C A Sklar

Summary

Affiliation: Memorial Sloan-Kettering Cancer Center
Country: USA

Publications

  1. ncbi request reprint Endocrine sequelae in survivors of childhood cancer
    Sharon E Oberfield
    College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Adolesc Med 13:161-9, viii. 2002
  2. ncbi request reprint Overview of the effects of cancer therapies: the nature, scale and breadth of the problem
    C A Sklar
    Long Term Follow Up Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Acta Paediatr Suppl 88:1-4. 1999
  3. ncbi request reprint Premature menopause in survivors of childhood cancer: a report from the childhood cancer survivor study
    Charles A Sklar
    Department of Pediatrics, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
    J Natl Cancer Inst 98:890-6. 2006
  4. ncbi request reprint Growth hormone treatment: cancer risk
    Charles A Sklar
    Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Horm Res 62:30-4. 2004
  5. ncbi request reprint Risk of disease recurrence and second neoplasms in survivors of childhood cancer treated with growth hormone: a report from the Childhood Cancer Survivor Study
    Charles A Sklar
    Department of Pediatrics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    J Clin Endocrinol Metab 87:3136-41. 2002
  6. ncbi request reprint Childhood brain tumors
    Charles A Sklar
    Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Pediatr Endocrinol Metab 15:669-73. 2002
  7. ncbi request reprint Endocrine complications of pediatric stem cell transplantation
    C Sklar
    Department of Pediatrics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, NY, NY 10021, USA
    Front Biosci 6:G17-22. 2001
  8. ncbi request reprint Abnormalities of the thyroid in survivors of Hodgkin's disease: data from the Childhood Cancer Survivor Study
    C Sklar
    Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Clin Endocrinol Metab 85:3227-32. 2000
  9. ncbi request reprint Changes in body mass index and prevalence of overweight in survivors of childhood acute lymphoblastic leukemia: role of cranial irradiation
    C A Sklar
    Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Med Pediatr Oncol 35:91-5. 2000
  10. doi request reprint Disorders of glucose homeostasis in young adults treated with total body irradiation during childhood: a pilot study
    W Chemaitilly
    Department of Pediatric Endocrinology, New York Presbyterian Hospital Weill Cornell Medical College and Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Bone Marrow Transplant 44:339-43. 2009

Research Grants

Detail Information

Publications48

  1. ncbi request reprint Endocrine sequelae in survivors of childhood cancer
    Sharon E Oberfield
    College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Adolesc Med 13:161-9, viii. 2002
    ..These abnormalities are most likely related directly to prior cancer treatment. This chapter focuses on a description of such disorders and offers suggestions for long-term endocrine management and follow-up evaluation...
  2. ncbi request reprint Overview of the effects of cancer therapies: the nature, scale and breadth of the problem
    C A Sklar
    Long Term Follow Up Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Acta Paediatr Suppl 88:1-4. 1999
    ..Growth hormone deficiency, primary hypothyroidism and primary ovarian failure are the endocrine disorders observed most often...
  3. ncbi request reprint Premature menopause in survivors of childhood cancer: a report from the childhood cancer survivor study
    Charles A Sklar
    Department of Pediatrics, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
    J Natl Cancer Inst 98:890-6. 2006
    ..However, published data pertaining to the risk and frequency of premature menopause are limited...
  4. ncbi request reprint Growth hormone treatment: cancer risk
    Charles A Sklar
    Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Horm Res 62:30-4. 2004
    ..Overall, the clinical data are reassuring, but continued surveillance is mandatory...
  5. ncbi request reprint Risk of disease recurrence and second neoplasms in survivors of childhood cancer treated with growth hormone: a report from the Childhood Cancer Survivor Study
    Charles A Sklar
    Department of Pediatrics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    J Clin Endocrinol Metab 87:3136-41. 2002
    ..The increased number of SN, particularly in survivors of acute leukemia, is of concern, but the data need to be interpreted with caution given the small number of events...
  6. ncbi request reprint Childhood brain tumors
    Charles A Sklar
    Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Pediatr Endocrinol Metab 15:669-73. 2002
    ..Disease recurrence remains the single most common cause of late deaths (70%). Neurological, neurocognitive, and endocrine disturbances are the most prevalent disabilities observed among long-term survivors of pediatric brain tumors...
  7. ncbi request reprint Endocrine complications of pediatric stem cell transplantation
    C Sklar
    Department of Pediatrics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, NY, NY 10021, USA
    Front Biosci 6:G17-22. 2001
    ..Leydig cell function, however, is retained in most males treated with standard forms of cytoreduction. Many patients demonstrate reduced bone mineral density and are at risk of developing osteoporosis in the future...
  8. ncbi request reprint Abnormalities of the thyroid in survivors of Hodgkin's disease: data from the Childhood Cancer Survivor Study
    C Sklar
    Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Clin Endocrinol Metab 85:3227-32. 2000
    ....
  9. ncbi request reprint Changes in body mass index and prevalence of overweight in survivors of childhood acute lymphoblastic leukemia: role of cranial irradiation
    C A Sklar
    Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Med Pediatr Oncol 35:91-5. 2000
    ..We evaluated changes in body mass index (BMI) in a cohort of ALL survivors, all of whom have been followed until completion of linear growth...
  10. doi request reprint Disorders of glucose homeostasis in young adults treated with total body irradiation during childhood: a pilot study
    W Chemaitilly
    Department of Pediatric Endocrinology, New York Presbyterian Hospital Weill Cornell Medical College and Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Bone Marrow Transplant 44:339-43. 2009
    ..Insulin resistance is frequently observed in adult survivors of HSCT treated with TBI in childhood. Underlying mechanisms may include radiation-induced growth hormone deficiency and changes in body composition...
  11. pmc Decreased adult height in survivors of childhood acute lymphoblastic leukemia: a report from the Childhood Cancer Survivor Study
    Eric J Chow
    Department of Pediatrics, University of Washington, Seattle, Washington, USA
    J Pediatr 150:370-5, 375.e1. 2007
    ..To determine risk factors associated with reduced adult height in survivors of childhood acute lymphoblastic leukemia (ALL)...
  12. ncbi request reprint Acute ovarian failure in the childhood cancer survivor study
    Wassim Chemaitilly
    Department of Pediatrics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA
    J Clin Endocrinol Metab 91:1723-8. 2006
    ..Its precise incidence is unknown, and data concerning its risk factors are limited...
  13. ncbi request reprint Long-term medical effects of childhood and adolescent rhabdomyosarcoma: a report from the childhood cancer survivor study
    Judith A Punyko
    Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Pediatr Blood Cancer 44:643-53. 2005
    ..This study was conducted to evaluate the incidence of adverse medical conditions and to assess the risk of developing these conditions in a cohort of long-term survivors of rhabdomyosarcoma (RMS) diagnosed before age 21...
  14. pmc Diabetes mellitus in long-term survivors of childhood cancer. Increased risk associated with radiation therapy: a report for the childhood cancer survivor study
    Lillian R Meacham
    Department of Pediatrics, Emory University, Atlanta, Georgia, USA
    Arch Intern Med 169:1381-8. 2009
    ..Childhood cancer survivors are at increased risk of morbidity and mortality. To further characterize this risk, this study aimed to compare the prevalence of diabetes mellitus (DM) in childhood cancer survivors and their siblings...
  15. ncbi request reprint Body mass index in long-term adult survivors of childhood cancer: a report of the Childhood Cancer Survivor Study
    Lillian R Meacham
    Department of Pediatrics, Emory University, Atlanta, Georgia 30322, USA
    Cancer 103:1730-9. 2005
    ..The goals of the current study were to determine the distribution of body mass index (BMI) of survivors of common pediatric malignancies and to identify factors associated with abnormal BMI...
  16. ncbi request reprint Long-term complications in survivors of advanced stage neuroblastoma
    Caroline Laverdiere
    Department of Pediatrics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Pediatr Blood Cancer 45:324-32. 2005
    ..Few studies have assessed late effects in neuroblastoma (NB) survivors, particularly those with advanced stage disease...
  17. ncbi request reprint Chronic health conditions in adult survivors of childhood cancer
    Kevin C Oeffinger
    Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York 10021, USA
    N Engl J Med 355:1572-82. 2006
    ..Only a few small studies have assessed the long-term morbidity that follows the treatment of childhood cancer. We determined the incidence and severity of chronic health conditions in adult survivors...
  18. ncbi request reprint Long-term outcomes of adult survivors of childhood cancer
    Leslie L Robison
    Department of Pediatrics, University of Minnesota Medical School and Cancer Center, Minneapolis, USA
    Cancer 104:2557-64. 2005
    ..The ongoing evaluation of large and diverse cohorts of cancer survivors will aid in further identifying individuals who should be the target of innovative intervention strategies...
  19. ncbi request reprint Endocrine and cardiovascular late effects among adult survivors of childhood brain tumors: Childhood Cancer Survivor Study
    James G Gurney
    Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA
    Cancer 97:663-73. 2003
    ....
  20. ncbi request reprint Effects of therapy on dentofacial development in long-term survivors of head and neck rhabdomyosarcoma: the memorial sloan-kettering cancer center experience
    Cherry L Estilo
    Dental Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Pediatr Hematol Oncol 25:215-22. 2003
    ..To describe potential effects of multimodality therapy on dental and facial development in long-term survivors of head and neck rhabdomyosarcoma...
  21. ncbi request reprint Final height in pediatric patients after hyperfractionated total body irradiation and stem cell transplantation
    W Chemaitilly
    Department of Pediatrics, New York Presbyterian Hospital, Weill Cornell Medical College, New York, NY, USA
    Bone Marrow Transplant 40:29-35. 2007
    ..Final height after hyperfractionated TBI was similar to that reported after fractionated TBI...
  22. doi request reprint Endocrine outcomes for children with embryonal brain tumors after risk-adapted craniospinal and conformal primary-site irradiation and high-dose chemotherapy with stem-cell rescue on the SJMB-96 trial
    Stephen J Laughton
    Division of Neuro Oncology, Department of Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    J Clin Oncol 26:1112-8. 2008
    ....
  23. ncbi request reprint Factors that affect final height and change in height standard deviation scores in survivors of childhood cancer treated with growth hormone: a report from the childhood cancer survivor study
    Carrie M Brownstein
    Memorial Sloan Kettering Cancer Center, Department of Pediatrics, 1275 York Avenue, New York, New York 10021, USA
    J Clin Endocrinol Metab 89:4422-7. 2004
    ....
  24. ncbi request reprint Growth hormone treatment and risk of second neoplasms in the childhood cancer survivor
    Berrin Ergun-Longmire
    Department of Pediatrics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York, 10021, USA
    J Clin Endocrinol Metab 91:3494-8. 2006
    ..In a previous report, although we did not find an increase in the risk of disease recurrence in survivors treated with GH, GH-treated survivors did have an increased risk of developing a second neoplasm (SN) (rate ratio, 3.21)...
  25. pmc Longitudinal changes in obesity and body mass index among adult survivors of childhood acute lymphoblastic leukemia: a report from the Childhood Cancer Survivor Study
    Edward G Garmey
    Department of Pediatrics and Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
    J Clin Oncol 26:4639-45. 2008
    ..We examined the rate of increase in the body mass index (BMI; kg/m(2)) after final height attainment in survivors of acute lymphoblastic leukemia (ALL) and a noncancer comparison group...
  26. ncbi request reprint Timing of menarche among survivors of childhood acute lymphoblastic leukemia: a report from the Childhood Cancer Survivor Study
    Eric J Chow
    Department of Pediatrics, University of Washington, Seattle, Washington, USA
    Pediatr Blood Cancer 50:854-8. 2008
    ..The objective of this study was to determine risk factors associated with abnormal timing of menarche among survivors of childhood acute lymphoblastic leukemia (ALL)...
  27. pmc Ocular late effects in childhood and adolescent cancer survivors: a report from the childhood cancer survivor study
    Kimberly F Whelan
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Pediatr Blood Cancer 54:103-9. 2010
    ..Approximately 80% of children currently survive 5 years following diagnosis of their cancer. Studies based on limited data have implicated certain cancer therapies in the development of ocular sequelae in these survivors...
  28. ncbi request reprint Growth hormone therapy in children after cranial/craniospinal radiation therapy: sexually dimorphic outcomes
    Shulamit E Lerner
    Division of Pediatric Endocrinology, Children s Hospital of New York Presbyterian, New York, New York 10032, USA
    J Clin Endocrinol Metab 89:6100-4. 2004
    ..This sexually dichotomous response may be due in part to the greater percentage of spinal growth remaining for boys vs. girls throughout childhood...
  29. ncbi request reprint Endocrine complications of hematopoietic stem cell transplantation
    Wassim Chemaitilly
    Department of Pediatrics, Schneider Children s Hospital, 269 01 76th Avenue, New Hyde Park, NY 11040, USA
    Endocrinol Metab Clin North Am 36:983-98; ix. 2007
    ..This article focuses on the late endocrine abnormalities that are most commonly observed following successful HSCT, with a special emphasis on pediatric HSCT recipients, for whom long-term follow-up data are increasingly available...
  30. doi request reprint Endocrine complications in long-term survivors of childhood cancers
    Wassim Chemaitilly
    Division of Endocrinology, Department of Pediatrics, Children s Hospital of Pittsburgh of UPMC, One Children s Hospital Drive, 4401 Penn Avenue, Pittsburgh, Pennsylvania 15224, USA
    Endocr Relat Cancer 17:R141-59. 2010
    ....
  31. ncbi request reprint Final height and body mass index among adult survivors of childhood brain cancer: childhood cancer survivor study
    James G Gurney
    Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Clin Endocrinol Metab 88:4731-9. 2003
    ..We did not find a corresponding elevated risk for obesity...
  32. doi request reprint Hypothyroidism after 131I-monoclonal antibody treatment of neuroblastoma
    Sonal Bhandari
    Department of Pediatrics, New York Presbyterian Weill Cornell Medical College, New York, New York, USA
    Pediatr Blood Cancer 55:76-80. 2010
    ..To determine the prevalence of and risk factors for primary hypothyroidism following treatment with a radiolabeled monoclonal antibody ((131)I-3F8) in children with neuroblastoma...
  33. ncbi request reprint Limitations on physical performance and daily activities among long-term survivors of childhood cancer
    Kirsten K Ness
    Division of Epidemiology and Clinical Research, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Ann Intern Med 143:639-47. 2005
    ..Survivors of childhood cancer may experience important disease- and treatment-related late effects, including functional limitations...
  34. ncbi request reprint Impact on survivors of retinoblastoma when informed of study results on risk of second cancers
    Charlene J Schulz
    Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Med Pediatr Oncol 41:36-43. 2003
    ..To assess the impact of providing research feedback to retinoblastoma survivors or their parents regarding the risk of second cancers...
  35. doi request reprint Genetic polymorphisms in the carbonyl reductase 3 gene CBR3 and the NAD(P)H:quinone oxidoreductase 1 gene NQO1 in patients who developed anthracycline-related congestive heart failure after childhood cancer
    Javier G Blanco
    Department of Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, New York, USA
    Cancer 112:2789-95. 2008
    ....
  36. pmc Risk of thyroid dysfunction and subsequent thyroid cancer among survivors of acute lymphoblastic leukemia: a report from the Childhood Cancer Survivor Study
    Eric J Chow
    Department of Pediatrics, University of Washington, Seattle, Washington, USA
    Pediatr Blood Cancer 53:432-7. 2009
    ..To determine the risk of thyroid dysfunction and subsequent thyroid cancer among childhood acute lymphoblastic leukemia (ALL) survivors...
  37. ncbi request reprint Genetic variation in the leptin receptor gene and obesity in survivors of childhood acute lymphoblastic leukemia: a report from the Childhood Cancer Survivor Study
    Julie A Ross
    Division of Pediatric Epidemiology and Clinical Research, Department of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA
    J Clin Oncol 22:3558-62. 2004
    ....
  38. doi request reprint Twenty years of follow-up among survivors of childhood and young adult acute myeloid leukemia: a report from the Childhood Cancer Survivor Study
    Daniel A Mulrooney
    Department of Pediatrics, University of Minnesota Medical School and Cancer Center, Minneapolis, MN 55455, USA
    Cancer 112:2071-9. 2008
    ..Limited data exist on the comprehensive assessment of late medical and social effects experienced by survivors of childhood and young adult acute myeloid leukemia (AML)...
  39. ncbi request reprint Study design and cohort characteristics of the Childhood Cancer Survivor Study: a multi-institutional collaborative project
    Leslie L Robison
    Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota
    Med Pediatr Oncol 38:229-39. 2002
    ..To facilitate such research, a multi-institutional consortium established the Childhood Cancer Survivor Study (CCSS), a large, diverse, and well-characterized cohort of 5-year survivors of childhood and adolescent cancer...
  40. doi request reprint Osteonecrosis in adult survivors of childhood cancer: a report from the childhood cancer survivor study
    Nina S Kadan-Lottick
    Section of Pediatric Hematology Oncology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Clin Oncol 26:3038-45. 2008
    ..Osteonecrosis (ON) is a potentially serious complication of therapy in survivors of childhood cancer. Our goals were to describe the incidence of ON and identify patient and treatment characteristics associated with elevated risk...
  41. ncbi request reprint Long-term health status among survivors of childhood cancer: does sex matter?
    Gregory T Armstrong
    Department of Epidemiology and Cancer Control, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Clin Oncol 25:4477-89. 2007
    ..With greater knowledge of sex-specific risks, the potential application of sex-specific therapy designed to avoid poor long-term adverse outcomes may become a viable strategy...
  42. ncbi request reprint Development of risk-based guidelines for pediatric cancer survivors: the Children's Oncology Group Long-Term Follow-Up Guidelines from the Children's Oncology Group Late Effects Committee and Nursing Discipline
    Wendy Landier
    Division of Pediatrics, City of Hope Comprehensive Cancer Center, Duarte, CA, USA
    J Clin Oncol 22:4979-90. 2004
    ..The Guidelines, and related Health Links, can be downloaded in their entirety at www.survivorshipguidelines.org...
  43. ncbi request reprint Thyroid cancer in childhood cancer survivors: a detailed evaluation of radiation dose response and its modifiers
    Cécile M Ronckers
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland
    Radiat Res 166:618-28. 2006
    ..In summary, we applied models derived from radiobiology to describe the radiation dose-response curve for thyroid cancer in an epidemiological study and found convincing evidence for a downturn in risk at high doses...
  44. ncbi request reprint Thyroid nodules and survivors of Hodgkin's disease
    Kevin C Oeffinger
    Am Fam Physician 68:1016, 1018-9; discussion 1019. 2003
  45. ncbi request reprint Long-term neurologic and neurosensory sequelae in adult survivors of a childhood brain tumor: childhood cancer survivor study
    Roger J Packer
    Department of Neurology, Center for Neuroscience and Behavioral Medicine, Children s National Medical Center, Washington, DC, USA
    J Clin Oncol 21:3255-61. 2003
    ..To describe the neurologic and neurosensory deficits in children with brain tumors (BTs), compare incidence of these deficits with that of a sibling control group, and evaluate the factors associated with the development of these deficits...
  46. ncbi request reprint Obesity in adult survivors of childhood acute lymphoblastic leukemia: a report from the Childhood Cancer Survivor Study
    Kevin C Oeffinger
    Department of Family Practice and Community Medicine, University of Texas Southwestern Medical Center at Dallas, 753900 9067, USA
    J Clin Oncol 21:1359-65. 2003
    ..To determine whether adult survivors (>or= 18 years of age) of childhood acute lymphoblastic leukemia (ALL) are at increased risk for obesity and to assess patient and treatment variables that influence risk...
  47. ncbi request reprint Physical inactivity in adult survivors of childhood acute lymphoblastic leukemia: a report from the childhood cancer survivor study
    Todd A Florin
    The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Cancer Epidemiol Biomarkers Prev 16:1356-63. 2007
    ..To determine if adult survivors of childhood acute lymphoblastic leukemia (ALL) are less active (and more inactive) than the general population and to identify modifying factors...
  48. ncbi request reprint Primary thyroid cancer after a first tumour in childhood (the Childhood Cancer Survivor Study): a nested case-control study
    Alice J Sigurdson
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7238, USA
    Lancet 365:2014-23. 2005
    ..We aimed to quantify the long-term risk of thyroid cancer after radiotherapy and chemotherapy...

Research Grants1

  1. PREMATURE MENOPAUSE IN SURVIVORS OF CHILDHOOD CANCER
    Charles Sklar; Fiscal Year: 2002
    ..The large size of the study population, the heterogeneity of diagnoses and exposures, combined with the extensive treatment data, will allow assessment of interaction between the major risk factors of interest. ..