Nicholas S Tolwinski

Summary

Affiliation: Memorial Sloan-Kettering Cancer Center
Country: USA

Publications

  1. pmc Wnt, Hedgehog and junctional Armadillo/beta-catenin establish planar polarity in the Drosophila embryo
    Pamela F Colosimo
    Program in Developmental Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America
    PLoS ONE 1:e9. 2006
  2. pmc Complex interactions between GSK3 and aPKC in Drosophila embryonic epithelial morphogenesis
    Nicole A Kaplan
    Program in Developmental Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America
    PLoS ONE 6:e18616. 2011
  3. ncbi Advances in pattern formation: Signaling and transcription
    Nicholas S Tolwinski
    Program in Developmental Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Fly (Austin) 2:156-8. 2008
  4. pmc Membrane bound axin is sufficient for Wingless signaling in Drosophila embryos
    Nicholas S Tolwinski
    Program in Developmental Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Genetics 181:1169-73. 2009
  5. doi Spatially defined Dsh-Lgl interaction contributes to directional tissue morphogenesis
    Nicole A Kaplan
    Program in Developmental Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 423, New York, NY 10021, USA
    J Cell Sci 123:3157-65. 2010
  6. doi GSK3beta affects apical-basal polarity and cell-cell adhesion by regulating aPKC levels
    Pamela F Colosimo
    Program in Developmental Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Dev Dyn 239:115-25. 2010
  7. pmc Epithelial polarity: interactions between junctions and apical-basal machinery
    Nicole A Kaplan
    Program in Developmental Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Genetics 183:897-904. 2009

Collaborators

  • Nicole A Kaplan
  • Pamela F Colosimo
  • Xiaoping Liu

Detail Information

Publications7

  1. pmc Wnt, Hedgehog and junctional Armadillo/beta-catenin establish planar polarity in the Drosophila embryo
    Pamela F Colosimo
    Program in Developmental Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America
    PLoS ONE 1:e9. 2006
    ..Our results suggest new roles for Hh and Wg as instructive polarizing cues that help establish directionality within a cell sheet, and a new polarity-signaling role for the membrane fraction of the oncoprotein Arm...
  2. pmc Complex interactions between GSK3 and aPKC in Drosophila embryonic epithelial morphogenesis
    Nicole A Kaplan
    Program in Developmental Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America
    PLoS ONE 6:e18616. 2011
    ..Finally, we propose a model explaining how regulation of aPKC protein levels can reorganize both adhesion and the cytoskeleton...
  3. ncbi Advances in pattern formation: Signaling and transcription
    Nicholas S Tolwinski
    Program in Developmental Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Fly (Austin) 2:156-8. 2008
    ..I will focus on early embryonic patterning through pair-rule genes, specificity of FGF signaling, and tissue regeneration...
  4. pmc Membrane bound axin is sufficient for Wingless signaling in Drosophila embryos
    Nicholas S Tolwinski
    Program in Developmental Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Genetics 181:1169-73. 2009
    ..I find that nuclear localization of APC2 appears to be required, but Axin can block signaling when tethered to the membrane. These results support the model where Axin regulates Armadillo localization and activity in the cytoplasm...
  5. doi Spatially defined Dsh-Lgl interaction contributes to directional tissue morphogenesis
    Nicole A Kaplan
    Program in Developmental Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 423, New York, NY 10021, USA
    J Cell Sci 123:3157-65. 2010
    ..We conclude that apical-basal proteins, used to establish polarity within a cell, can be independently co-opted to function in epithelial morphogenesis...
  6. doi GSK3beta affects apical-basal polarity and cell-cell adhesion by regulating aPKC levels
    Pamela F Colosimo
    Program in Developmental Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Dev Dyn 239:115-25. 2010
    ..These results suggest that the Wnt pathway component GSK3 beta regulates the polarity determinant aPKC, which in turn affects cell-cell contacts during the development of polarized tissues...
  7. pmc Epithelial polarity: interactions between junctions and apical-basal machinery
    Nicole A Kaplan
    Program in Developmental Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Genetics 183:897-904. 2009
    ..We propose a model where zw3 regulates protein levels of apical and adhesion components and suggest that a reciprocal interaction between junctions and polarity modules functions to maintain stable apical and basolateral domains...