Affiliation: Memorial Sloan-Kettering Cancer Center
Shia J. Immunohistochemistry versus microsatellite instability testing for screening colorectal cancer patients at risk for hereditary nonpolyposis colorectal cancer syndrome. Part I. The utility of immunohistochemistry. J Mol Diagn. 2008;10:293-300 pubmed publisher
Liu S, Gӧnen M, Stadler Z, Weiser M, Hechtman J, Vakiani E, et al
. Cellular localization of PD-L1 expression in mismatch-repair-deficient and proficient colorectal carcinomas. Mod Pathol. 2018;: pubmed publisher
..These findings may serve to inform further efforts aiming to evaluate PD-L1 immunohistochemistry vis-à-vis molecular sub-classification as predictive biomarkers in the treatment of colorectal carcinoma. ..
Hechtman J, Abou Alfa G, Stadler Z, Mandelker D, Roehrl M, Zehir A, et al
. Somatic HNF1A mutations in the malignant transformation of hepatocellular adenomas: a retrospective analysis of data from MSK-IMPACT and TCGA. Hum Pathol. 2018;: pubmed publisher
..Hepatocellular adenomas with Hepatocyte-Nuclear-Factor-1-Homeobox-A mutation or adenomatosis with loss of Liver-Fatty-Acid-Binding-Protein warrant thorough sampling and examination. ..
Ye J, Zhou Y, Weiser M, GÃ¶nen M, Zhang L, Samdani T, et al
. Immunohistochemical detection of ARID1A in colorectal carcinoma: loss of staining is associated with sporadic microsatellite unstable tumors with medullary histology and high TNM stage. Hum Pathol. 2014;45:2430-6 pubmed publisher
Shia J. An update on tumors of the anal canal. Arch Pathol Lab Med. 2010;134:1601-11 pubmed publisher
..Although most anal canal tumors are of squamous lineage, a complex variety of other tumors also occurs. Recognition of such diverse tumor entities will allow accurate pathologic diagnosis and most optimal clinical management. ..
Shia J, Stadler Z, Weiser M, Vakiani E, Mendelsohn R, Markowitz A, et al
. Mismatch repair deficient-crypts in non-neoplastic colonic mucosa in Lynch syndrome: insights from an illustrative case. Fam Cancer. 2015;14:61-8 pubmed publisher
Shia J. Evolving approach and clinical significance of detecting DNA mismatch repair deficiency in colorectal carcinoma. Semin Diagn Pathol. 2015;32:352-61 pubmed publisher
..Special emphasis will be placed on the evolving nature and the clinical importance of the disease definitions and the detection strategies. ..
Le Rolle A, Chiu T, Fara M, Shia J, Zeng Z, Weiser M, et al
. The prognostic significance of CXCL1 hypersecretion by human colorectal cancer epithelia and myofibroblasts. J Transl Med. 2015;13:199 pubmed publisher
..28; 95% CI 0.11-0.72). High CXCL1 expression is a poor prognostic biomarker in metastatic CRC. CXCL1 inhibition suppressed tumorigenic growth of KRAS mutant CRC cells. ..
Shia J, Wang H, Nash G, Klimstra D. Lymph node staging in colorectal cancer: revisiting the benchmark of at least 12 lymph nodes in R0 resection. J Am Coll Surg. 2012;214:348-55 pubmed publisher