Viviane Tabar

Summary

Affiliation: Memorial Sloan-Kettering Cancer Center
Country: USA

Publications

  1. ncbi request reprint Migration and differentiation of neural precursors derived from human embryonic stem cells in the rat brain
    Viviane Tabar
    Nat Biotechnol 23:601-6. 2005
  2. pmc Therapeutic cloning in individual parkinsonian mice
    Viviane Tabar
    Department of Neurosurgery, Sloan Kettering Institute, 1275 York Ave, New York, New York 10065, USA
    Nat Med 14:379-81. 2008
  3. pmc Transgene excision has no impact on in vivo integration of human iPS derived neural precursors
    Tamara Major
    Department of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America
    PLoS ONE 6:e24687. 2011
  4. pmc Long-term impact of radiation on the stem cell and oligodendrocyte precursors in the brain
    Georgia Panagiotakos
    Department of Neurosurgery, Sloan Kettering Institute for Cancer Research, New York, New York, United States of America
    PLoS ONE 2:e588. 2007
  5. ncbi request reprint Making a pituitary gland in a dish
    Viviane Tabar
    Department of Neurosurgery and Center for Stem Cell Biology, Memorial Sloan Kettering Center for Cancer Research, New York, NY, 10065 USA
    Cell Stem Cell 9:490-1. 2011
  6. pmc Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs
    Gabsang Lee
    Developmental Biology Program, Sloan Kettering Institute, 1275 York Ave, USA
    Nature 461:402-6. 2009
  7. ncbi request reprint Isolation and directed differentiation of neural crest stem cells derived from human embryonic stem cells
    Gabsang Lee
    Developmental Biology Program, Sloan Kettering Institute, 1275 York Ave, New York, New York 10021, USA
    Nat Biotechnol 25:1468-75. 2007
  8. ncbi request reprint Inhibition of notch signaling in glioblastoma targets cancer stem cells via an endothelial cell intermediate
    Koos E Hovinga
    Department of Neurosurgery, Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, NY, USA
    Stem Cells 28:1019-29. 2010
  9. pmc Derivation of midbrain dopamine neurons from human embryonic stem cells
    Anselme L Perrier
    Laboratory of Stem Cell and Tumor Biology, Division of Neurosurgery and Developmental Biology Program, and Cell Biology Program, Sloan Kettering Institute, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 101:12543-8. 2004
  10. pmc Human ES cell-derived neural rosettes reveal a functionally distinct early neural stem cell stage
    Yechiel Elkabetz
    Developmental Biology Program, Sloan Kettering Institute, New York, NY 10021, USA
    Genes Dev 22:152-65. 2008

Research Grants

Collaborators

Detail Information

Publications28

  1. ncbi request reprint Migration and differentiation of neural precursors derived from human embryonic stem cells in the rat brain
    Viviane Tabar
    Nat Biotechnol 23:601-6. 2005
    ..We found no evidence of cell fusion, suggesting that hES cell progeny are capable of responding appropriately to host cues in the subventricular zone...
  2. pmc Therapeutic cloning in individual parkinsonian mice
    Viviane Tabar
    Department of Neurosurgery, Sloan Kettering Institute, 1275 York Ave, New York, New York 10065, USA
    Nat Med 14:379-81. 2008
    ..Derivation of 187 ntES cell lines from 24 parkinsonian mice, dopaminergic differentiation, and transplantation into individually matched host mice showed therapeutic efficacy and lack of immunological response...
  3. pmc Transgene excision has no impact on in vivo integration of human iPS derived neural precursors
    Tamara Major
    Department of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America
    PLoS ONE 6:e24687. 2011
    ..There was no teratoma or other tumor formation 12 weeks after grafting in any of the 26 animals used in the study. Thus neither factor excision nor persistence of c-myc impact the behavior of hiPS lines in vivo...
  4. pmc Long-term impact of radiation on the stem cell and oligodendrocyte precursors in the brain
    Georgia Panagiotakos
    Department of Neurosurgery, Sloan Kettering Institute for Cancer Research, New York, New York, United States of America
    PLoS ONE 2:e588. 2007
    ..The cellular basis of long term radiation damage in the brain is not fully understood...
  5. ncbi request reprint Making a pituitary gland in a dish
    Viviane Tabar
    Department of Neurosurgery and Center for Stem Cell Biology, Memorial Sloan Kettering Center for Cancer Research, New York, NY, 10065 USA
    Cell Stem Cell 9:490-1. 2011
    ..The adenohypophysis secretes multiple hormones that control vital physiological functions. A recent article in Nature (Suga et al., 2011) describes a 3D protocol for the derivation of several endocrine pituitary cell types from mouse ESCs...
  6. pmc Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs
    Gabsang Lee
    Developmental Biology Program, Sloan Kettering Institute, 1275 York Ave, USA
    Nature 461:402-6. 2009
    ..Our study illustrates the promise of iPSC technology for gaining new insights into human disease pathogenesis and treatment...
  7. ncbi request reprint Isolation and directed differentiation of neural crest stem cells derived from human embryonic stem cells
    Gabsang Lee
    Developmental Biology Program, Sloan Kettering Institute, 1275 York Ave, New York, New York 10021, USA
    Nat Biotechnol 25:1468-75. 2007
    ..The availability of unlimited numbers of human NCS cells offers new opportunities for studies of neural crest development and for efforts to model and treat neural crest-related disorders...
  8. ncbi request reprint Inhibition of notch signaling in glioblastoma targets cancer stem cells via an endothelial cell intermediate
    Koos E Hovinga
    Department of Neurosurgery, Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, NY, USA
    Stem Cells 28:1019-29. 2010
    ..Three-dimensional explant systems provide a novel approach for the study of tumor and microenvironment interactions...
  9. pmc Derivation of midbrain dopamine neurons from human embryonic stem cells
    Anselme L Perrier
    Laboratory of Stem Cell and Tumor Biology, Division of Neurosurgery and Developmental Biology Program, and Cell Biology Program, Sloan Kettering Institute, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 101:12543-8. 2004
    ..This experimental system also provides a powerful tool to probe the molecular mechanisms that control the development and function of human midbrain DA neurons...
  10. pmc Human ES cell-derived neural rosettes reveal a functionally distinct early neural stem cell stage
    Yechiel Elkabetz
    Developmental Biology Program, Sloan Kettering Institute, New York, NY 10021, USA
    Genes Dev 22:152-65. 2008
    ..In addition, the R-NSC-specific genetic markers presented here offer new tools for harnessing the differentiation potential of human ESCs...
  11. doi request reprint BAC transgenesis in human embryonic stem cells as a novel tool to define the human neural lineage
    Dimitris G Placantonakis
    Department of Neurosurgery, Sloan Kettering Institute for Cancer Research, New York, New York, USA
    Stem Cells 27:521-32. 2009
    ....
  12. ncbi request reprint Optical bioluminescence imaging of human ES cell progeny in the rodent CNS
    Michelle S Bradbury
    Department of Radiology, Sloan Kettering Institute for Cancer Research, New York City, New York, USA
    J Neurochem 102:2029-39. 2007
    ..In conclusion, our data suggest that optical bioluminescence imaging can serve as an essential tool for the development of hESC-based grafting strategies in the CNS...
  13. ncbi request reprint Directed differentiation and transplantation of human embryonic stem cell-derived motoneurons
    Hyojin Lee
    Developmental Biology and Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Stem Cells 25:1931-9. 2007
    ..Disclosure of potential conflicts of interest is found at the end of this article...
  14. doi request reprint Pluripotent stem cells in regenerative medicine: challenges and recent progress
    Viviane Tabar
    Center for Stem Cell Biology and Department of Neurosurgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York 10065, USA
    Nat Rev Genet 15:82-92. 2014
    ..In this Review, we discuss recent progress in directed differentiation, some of the new technologies that have facilitated the success of hPSC therapies and the remaining hurdles on the road towards developing hPSC-based cell therapies. ..
  15. ncbi request reprint Neural subtype specification of fertilization and nuclear transfer embryonic stem cells and application in parkinsonian mice
    Tiziano Barberi
    Laboratory of Stem Cell and Tumor Biology, Division of Neurosurgery and Developmental Biology Program, Weill Medical College of Cornell University, New York, New York 10021, USA
    Nat Biotechnol 21:1200-7. 2003
    ..Furthermore, transplantation of ES and ntES cell-derived dopaminergic neurons corrected the phenotype of a mouse model of Parkinson disease, demonstrating an in vivo application of therapeutic cloning in neural disease...
  16. doi request reprint A phase 2 trial of stereotactic radiosurgery boost after surgical resection for brain metastases
    Cameron Brennan
    Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York Department of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, New York
    Int J Radiat Oncol Biol Phys 88:130-6. 2014
    ..To evaluate local control after surgical resection and postoperative stereotactic radiosurgery (SRS) for brain metastases...
  17. doi request reprint Organotypic explant culture of glioblastoma multiforme and subsequent single-cell suspension
    Fumiko Shimizu
    Department of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Curr Protoc Stem Cell Biol . 2011
    ..In this unit, we describe a detailed protocol for preparing GBM explants, and discuss strengths, as well as limitations of the explant system as an in vitro 3D model of GBM...
  18. pmc Dishevelled 2 signaling promotes self-renewal and tumorigenicity in human gliomas
    Teodoro Pulvirenti
    Cell Biology Program, Department of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York 10021, USA
    Cancer Res 71:7280-90. 2011
    ..The data therefore suggest that both canonical and noncanonical Wnt signaling pathways downstream of Dvl2 cooperate to maintain the proliferative capacity of human glioblastomas...
  19. pmc Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson's disease
    Sonja Kriks
    Center for Stem Cell Biology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA
    Nature 480:547-51. 2011
    ..Excellent DA neuron survival, function and lack of neural overgrowth in the three animal models indicate promise for the development of cell-based therapies in Parkinson's disease...
  20. pmc Stoichiometric and temporal requirements of Oct4, Sox2, Klf4, and c-Myc expression for efficient human iPSC induction and differentiation
    Eirini P Papapetrou
    Center for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 106:12759-64. 2009
    ..The vector system described here presents a powerful tool for mechanistic studies of reprogramming and the optimization of hiPSC generation...
  21. doi request reprint Glioblastoma stem-like cells give rise to tumour endothelium
    Rong Wang
    Department of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Nature 468:829-33. 2010
    ....
  22. ncbi request reprint Pituitary gland with suprasellar extension: a normal variant. Case illustration
    Sasan Karimi
    Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Room C 278, New York, New York 10021, USA
    J Neurosurg 105:75. 2006
  23. pmc Specification of functional cranial placode derivatives from human pluripotent stem cells
    Zehra Dincer
    Center for Stem Cell Biology, Sloan Kettering Institute, 1275 York Ave, New York, NY 10065, USA Developmental Biology Program, Sloan Kettering Institute, 1275 York Ave, New York, NY 10065, USA Weill Graduate School of Medical Sciences of Cornell University, New York, NY 10021, USA
    Cell Rep 5:1387-402. 2013
    ..Our results establish a powerful experimental platform to study human cranial placode development and set the stage for the development of human cell-based therapies in sensory and endocrine disease. ..
  24. doi request reprint Presurgical evaluation of language using functional magnetic resonance imaging in brain tumor patients with previous surgery
    Kyung K Peck
    Department of Radiology and Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Neurosurgery 64:644-52; discussion 652-3. 2009
    ....
  25. ncbi request reprint Brain tumor stem cells
    Georgia Panagiotakos
    Division of Neurosurgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, C711, New York, NY 10021, USA
    Curr Neurol Neurosci Rep 7:215-20. 2007
    ..Ongoing work aims at the identification of unique pathways governing self-renewal of these putative stem cells and at their validation as ultimate therapeutic targets...
  26. pmc Radiation therapy for epithelial ovarian cancer brain metastases: clinical outcomes and predictors of survival
    Sewit Teckie
    Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, USA
    Radiat Oncol 8:36. 2013
    ..Brain metastases (BM) and leptomeningeal disease (LMD) are uncommon in epithelial ovarian cancer (EOC). We investigate the outcomes of modern radiation therapy (RT) as a primary treatment modality in patients with EOC BM and LMD...
  27. ncbi request reprint Parthenogenetic stem cells in nonhuman primates
    Jose B Cibelli
    Advanced Cell Technology, One Innovation Drive, Worcester, MA 01605, USA
    Science 295:819. 2002
  28. pmc Nonhuman primate parthenogenetic stem cells
    Kent E Vrana
    Center for Neurobehavioral Study of Alcohol, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Proc Natl Acad Sci U S A 100:11911-6. 2003
    ..These results suggest that stem cells derived from the parthenogenetically activated nonhuman primate egg provide a potential source for autologous cell therapy in the female and bypass the need for creating a competent embryo...

Research Grants5

  1. Radiation Damage Repair in the Brain via Human ES cells
    Viviane Tabar; Fiscal Year: 2004
    ..If successful, we plan to initiate future studies addressing the functional impact of hES-derived neural precursor grafts on radiation-induced cognitive decline. This grant will only use the INIH-approved cell line: HI. NIH code WA01. ..
  2. CNS Radiation Injury: Regeneration via Human ES Cells
    Viviane Tabar; Fiscal Year: 2007
    ..This proposal will use exclusively NIH approved hES lines: WA-01 and WA-09. ..
  3. CNS Radiation Injury: Regeneration via Human ES Cells
    Viviane Tabar; Fiscal Year: 2009
    ..This proposal will use exclusively NIH approved hES lines: WA-01 and WA-09. ..
  4. CNS Radiation Injury: Regeneration via Human ES Cells
    Viviane Tabar; Fiscal Year: 2010
    ..This proposal will use exclusively NIH approved hES lines: WA-01 and WA-09. ..