Affiliation: Memorial Sloan-Kettering Cancer Center
- Migration and differentiation of neural precursors derived from human embryonic stem cells in the rat brainViviane Tabar
Nat Biotechnol 23:601-6. 2005..We found no evidence of cell fusion, suggesting that hES cell progeny are capable of responding appropriately to host cues in the subventricular zone...
- Therapeutic cloning in individual parkinsonian miceViviane Tabar
Department of Neurosurgery, Sloan Kettering Institute, 1275 York Ave, New York, New York 10065, USA
Nat Med 14:379-81. 2008..Derivation of 187 ntES cell lines from 24 parkinsonian mice, dopaminergic differentiation, and transplantation into individually matched host mice showed therapeutic efficacy and lack of immunological response...
- Long-term impact of radiation on the stem cell and oligodendrocyte precursors in the brainGeorgia Panagiotakos
Department of Neurosurgery, Sloan Kettering Institute for Cancer Research, New York, New York, United States of America
PLoS ONE 2:e588. 2007..The cellular basis of long term radiation damage in the brain is not fully understood...
- Making a pituitary gland in a dishViviane Tabar
Department of Neurosurgery and Center for Stem Cell Biology, Memorial Sloan Kettering Center for Cancer Research, New York, NY, 10065 USA
Cell Stem Cell 9:490-1. 2011..The adenohypophysis secretes multiple hormones that control vital physiological functions. A recent article in Nature (Suga et al., 2011) describes a 3D protocol for the derivation of several endocrine pituitary cell types from mouse ESCs...
- Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCsGabsang Lee
Developmental Biology Program, Sloan Kettering Institute, 1275 York Ave, USA
Nature 461:402-6. 2009..Our study illustrates the promise of iPSC technology for gaining new insights into human disease pathogenesis and treatment...
- Isolation and directed differentiation of neural crest stem cells derived from human embryonic stem cellsGabsang Lee
Developmental Biology Program, Sloan Kettering Institute, 1275 York Ave, New York, New York 10021, USA
Nat Biotechnol 25:1468-75. 2007..The availability of unlimited numbers of human NCS cells offers new opportunities for studies of neural crest development and for efforts to model and treat neural crest-related disorders...
- Transgene excision has no impact on in vivo integration of human iPS derived neural precursorsTamara Major
Department of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America
PLoS ONE 6:e24687. 2011..There was no teratoma or other tumor formation 12 weeks after grafting in any of the 26 animals used in the study. Thus neither factor excision nor persistence of c-myc impact the behavior of hiPS lines in vivo...
- Derivation of midbrain dopamine neurons from human embryonic stem cellsAnselme L Perrier
Laboratory of Stem Cell and Tumor Biology, Division of Neurosurgery and Developmental Biology Program, and Cell Biology Program, Sloan Kettering Institute, New York, NY 10021, USA
Proc Natl Acad Sci U S A 101:12543-8. 2004..This experimental system also provides a powerful tool to probe the molecular mechanisms that control the development and function of human midbrain DA neurons...
- Inhibition of notch signaling in glioblastoma targets cancer stem cells via an endothelial cell intermediateKoos E Hovinga
Department of Neurosurgery, Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, NY, USA
Stem Cells 28:1019-29. 2010..Three-dimensional explant systems provide a novel approach for the study of tumor and microenvironment interactions...
- BAC transgenesis in human embryonic stem cells as a novel tool to define the human neural lineageDimitris G Placantonakis
Department of Neurosurgery, Sloan Kettering Institute for Cancer Research, New York, New York, USA
Stem Cells 27:521-32. 2009....
- Human ES cell-derived neural rosettes reveal a functionally distinct early neural stem cell stageYechiel Elkabetz
Developmental Biology Program, Sloan Kettering Institute, New York, NY 10021, USA
Genes Dev 22:152-65. 2008..In addition, the R-NSC-specific genetic markers presented here offer new tools for harnessing the differentiation potential of human ESCs...
- Directed differentiation and transplantation of human embryonic stem cell-derived motoneuronsHyojin Lee
Developmental Biology and Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Stem Cells 25:1931-9. 2007..Disclosure of potential conflicts of interest is found at the end of this article...
- Optical bioluminescence imaging of human ES cell progeny in the rodent CNSMichelle S Bradbury
Department of Radiology, Sloan Kettering Institute for Cancer Research, New York City, New York, USA
J Neurochem 102:2029-39. 2007..In conclusion, our data suggest that optical bioluminescence imaging can serve as an essential tool for the development of hESC-based grafting strategies in the CNS...
- A phase 2 trial of stereotactic radiosurgery boost after surgical resection for brain metastasesCameron Brennan
Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York Department of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, New York
Int J Radiat Oncol Biol Phys 88:130-6. 2014..To evaluate local control after surgical resection and postoperative stereotactic radiosurgery (SRS) for brain metastases...
- Pluripotent stem cells in regenerative medicine: challenges and recent progressViviane Tabar
Center for Stem Cell Biology and Department of Neurosurgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York 10065, USA
Nat Rev Genet 15:82-92. 2014..In this Review, we discuss recent progress in directed differentiation, some of the new technologies that have facilitated the success of hPSC therapies and the remaining hurdles on the road towards developing hPSC-based cell therapies. ..
- Dishevelled 2 signaling promotes self-renewal and tumorigenicity in human gliomasTeodoro Pulvirenti
Cell Biology Program, Department of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York 10021, USA
Cancer Res 71:7280-90. 2011..The data therefore suggest that both canonical and noncanonical Wnt signaling pathways downstream of Dvl2 cooperate to maintain the proliferative capacity of human glioblastomas...
- Organotypic explant culture of glioblastoma multiforme and subsequent single-cell suspensionFumiko Shimizu
Department of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA
Curr Protoc Stem Cell Biol . 2011..In this unit, we describe a detailed protocol for preparing GBM explants, and discuss strengths, as well as limitations of the explant system as an in vitro 3D model of GBM...
- Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson's diseaseSonja Kriks
Center for Stem Cell Biology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA
Nature 480:547-51. 2011..Excellent DA neuron survival, function and lack of neural overgrowth in the three animal models indicate promise for the development of cell-based therapies in Parkinson's disease...
- Glioblastoma stem-like cells give rise to tumour endotheliumRong Wang
Department of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
Nature 468:829-33. 2010....
- Stoichiometric and temporal requirements of Oct4, Sox2, Klf4, and c-Myc expression for efficient human iPSC induction and differentiationEirini P Papapetrou
Center for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
Proc Natl Acad Sci U S A 106:12759-64. 2009..The vector system described here presents a powerful tool for mechanistic studies of reprogramming and the optimization of hiPSC generation...
- Pituitary gland with suprasellar extension: a normal variant. Case illustrationSasan Karimi
Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Room C 278, New York, New York 10021, USA
J Neurosurg 105:75. 2006
- Specification of functional cranial placode derivatives from human pluripotent stem cellsZehra Dincer
Center for Stem Cell Biology, Sloan Kettering Institute, 1275 York Ave, New York, NY 10065, USA Developmental Biology Program, Sloan Kettering Institute, 1275 York Ave, New York, NY 10065, USA Weill Graduate School of Medical Sciences of Cornell University, New York, NY 10021, USA
Cell Rep 5:1387-402. 2013..Our results establish a powerful experimental platform to study human cranial placode development and set the stage for the development of human cell-based therapies in sensory and endocrine disease. ..
- Phase II study of bevacizumab, temozolomide, and hypofractionated stereotactic radiotherapy for newly diagnosed glioblastomaAntonio Omuro
Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, New York
Clin Cancer Res 20:5023-31. 2014..We conducted a phase II trial in newly diagnosed glioblastoma utilizing a novel hypofractionated stereotactic radiotherapy (HFSRT) schedule combined with temozolomide and bevacizumab...
- Neural subtype specification of fertilization and nuclear transfer embryonic stem cells and application in parkinsonian miceTiziano Barberi
Laboratory of Stem Cell and Tumor Biology, Division of Neurosurgery and Developmental Biology Program, Weill Medical College of Cornell University, New York, New York 10021, USA
Nat Biotechnol 21:1200-7. 2003..Furthermore, transplantation of ES and ntES cell-derived dopaminergic neurons corrected the phenotype of a mouse model of Parkinson disease, demonstrating an in vivo application of therapeutic cloning in neural disease...
- Presurgical evaluation of language using functional magnetic resonance imaging in brain tumor patients with previous surgeryKyung K Peck
Department of Radiology and Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York, USA
Neurosurgery 64:644-52; discussion 652-3. 2009....
- Brain tumor stem cellsGeorgia Panagiotakos
Division of Neurosurgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, C711, New York, NY 10021, USA
Curr Neurol Neurosci Rep 7:215-20. 2007..Ongoing work aims at the identification of unique pathways governing self-renewal of these putative stem cells and at their validation as ultimate therapeutic targets...
- Use of human embryonic stem cells to model pediatric gliomas with H3.3K27M histone mutationKosuke Funato
Department of Neurosurgery, Center for Stem Cell Biology and Brain Tumor Center, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
Science 346:1529-33. 2014..Drug screening assays identified a compound targeting the protein menin as an inhibitor of tumor cell growth in vitro and in mice. ..
- Radiation therapy for epithelial ovarian cancer brain metastases: clinical outcomes and predictors of survivalSewit Teckie
Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, USA
Radiat Oncol 8:36. 2013..Brain metastases (BM) and leptomeningeal disease (LMD) are uncommon in epithelial ovarian cancer (EOC). We investigate the outcomes of modern radiation therapy (RT) as a primary treatment modality in patients with EOC BM and LMD...
- Parthenogenetic stem cells in nonhuman primatesJose B Cibelli
Advanced Cell Technology, One Innovation Drive, Worcester, MA 01605, USA
Science 295:819. 2002
- Nonhuman primate parthenogenetic stem cellsKent E Vrana
Center for Neurobehavioral Study of Alcohol, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Proc Natl Acad Sci U S A 100:11911-6. 2003..These results suggest that stem cells derived from the parthenogenetically activated nonhuman primate egg provide a potential source for autologous cell therapy in the female and bypass the need for creating a competent embryo...
- Radiation Damage Repair in the Brain via Human ES cellsViviane Tabar; Fiscal Year: 2004..If successful, we plan to initiate future studies addressing the functional impact of hES-derived neural precursor grafts on radiation-induced cognitive decline. This grant will only use the INIH-approved cell line: HI. NIH code WA01. ..