M J Scanlan

Summary

Affiliation: Memorial Sloan-Kettering Cancer Center
Country: USA

Publications

  1. pmc Serological identification of embryonic neural proteins as highly immunogenic tumor antigens in small cell lung cancer
    A O Gure
    Ludwig Institute for Cancer Research, New York Branch at Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 97:4198-203. 2000
  2. ncbi Antigens recognized by autologous antibody in patients with renal-cell carcinoma
    M J Scanlan
    Ludwig Institute for Cancer Research, New York Branch at Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Int J Cancer 83:456-64. 1999
  3. ncbi The cancer/testis genes: review, standardization, and commentary
    Matthew J Scanlan
    Ludwig Institute for Cancer Research, New York Branch of Human Cancer Immunology at Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Cancer Immun 4:1. 2004
  4. ncbi Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression
    M J Scanlan
    Ludwig Institute for Cancer Research, New York Branch of Human Cancer Immunology at Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Cancer Immun 1:4. 2001
  5. ncbi Cancer/testis antigens: an expanding family of targets for cancer immunotherapy
    Matthew J Scanlan
    Ludwig Institute for Cancer Research, New York Branch at Memorial Sloan Kettering Cancer Center, Weill Medical College of Cornell University, Department of Pathology, New York, NY 10021, USA
    Immunol Rev 188:22-32. 2002
  6. ncbi Cancer-related serological recognition of human colon cancer: identification of potential diagnostic and immunotherapeutic targets
    Matthew J Scanlan
    Ludwig Institute for Cancer Research, New York Branch at Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Cancer Res 62:4041-7. 2002
  7. ncbi Identification of cancer/testis genes by database mining and mRNA expression analysis
    Matthew J Scanlan
    Ludwig Institute for Cancer Research, New York Branch at Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Int J Cancer 98:485-92. 2002
  8. pmc Challenges to the development of antigen-specific breast cancer vaccines
    M J Scanlan
    Ludwig Institute for Cancer Research, Memorial Sloan0Kettering Cancer Center, New York 10021, USA
    Breast Cancer Res 3:95-8. 2001
  9. ncbi Expression of cancer-testis antigens in lung cancer: definition of bromodomain testis-specific gene (BRDT) as a new CT gene, CT9
    M J Scanlan
    Ludwig Institute for Cancer Research, New York Branch at Memorial Sloan Kettering Cancer Center, New York 10021, USA
    Cancer Lett 150:155-64. 2000
  10. ncbi Isoforms of the human PDZ-73 protein exhibit differential tissue expression
    M J Scanlan
    Ludwig Institute for Cancer Research, New York Branch at Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Biochim Biophys Acta 1445:39-52. 1999

Collaborators

Detail Information

Publications42

  1. pmc Serological identification of embryonic neural proteins as highly immunogenic tumor antigens in small cell lung cancer
    A O Gure
    Ludwig Institute for Cancer Research, New York Branch at Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 97:4198-203. 2000
    ..Although paraneoplastic neurological syndromes have been associated with several SCLC antigens, neurological symptoms have not been observed in patients with anti-SOX or anti-ZIC2 antibodies...
  2. ncbi Antigens recognized by autologous antibody in patients with renal-cell carcinoma
    M J Scanlan
    Ludwig Institute for Cancer Research, New York Branch at Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Int J Cancer 83:456-64. 1999
    ..Our results demonstrate the potential of the SEREX approach for the analysis of the humoral immune response against human cancer...
  3. ncbi The cancer/testis genes: review, standardization, and commentary
    Matthew J Scanlan
    Ludwig Institute for Cancer Research, New York Branch of Human Cancer Immunology at Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Cancer Immun 4:1. 2004
    ....
  4. ncbi Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression
    M J Scanlan
    Ludwig Institute for Cancer Research, New York Branch of Human Cancer Immunology at Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Cancer Immun 1:4. 2001
    ..This study adds to the growing list of breast cancer antigens defined by SEREX and to the ultimate objective of identifying the complete repertoire of immunogenic gene products in human cancer (the cancer immunome)...
  5. ncbi Cancer/testis antigens: an expanding family of targets for cancer immunotherapy
    Matthew J Scanlan
    Ludwig Institute for Cancer Research, New York Branch at Memorial Sloan Kettering Cancer Center, Weill Medical College of Cornell University, Department of Pathology, New York, NY 10021, USA
    Immunol Rev 188:22-32. 2002
    ..Since CT antigens are immunogenic and highly restricted to tumors, their discovery has led directly to the development of antigen-specific cancer vaccines, and clinical trials with MAGE-A and NY-ESO-1 are in progress...
  6. ncbi Cancer-related serological recognition of human colon cancer: identification of potential diagnostic and immunotherapeutic targets
    Matthew J Scanlan
    Ludwig Institute for Cancer Research, New York Branch at Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Cancer Res 62:4041-7. 2002
    ..In contrast, 9 of 9 colon cancer specimens showed overexpression of KNSL6 mRNA, ranging from 5 to 44 times the level detected in normal colon tissue, indicating that this antigen could also be a valuable therapeutic target...
  7. ncbi Identification of cancer/testis genes by database mining and mRNA expression analysis
    Matthew J Scanlan
    Ludwig Institute for Cancer Research, New York Branch at Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Int J Cancer 98:485-92. 2002
    ..This study demonstrates the merits of database mining with respect to the identification of tissue-restricted gene products expressed in cancer...
  8. pmc Challenges to the development of antigen-specific breast cancer vaccines
    M J Scanlan
    Ludwig Institute for Cancer Research, Memorial Sloan0Kettering Cancer Center, New York 10021, USA
    Breast Cancer Res 3:95-8. 2001
    ..The development of a polyvalent breast cancer vaccine, directed against a panel of tumor-associated antigens, may counteract this form of immune escape...
  9. ncbi Expression of cancer-testis antigens in lung cancer: definition of bromodomain testis-specific gene (BRDT) as a new CT gene, CT9
    M J Scanlan
    Ludwig Institute for Cancer Research, New York Branch at Memorial Sloan Kettering Cancer Center, New York 10021, USA
    Cancer Lett 150:155-64. 2000
    ..The coexpression pattern of these antigens provides a foundation for developing a polyvalent lung cancer vaccine...
  10. ncbi Isoforms of the human PDZ-73 protein exhibit differential tissue expression
    M J Scanlan
    Ludwig Institute for Cancer Research, New York Branch at Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Biochim Biophys Acta 1445:39-52. 1999
    ..The existence of multiple PDZ-73 isoforms with variations in tissue distribution, PDZ domains, protein degradation sequences and carboxyl terminal structure indicate that these isoforms have distinct tissue-specific functions...
  11. ncbi Characterization of human colon cancer antigens recognized by autologous antibodies
    M J Scanlan
    Ludwig Institute for Cancer Research, New York Branch at Memorial Sloan Kettering Cancer Center, NY 10021, USA
    Int J Cancer 76:652-8. 1998
    ..Our results on colon cancer illustrate both the complexity and the potential of the SEREX approach for analysis of the humoral immune response against human cancer...
  12. pmc A testicular antigen aberrantly expressed in human cancers detected by autologous antibody screening
    Y T Chen
    Cornell University Medical College, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 94:1914-8. 1997
    ..These antigens, initially detected by either cytotoxic T cells (MAGE, BAGE, GAGE-1) or antibodies [HOM-MEL-40(SSX2), NY-ESO-1], represent a pool of antigenic targets for cancer vaccination...
  13. ncbi Cancer-testis antigens and ING1 tumor suppressor gene product are breast cancer antigens: characterization of tissue-specific ING1 transcripts and a homologue gene
    D Jager
    Department of Pathology, Cornell University Medical College, New York, New York 10021, USA
    Cancer Res 59:6197-204. 1999
    ..The basis of the immunogenicity of ING1 and the biological role of ING1 and ING2 need further exploration...
  14. ncbi CT10: a new cancer-testis (CT) antigen homologous to CT7 and the MAGE family, identified by representational-difference analysis
    A O Gure
    Ludwig Institute for Cancer Research, New York Branch at Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Int J Cancer 85:726-32. 2000
    ..CT10 mRNA is expressed in testis and in 20 to 30% of various human cancers. A serological survey identified 2 melanoma patients with anti-CT10 antibody, demonstrating the immunogenicity of CT10 in humans...
  15. pmc A survey of the humoral immune response of cancer patients to a panel of human tumor antigens
    E Stockert
    Ludwig Institute for Cancer Research, New York Branch at Memorial Sloan Kettering Cancer Center, New York 10021, USA
    J Exp Med 187:1349-54. 1998
    ..As the proportion of melanomas expressing NY-ESO-1 is 20-40% and only patients with NY-ESO-1(+) tumors have antibody, this would suggest that a high percentage of patients with NY-ESO-1(+) tumors develop an antibody response to NY-ESO-1...
  16. ncbi Identification of a tissue-specific putative transcription factor in breast tissue by serological screening of a breast cancer library
    D Jager
    Weill Medical College of Cornell University, New York, New York 10021, USA
    Cancer Res 61:2055-61. 2001
    ..The exon structure of NY-BR-1.1 remains to be defined. Using human genome database, NY-BR-1 was localized to chromosome 10p11-p12, and NY-BR-1.1 was tentatively localized to chromosome 9...
  17. ncbi SSX: a multigene family with several members transcribed in normal testis and human cancer
    A O Gure
    Ludwig Institute for Cancer Research, New York Branch, Memorial Sloan Kettering Cancer Center, New York, USA
    Int J Cancer 72:965-71. 1997
    ..In addition, analysis of a panel of 12 melanoma cell lines showed strong mRNA expression of either SSX1 (3/12), SSX2 (3/12), SSX4 (1/12), or SSX5 (1/12), indicating variable activation of the genes in malignant cells...
  18. ncbi Serological cloning of a melanocyte rab guanosine 5'-triphosphate-binding protein and a chromosome condensation protein from a melanoma complementary DNA library
    D Jager
    Department of Pathology, Weill Medical College of Cornell University, New York, New York 10021, USA
    Cancer Res 60:3584-91. 2000
    ..This mitosis-related expression suggests hCAP-G as a possible proliferation marker and a potential prognostic indicator in cancer. These findings provide further support that SEREX can define biologically significant molecules in cancer...
  19. pmc Molecular cloning of fibroblast activation protein alpha, a member of the serine protease family selectively expressed in stromal fibroblasts of epithelial cancers
    M J Scanlan
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021
    Proc Natl Acad Sci U S A 91:5657-61. 1994
    ....
  20. ncbi The gene for fibroblast activation protein alpha (FAP), a putative cell surface-bound serine protease expressed in cancer stroma and wound healing, maps to chromosome band 2q23
    S Mathew
    Department of Human Genetics and Cell Biology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Genomics 25:335-7. 1995
  21. ncbi Human lung cancer antigens recognized by autologous antibodies: definition of a novel cDNA derived from the tumor suppressor gene locus on chromosome 3p21.3
    A O Gure
    Ludwig Institute for Cancer Research, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Cancer Res 58:1034-41. 1998
    ..Considering the high frequency of 3p21 alterations in lung cancer and the fact that the tumor suppressor gene or genes in this locus have not been identified, additional studies on the NY-LU-12 gene and its product are warranted...
  22. pmc Serological analysis of Melan-A(MART-1), a melanocyte-specific protein homogeneously expressed in human melanomas
    Y T Chen
    Ludwig Institute for Cancer Research, New York Branch at Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 93:5915-9. 1996
    ..Analysis of 21 melanoma specimens showed homogenous staining of tumor cell cytoplasm in 16 of 17 Melan-A mRNA-positive cases and no reactivity with the three Melan-A mRNA-negative cases...
  23. ncbi Fibroblast activation protein: purification, epitope mapping and induction by growth factors
    W J Rettig
    Program of Immunology, Memorial Sloan Kettering Cancer Center, New York, NY 10021
    Int J Cancer 58:385-92. 1994
    ..FAP and CD26 may belong to a family of structurally related but functionally distinct activation proteins that are expressed on different cell types and show unique modes of regulation in normal and malignant cells...
  24. ncbi The humoral immune response to head and neck cancer antigens as defined by the serological analysis of tumor antigens by recombinant cDNA expression cloning
    Hilary A Vaughan
    Cancer Vaccine Laboratory, Ludwig Institute for Cancer Research, Austin Health, Studley Road, Heidelberg, 3084, Australia
    Cancer Immun 4:5. 2004
    ..Whether AU-HN-15 represents a tumor-antigen target suitable for prognostic or therapeutic purposes is still being analyzed...
  25. ncbi SCP-1 cancer/testis antigen is a prognostic indicator and a candidate target for immunotherapy in epithelial ovarian cancer
    Jonathan Tammela
    Division of Gynecologic Oncology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Cancer Immun 4:10. 2004
    ..The present study shows that SCP-1 mRNA expression in patients with EOC is associated with a poorer chance of survival. These findings imply that further evaluation of SCP-1 as a potential target for vaccine therapy in EOC is warranted...
  26. ncbi Serological analysis of expression cDNA libraries (SEREX): an immunoscreening technique for identifying immunogenic tumor antigens
    Yao Tseng Chen
    Weill Medical College of Cornell University and Ludwig Institute for Cancer Research, New York Branch, NY, USA
    Methods Mol Med 103:207-16. 2005
    ..Several tumor antigens identified by SEREX on various types of cancer indeed showed such characteristics and these antigens are being tested as targets for therapeutic cancer vaccines...
  27. ncbi Identification of the gonad-specific anion transporter SLCO6A1 as a cancer/testis (CT) antigen expressed in human lung cancer
    Sang Yull Lee
    Ludwig Institute for Cancer Research, New York Branch at Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Cancer Immun 4:13. 2004
    ..The analysis also permits us to estimate the eventual size of the SEREX-defined cancer immunome at around 4000 genes. This emphasizes the importance of continued SEREX screening to define the cancer immunome...
  28. ncbi Tumor associated antigen recognition by autologous serum in patients with breast cancer
    Feng Qian
    Department of Biology, Indiana University, Bloomington, IN 47405, USA
    Int J Mol Med 15:137-44. 2005
    ..These clones did not react with sera from a panel of 25 healthy adult individuals. Our results demonstrate the utility of the SEREX approach for the identification of potential tumor associated antigens in human breast cancer...
  29. pmc Identification of cancer/testis-antigen genes by massively parallel signature sequencing
    Yao Tseng Chen
    Weill Medical College of Cornell University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 102:7940-5. 2005
    ..Thus, MPSS analysis has resulted in a significant extension of our knowledge of CT antigens, leading to the discovery of a distinctive X-linked CT-antigen gene family...
  30. ncbi Glycoprotein A34, a novel target for antibody-based cancer immunotherapy
    Matthew J Scanlan
    Ludwig Institute for Cancer Research, New York Branch of Human Cancer Immunology at Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Cancer Immun 6:2. 2006
    ..The A34 antigen and monoclonal antibody may be of considerable value for immunotherapy of different types of cancer...
  31. doi Identification of human tumor antigens by serological analysis of recombinant cDNA expression libraries (SEREX)
    Matthew J Scanlan
    Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Curr Protoc Immunol . 2005
    ..Application of this technique has led to the discovery of a number of provocative tumor antigens...
  32. ncbi Human Mena protein, a serex-defined antigen overexpressed in breast cancer eliciting both humoral and CD8+ T-cell immune response
    Francesca Di Modugno
    Laboratory of Experimental Chemotherapy, Regina Elena Cancer Institute, Rome, Italy
    Int J Cancer 109:909-18. 2004
    ..The present findings highlight the emerging role that overexpression of cytoskeleton regulatory components may have in the induction of a specific antitumor immune response...
  33. ncbi NY-ESO-1 expression and immunogenicity in malignant and benign breast tumors
    Yurika Sugita
    Department of Surgery and Clinical Oncology, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita City, Osaka 565 0871, Japan
    Cancer Res 64:2199-204. 2004
    ....
  34. ncbi A new member of the NY-ESO-1 gene family is ubiquitously expressed in somatic tissues and evolutionarily conserved
    Birgit Alpen
    Weill Medical College of Cornell University, New York, NY 10021, USA
    Gene 297:141-9. 2002
    ..In addition, an intronless and presumably non-coding, copy of the mESO3, psimESO3, was identified on mouse chromosome 15. No counterpart of the ESO1 or 2 genes was found in rodents...
  35. pmc A monoclonal antibody recognizing human cancers with amplification/overexpression of the human epidermal growth factor receptor
    Achim A Jungbluth
    Ludwig Institute for Cancer Research, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 100:639-44. 2003
    ..Our study also indicates that DeltaEGFR is restricted to glioblastoma, in contrast to other reports that this mutation is found in tumors outside the brain...
  36. pmc Immunomic analysis of human sarcoma
    Sang Yull Lee
    Ludwig Institute for Cancer Research, New York Branch at Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 100:2651-6. 2003
    ..NY-SAR-35 is therefore a potential target for cancer vaccines and monoclonal antibody-based immunotherapies...
  37. ncbi Serological identification of antigens associated with renal cell carcinoma
    Ekaterina P Koroleva
    Engelhardt Institute of Molecular Biology, Russian Academy of Science, Belozersky Institute of Physico Chemical Biology, Moscow State University, Moscow, Russia
    Russ J Immunol 7:229-38. 2002
    ..As a result, we identified four antigens with a cancer-related serological profile, which may be used for the diagnostics of renal cancer...
  38. ncbi Identification of tumor-restricted antigens NY-BR-1, SCP-1, and a new cancer/testis-like antigen NW-BR-3 by serological screening of a testicular library with breast cancer serum
    Dirk Jager
    II Medizinische Klinik, Hämatologie Onkologie, Krankenhaus Nordwest, Frankfurt, Germany
    Cancer Immun 2:5. 2002
    ..This study provides further evidence that SEREX is a powerful tool to identify new tumor antigens potentially relevant for immunotherapy approaches...
  39. ncbi Expression of cancer/testis (CT) antigens in lung cancer
    Kouhei Tajima
    Division of Immunology, Aichi Cancer Center Research Institute, 1 1, Kanokoden, Chikusa ku, Nagoya, Aichi 464 8681, Japan
    Lung Cancer 42:23-33. 2003
    ..In addition, in silico surveys of dbEST database were used for identification of new CT antigens. We identified a novel gene, TES101RP, expressed only in some small cell lung cancers (SCLC) and in testis, as confirmed by RT-PCR analysis...
  40. ncbi NY-ESO-1 and LAGE-1 cancer-testis antigens are potential targets for immunotherapy in epithelial ovarian cancer
    Kunle Odunsi
    Division of Gynecologic Oncology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Cancer Res 63:6076-83. 2003
    ..These findings indicate that NY-ESO-1 and LAGE-1 are attractive targets for antigen-specific immunotherapy in EOC...
  41. ncbi Identification of breast cancer-restricted antigens by antibody screening of SKBR3 cDNA library using a preselected patient's serum
    Stefania Forti
    Department of Experimental Oncology, Istituto Nazionale Tumori, Milano, Italy
    Breast Cancer Res Treat 73:245-56. 2002
    ....
  42. pmc Frequent and specific immunity to the embryonal stem cell-associated antigen SOX2 in patients with monoclonal gammopathy
    Radek Spisek
    Laboratory of Tumor Immunology and Immunotherapy, The Rockefeller University, New York, NY 10021, USA
    J Exp Med 204:831-40. 2007
    ..Harnessing immunity to antigens expressed by tumor progenitor cells may be critical for prevention and therapy of human cancer...