Research Topics
| Peter G SteinherzSummaryAffiliation: Memorial Sloan-Kettering Cancer Center Country: USA Publications
Research Grants
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Detail Information
Publications
Autonomous growth potential of leukemia blast cells is associated with poor prognosis in human acute leukemiasYing Yan
The Saint Luke s Cancer Institute, 4321 Washington, Suite 4000 Kansas City, Missouri 64111, USA
J Hematol Oncol 2:51. 2009..Patients whose leukemic blasts grew indolently or whose leukemia cells failed to induce growth had a significantly longer DFS and more favorable clinical course...
Phase I study of gemcitabine (difluorodeoxycytidine) in children with relapsed or refractory leukemia (CCG-0955): a report from the Children's Cancer GroupP G Steinherz
Leuk Lymphoma 43:1945-50. 2002..This is the recommended phase II dose schedule for children with leukemia. The activity of the drug at this schedule in heavily pretreated, refractory patients warrants a phase II trial in hematologic malignancies...- Clofarabine induced durable complete remission in heavily pretreated adolescents with relapsed and refractory leukemiaPeter G Steinherz
Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
J Pediatr Hematol Oncol 29:656-8. 2007..The remissions were sustained with repeated cycles of monotherapy for 47, 59, and 64 weeks, respectively... - Human granulocyte colony-stimulating factor in children with high-risk acute lymphoblastic leukemia: a Children's Cancer Group StudyJohn A Heath
Department of Pediatrics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
J Clin Oncol 21:1612-7. 2003.... 
Effect of hemodialysis on the plasma levels of clofarabinePeter G Steinherz
Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York, USA
Pediatr Blood Cancer 55:196-8. 2010..Post-dialysis, while the clofarabine was still infusing, the level was 95.8 ng/ml. Hemodialysis does decrease clofarabine levels, but given its large volume distribution, hemodialysis may not be effective for clofarabine overdose...- Remission re-induction chemotherapy with clofarabine, topotecan, thiotepa, and vinorelbine for patients with relapsed or refractory leukemiaPeter G Steinherz
Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA
Pediatr Blood Cancer 54:687-93. 2010.... - Imatinib mesylate in Philadelphia chromosome-positive leukemia of childhoodE Anders Kolb
Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Cancer 98:2643-50. 2003..However, to our knowledge, there are few data regarding imatinib safety, efficacy, and response monitoring in patients age < 18 years... - Improved long-term survival with combined modality therapy for pediatric nasopharynx cancerS L Wolden
Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Int J Radiat Oncol Biol Phys 46:859-64. 2000..33%, p < 0.05) over radiation alone. The 10-year actuarial rate of severe complications was 24%.60 Gy are used for gross disease. The addition of chemotherapy decreases the risk of distant metastases and increases survival... - Allogeneic hematopoietic stem cell transplantation for pediatric patients with treatment-related myelodysplastic syndrome or acute myelogenous leukemiaRachel Kobos
Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
Biol Blood Marrow Transplant 18:473-80. 2012..In addition, the use of a TCD transplantation with BU-MEL-FLU as cytoreduction may decrease the toxicity of transplantation in heavily pretreated patients without an increase in relapse rate... - Factors associated with relapse and survival in Wilms tumor: a multivariate analysisJoshua N Honeyman
Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
J Pediatr Surg 47:1228-33. 2012..Lymph node metastasis and anaplasia predict relapse-free survival in Wilms tumor. We performed a multivariate analysis of our institutional database to identify factors independently associated with relapse-free and overall survival... - Eradication of cryptosporidium from a defunctionalized colon limb by refeeding stoma effluentEmma L Sidebotham
Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
J Pediatr Surg 45:E33-6. 2010..Refeeding of the ileostomy output into the colon effectively eradicated cryptosporidium from the colon and permitted closure of the ileostomy... - Reduced folate carrier and dihydrofolate reductase expression in acute lymphocytic leukemia may predict outcome: a Children's Cancer Group StudyAdam S Levy
Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA
J Pediatr Hematol Oncol 25:688-95. 2003..Additional studies are necessary to clarify the mechanism for the correlation of low DHFR expression with poor outcome... - Pythium insidiosum pleuropericarditis complicating pneumonia in a child with leukemiaJohn A Heath
Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, NY, 10021, USA
Clin Infect Dis 35:E60-4. 2002..After completing a 12-month course of intravenously administered liposomal amphotericin B (AmBisome; Fujisawa Healthcare) and itraconazole, the patient remained alive, in clinical remission, and symptom free... - Late cardiotoxicity after bolus versus infusion anthracycline therapy for childhood cancersMonesha Gupta
Department of Pediatrics, Division of Cardiology, Memorial Sloan Kettering Cancer Center, New York, New York, USA
Med Pediatr Oncol 40:343-7. 2003..To compare the long-term myocardial function of patients who had been treated with infusion anthracycline therapy (administered continuously over >24 hr, IG) versus bolus therapy (administered over <30 min, BG)... - A new multidrug reinduction protocol with topotecan, vinorelbine, thiotepa, dexamethasone, and gemcitabine for relapsed or refractory acute leukemiaE A Kolb
Department of Pediatrics at Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA
Leukemia 17:1967-72. 2003..Further studies are warranted to evaluate the role of the TVTG combination in the treatment of leukemia... - Diaziquone and 2,2'-anhydro-arabinosyl-5-fluorocytosine for the treatment of children with relapsed or refractory acute nonlymphoblastic leukemiaP A Meyers
Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York 10021
Cancer 64:2416-9. 1989..Although AZQ and AAFC are active in childhood ANLL with acceptable toxicity, the combination does not appear more active than AZQ used alone. Future studies should define the role of AZQ in combination with other agents... - Ten-year survival of children with acute lymphoblastic leukemia: a report from the Children's Oncology GroupMichael E Trigg
Jefferson Medical College, Thomas Jefferson University, USA
Leuk Lymphoma 49:1142-54. 2008..This is the largest series of children on concurrent studies who were observed more than 10 years... - Pediatric AML: past, present, and futureKenan Onel
Cancer Invest 20:1117. 2002 - Early postinduction intensification therapy improves survival for children and adolescents with high-risk acute lymphoblastic leukemia: a report from the Children's Oncology GroupNita L Seibel
Hematology Oncology, Children s National Medical Center and George Washington University School of Medicine and Public Health, 111 Michigan Avenue NW, Washington, DC 20010, USA
Blood 111:2548-55. 2008..Longer duration PII provided no benefit. Stronger intensity but not prolonged duration PII improved outcome for patients with higher-risk ALL. This study is registered at http://clinicaltrials.gov as NCT00002812... - Methotrexate leukoencephalopathy presenting as Klüver-Bucy syndrome and uncinate seizuresNuno Lobo Antunes
Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Pediatr Neurol 26:305-8. 2002..It may be prudent to verify normal cerebrospinal fluid dynamics before the administration of intraventricular methotrexate in children with a history of central nervous system leukemia...
Research Grants
- CHILDRENS CANCER GROUPPeter Steinherz; Fiscal Year: 2002..Members of the affiliate hospitals have been participating in CCG studies and have proven their ability to conduct the clinical studies and provide material for laboratory evaluation. ..