cell-mediated antitumor activity with minimal autoimmunity...
  25. ncbi request reprint Interleukin-15 enhances immune reconstitution after allogeneic bone marrow transplantation
    Onder Alpdogan
    Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Blood 105:865-73. 2005
    ..Finally, we found that IL-15 administration could enhance graft-versus-leukemia activity. In conclusion, IL-15 can be administered safely to recipients of a T-cell-depleted allo BMT to enhance CD8+ T, NK, and NK T-cell reconstitution...
  26. pmc GITR activation induces an opposite effect on alloreactive CD4(+) and CD8(+) T cells in graft-versus-host disease
    Stephanie J Muriglan
    Department of Medicine and Immunology, Memorial Sloan Kettering Cancer Center, Kettering 425, Mailbox 111, 1275 York Ave, New York, NY 10021, USA
    J Exp Med 200:149-57. 2004
    ..Our findings indicate that GITR has opposite effects on the regulation of alloreactive CD4(+) and CD8(+) T cells...
  27. ncbi request reprint Increasing T-cell age reduces effector activity but preserves proliferative capacity in a murine allogeneic major histocompatibility complex-mismatched bone marrow transplant model
    Jeff S Friedman
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    Biol Blood Marrow Transplant 10:448-60. 2004
    ..We suggest that the lack of effector activity demonstrated by old T cells in vivo is a reflection of a cell-autonomous defect downstream of signals required for antigen-driven proliferation...
  28. pmc Absence of inducible costimulator on alloreactive T cells reduces graft versus host disease and induces Th2 deviation
    Vanessa M Hubbard
    Department of Medicine and ImmunologyMemorial Sloan Kettering Cancer Center, Kettering 406D, Mailbox 111, 1275 York Ave, New York, NY 10021, USA
    Blood 106:3285-92. 2005
    ..In conclusion, alloreactive ICOS-/- donor T cells induce less GVHD due to a Th2 immune deviation while GVL activity is slightly diminished...
  29. pmc CCR2 is required for CD8-induced graft-versus-host disease
    Theis H Terwey
    Department of Medicine and Immunology, Memorial Sloan Kettering Cancer Center, Kettering 406D, Mailbox 111, 1275 York Ave, New York, NY 10021, USA
    Blood 106:3322-30. 2005
    ..Interestingly, the graft-versus-tumor effect mediated by CCR2-/- CD8+ T cells was preserved, which suggests that interference with T-cell migration by blockade of CCR2 signaling can separate GVHD from GVT activity...
  30. pmc Remodeling specific immunity by use of MHC tetramers: demonstration in a graft-versus-host disease model
    Barry J Kappel
    Department of Molecular Pharmacology, Memorial Sloan Kettering Cancer Center, Howard 719, Mailbox 531, 1275 York Ave, New York, NY 10021, USA
    Blood 107:2045-51. 2006
    ....
  31. pmc Absence of beta7 integrin results in less graft-versus-host disease because of decreased homing of alloreactive T cells to intestine
    Elisha Waldman
    Memorial Sloan Kettering Cancer Center, Kettering 406D, Mailbox 111, 1275 York Ave, New York, NY 10021, USA
    Blood 107:1703-11. 2006
    ..Our data suggest that strategies to target the beta7 integrin have the clinical potential to alleviate or prevent GVHD while sparing or potentiating GVT activity...
  32. pmc Keratinocyte growth factor (KGF) is required for postnatal thymic regeneration
    Onder Alpdogan
    Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Blood 107:2453-60. 2006
    ..We conclude that KGF plays a critical role in postnatal thymic regeneration and may be useful in treating immune deficiency conditions...
  33. pmc IL-7 enhances peripheral T cell reconstitution after allogeneic hematopoietic stem cell transplantation
    Onder Alpdogan
    Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    J Clin Invest 112:1095-107. 2003
    ....
  34. ncbi request reprint Insulin-like growth factor-I enhances lymphoid and myeloid reconstitution after allogeneic bone marrow transplantation
    Onder Alpdogan
    3 Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
    Transplantation 75:1977-83. 2003
    ..Previous studies in murine syngeneic BMT models have demonstrated that posttransplantation insulin-like growth factor (IGF)-I administration could enhance immune reconstitution...
  35. ncbi request reprint LPAM (alpha 4 beta 7 integrin) is an important homing integrin on alloreactive T cells in the development of intestinal graft-versus-host disease
    Aleksandra Petrovic
    Departmentof Pedicatrics, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
    Blood 103:1542-7. 2004
    ..We conclude that the alpha(4)beta(7) integrin is important for the invasion of alloreactive donor T cells into the gut and the subsequent development of intestinal GVHD and overall GVHD morbidity and mortality...
  36. ncbi request reprint Nature's TRAIL--on a path to cancer immunotherapy
    Mark J Smyth
    Cancer Immunology Program, Sir Donald and Lady Trescowthick Laboratories, Peter MacCallum Cancer Institute, East Melbourne, Victoria 3002, Australia
    Immunity 18:1-6. 2003
    ....
  37. ncbi request reprint IL-7 and IL-15: therapeutic cytokines for immunodeficiency
    Onder Alpdogan
    Department of Medicine, Memorial Sloan Kettering Cancer Center, 406D, Mailbox 111 1275 York Avenue, New York, NY 10021, USA
    Trends Immunol 26:56-64. 2005
    ..In this Review, we discuss recent findings regarding the effects of IL-7 and IL-15 on lymphopoiesis and their potential use for the treatment of immunodeficiency...
  38. pmc Clinical strategies to enhance T cell reconstitution
    Gabrielle L Goldberg
    Department of Immunology, Laboratory of the Immunology of Bone Marrow Transplantation, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Semin Immunol 19:289-96. 2007
    ....
  39. pmc Kinetics of gene expression in murine cutaneous graft-versus-host disease
    Philip B Sugerman
    straZeneca Research and Development Boston, Waltham, Massachusetts, USA
    Am J Pathol 164:2189-202. 2004
    ..The kinetics of gene expression were consistent with the evolution of cutaneous pathology as well as with current models of disease progression during cutaneous GVHD...

Research Grants23

  1. Strategies to enhance immune reconstitution after BMT
    Marcel van den Brink; Fiscal Year: 2002
    ....
  2. T cell homing in intestinal graft-versus-host disease
    Marcel van den Brink; Fiscal Year: 2009
    ..These studies will contribute to a better mechanistic understanding of intestinal GVHD and provide preclinical data for new strategies to treat or prevent intestinal GVHD, while sparing GVT activity. ..
  3. CEACAM-1a regulates graft-versus-host-disease after allogeneic HSCT
    Marcel van den Brink; Fiscal Year: 2009
    ..abstract_text> ..
  4. Strategies to enhance immune reconstitution after BMT
    Marcel van den Brink; Fiscal Year: 2009
    ....
  5. Strategies to Enhance Lymphoid Recovery After Radiation-Induced Injury
    Marcel van den Brink; Fiscal Year: 2009
    ..We will now test the application of these strategies as treatment for victims of radiation injury. ..
  6. Strategies to Enhance Lymphoid Recovery After Radiation-Induced Injury
    Marcel R m van den Brink; Fiscal Year: 2010
    ..We will now test the application of these strategies as treatment for victims of radiation injury. ..
  7. CEACAM-1a regulates graft-versus-host-disease after allogeneic HSCT
    Marcel R m van den Brink; Fiscal Year: 2010
    ..abstract_text> ..
  8. Strategies to enhance immune reconstitution after BMT
    Marcel R m van den Brink; Fiscal Year: 2010
    ....
  9. Strategies to enhance immune reconstitution after BMT
    Marcel van den Brink; Fiscal Year: 2007
    ....
  10. T cell homing in intestinal graft-versus-host disease
    Marcel van den Brink; Fiscal Year: 2007
    ..These studies will contribute to a better mechanistic understanding of intestinal GVHD and provide preclinical data for new strategies to treat or prevent intestinal GVHD, while sparing GVT activity. ..
  11. The role of TRAIL in bone marrow transplantation
    Marcel van den Brink; Fiscal Year: 2002
    ..These studies could provide a better mechanistic understanding of the role of the TRAIL pathway in (a) T cell cytotoxicity in vivo, and (b) GVHD, GVT and engraftment after BMT, which could have immediate clinical applicability. ..
  12. Strategies to enhance immune reconstitution after BMT
    Marcel van den Brink; Fiscal Year: 2003
    ....
  13. The role of TRAIL in bone marrow transplantation
    Marcel van den Brink; Fiscal Year: 2003
    ..These studies could provide a better mechanistic understanding of the role of the TRAIL pathway in (a) T cell cytotoxicity in vivo, and (b) GVHD, GVT and engraftment after BMT, which could have immediate clinical applicability. ..
  14. Strategies to enhance immune reconstitution after BMT
    Marcel van den Brink; Fiscal Year: 2004
    ....
  15. The role of TRAIL in bone marrow transplantation
    Marcel van den Brink; Fiscal Year: 2004
    ..These studies could provide a better mechanistic understanding of the role of the TRAIL pathway in (a) T cell cytotoxicity in vivo, and (b) GVHD, GVT and engraftment after BMT, which could have immediate clinical applicability. ..
  16. Strategies to enhance immune reconstitution after BMT
    Marcel van den Brink; Fiscal Year: 2005
    ....
  17. Strategies to enhance immune reconstitution after BMT
    Marcel R m van den Brink; Fiscal Year: 2010
    ....
  18. The role of TRAIL in bone marrow transplantation
    Marcel van den Brink; Fiscal Year: 2005
    ..These studies could provide a better mechanistic understanding of the role of the TRAIL pathway in (a) T cell cytotoxicity in vivo, and (b) GVHD, GVT and engraftment after BMT, which could have immediate clinical applicability. ..
  19. T cell homing in intestinal graft-versus-host disease
    Marcel van den Brink; Fiscal Year: 2006
    ..These studies will contribute to a better mechanistic understanding of intestinal GVHD and provide preclinical data for new strategies to treat or prevent intestinal GVHD, while sparing GVT activity. ..
  20. Strategies to enhance immune reconstitution after BMT
    Marcel van den Brink; Fiscal Year: 2006
    ....