Jinru Shia


Affiliation: Memorial Sloan-Kettering Cancer Center
Country: USA


  1. Shia J. Immunohistochemistry versus microsatellite instability testing for screening colorectal cancer patients at risk for hereditary nonpolyposis colorectal cancer syndrome. Part I. The utility of immunohistochemistry. J Mol Diagn. 2008;10:293-300 pubmed publisher
  2. Liu S, Gӧnen M, Stadler Z, Weiser M, Hechtman J, Vakiani E, et al. Cellular localization of PD-L1 expression in mismatch-repair-deficient and proficient colorectal carcinomas. Mod Pathol. 2018;: pubmed publisher
    ..These findings may serve to inform further efforts aiming to evaluate PD-L1 immunohistochemistry vis-à-vis molecular sub-classification as predictive biomarkers in the treatment of colorectal carcinoma. ..
  3. Hechtman J, Abou Alfa G, Stadler Z, Mandelker D, Roehrl M, Zehir A, et al. Somatic HNF1A mutations in the malignant transformation of hepatocellular adenomas: a retrospective analysis of data from MSK-IMPACT and TCGA. Hum Pathol. 2018;: pubmed publisher
    ..Hepatocellular adenomas with Hepatocyte-Nuclear-Factor-1-Homeobox-A mutation or adenomatosis with loss of Liver-Fatty-Acid-Binding-Protein warrant thorough sampling and examination. ..
  4. Ye J, Zhou Y, Weiser M, Gönen M, Zhang L, Samdani T, et al. Immunohistochemical detection of ARID1A in colorectal carcinoma: loss of staining is associated with sporadic microsatellite unstable tumors with medullary histology and high TNM stage. Hum Pathol. 2014;45:2430-6 pubmed publisher
  5. Shia J. An update on tumors of the anal canal. Arch Pathol Lab Med. 2010;134:1601-11 pubmed publisher
    ..Although most anal canal tumors are of squamous lineage, a complex variety of other tumors also occurs. Recognition of such diverse tumor entities will allow accurate pathologic diagnosis and most optimal clinical management. ..
  6. Shia J, Stadler Z, Weiser M, Vakiani E, Mendelsohn R, Markowitz A, et al. Mismatch repair deficient-crypts in non-neoplastic colonic mucosa in Lynch syndrome: insights from an illustrative case. Fam Cancer. 2015;14:61-8 pubmed publisher
  7. Shia J. Evolving approach and clinical significance of detecting DNA mismatch repair deficiency in colorectal carcinoma. Semin Diagn Pathol. 2015;32:352-61 pubmed publisher
    ..Special emphasis will be placed on the evolving nature and the clinical importance of the disease definitions and the detection strategies. ..
  8. Le Rolle A, Chiu T, Fara M, Shia J, Zeng Z, Weiser M, et al. The prognostic significance of CXCL1 hypersecretion by human colorectal cancer epithelia and myofibroblasts. J Transl Med. 2015;13:199 pubmed publisher
    ..28; 95% CI 0.11-0.72). High CXCL1 expression is a poor prognostic biomarker in metastatic CRC. CXCL1 inhibition suppressed tumorigenic growth of KRAS mutant CRC cells. ..
  9. Shia J, Wang H, Nash G, Klimstra D. Lymph node staging in colorectal cancer: revisiting the benchmark of at least 12 lymph nodes in R0 resection. J Am Coll Surg. 2012;214:348-55 pubmed publisher

More Information


  1. Silva V, Askan G, Daniel T, Lowery M, Klimstra D, Abou Alfa G, et al. Biliary carcinomas: pathology and the role of DNA mismatch repair deficiency. Chin Clin Oncol. 2016;5:62 pubmed publisher
  2. Lee L, Yantiss R, Sadot E, Ren B, Calvacanti M, Hechtman J, et al. Diagnosing colorectal medullary carcinoma: interobserver variability and clinicopathological implications. Hum Pathol. 2017;62:74-82 pubmed publisher
    ..Until such evidence becomes available, caution should be exercised when making this diagnosis, as well as when comparing results across different studies. ..
  3. Wang T, Stadler Z, Zhang L, Weiser M, Basturk O, Hechtman J, et al. Immunohistochemical null-phenotype for mismatch repair proteins in colonic carcinoma associated with concurrent MLH1 hypermethylation and MSH2 somatic mutations. Fam Cancer. 2018;17:225-228 pubmed publisher
  4. Lee L, Sadot E, Ivelja S, Vakiani E, Hechtman J, Sevinsky C, et al. ARID1A expression in early stage colorectal adenocarcinoma: an exploration of its prognostic significance. Hum Pathol. 2016;53:97-104 pubmed publisher
    ..Such data are clinically relevant, as efforts are ongoing in identifying markers that can detect the small but significant subset of early stage CRCs that will have a poor outcome. ..