Research Topics
| C A SklarSummaryAffiliation: Memorial Sloan-Kettering Cancer Center Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Endocrine sequelae in survivors of childhood cancerSharon E Oberfield
College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Adolesc Med 13:161-9, viii. 2002..These abnormalities are most likely related directly to prior cancer treatment. This chapter focuses on a description of such disorders and offers suggestions for long-term endocrine management and follow-up evaluation...- Overview of the effects of cancer therapies: the nature, scale and breadth of the problemC A Sklar
Long Term Follow Up Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Acta Paediatr Suppl 88:1-4. 1999..Growth hormone deficiency, primary hypothyroidism and primary ovarian failure are the endocrine disorders observed most often... - Premature menopause in survivors of childhood cancer: a report from the childhood cancer survivor studyCharles A Sklar
Department of Pediatrics, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
J Natl Cancer Inst 98:890-6. 2006..However, published data pertaining to the risk and frequency of premature menopause are limited... - Growth hormone treatment: cancer riskCharles A Sklar
Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Horm Res 62:30-4. 2004..Overall, the clinical data are reassuring, but continued surveillance is mandatory... - Risk of disease recurrence and second neoplasms in survivors of childhood cancer treated with growth hormone: a report from the Childhood Cancer Survivor StudyCharles A Sklar
Department of Pediatrics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
J Clin Endocrinol Metab 87:3136-41. 2002..The increased number of SN, particularly in survivors of acute leukemia, is of concern, but the data need to be interpreted with caution given the small number of events... - Childhood brain tumorsCharles A Sklar
Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
J Pediatr Endocrinol Metab 15:669-73. 2002..Disease recurrence remains the single most common cause of late deaths (70%). Neurological, neurocognitive, and endocrine disturbances are the most prevalent disabilities observed among long-term survivors of pediatric brain tumors... - Endocrine complications of pediatric stem cell transplantationC Sklar
Department of Pediatrics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, NY, NY 10021, USA
Front Biosci 6:G17-22. 2001..Leydig cell function, however, is retained in most males treated with standard forms of cytoreduction. Many patients demonstrate reduced bone mineral density and are at risk of developing osteoporosis in the future... - Abnormalities of the thyroid in survivors of Hodgkin's disease: data from the Childhood Cancer Survivor StudyC Sklar
Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
J Clin Endocrinol Metab 85:3227-32. 2000.... - Changes in body mass index and prevalence of overweight in survivors of childhood acute lymphoblastic leukemia: role of cranial irradiationC A Sklar
Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York, USA
Med Pediatr Oncol 35:91-5. 2000..We evaluated changes in body mass index (BMI) in a cohort of ALL survivors, all of whom have been followed until completion of linear growth... - Disorders of glucose homeostasis in young adults treated with total body irradiation during childhood: a pilot studyW Chemaitilly
Department of Pediatric Endocrinology, New York Presbyterian Hospital Weill Cornell Medical College and Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Bone Marrow Transplant 44:339-43. 2009..Insulin resistance is frequently observed in adult survivors of HSCT treated with TBI in childhood. Underlying mechanisms may include radiation-induced growth hormone deficiency and changes in body composition... - Decreased adult height in survivors of childhood acute lymphoblastic leukemia: a report from the Childhood Cancer Survivor StudyEric J Chow
Department of Pediatrics, University of Washington, Seattle, Washington, USA
J Pediatr 150:370-5, 375.e1. 2007..To determine risk factors associated with reduced adult height in survivors of childhood acute lymphoblastic leukemia (ALL)... - Acute ovarian failure in the childhood cancer survivor studyWassim Chemaitilly
Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA
J Clin Endocrinol Metab 91:1723-8. 2006..These results will facilitate patient counseling and selection of candidates for newer fertility preservation techniques... - Long-term medical effects of childhood and adolescent rhabdomyosarcoma: a report from the childhood cancer survivor studyJudith A Punyko
Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota 55455, USA
Pediatr Blood Cancer 44:643-53. 2005..8, 1.9-7.5). CONCLUSIONS: Survivors are at risk for developing sequelae many years after their initial diagnosis and treatment. Continued medical surveillance is necessary to ensure the long-term health and well-being of RMS survivors... - Diabetes mellitus in long-term survivors of childhood cancer. Increased risk associated with radiation therapy: a report for the childhood cancer survivor studyLillian R Meacham
Department of Pediatrics, Emory University, Atlanta, Georgia, USA
Arch Intern Med 169:1381-8. 2009..Childhood cancer survivors are at increased risk of morbidity and mortality. To further characterize this risk, this study aimed to compare the prevalence of diabetes mellitus (DM) in childhood cancer survivors and their siblings... - Body mass index in long-term adult survivors of childhood cancer: a report of the Childhood Cancer Survivor StudyLillian R Meacham
Department of Pediatrics, Emory University, Atlanta, Georgia 30322, USA
Cancer 103:1730-9. 2005..The goals of the current study were to determine the distribution of body mass index (BMI) of survivors of common pediatric malignancies and to identify factors associated with abnormal BMI... - Chronic health conditions in adult survivors of childhood cancerKevin C Oeffinger
Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York 10021, USA
N Engl J Med 355:1572-82. 2006..Only a few small studies have assessed the long-term morbidity that follows the treatment of childhood cancer. We determined the incidence and severity of chronic health conditions in adult survivors... - Long-term outcomes of adult survivors of childhood cancerLeslie L Robison
Department of Pediatrics, University of Minnesota Medical School and Cancer Center, Minneapolis, USA
Cancer 104:2557-64. 2005..The ongoing evaluation of large and diverse cohorts of cancer survivors will aid in further identifying individuals who should be the target of innovative intervention strategies... - Endocrine and cardiovascular late effects among adult survivors of childhood brain tumors: Childhood Cancer Survivor StudyJames G Gurney
Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA
Cancer 97:663-73. 2003.... - Effects of therapy on dentofacial development in long-term survivors of head and neck rhabdomyosarcoma: the memorial sloan-kettering cancer center experienceCherry L Estilo
Dental Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
J Pediatr Hematol Oncol 25:215-22. 2003..To describe potential effects of multimodality therapy on dental and facial development in long-term survivors of head and neck rhabdomyosarcoma... - Final height in pediatric patients after hyperfractionated total body irradiation and stem cell transplantationW Chemaitilly
Department of Pediatrics, New York Presbyterian Hospital, Weill Cornell Medical College, New York, NY, USA
Bone Marrow Transplant 40:29-35. 2007..Final height after hyperfractionated TBI was similar to that reported after fractionated TBI... - Endocrine outcomes for children with embryonal brain tumors after risk-adapted craniospinal and conformal primary-site irradiation and high-dose chemotherapy with stem-cell rescue on the SJMB-96 trialStephen J Laughton
Division of Neuro Oncology, Department of Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
J Clin Oncol 26:1112-8. 2008.... - Factors that affect final height and change in height standard deviation scores in survivors of childhood cancer treated with growth hormone: a report from the childhood cancer survivor studyCarrie M Brownstein
Memorial Sloan-Kettering Cancer Center, Department of Pediatrics, 1275 York Avenue, New York, New York 10021, USA
J Clin Endocrinol Metab 89:4422-7. 2004.... - Growth hormone treatment and risk of second neoplasms in the childhood cancer survivorBerrin Ergun-Longmire
Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York, 10021, USA
J Clin Endocrinol Metab 91:3494-8. 2006..Continued surveillance is essential... - Longitudinal changes in obesity and body mass index among adult survivors of childhood acute lymphoblastic leukemia: a report from the Childhood Cancer Survivor StudyEdward G Garmey
Department of Pediatrics and Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
J Clin Oncol 26:4639-45. 2008..We examined the rate of increase in the body mass index (BMI; kg/m(2)) after final height attainment in survivors of acute lymphoblastic leukemia (ALL) and a noncancer comparison group... - Timing of menarche among survivors of childhood acute lymphoblastic leukemia: a report from the Childhood Cancer Survivor StudyEric J Chow
Department of Pediatrics, University of Washington, Seattle, Washington, USA
Pediatr Blood Cancer 50:854-8. 2008..The objective of this study was to determine risk factors associated with abnormal timing of menarche among survivors of childhood acute lymphoblastic leukemia (ALL)... - Ocular late effects in childhood and adolescent cancer survivors: a report from the childhood cancer survivor studyKimberly F Whelan
Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, USA
Pediatr Blood Cancer 54:103-9. 2010..Approximately 80% of children currently survive 5 years following diagnosis of their cancer. Studies based on limited data have implicated certain cancer therapies in the development of ocular sequelae in these survivors... - Growth hormone therapy in children after cranial/craniospinal radiation therapy: sexually dimorphic outcomesShulamit E Lerner
Division of Pediatric Endocrinology, Children's Hospital of New York-Presbyterian, New York, New York 10032, USA
J Clin Endocrinol Metab 89:6100-4. 2004..This sexually dichotomous response may be due in part to the greater percentage of spinal growth remaining for boys vs. girls throughout childhood... - Endocrine complications of hematopoietic stem cell transplantationWassim Chemaitilly
Department of Pediatrics, Schneider Children s Hospital, 269 01 76th Avenue, New Hyde Park, NY 11040, USA
Endocrinol Metab Clin North Am 36:983-98; ix. 2007..This article focuses on the late endocrine abnormalities that are most commonly observed following successful HSCT, with a special emphasis on pediatric HSCT recipients, for whom long-term follow-up data are increasingly available... - Endocrine complications in long-term survivors of childhood cancersWassim Chemaitilly
Division of Endocrinology, Department of Pediatrics, Children s Hospital of Pittsburgh of UPMC, One Children s Hospital Drive, 4401 Penn Avenue, Pittsburgh, Pennsylvania 15224, USA
Endocr Relat Cancer 17:R141-59. 2010.... - Final height and body mass index among adult survivors of childhood brain cancer: childhood cancer survivor studyJames G Gurney
Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota 55455, USA
J Clin Endocrinol Metab 88:4731-9. 2003..We did not find a corresponding elevated risk for obesity... - Hypothyroidism after 131I-monoclonal antibody treatment of neuroblastomaSonal Bhandari
Department of Pediatrics, New York Presbyterian Weill Cornell Medical College, New York, New York, USA
Pediatr Blood Cancer 55:76-80. 2010..To determine the prevalence of and risk factors for primary hypothyroidism following treatment with a radiolabeled monoclonal antibody ((131)I-3F8) in children with neuroblastoma... - Limitations on physical performance and daily activities among long-term survivors of childhood cancerKirsten K Ness
Division of Epidemiology and Clinical Research, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota 55455, USA
Ann Intern Med 143:639-47. 2005..Survivors of childhood cancer may experience important disease- and treatment-related late effects, including functional limitations... - Impact on survivors of retinoblastoma when informed of study results on risk of second cancersCharlene J Schulz
Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA
Med Pediatr Oncol 41:36-43. 2003..Additional studies are needed to identify individuals who experience greater levels of distress following feedback in an attempt to provide improved methods of feedback and support... - Genetic polymorphisms in the carbonyl reductase 3 gene CBR3 and the NAD(P)H:quinone oxidoreductase 1 gene NQO1 in patients who developed anthracycline-related congestive heart failure after childhood cancerJavier G Blanco
Department of Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, New York, USA
Cancer 112:2789-95. 2008.... - Risk of thyroid dysfunction and subsequent thyroid cancer among survivors of acute lymphoblastic leukemia: a report from the Childhood Cancer Survivor StudyEric J Chow
Department of Pediatrics, University of Washington, Seattle, Washington, USA
Pediatr Blood Cancer 53:432-7. 2009..To determine the risk of thyroid dysfunction and subsequent thyroid cancer among childhood acute lymphoblastic leukemia (ALL) survivors... - Genetic variation in the leptin receptor gene and obesity in survivors of childhood acute lymphoblastic leukemia: a report from the Childhood Cancer Survivor StudyJulie A Ross
Division of Pediatric Epidemiology and Clinical Research, Department of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA
J Clin Oncol 22:3558-62. 2004.... - Twenty years of follow-up among survivors of childhood and young adult acute myeloid leukemia: a report from the Childhood Cancer Survivor StudyDaniel A Mulrooney
Department of Pediatrics, University of Minnesota Medical School and Cancer Center, Minneapolis, MN 55455, USA
Cancer 112:2071-9. 2008..Limited data exist on the comprehensive assessment of late medical and social effects experienced by survivors of childhood and young adult acute myeloid leukemia (AML)... - Study design and cohort characteristics of the Childhood Cancer Survivor Study: a multi-institutional collaborative projectLeslie L Robison
Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota
Med Pediatr Oncol 38:229-39. 2002..It serves as a resource for addressing important issues such as risk of second malignancies, endocrine and reproductive outcome, cardiopulmonary complications, and psychosocial implications, among this unique and ever-growing population... - Osteonecrosis in adult survivors of childhood cancer: a report from the childhood cancer survivor studyNina S Kadan-Lottick
Section of Pediatric Hematology Oncology, Yale University School of Medicine, New Haven, CT 06520, USA
J Clin Oncol 26:3038-45. 2008..Osteonecrosis (ON) is a potentially serious complication of therapy in survivors of childhood cancer. Our goals were to describe the incidence of ON and identify patient and treatment characteristics associated with elevated risk... - Long-term health status among survivors of childhood cancer: does sex matter?Gregory T Armstrong
Department of Epidemiology and Cancer Control, St Jude Children s Research Hospital, Memphis, TN 38105, USA
J Clin Oncol 25:4477-89. 2007..With greater knowledge of sex-specific risks, the potential application of sex-specific therapy designed to avoid poor long-term adverse outcomes may become a viable strategy... - Development of risk-based guidelines for pediatric cancer survivors: the Children's Oncology Group Long-Term Follow-Up Guidelines from the Children's Oncology Group Late Effects Committee and Nursing DisciplineWendy Landier
Division of Pediatrics, City of Hope Comprehensive Cancer Center, Duarte, CA, USA
J Clin Oncol 22:4979-90. 2004..The Guidelines, and related Health Links, can be downloaded in their entirety at www.survivorshipguidelines.org... - Thyroid cancer in childhood cancer survivors: a detailed evaluation of radiation dose response and its modifiersCécile M Ronckers
Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland
Radiat Res 166:618-28. 2006..In summary, we applied models derived from radiobiology to describe the radiation dose-response curve for thyroid cancer in an epidemiological study and found convincing evidence for a downturn in risk at high doses... - Thyroid nodules and survivors of Hodgkin's diseaseKevin C Oeffinger
Am Fam Physician 68:1016, 1018-9; discussion 1019. 2003 - Long-term neurologic and neurosensory sequelae in adult survivors of a childhood brain tumor: childhood cancer survivor studyRoger J Packer
Department of Neurology, Center for Neuroscience and Behavioral Medicine, Children s National Medical Center, Washington, DC, USA
J Clin Oncol 21:3255-61. 2003..To describe the neurologic and neurosensory deficits in children with brain tumors (BTs), compare incidence of these deficits with that of a sibling control group, and evaluate the factors associated with the development of these deficits... - Obesity in adult survivors of childhood acute lymphoblastic leukemia: a report from the Childhood Cancer Survivor StudyKevin C Oeffinger
Department of Family Practice and Community Medicine, University of Texas Southwestern Medical Center at Dallas, 753900 9067, USA
J Clin Oncol 21:1359-65. 2003..To determine whether adult survivors (>or= 18 years of age) of childhood acute lymphoblastic leukemia (ALL) are at increased risk for obesity and to assess patient and treatment variables that influence risk... - Physical inactivity in adult survivors of childhood acute lymphoblastic leukemia: a report from the childhood cancer survivor studyTodd A Florin
The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
Cancer Epidemiol Biomarkers Prev 16:1356-63. 2007..To determine if adult survivors of childhood acute lymphoblastic leukemia (ALL) are less active (and more inactive) than the general population and to identify modifying factors... - Primary thyroid cancer after a first tumour in childhood (the Childhood Cancer Survivor Study): a nested case-control studyAlice J Sigurdson
Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7238, USA
Lancet 365:2014-23. 2005..We aimed to quantify the long-term risk of thyroid cancer after radiotherapy and chemotherapy...
Research Grants
- PREMATURE MENOPAUSE IN SURVIVORS OF CHILDHOOD CANCERCharles Sklar; Fiscal Year: 2002..The large size of the study population, the heterogeneity of diagnoses and exposures, combined with the extensive treatment data, will allow assessment of interaction between the major risk factors of interest. ..