Joseph C Sun

Summary

Affiliation: Memorial Sloan-Kettering Cancer Center
Country: USA

Publications

  1. doi request reprint Transcriptional Control of NK Cells
    Joseph C Sun
    Memorial Sloan Kettering Cancer Center, Department of Immunology and Microbial Pathogenesis, Weill Cornell Medical College, 408 East 69th Street, ZRC 1402, New York, NY, 10065, USA
    Curr Top Microbiol Immunol 395:1-36. 2016
  2. pmc Immunological memory within the innate immune system
    Joseph C Sun
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA Immunology and Microbial Pathogenesis Program, Weill Cornell Medical College, New York, NY, USA
    EMBO J 33:1295-303. 2014
  3. pmc Re-educating natural killer cells
    Joseph C Sun
    Department of Immunology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    J Exp Med 207:2049-52. 2010
  4. pmc NK cells and immune "memory"
    Joseph C Sun
    Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    J Immunol 186:1891-7. 2011
  5. pmc Nfil3-independent lineage maintenance and antiviral response of natural killer cells
    Matthew A Firth
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065
    J Exp Med 210:2981-90. 2013
  6. pmc The transcription factor Zbtb32 controls the proliferative burst of virus-specific natural killer cells responding to infection
    Aimee M Beaulieu
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Nat Immunol 15:546-53. 2014
  7. pmc Stage-specific regulation of natural killer cell homeostasis and response against viral infection by microRNA-155
    Carolyn L Zawislak
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 110:6967-72. 2013
  8. pmc IL-2-dependent tuning of NK cell sensitivity for target cells is controlled by regulatory T cells
    Georg Gasteiger
    Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    J Exp Med 210:1167-78. 2013
  9. doi request reprint Type I IFN promotes NK cell expansion during viral infection by protecting NK cells against fratricide
    Sharline Madera
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065 Department of Immunology and Microbial Pathogenesis, Weill Cornell Medical College, New York, NY 10065
    J Exp Med 213:225-33. 2016
  10. pmc MicroRNA function in NK-cell biology
    Aimee M Beaulieu
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Immunol Rev 253:40-52. 2013

Collaborators

  • Lewis L Lanier
  • Ashutosh Chaudhry
  • Li Fan Lu
  • Toshinori Nakayama
  • Aymen Al-Shamkhani
  • Masato Kubo
  • Jarrod A Dudakov
  • Xin Liu
  • Mark H Kaplan
  • Charles C Kim
  • Aimee M Beaulieu
  • Timothy E O'Sullivan
  • Sharline Madera
  • Matthew A Firth
  • Georg Gasteiger
  • Carolyn L Zawislak
  • Theresa L Geiger
  • Alexander Y Rudensky
  • Saskia Hemmers
  • Alan M Hanash
  • Michael A Curran
  • Natalie A Bezman
  • Morgan Huse
  • Amanda M Holland
  • Ernesto Merino
  • Joshua N Beilke
  • Moritz Rapp
  • Helen H Kang
  • Lexus R Johnson
  • Margaret H O'Connor
  • Marcel R van den Brink
  • Michael C Abt
  • Clair D Geary
  • Eric G Pamer
  • Paul B Rothman
  • Eliseo F Castillo
  • James P Allison
  • Steven L Reiner
  • Welby Montalvo
  • Jenny Karo
  • Myoungjoo Kim
  • Mehrdad Matloubian
  • Paula D Bos
  • Jang Eun Lee
  • Eric Vivier
  • Audrey Le Floc'h
  • Kimberly S Schluns
  • David Canner
  • Gabriel B Loeb
  • Marcel R m van den Brink
  • Odette M Smith
  • Johannes L Zakrzewski
  • Mallory L West
  • Jessie Brill
  • Roshni Basu
  • Thushara P Abeyweera
  • Jennifer J Tsai
  • Natalie V Singer

Detail Information

Publications23

  1. doi request reprint Transcriptional Control of NK Cells
    Joseph C Sun
    Memorial Sloan Kettering Cancer Center, Department of Immunology and Microbial Pathogenesis, Weill Cornell Medical College, 408 East 69th Street, ZRC 1402, New York, NY, 10065, USA
    Curr Top Microbiol Immunol 395:1-36. 2016
    ..This chapter highlights the transcription factors that are unique to NK cells, or shared between NK cells and other hematopoietic cell lineages, but govern the biology of this cytolytic lymphocyte. ..
  2. pmc Immunological memory within the innate immune system
    Joseph C Sun
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA Immunology and Microbial Pathogenesis Program, Weill Cornell Medical College, New York, NY, USA
    EMBO J 33:1295-303. 2014
    ..The surprising longevity and enhanced responses of previously primed NK cells will be discussed in the context of several immunization settings. ..
  3. pmc Re-educating natural killer cells
    Joseph C Sun
    Department of Immunology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    J Exp Med 207:2049-52. 2010
    ..This newfound ability of mature NK cells to be "re-educated" may be clinically applicable in the immunotherapeutic use of NK cells against infection and cancer...
  4. pmc NK cells and immune "memory"
    Joseph C Sun
    Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    J Immunol 186:1891-7. 2011
    ....
  5. pmc Nfil3-independent lineage maintenance and antiviral response of natural killer cells
    Matthew A Firth
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065
    J Exp Med 210:2981-90. 2013
    ....
  6. pmc The transcription factor Zbtb32 controls the proliferative burst of virus-specific natural killer cells responding to infection
    Aimee M Beaulieu
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Nat Immunol 15:546-53. 2014
    ..Our data support a model in which Zbtb32 acts as a cellular 'hub' through which proinflammatory signals instruct a 'proliferation-permissive' state in NK cells, thereby allowing their prolific expansion in response to viral infection. ..
  7. pmc Stage-specific regulation of natural killer cell homeostasis and response against viral infection by microRNA-155
    Carolyn L Zawislak
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 110:6967-72. 2013
    ..NK cells constitutively expressing Noxa and SOCS1 exhibit profound defects in expansion during the response to MCMV infection, suggesting that their regulation by miR-155 promotes antiviral immunity...
  8. pmc IL-2-dependent tuning of NK cell sensitivity for target cells is controlled by regulatory T cells
    Georg Gasteiger
    Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    J Exp Med 210:1167-78. 2013
    ..Our results suggest that IL-2-dependent adaptive-innate lymphocyte cross talk tunes NK cell reactivity and that T reg cells restrain NK cell cytotoxicity by limiting the availability of IL-2...
  9. doi request reprint Type I IFN promotes NK cell expansion during viral infection by protecting NK cells against fratricide
    Sharline Madera
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065 Department of Immunology and Microbial Pathogenesis, Weill Cornell Medical College, New York, NY 10065
    J Exp Med 213:225-33. 2016
    ..Our study reveals a novel type I IFN-dependent mechanism by which NK cells evade mechanisms of cell death after viral infection. ..
  10. pmc MicroRNA function in NK-cell biology
    Aimee M Beaulieu
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Immunol Rev 253:40-52. 2013
    ..Furthermore, we discuss the impact of NK cells on the entire immune system during global and specific microRNA ablation in the settings of inflammation, infection, and immune dysregulation...
  11. pmc A Single miRNA-mRNA Interaction Affects the Immune Response in a Context- and Cell-Type-Specific Manner
    Li Fan Lu
    Howard Hughes Medical Institute and Immunology Program, and Ludwig Center, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA Division of Biological Sciences and Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA
    Immunity 43:52-64. 2015
    ..Our data suggest that the role of a single miRNA-mRNA interaction is dependent on cell type and biological context...
  12. pmc Nfil3 is crucial for development of innate lymphoid cells and host protection against intestinal pathogens
    Theresa L Geiger
    Immunology Program Adult Bone Marrow Transplant Service and Infectious Diseases Service, Department of Medicine and Lucille Castori Center for Microbes, Inflammation, and Cancer, Memorial Sloan Kettering Cancer Center, New York, NY 10065
    J Exp Med 211:1723-31. 2014
    ..Lastly, a marked defect in type 2 ILCs (ILC2s) was also observed in the lungs and visceral adipose tissue of Nfil3-deficient mice, revealing a general requirement for Nfil3 in the development of all ILC lineages...
  13. pmc IL-2-dependent adaptive control of NK cell homeostasis
    Georg Gasteiger
    Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    J Exp Med 210:1179-87. 2013
    ..Thus, T reg cells restrain the IL-2-dependent CD4(+) T cell help for CD127(+) immature NK cells. These findings highlight the adaptive control of innate lymphocyte homeostasis...
  14. pmc Proinflammatory cytokine signaling required for the generation of natural killer cell memory
    Joseph C Sun
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    J Exp Med 209:947-54. 2012
    ..Understanding the full contribution of inflammatory cytokine signaling to the NK cell response against viral infection will be of interest for the development of vaccines and therapeutics...
  15. doi request reprint Natural Killer Cell Memory
    Timothy E O'Sullivan
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA
    Immunity 43:634-45. 2015
    ..In this review, we discuss evidence of NK cell memory and the mechanisms involved in the generation and survival of these innate lymphocytes. ..
  16. doi request reprint Molecular Programming of Immunological Memory in Natural Killer Cells
    Aimee M Beaulieu
    Memorial Sloan Kettering Cancer Center, 408 East 69th Street, ZRC 1402, 10065, New York, NY, USA
    Adv Exp Med Biol 850:81-91. 2015
    ..A greater understanding of the molecular mechanisms controlling NK cell responses will provide novel strategies for tailoring vaccines to target infectious disease...
  17. pmc Cutting edge: stage-specific requirement of IL-18 for antiviral NK cell expansion
    Sharline Madera
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065
    J Immunol 194:1408-12. 2015
    ..During MCMV infection, NK cells required MyD88, but not IL-1R, for optimal expansion. Thus, an IL-18-MyD88 signaling axis facilitates the prolific expansion of NK cells in response to primary viral infection, but not recall responses. ..
  18. doi request reprint Generation of Natural Killer Cell Memory during Viral Infection
    Timothy E O'Sullivan
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, N Y, USA
    J Innate Immun 7:557-62. 2015
    ..In this review, we will discuss the current evidence for viral-induced NK cell memory in both mice and humans. ..
  19. doi request reprint BNIP3- and BNIP3L-Mediated Mitophagy Promotes the Generation of Natural Killer Cell Memory
    Timothy E O'Sullivan
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Immunity 43:331-42. 2015
    ..Thus, our study reveals the functional importance of mitophagy during the dynamic response of these cytolytic innate lymphocytes...
  20. pmc NK cell development, homeostasis and function: parallels with CD8⁺ T cells
    Joseph C Sun
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Nat Rev Immunol 11:645-57. 2011
    ..In this Review, we highlight the many stages that an NK cell progresses through during its remarkable lifetime, discussing similarities and differences with its close relative, the cytotoxic CD8(+) T cell...
  21. pmc Systemic 4-1BB activation induces a novel T cell phenotype driven by high expression of Eomesodermin
    Michael A Curran
    Department of Immunology, MD Anderson Cancer Center, Houston, TX 77030, USA
    J Exp Med 210:743-55. 2013
    ....
  22. doi request reprint Protein kinase C-θ clustering at immunological synapses amplifies effector responses in NK cells
    Ernesto Merino
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    J Immunol 189:4859-69. 2012
    ..Taken together, our results provide a cell biological basis for the role of PKCθ clustering during NK cell activation, and highlight the importance of subcellular compartmentalization for lymphocyte signal transduction...
  23. pmc Extrathymic development of murine T cells after bone marrow transplantation
    Amanda M Holland
    Department of Immunology, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    J Clin Invest 122:4716-26. 2012
    ..These findings demonstrate the potential of extrathymic T cell development for T cell reconstitution in patients with limited thymic function...