Affiliation: Memorial Sloan-Kettering Cancer Center
- Development of a minimal saponin vaccine adjuvant based on QS-21Alberto Fernández-Tejada
Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York 10065, USA
Nat Chem 6:635-43. 2014..Overall, these studies have yielded critical insights into saponin structure-function relationships, provided practical synthetic access to non-toxic adjuvants, and established a platform for detailed mechanistic studies...
- Biomimetic diversity-oriented synthesis of benzannulated medium rings via ring expansionRenato A Bauer
Tri Institutional Training Program in Chemical Biology, Memorial Sloan Kettering Cancer Center, New York, New York, USA
Nat Chem Biol 9:21-9. 2013..Cheminformatic analysis of the resulting first-generation library confirms that these molecules occupy chemical space overlapping with medium-ring natural products and distinct from that of synthetic drugs and drug-like libraries...
- Active site remodelling accompanies thioester bond formation in the SUMO E1Shaun K Olsen
Structural Biology, Sloan Kettering Institute, New York, New York 10065, USA
Nature 463:906-12. 2010..These changes displace side chains required for adenylation with side chains required for thioester bond formation. Mutational and biochemical analyses indicate these mechanisms are conserved in other E1s...
- A diversity-oriented synthesis approach to macrocycles via oxidative ring expansionFelix Kopp
Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA
Nat Chem Biol 8:358-65. 2012..Cheminformatic analysis indicates that these macrocycles access regions of chemical space that overlap with natural products, distinct from currently targeted synthetic drugs...
- Current progress in natural product-like libraries for discovery screeningDerek S Tan
Tri Institutional Research Program and Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, 1275 York Ave, Box 422, New York, NY 10021, USA
Comb Chem High Throughput Screen 7:631-43. 2004..Examples of successful applications in discovery screening are described for each category. These studies highlight the exciting potential of natural product-like libraries in both chemical biology and drug discovery...
- Diversity-oriented synthesis: exploring the intersections between chemistry and biologyDerek S Tan
Tri Institutional Research Program, Memorial Sloan Kettering Cancer Center, 1275 York Ave, Box 422, New York, New York 10021, USA
Nat Chem Biol 1:74-84. 2005..DOS has provided powerful probes to investigate biological mechanisms and also served as a new driving force for advancing synthetic organic chemistry...
- Advancing chemistry and biology through diversity-oriented synthesis of natural product-like librariesShiying Shang
Pharmacology Program, Weill Graduate School of Medical Sciences of Cornell University, Ithaca, New York, USA
Curr Opin Chem Biol 9:248-58. 2005..Larger-scale evaluation of these approaches is on the horizon, using screening data that will be made publicly available in the new PubChem database...
- Small molecule inhibition of microbial natural product biosynthesis-an emerging antibiotic strategyJustin S Cisar
Tri Institutional Training Program in Chemical Biology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 422, New York, NY 10065, USA
Chem Soc Rev 37:1320-9. 2008..In this tutorial review, we describe several recent examples of designed small molecule inhibitors of microbial natural product biosynthesis and their use in evaluating this emerging antibiotic strategy...
- Discovery and applications of small molecule probes for studying biological processesJustin S Potuzak
Memorial Sloan Kettering Cancer Center, 1275 York Ave, Box 422, New York, NY 10021, USA
Biotechnol Genet Eng Rev 21:11-78. 2004
- Small-molecule inhibition of siderophore biosynthesis in Mycobacterium tuberculosis and Yersinia pestisJulian A Ferreras
Department of Microbiology and Immunology, Weill Medical College of Cornell University, 1300 York Ave, Box 62, New York, New York 10021, USA
Nat Chem Biol 1:29-32. 2005..tuberculosis and Y. pestis. This new antibiotic inhibits siderophore biosynthesis and growth of M. tuberculosis and Y. pestis under iron-limiting conditions...
- An acid-stable tert-butyldiarylsilyl (TBDAS) linker for solid-phase organic synthesisChristine M Diblasi
Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 422, New York, New York 10021, USA
Org Lett 7:1777-80. 2005..Solid-phase acetal deprotection, olefination, asymmetric allylation, and silyl protecting group deblocking reactions have been demonstrated with TBDAS-linked substrates...
- Sweet surrender to chemical geneticsDerek S Tan
Nat Biotechnol 20:561-3. 2002