Katharina Schlacher

Summary

Affiliation: Memorial Sloan-Kettering Cancer Center
Country: USA

Publications

  1. doi request reprint A distinct replication fork protection pathway connects Fanconi anemia tumor suppressors to RAD51-BRCA1/2
    Katharina Schlacher
    Developmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Cancer Cell 22:106-16. 2012
  2. pmc Double-strand break repair-independent role for BRCA2 in blocking stalled replication fork degradation by MRE11
    Katharina Schlacher
    Developmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Cell 145:529-42. 2011
  3. pmc Plasticity of BRCA2 function in homologous recombination: genetic interactions of the PALB2 and DNA binding domains
    Nicolas Siaud
    Developmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America
    PLoS Genet 7:e1002409. 2011

Collaborators

  • Bing Xia
  • Nicolas Siaud
  • Akinori Egashira
  • Isabel Lam
  • Maria Jasin
  • Maria A Barbera
  • Nicole Christ

Detail Information

Publications3

  1. doi request reprint A distinct replication fork protection pathway connects Fanconi anemia tumor suppressors to RAD51-BRCA1/2
    Katharina Schlacher
    Developmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Cancer Cell 22:106-16. 2012
    ..Collective results imply a unified molecular mechanism for repair-independent functions of FA, RAD51, and BRCA1/2 proteins in preventing genomic instability and suppressing tumorigenesis...
  2. pmc Double-strand break repair-independent role for BRCA2 in blocking stalled replication fork degradation by MRE11
    Katharina Schlacher
    Developmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Cell 145:529-42. 2011
    ..Thus, BRCA2 prevents rather than repairs nucleolytic lesions at stalled replication forks to maintain genomic integrity and hence likely suppresses tumorigenesis through this replication-specific function...
  3. pmc Plasticity of BRCA2 function in homologous recombination: genetic interactions of the PALB2 and DNA binding domains
    Nicolas Siaud
    Developmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America
    PLoS Genet 7:e1002409. 2011
    ..The occurrence of disease-causing mutations throughout BRCA2 suggests sub-optimal HR from a variety of domain modulations...