Joseph C Sun

Summary

Affiliation: Memorial Sloan-Kettering Cancer Center
Country: USA

Publications

  1. doi request reprint NK cells and immune "memory"
    Joseph C Sun
    Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    J Immunol 186:1891-7. 2011
  2. pmc Nfil3-independent lineage maintenance and antiviral response of natural killer cells
    Matthew A Firth
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065
    J Exp Med 210:2981-90. 2013
  3. pmc Stage-specific regulation of natural killer cell homeostasis and response against viral infection by microRNA-155
    Carolyn L Zawislak
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 110:6967-72. 2013
  4. pmc IL-2-dependent tuning of NK cell sensitivity for target cells is controlled by regulatory T cells
    Georg Gasteiger
    Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    J Exp Med 210:1167-78. 2013
  5. pmc MicroRNA function in NK-cell biology
    Aimee M Beaulieu
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Immunol Rev 253:40-52. 2013
  6. pmc IL-2-dependent adaptive control of NK cell homeostasis
    Georg Gasteiger
    Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    J Exp Med 210:1179-87. 2013
  7. pmc Proinflammatory cytokine signaling required for the generation of natural killer cell memory
    Joseph C Sun
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    J Exp Med 209:947-54. 2012
  8. doi request reprint Protein kinase C-θ clustering at immunological synapses amplifies effector responses in NK cells
    Ernesto Merino
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    J Immunol 189:4859-69. 2012
  9. pmc Extrathymic development of murine T cells after bone marrow transplantation
    Amanda M Holland
    Department of Immunology, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    J Clin Invest 122:4716-26. 2012
  10. doi request reprint NK cell development, homeostasis and function: parallels with CD8⁺ T cells
    Joseph C Sun
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Nat Rev Immunol 11:645-57. 2011

Collaborators

  • Lewis L Lanier
  • Masato Kubo
  • Jarrod A Dudakov
  • Xin Liu
  • Mark H Kaplan
  • Charles C Kim
  • Georg Gasteiger
  • Aimee M Beaulieu
  • Matthew A Firth
  • Alexander Y Rudensky
  • Carolyn L Zawislak
  • Saskia Hemmers
  • Natalie A Bezman
  • Morgan Huse
  • Amanda M Holland
  • Ernesto Merino
  • David Canner
  • Audrey Le Floc'h
  • Sharline Madera
  • Kimberly S Schluns
  • Mehrdad Matloubian
  • Jenny Karo
  • Eric Vivier
  • Eliseo F Castillo
  • Paul B Rothman
  • Jang Eun Lee
  • Paula D Bos
  • Gabriel B Loeb
  • Jessie Brill
  • Odette M Smith
  • Jennifer J Tsai
  • Johannes L Zakrzewski
  • Natalie V Singer
  • Roshni Basu
  • Alan M Hanash
  • Thushara P Abeyweera
  • Mallory L West
  • Marcel R m van den Brink

Detail Information

Publications10

  1. doi request reprint NK cells and immune "memory"
    Joseph C Sun
    Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    J Immunol 186:1891-7. 2011
    ....
  2. pmc Nfil3-independent lineage maintenance and antiviral response of natural killer cells
    Matthew A Firth
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065
    J Exp Med 210:2981-90. 2013
    ....
  3. pmc Stage-specific regulation of natural killer cell homeostasis and response against viral infection by microRNA-155
    Carolyn L Zawislak
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 110:6967-72. 2013
    ..NK cells constitutively expressing Noxa and SOCS1 exhibit profound defects in expansion during the response to MCMV infection, suggesting that their regulation by miR-155 promotes antiviral immunity...
  4. pmc IL-2-dependent tuning of NK cell sensitivity for target cells is controlled by regulatory T cells
    Georg Gasteiger
    Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    J Exp Med 210:1167-78. 2013
    ..Our results suggest that IL-2-dependent adaptive-innate lymphocyte cross talk tunes NK cell reactivity and that T reg cells restrain NK cell cytotoxicity by limiting the availability of IL-2...
  5. pmc MicroRNA function in NK-cell biology
    Aimee M Beaulieu
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Immunol Rev 253:40-52. 2013
    ..Furthermore, we discuss the impact of NK cells on the entire immune system during global and specific microRNA ablation in the settings of inflammation, infection, and immune dysregulation...
  6. pmc IL-2-dependent adaptive control of NK cell homeostasis
    Georg Gasteiger
    Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    J Exp Med 210:1179-87. 2013
    ..Thus, T reg cells restrain the IL-2-dependent CD4(+) T cell help for CD127(+) immature NK cells. These findings highlight the adaptive control of innate lymphocyte homeostasis...
  7. pmc Proinflammatory cytokine signaling required for the generation of natural killer cell memory
    Joseph C Sun
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    J Exp Med 209:947-54. 2012
    ..Understanding the full contribution of inflammatory cytokine signaling to the NK cell response against viral infection will be of interest for the development of vaccines and therapeutics...
  8. doi request reprint Protein kinase C-θ clustering at immunological synapses amplifies effector responses in NK cells
    Ernesto Merino
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    J Immunol 189:4859-69. 2012
    ..Taken together, our results provide a cell biological basis for the role of PKCθ clustering during NK cell activation, and highlight the importance of subcellular compartmentalization for lymphocyte signal transduction...
  9. pmc Extrathymic development of murine T cells after bone marrow transplantation
    Amanda M Holland
    Department of Immunology, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    J Clin Invest 122:4716-26. 2012
    ..These findings demonstrate the potential of extrathymic T cell development for T cell reconstitution in patients with limited thymic function...
  10. doi request reprint NK cell development, homeostasis and function: parallels with CD8⁺ T cells
    Joseph C Sun
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Nat Rev Immunol 11:645-57. 2011
    ..In this Review, we highlight the many stages that an NK cell progresses through during its remarkable lifetime, discussing similarities and differences with its close relative, the cytotoxic CD8(+) T cell...