Joseph C Sun


Affiliation: Memorial Sloan-Kettering Cancer Center
Country: USA


  1. Geary C, Krishna C, Lau C, Adams N, Gearty S, Pritykin Y, et al. Non-redundant ISGF3 Components Promote NK Cell Survival in an Auto-regulatory Manner during Viral Infection. Cell Rep. 2018;24:1949-1957.e6 pubmed publisher
    ..Thus, our findings demonstrate that individual ISGF3 components are crucial cell-autonomous and non-redundant regulators of the NK cell response to viral infection. ..
  2. Lau C, Adams N, Geary C, Weizman O, Rapp M, Pritykin Y, et al. Epigenetic control of innate and adaptive immune memory. Nat Immunol. 2018;19:963-972 pubmed publisher
    ..Overall, our study reveals the dynamic nature of epigenetic modifications during the generation of innate and adaptive lymphocyte memory. ..
  3. Karo J, Schatz D, Sun J. The RAG recombinase dictates functional heterogeneity and cellular fitness in natural killer cells. Cell. 2014;159:94-107 pubmed publisher
  4. O Sullivan T, Sun J. Determination of the Fate and Function of Innate Lymphoid Cells Following Adoptive Transfer of Innate Lymphoid Cell Precursors. Methods Mol Biol. 2018;1799:109-119 pubmed publisher
    ..Here we describe methodology to identify and isolate bone marrow CHILP and ILC2 progenitor (ILC2P) cells based on cell surface marker expression for adoptive transfer into lymphopenic mice to track the fate of developing ILCs. ..
  5. Lau C, Sun J. The widening spectrum of immunological memory. Curr Opin Immunol. 2018;54:42-49 pubmed publisher
    ..In this article, we review recent work describing memory-like features within the innate immune system, and provide evidence that immunological memory may be more nuanced than previously appreciated. ..
  6. Sun J. Transcriptional Control of NK Cells. Curr Top Microbiol Immunol. 2016;395:1-36 pubmed publisher
    ..This chapter highlights the transcription factors that are unique to NK cells, or shared between NK cells and other hematopoietic cell lineages, but govern the biology of this cytolytic lymphocyte. ..
  7. Madera S, Sun J. Cutting edge: stage-specific requirement of IL-18 for antiviral NK cell expansion. J Immunol. 2015;194:1408-12 pubmed publisher
    ..During MCMV infection, NK cells required MyD88, but not IL-1R, for optimal expansion. Thus, an IL-18-MyD88 signaling axis facilitates the prolific expansion of NK cells in response to primary viral infection, but not recall responses. ..
  8. Rapp M, Wiedemann G, Sun J. Memory responses of innate lymphocytes and parallels with T cells. Semin Immunopathol. 2018;40:343-355 pubmed publisher
    ..In this review, we discuss the requirements for memory NK cell generation and highlight the similarities with the formation of memory T cells. ..
  9. Adams N, Lau C, Fan X, Rapp M, Geary C, Weizman O, et al. Transcription Factor IRF8 Orchestrates the Adaptive Natural Killer Cell Response. Immunity. 2018;48:1172-1182.e6 pubmed publisher
    ..These findings identify the function and cell-type-specific regulation of IRF8 in NK-cell-mediated antiviral immunity and provide a mechanistic understanding of viral susceptibility in patients with IRF8 mutations. ..

More Information


  1. Geiger T, Sun J. Development and maturation of natural killer cells. Curr Opin Immunol. 2016;39:82-9 pubmed publisher
    ..Here we will review our current understanding of the molecular mechanisms driving development of NK cells from the common lymphoid progenitor (CLP) to mature NK cells, and from activated effectors to long-lived memory NK cells. ..
  2. O Sullivan T, Sun J, Lanier L. Natural Killer Cell Memory. Immunity. 2015;43:634-45 pubmed publisher
    ..In this review, we discuss evidence of NK cell memory and the mechanisms involved in the generation and survival of these innate lymphocytes. ..
  3. Beaulieu A, Sun J. Tracking Effector and Memory NK Cells During MCMV Infection. Methods Mol Biol. 2016;1441:1-12 pubmed publisher
    ..Here we describe an adoptive transfer model in which the expansion, contraction, and memory cell persistence of transferred Ly49H(+) NK cells are tracked in congenic C57BL/6 hosts following MCMV infection. ..
  4. Adams N, O Sullivan T, Geary C, Karo J, Amezquita R, Joshi N, et al. NK Cell Responses Redefine Immunological Memory. J Immunol. 2016;197:2963-2970 pubmed
    ..In this review, we highlight the intracellular and extracellular requirements for memory NK cell generation and describe the emerging evidence for memory precursor NK cells and their derivation. ..
  5. Madera S, Geary C, Lau C, Pikovskaya O, Reiner S, Sun J. Cutting Edge: Divergent Requirement of T-Box Transcription Factors in Effector and Memory NK Cells. J Immunol. 2018;200:1977-1981 pubmed publisher
    ..These findings uncover a nonredundant and stage-specific influence of T-box transcription factors in the antiviral NK cell response. ..
  6. Geiger T, Abt M, Gasteiger G, Firth M, O Connor M, Geary C, et al. Nfil3 is crucial for development of innate lymphoid cells and host protection against intestinal pathogens. J Exp Med. 2014;211:1723-31 pubmed publisher
    ..Lastly, a marked defect in type 2 ILCs (ILC2s) was also observed in the lungs and visceral adipose tissue of Nfil3-deficient mice, revealing a general requirement for Nfil3 in the development of all ILC lineages. ..
  7. O Sullivan T, Geary C, Weizman O, Geiger T, Rapp M, Dorn G, et al. Atg5 Is Essential for the Development and Survival of Innate Lymphocytes. Cell Rep. 2016;15:1910-9 pubmed publisher
    ..These findings highlight the essential role for autophagy in ILC development and lymphocyte survival during lymphopenia. ..
  8. O Sullivan T, Rapp M, Fan X, Weizman O, Bhardwaj P, Adams N, et al. Adipose-Resident Group 1 Innate Lymphoid Cells Promote Obesity-Associated Insulin Resistance. Immunity. 2016;45:428-41 pubmed publisher
    ..Thus, adipose-resident ILC1s contribute to obesity-related pathology in response to dysregulated local proinflammatory cytokine production. ..
  9. Geary C, Sun J. Memory responses of natural killer cells. Semin Immunol. 2017;31:11-19 pubmed publisher
    ..In this review, we discuss the various conditions that promote generation of these two categories of memory NK cells, and the mechanistic requirements underlying these processes. ..
  10. Rapp M, Lau C, Adams N, Weizman O, O Sullivan T, Geary C, et al. Core-binding factor β and Runx transcription factors promote adaptive natural killer cell responses. Sci Immunol. 2017;2: pubmed publisher
    ..Thus, our study reveals a mechanism whereby STAT4-mediated epigenetic control of individual Runx transcription factors promotes the adaptive behavior of antiviral NK cells. ..
  11. O Sullivan T, Johnson L, Kang H, Sun J. BNIP3- and BNIP3L-Mediated Mitophagy Promotes the Generation of Natural Killer Cell Memory. Immunity. 2015;43:331-42 pubmed publisher
    ..Thus, our study reveals the functional importance of mitophagy during the dynamic response of these cytolytic innate lymphocytes. ..
  12. O Sullivan T, Sun J. Innate Lymphoid Cell Immunometabolism. J Mol Biol. 2017;429:3577-3586 pubmed publisher
    ..Finally, this review discusses the challenges and open questions in the rapidly expanding field of immunometabolism. ..
  13. Weizman O, Adams N, Schuster I, Krishna C, Pritykin Y, Lau C, et al. ILC1 Confer Early Host Protection at Initial Sites of Viral Infection. Cell. 2017;171:795-808.e12 pubmed publisher
    ..Thus, ILC1 contribute an essential role in viral immunosurveillance at sites of initial infection in response to local cDC1-derived proinflammatory cytokines. ..
  14. Johnson L, Weizman O, Rapp M, Way S, Sun J. Epitope-Specific Vaccination Limits Clonal Expansion of Heterologous Naive T Cells during Viral Challenge. Cell Rep. 2016;17:636-644 pubmed publisher
    ..These findings have important implications in pathogen vaccination strategies that depend on the targeting of multiple T cell epitopes. ..
  15. Madera S, Rapp M, Firth M, Beilke J, Lanier L, Sun J. Type I IFN promotes NK cell expansion during viral infection by protecting NK cells against fratricide. J Exp Med. 2016;213:225-33 pubmed publisher
    ..Our study reveals a novel type I IFN-dependent mechanism by which NK cells evade mechanisms of cell death after viral infection. ..