Research Topics
Genomes and Genes
Species | M J ScanlanSummaryAffiliation: Memorial Sloan-Kettering Cancer Center Country: USA Publications
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Detail Information
Publications
Serological identification of embryonic neural proteins as highly immunogenic tumor antigens in small cell lung cancerA O Gure
Ludwig Institute for Cancer Research, New York Branch at Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Proc Natl Acad Sci U S A 97:4198-203. 2000..Although paraneoplastic neurological syndromes have been associated with several SCLC antigens, neurological symptoms have not been observed in patients with anti-SOX or anti-ZIC2 antibodies...
Antigens recognized by autologous antibody in patients with renal-cell carcinomaM J Scanlan
Ludwig Institute for Cancer Research, New York Branch at Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Int J Cancer 83:456-64. 1999..Our results demonstrate the potential of the SEREX approach for the analysis of the humoral immune response against human cancer...- The cancer/testis genes: review, standardization, and commentaryMatthew J Scanlan
Ludwig Institute for Cancer Research, New York Branch of Human Cancer Immunology at Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
Cancer Immun 4:1. 2004.... - Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expressionM J Scanlan
Ludwig Institute for Cancer Research, New York Branch of Human Cancer Immunology at Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
Cancer Immun 1:4. 2001..This study adds to the growing list of breast cancer antigens defined by SEREX and to the ultimate objective of identifying the complete repertoire of immunogenic gene products in human cancer (the cancer immunome)... - Cancer/testis antigens: an expanding family of targets for cancer immunotherapyMatthew J Scanlan
Ludwig Institute for Cancer Research, New York Branch at Memorial Sloan Kettering Cancer Center, Weill Medical College of Cornell University, Department of Pathology, New York, NY 10021, USA
Immunol Rev 188:22-32. 2002..Since CT antigens are immunogenic and highly restricted to tumors, their discovery has led directly to the development of antigen-specific cancer vaccines, and clinical trials with MAGE-A and NY-ESO-1 are in progress... - Cancer-related serological recognition of human colon cancer: identification of potential diagnostic and immunotherapeutic targetsMatthew J Scanlan
Ludwig Institute for Cancer Research, New York Branch at Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Cancer Res 62:4041-7. 2002..In contrast, 9 of 9 colon cancer specimens showed overexpression of KNSL6 mRNA, ranging from 5 to 44 times the level detected in normal colon tissue, indicating that this antigen could also be a valuable therapeutic target... - Identification of cancer/testis genes by database mining and mRNA expression analysisMatthew J Scanlan
Ludwig Institute for Cancer Research, New York Branch at Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Int J Cancer 98:485-92. 2002..This study demonstrates the merits of database mining with respect to the identification of tissue-restricted gene products expressed in cancer... - Challenges to the development of antigen-specific breast cancer vaccinesM J Scanlan
Ludwig Institute for Cancer Research, Memorial Sloan0Kettering Cancer Center, New York 10021, USA
Breast Cancer Res 3:95-8. 2001..The development of a polyvalent breast cancer vaccine, directed against a panel of tumor-associated antigens, may counteract this form of immune escape... - Expression of cancer-testis antigens in lung cancer: definition of bromodomain testis-specific gene (BRDT) as a new CT gene, CT9M J Scanlan
Ludwig Institute for Cancer Research, New York Branch at Memorial Sloan Kettering Cancer Center, New York 10021, USA
Cancer Lett 150:155-64. 2000..The coexpression pattern of these antigens provides a foundation for developing a polyvalent lung cancer vaccine... - Isoforms of the human PDZ-73 protein exhibit differential tissue expressionM J Scanlan
Ludwig Institute for Cancer Research, New York Branch at Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
Biochim Biophys Acta 1445:39-52. 1999..The existence of multiple PDZ-73 isoforms with variations in tissue distribution, PDZ domains, protein degradation sequences and carboxyl terminal structure indicate that these isoforms have distinct tissue-specific functions... - Characterization of human colon cancer antigens recognized by autologous antibodiesM J Scanlan
Ludwig Institute for Cancer Research, New York Branch at Memorial Sloan Kettering Cancer Center, NY 10021, USA
Int J Cancer 76:652-8. 1998..Our results on colon cancer illustrate both the complexity and the potential of the SEREX approach for analysis of the humoral immune response against human cancer... - A testicular antigen aberrantly expressed in human cancers detected by autologous antibody screeningY T Chen
Cornell University Medical College, New York, NY 10021, USA
Proc Natl Acad Sci U S A 94:1914-8. 1997..These antigens, initially detected by either cytotoxic T cells (MAGE, BAGE, GAGE-1) or antibodies [HOM-MEL-40(SSX2), NY-ESO-1], represent a pool of antigenic targets for cancer vaccination... - Cancer-testis antigens and ING1 tumor suppressor gene product are breast cancer antigens: characterization of tissue-specific ING1 transcripts and a homologue geneD Jager
Department of Pathology, Cornell University Medical College, New York, New York 10021, USA
Cancer Res 59:6197-204. 1999..The basis of the immunogenicity of ING1 and the biological role of ING1 and ING2 need further exploration... - CT10: a new cancer-testis (CT) antigen homologous to CT7 and the MAGE family, identified by representational-difference analysisA O Gure
Ludwig Institute for Cancer Research, New York Branch at Memorial Sloan Kettering Cancer Center, New York, NY, USA
Int J Cancer 85:726-32. 2000..CT10 mRNA is expressed in testis and in 20 to 30% of various human cancers. A serological survey identified 2 melanoma patients with anti-CT10 antibody, demonstrating the immunogenicity of CT10 in humans... - A survey of the humoral immune response of cancer patients to a panel of human tumor antigensE Stockert
Ludwig Institute for Cancer Research, New York Branch at Memorial Sloan Kettering Cancer Center, New York 10021, USA
J Exp Med 187:1349-54. 1998..As the proportion of melanomas expressing NY-ESO-1 is 20-40% and only patients with NY-ESO-1(+) tumors have antibody, this would suggest that a high percentage of patients with NY-ESO-1(+) tumors develop an antibody response to NY-ESO-1... - Identification of a tissue-specific putative transcription factor in breast tissue by serological screening of a breast cancer libraryD Jager
Weill Medical College of Cornell University, New York, New York 10021, USA
Cancer Res 61:2055-61. 2001..The exon structure of NY-BR-1.1 remains to be defined. Using human genome database, NY-BR-1 was localized to chromosome 10p11-p12, and NY-BR-1.1 was tentatively localized to chromosome 9... - SSX: a multigene family with several members transcribed in normal testis and human cancerA O Gure
Ludwig Institute for Cancer Research, New York Branch, Memorial Sloan Kettering Cancer Center, New York, USA
Int J Cancer 72:965-71. 1997..In addition, analysis of a panel of 12 melanoma cell lines showed strong mRNA expression of either SSX1 (3/12), SSX2 (3/12), SSX4 (1/12), or SSX5 (1/12), indicating variable activation of the genes in malignant cells... - Serological cloning of a melanocyte rab guanosine 5'-triphosphate-binding protein and a chromosome condensation protein from a melanoma complementary DNA libraryD Jager
Department of Pathology, Weill Medical College of Cornell University, New York, New York 10021, USA
Cancer Res 60:3584-91. 2000..This mitosis-related expression suggests hCAP-G as a possible proliferation marker and a potential prognostic indicator in cancer. These findings provide further support that SEREX can define biologically significant molecules in cancer... - Molecular cloning of fibroblast activation protein alpha, a member of the serine protease family selectively expressed in stromal fibroblasts of epithelial cancersM J Scanlan
Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021
Proc Natl Acad Sci U S A 91:5657-61. 1994.... - The gene for fibroblast activation protein alpha (FAP), a putative cell surface-bound serine protease expressed in cancer stroma and wound healing, maps to chromosome band 2q23S Mathew
Department of Human Genetics and Cell Biology, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA
Genomics 25:335-7. 1995 - Human lung cancer antigens recognized by autologous antibodies: definition of a novel cDNA derived from the tumor suppressor gene locus on chromosome 3p21.3A O Gure
Ludwig Institute for Cancer Research, Memorial Sloan Kettering Cancer Center, New York, New York, USA
Cancer Res 58:1034-41. 1998..Considering the high frequency of 3p21 alterations in lung cancer and the fact that the tumor suppressor gene or genes in this locus have not been identified, additional studies on the NY-LU-12 gene and its product are warranted... - Serological analysis of Melan-A(MART-1), a melanocyte-specific protein homogeneously expressed in human melanomasY T Chen
Ludwig Institute for Cancer Research, New York Branch at Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Proc Natl Acad Sci U S A 93:5915-9. 1996..Analysis of 21 melanoma specimens showed homogenous staining of tumor cell cytoplasm in 16 of 17 Melan-A mRNA-positive cases and no reactivity with the three Melan-A mRNA-negative cases... - Fibroblast activation protein: purification, epitope mapping and induction by growth factorsW J Rettig
Program of Immunology, Memorial Sloan Kettering Cancer Center, New York, NY 10021
Int J Cancer 58:385-92. 1994..FAP and CD26 may belong to a family of structurally related but functionally distinct activation proteins that are expressed on different cell types and show unique modes of regulation in normal and malignant cells... - The humoral immune response to head and neck cancer antigens as defined by the serological analysis of tumor antigens by recombinant cDNA expression cloningHilary A Vaughan
Cancer Vaccine Laboratory, Ludwig Institute for Cancer Research, Austin Health, Studley Road, Heidelberg, 3084, Australia
Cancer Immun 4:5. 2004..Whether AU-HN-15 represents a tumor-antigen target suitable for prognostic or therapeutic purposes is still being analyzed... - SCP-1 cancer/testis antigen is a prognostic indicator and a candidate target for immunotherapy in epithelial ovarian cancerJonathan Tammela
Division of Gynecologic Oncology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
Cancer Immun 4:10. 2004..The present study shows that SCP-1 mRNA expression in patients with EOC is associated with a poorer chance of survival. These findings imply that further evaluation of SCP-1 as a potential target for vaccine therapy in EOC is warranted... - Serological analysis of expression cDNA libraries (SEREX): an immunoscreening technique for identifying immunogenic tumor antigensYao-Tseng Chen
Weill Medical College of Cornell University and Ludwig Institute for Cancer Research, New York Branch, NY, USA
Methods Mol Med 103:207-16. 2005..Several tumor antigens identified by SEREX on various types of cancer indeed showed such characteristics and these antigens are being tested as targets for therapeutic cancer vaccines... - Identification of the gonad-specific anion transporter SLCO6A1 as a cancer/testis (CT) antigen expressed in human lung cancerSang-Yull Lee
Ludwig Institute for Cancer Research, New York Branch at Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
Cancer Immun 4:13. 2004..The analysis also permits us to estimate the eventual size of the SEREX-defined cancer immunome at around 4000 genes. This emphasizes the importance of continued SEREX screening to define the cancer immunome... - Tumor associated antigen recognition by autologous serum in patients with breast cancerFeng Qian
Department of Biology, Indiana University, Bloomington, IN 47405, USA
Int J Mol Med 15:137-44. 2005..These clones did not react with sera from a panel of 25 healthy adult individuals. Our results demonstrate the utility of the SEREX approach for the identification of potential tumor associated antigens in human breast cancer... - Identification of cancer/testis-antigen genes by massively parallel signature sequencingYao Tseng Chen
Weill Medical College of Cornell University, New York, NY 10021, USA
Proc Natl Acad Sci U S A 102:7940-5. 2005..Thus, MPSS analysis has resulted in a significant extension of our knowledge of CT antigens, leading to the discovery of a distinctive X-linked CT-antigen gene family... - Glycoprotein A34, a novel target for antibody-based cancer immunotherapyMatthew J Scanlan
Ludwig Institute for Cancer Research, New York Branch of Human Cancer Immunology at Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
Cancer Immun 6:2. 2006..The A34 antigen and monoclonal antibody may be of considerable value for immunotherapy of different types of cancer... - Identification of human tumor antigens by serological analysis of recombinant cDNA expression libraries (SEREX)Matthew J Scanlan
Memorial Sloan-Kettering Cancer Center, New York, New York, USA
Curr Protoc Immunol . 2005..Application of this technique has led to the discovery of a number of provocative tumor antigens... - Human Mena protein, a serex-defined antigen overexpressed in breast cancer eliciting both humoral and CD8+ T-cell immune responseFrancesca Di Modugno
Laboratory of Experimental Chemotherapy, Regina Elena Cancer Institute, Rome, Italy
Int J Cancer 109:909-18. 2004..The present findings highlight the emerging role that overexpression of cytoskeleton regulatory components may have in the induction of a specific antitumor immune response... - NY-ESO-1 expression and immunogenicity in malignant and benign breast tumorsYurika Sugita
Department of Surgery and Clinical Oncology, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita City, Osaka 565 0871, Japan
Cancer Res 64:2199-204. 2004.... - A new member of the NY-ESO-1 gene family is ubiquitously expressed in somatic tissues and evolutionarily conservedBirgit Alpen
Weill Medical College of Cornell University, New York, NY 10021, USA
Gene 297:141-9. 2002..In addition, an intronless and presumably non-coding, copy of the mESO3, psimESO3, was identified on mouse chromosome 15. No counterpart of the ESO1 or 2 genes was found in rodents... - A monoclonal antibody recognizing human cancers with amplification/overexpression of the human epidermal growth factor receptorAchim A Jungbluth
Ludwig Institute for Cancer Research, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
Proc Natl Acad Sci U S A 100:639-44. 2003..Our study also indicates that DeltaEGFR is restricted to glioblastoma, in contrast to other reports that this mutation is found in tumors outside the brain... - Immunomic analysis of human sarcomaSang Yull Lee
Ludwig Institute for Cancer Research, New York Branch at Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
Proc Natl Acad Sci U S A 100:2651-6. 2003..NY-SAR-35 is therefore a potential target for cancer vaccines and monoclonal antibody-based immunotherapies... - Serological identification of antigens associated with renal cell carcinomaEkaterina P Koroleva
Engelhardt Institute of Molecular Biology, Russian Academy of Science, Belozersky Institute of Physico Chemical Biology, Moscow State University, Moscow, Russia
Russ J Immunol 7:229-38. 2002..As a result, we identified four antigens with a cancer-related serological profile, which may be used for the diagnostics of renal cancer... - Identification of tumor-restricted antigens NY-BR-1, SCP-1, and a new cancer/testis-like antigen NW-BR-3 by serological screening of a testicular library with breast cancer serumDirk Jager
II Medizinische Klinik, Hämatologie Onkologie, Krankenhaus Nordwest, Frankfurt, Germany
Cancer Immun 2:5. 2002..This study provides further evidence that SEREX is a powerful tool to identify new tumor antigens potentially relevant for immunotherapy approaches... - Expression of cancer/testis (CT) antigens in lung cancerKouhei Tajima
Division of Immunology, Aichi Cancer Center Research Institute, 1-1, Kanokoden, Chikusa-ku, Nagoya, Aichi 464-8681, Japan
Lung Cancer 42:23-33. 2003..In addition, in silico surveys of dbEST database were used for identification of new CT antigens. We identified a novel gene, TES101RP, expressed only in some small cell lung cancers (SCLC) and in testis, as confirmed by RT-PCR analysis... - NY-ESO-1 and LAGE-1 cancer-testis antigens are potential targets for immunotherapy in epithelial ovarian cancerKunle Odunsi
Division of Gynecologic Oncology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
Cancer Res 63:6076-83. 2003..These findings indicate that NY-ESO-1 and LAGE-1 are attractive targets for antigen-specific immunotherapy in EOC... - Identification of breast cancer-restricted antigens by antibody screening of SKBR3 cDNA library using a preselected patient's serumStefania Forti
Department of Experimental Oncology, Istituto Nazionale Tumori, Milano, Italy
Breast Cancer Res Treat 73:245-56. 2002.... - Frequent and specific immunity to the embryonal stem cell-associated antigen SOX2 in patients with monoclonal gammopathyRadek Spisek
Laboratory of Tumor Immunology and Immunotherapy, The Rockefeller University, New York, NY 10021, USA
J Exp Med 204:831-40. 2007..Harnessing immunity to antigens expressed by tumor progenitor cells may be critical for prevention and therapy of human cancer...