DEREK TAN

Summary

Affiliation: Memorial Sloan-Kettering Cancer Center
Country: USA

Publications

  1. pmc Biomimetic diversity-oriented synthesis of benzannulated medium rings via ring expansion
    Renato A Bauer
    Tri Institutional Training Program in Chemical Biology, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Nat Chem Biol 9:21-9. 2013
  2. pmc Active site remodelling accompanies thioester bond formation in the SUMO E1
    Shaun K Olsen
    Structural Biology, Sloan Kettering Institute, New York, New York 10065, USA
    Nature 463:906-12. 2010
  3. pmc A diversity-oriented synthesis approach to macrocycles via oxidative ring expansion
    Felix Kopp
    Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Nat Chem Biol 8:358-65. 2012
  4. ncbi request reprint Diversity-oriented synthesis: exploring the intersections between chemistry and biology
    Derek S Tan
    Tri Institutional Research Program, Memorial Sloan Kettering Cancer Center, 1275 York Ave, Box 422, New York, New York 10021, USA
    Nat Chem Biol 1:74-84. 2005
  5. ncbi request reprint Current progress in natural product-like libraries for discovery screening
    Derek S Tan
    Tri Institutional Research Program and Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, 1275 York Ave, Box 422, New York, NY 10021, USA
    Comb Chem High Throughput Screen 7:631-43. 2004
  6. ncbi request reprint Advancing chemistry and biology through diversity-oriented synthesis of natural product-like libraries
    Shiying Shang
    Pharmacology Program, Weill Graduate School of Medical Sciences of Cornell University, Ithaca, New York, USA
    Curr Opin Chem Biol 9:248-58. 2005
  7. ncbi request reprint Small-molecule inhibition of siderophore biosynthesis in Mycobacterium tuberculosis and Yersinia pestis
    Julian A Ferreras
    Department of Microbiology and Immunology, Weill Medical College of Cornell University, 1300 York Ave, Box 62, New York, New York 10021, USA
    Nat Chem Biol 1:29-32. 2005
  8. ncbi request reprint Discovery and applications of small molecule probes for studying biological processes
    Justin S Potuzak
    Memorial Sloan Kettering Cancer Center, 1275 York Ave, Box 422, New York, NY 10021, USA
    Biotechnol Genet Eng Rev 21:11-78. 2004
  9. pmc Small molecule inhibition of microbial natural product biosynthesis-an emerging antibiotic strategy
    Justin S Cisar
    Tri Institutional Training Program in Chemical Biology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 422, New York, NY 10065, USA
    Chem Soc Rev 37:1320-9. 2008
  10. ncbi request reprint An acid-stable tert-butyldiarylsilyl (TBDAS) linker for solid-phase organic synthesis
    Christine M Diblasi
    Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 422, New York, New York 10021, USA
    Org Lett 7:1777-80. 2005

Collaborators

  • Christopher D Lima
  • LUIS E QUADRI
  • Renato A Bauer
  • Felix Kopp
  • Shaun K Olsen
  • Justin S Cisar
  • Shiying Shang
  • Julian A Ferreras
  • Christine M Diblasi
  • Justin S Potuzak
  • Todd A Wenderski
  • Christopher F Stratton
  • Lakshmi B Akella
  • Allan D Capili
  • Xuequan Lu
  • Federico Di Lello
  • Jae Sang Ryu
  • Daniel E Macks
  • Sirkka B Moilanen

Detail Information

Publications11

  1. pmc Biomimetic diversity-oriented synthesis of benzannulated medium rings via ring expansion
    Renato A Bauer
    Tri Institutional Training Program in Chemical Biology, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Nat Chem Biol 9:21-9. 2013
    ..Cheminformatic analysis of the resulting first-generation library confirms that these molecules occupy chemical space overlapping with medium-ring natural products and distinct from that of synthetic drugs and drug-like libraries...
  2. pmc Active site remodelling accompanies thioester bond formation in the SUMO E1
    Shaun K Olsen
    Structural Biology, Sloan Kettering Institute, New York, New York 10065, USA
    Nature 463:906-12. 2010
    ..These changes displace side chains required for adenylation with side chains required for thioester bond formation. Mutational and biochemical analyses indicate these mechanisms are conserved in other E1s...
  3. pmc A diversity-oriented synthesis approach to macrocycles via oxidative ring expansion
    Felix Kopp
    Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Nat Chem Biol 8:358-65. 2012
    ..Cheminformatic analysis indicates that these macrocycles access regions of chemical space that overlap with natural products, distinct from currently targeted synthetic drugs...
  4. ncbi request reprint Diversity-oriented synthesis: exploring the intersections between chemistry and biology
    Derek S Tan
    Tri Institutional Research Program, Memorial Sloan Kettering Cancer Center, 1275 York Ave, Box 422, New York, New York 10021, USA
    Nat Chem Biol 1:74-84. 2005
    ..DOS has provided powerful probes to investigate biological mechanisms and also served as a new driving force for advancing synthetic organic chemistry...
  5. ncbi request reprint Current progress in natural product-like libraries for discovery screening
    Derek S Tan
    Tri Institutional Research Program and Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, 1275 York Ave, Box 422, New York, NY 10021, USA
    Comb Chem High Throughput Screen 7:631-43. 2004
    ..Examples of successful applications in discovery screening are described for each category. These studies highlight the exciting potential of natural product-like libraries in both chemical biology and drug discovery...
  6. ncbi request reprint Advancing chemistry and biology through diversity-oriented synthesis of natural product-like libraries
    Shiying Shang
    Pharmacology Program, Weill Graduate School of Medical Sciences of Cornell University, Ithaca, New York, USA
    Curr Opin Chem Biol 9:248-58. 2005
    ..Larger-scale evaluation of these approaches is on the horizon, using screening data that will be made publicly available in the new PubChem database...
  7. ncbi request reprint Small-molecule inhibition of siderophore biosynthesis in Mycobacterium tuberculosis and Yersinia pestis
    Julian A Ferreras
    Department of Microbiology and Immunology, Weill Medical College of Cornell University, 1300 York Ave, Box 62, New York, New York 10021, USA
    Nat Chem Biol 1:29-32. 2005
    ..tuberculosis and Y. pestis. This new antibiotic inhibits siderophore biosynthesis and growth of M. tuberculosis and Y. pestis under iron-limiting conditions...
  8. ncbi request reprint Discovery and applications of small molecule probes for studying biological processes
    Justin S Potuzak
    Memorial Sloan Kettering Cancer Center, 1275 York Ave, Box 422, New York, NY 10021, USA
    Biotechnol Genet Eng Rev 21:11-78. 2004
  9. pmc Small molecule inhibition of microbial natural product biosynthesis-an emerging antibiotic strategy
    Justin S Cisar
    Tri Institutional Training Program in Chemical Biology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 422, New York, NY 10065, USA
    Chem Soc Rev 37:1320-9. 2008
    ..In this tutorial review, we describe several recent examples of designed small molecule inhibitors of microbial natural product biosynthesis and their use in evaluating this emerging antibiotic strategy...
  10. ncbi request reprint An acid-stable tert-butyldiarylsilyl (TBDAS) linker for solid-phase organic synthesis
    Christine M Diblasi
    Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 422, New York, New York 10021, USA
    Org Lett 7:1777-80. 2005
    ..Solid-phase acetal deprotection, olefination, asymmetric allylation, and silyl protecting group deblocking reactions have been demonstrated with TBDAS-linked substrates...
  11. ncbi request reprint Sweet surrender to chemical genetics
    Derek S Tan
    Nat Biotechnol 20:561-3. 2002

Research Grants9

  1. New Molecular Targets for Refractory Prostate Cancer
    DEREK TAN; Fiscal Year: 2005
    ..abstract_text> ..
  2. Acquisition of a High Resolution Mass Spectrometer (LC-TOF-MS)
    DEREK TAN; Fiscal Year: 2007
    ..Bayard Clarkson, who is investigating kinase inhibitors as new treatments for chronic myeloid leukemia; (5) Dr. Derek Tan, who is developing diversity-oriented syntheses of natural product-based libraries for high-throughput screening ..
  3. Acquisition of a CryoProbe for a 600 MHz NMR Spectrometer
    DEREK TAN; Fiscal Year: 2007
    ..Bayard Clarkson, who is investigating kinase inhibitors as new treatments for chronic myeloid leukemia; (5) Dr. Derek Tan, who is developing diversity-oriented syntheses of natural product-based libraries for high-throughput screening ..
  4. Siderophore Biosynthesis Inhibitors as New Antibiotics for Biodefense
    DEREK TAN; Fiscal Year: 2007
    ..Public Health Relevance Statement: This project aims to develop new antibiotics to treat plague, yersiniosis, and other infectious diseases that are important in biodefense and global public health. ..
  5. Diversity-Oriented Synthesis:Natural Product-based(RMI)
    DEREK TAN; Fiscal Year: 2007
    ....
  6. Diversity-Oriented Synthesis of Natural Product-based L*
    DEREK TAN; Fiscal Year: 2007
    ..abstract_text> ..
  7. Siderophore Biosynthesis Inhibitors as New Antibiotics for Biodefense
    DEREK TAN; Fiscal Year: 2009
    ..Public Health Relevance Statement: This project aims to develop new antibiotics to treat plague, yersiniosis, and other infectious diseases that are important in biodefense and global public health. ..
  8. Siderophore Biosynthesis Inhibitors as New Antibiotics for Biodefense
    Derek S Tan; Fiscal Year: 2010
    ..Public Health Relevance Statement: This project aims to develop new antibiotics to treat plague, yersiniosis, and other infectious diseases that are important in biodefense and global public health. ..