Joseph C Sun

Summary

Affiliation: Memorial Sloan-Kettering Cancer Center
Country: USA

Publications

  1. ncbi request reprint Immunological memory within the innate immune system
    Joseph C Sun
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA Immunology and Microbial Pathogenesis Program, Weill Cornell Medical College, New York, NY, USA
    EMBO J 33:1295-303. 2014
  2. pmc Re-educating natural killer cells
    Joseph C Sun
    Department of Immunology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    J Exp Med 207:2049-52. 2010
  3. doi request reprint NK cells and immune "memory"
    Joseph C Sun
    Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    J Immunol 186:1891-7. 2011
  4. pmc Nfil3-independent lineage maintenance and antiviral response of natural killer cells
    Matthew A Firth
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065
    J Exp Med 210:2981-90. 2013
  5. ncbi request reprint The transcription factor Zbtb32 controls the proliferative burst of virus-specific natural killer cells responding to infection
    Aimee M Beaulieu
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Nat Immunol 15:546-53. 2014
  6. pmc Stage-specific regulation of natural killer cell homeostasis and response against viral infection by microRNA-155
    Carolyn L Zawislak
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 110:6967-72. 2013
  7. pmc IL-2-dependent tuning of NK cell sensitivity for target cells is controlled by regulatory T cells
    Georg Gasteiger
    Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    J Exp Med 210:1167-78. 2013
  8. pmc IL-2-dependent adaptive control of NK cell homeostasis
    Georg Gasteiger
    Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    J Exp Med 210:1179-87. 2013
  9. pmc MicroRNA function in NK-cell biology
    Aimee M Beaulieu
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Immunol Rev 253:40-52. 2013
  10. doi request reprint NK cell development, homeostasis and function: parallels with CD8⁺ T cells
    Joseph C Sun
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Nat Rev Immunol 11:645-57. 2011

Collaborators

  • Lewis L Lanier
  • Toshinori Nakayama
  • Aymen Al-Shamkhani
  • Masato Kubo
  • Jarrod A Dudakov
  • Xin Liu
  • Mark H Kaplan
  • Charles C Kim
  • Aimee M Beaulieu
  • Georg Gasteiger
  • Carolyn L Zawislak
  • Matthew A Firth
  • Alexander Y Rudensky
  • Saskia Hemmers
  • Natalie A Bezman
  • Michael A Curran
  • Morgan Huse
  • Amanda M Holland
  • Ernesto Merino
  • David Canner
  • Eric Vivier
  • Welby Montalvo
  • Audrey Le Floc'h
  • Myoungjoo Kim
  • Eliseo F Castillo
  • Sharline Madera
  • Kimberly S Schluns
  • Mehrdad Matloubian
  • Steven L Reiner
  • Paul B Rothman
  • Jang Eun Lee
  • Paula D Bos
  • James P Allison
  • Jenny Karo
  • Gabriel B Loeb
  • Theresa L Geiger
  • Jessie Brill
  • Johannes L Zakrzewski
  • Odette M Smith
  • Natalie V Singer
  • Roshni Basu
  • Alan M Hanash
  • Thushara P Abeyweera
  • Mallory L West
  • Marcel R m van den Brink
  • Jennifer J Tsai

Detail Information

Publications14

  1. ncbi request reprint Immunological memory within the innate immune system
    Joseph C Sun
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA Immunology and Microbial Pathogenesis Program, Weill Cornell Medical College, New York, NY, USA
    EMBO J 33:1295-303. 2014
    ..The surprising longevity and enhanced responses of previously primed NK cells will be discussed in the context of several immunization settings. ..
  2. pmc Re-educating natural killer cells
    Joseph C Sun
    Department of Immunology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    J Exp Med 207:2049-52. 2010
    ..This newfound ability of mature NK cells to be "re-educated" may be clinically applicable in the immunotherapeutic use of NK cells against infection and cancer...
  3. doi request reprint NK cells and immune "memory"
    Joseph C Sun
    Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    J Immunol 186:1891-7. 2011
    ....
  4. pmc Nfil3-independent lineage maintenance and antiviral response of natural killer cells
    Matthew A Firth
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065
    J Exp Med 210:2981-90. 2013
    ....
  5. ncbi request reprint The transcription factor Zbtb32 controls the proliferative burst of virus-specific natural killer cells responding to infection
    Aimee M Beaulieu
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Nat Immunol 15:546-53. 2014
    ..Our data support a model in which Zbtb32 acts as a cellular 'hub' through which proinflammatory signals instruct a 'proliferation-permissive' state in NK cells, thereby allowing their prolific expansion in response to viral infection. ..
  6. pmc Stage-specific regulation of natural killer cell homeostasis and response against viral infection by microRNA-155
    Carolyn L Zawislak
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 110:6967-72. 2013
    ..NK cells constitutively expressing Noxa and SOCS1 exhibit profound defects in expansion during the response to MCMV infection, suggesting that their regulation by miR-155 promotes antiviral immunity...
  7. pmc IL-2-dependent tuning of NK cell sensitivity for target cells is controlled by regulatory T cells
    Georg Gasteiger
    Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    J Exp Med 210:1167-78. 2013
    ..Our results suggest that IL-2-dependent adaptive-innate lymphocyte cross talk tunes NK cell reactivity and that T reg cells restrain NK cell cytotoxicity by limiting the availability of IL-2...
  8. pmc IL-2-dependent adaptive control of NK cell homeostasis
    Georg Gasteiger
    Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    J Exp Med 210:1179-87. 2013
    ..Thus, T reg cells restrain the IL-2-dependent CD4(+) T cell help for CD127(+) immature NK cells. These findings highlight the adaptive control of innate lymphocyte homeostasis...
  9. pmc MicroRNA function in NK-cell biology
    Aimee M Beaulieu
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Immunol Rev 253:40-52. 2013
    ..Furthermore, we discuss the impact of NK cells on the entire immune system during global and specific microRNA ablation in the settings of inflammation, infection, and immune dysregulation...
  10. doi request reprint NK cell development, homeostasis and function: parallels with CD8⁺ T cells
    Joseph C Sun
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Nat Rev Immunol 11:645-57. 2011
    ..In this Review, we highlight the many stages that an NK cell progresses through during its remarkable lifetime, discussing similarities and differences with its close relative, the cytotoxic CD8(+) T cell...
  11. pmc Proinflammatory cytokine signaling required for the generation of natural killer cell memory
    Joseph C Sun
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    J Exp Med 209:947-54. 2012
    ..Understanding the full contribution of inflammatory cytokine signaling to the NK cell response against viral infection will be of interest for the development of vaccines and therapeutics...
  12. pmc Systemic 4-1BB activation induces a novel T cell phenotype driven by high expression of Eomesodermin
    Michael A Curran
    Department of Immunology, MD Anderson Cancer Center, Houston, TX 77030, USA
    J Exp Med 210:743-55. 2013
    ....
  13. pmc Extrathymic development of murine T cells after bone marrow transplantation
    Amanda M Holland
    Department of Immunology, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    J Clin Invest 122:4716-26. 2012
    ..These findings demonstrate the potential of extrathymic T cell development for T cell reconstitution in patients with limited thymic function...
  14. doi request reprint Protein kinase C-θ clustering at immunological synapses amplifies effector responses in NK cells
    Ernesto Merino
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    J Immunol 189:4859-69. 2012
    ..Taken together, our results provide a cell biological basis for the role of PKCθ clustering during NK cell activation, and highlight the importance of subcellular compartmentalization for lymphocyte signal transduction...