Research Topics
Species | Jaya M SatagopanSummaryAffiliation: Memorial Sloan-Kettering Cancer Center Country: USA Publications
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Publications
Ovarian cancer risk in Ashkenazi Jewish carriers of BRCA1 and BRCA2 mutationsJaya M Satagopan
Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Clin Cancer Res 8:3776-81. 2002..To address this, we have used a case-control design that does not involve familial aggregation to estimate the lifetime penetrance of ovarian cancer due to BRCA1 and BRCA2 mutations...- Frequency of BRCA1 and BRCA2 mutations in unselected Ashkenazi Jewish patients with colorectal cancerTomas Kirchhoff
Clinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
J Natl Cancer Inst 96:68-70. 2004..22 to 1.14). We thus recommend that counseling for colorectal cancer screening and prevention in individuals with BRCA mutations be based on the personal and family history of colorectal cancer or associated syndromic malignancies... - Risk-reducing salpingo-oophorectomy in women with a BRCA1 or BRCA2 mutationNoah D Kauff
Clinical Genetics Service, Memorial Sloan Kettering Cancer Center, New York 10021, USA
N Engl J Med 346:1609-15. 2002..We prospectively compared the effect of risk-reducing salpingo-oophorectomy with that of surveillance for ovarian cancer on the incidence of subsequent breast cancer and BRCA-related gynecologic cancers in women with BRCA mutations... - BRCA1 and BRCA2 germline mutations in lymphoma patientsOrit Yossepowitch
Clinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Leuk Lymphoma 44:127-31. 2003..This data indicate that germline BRCA mutations are not associated with an increased risk for lymphoid malignancies... 
Prospective study of sunburn and sun behavior patterns during adolescenceStephen W Dusza
Department of Medicine, Memorial Sloan Kettering Cancer Center, Dermatology Service, New York, NY 10022, USA
Pediatrics 129:309-17. 2012..Early childhood UV light radiation (UVR) exposures have been shown to be associated with melanoma development later in life. The objective of this study was to assess sunburn and changes in sunburn and sun behaviors during periadolescence...- TMPRSS2-ERG gene fusion is associated with low Gleason scores and not with high-grade morphological featuresSamson W Fine
Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
Mod Pathol 23:1325-33. 2010..These findings indicate that translocation/deletion of TMPRSS2-ERG is not associated with histological features of aggressive prostate cancer... - Clinical and dermoscopic stability and volatility of melanocytic nevi in a population-based cohort of children in Framingham school systemAlon Scope
Dermatology Service, Memorial Sloan Kettering Cancer Center, New York, New York 10022, USA
J Invest Dermatol 131:1615-21. 2011..In conclusion, the relative stability of dermoscopic pattern of individual nevi in the face of the overall volatility of nevi during adolescence suggests that specific dermoscopic patterns may represent distinct biological nevus subsets... - Variants in activators and downstream targets of ATM, radiation exposure, and contralateral breast cancer risk in the WECARE studyJennifer D Brooks
Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
Hum Mutat 33:158-64. 2012..This suggests that carriers of this haplotype may be susceptible to the DNA-damaging effects of radiation therapy associated with radiation-induced breast cancer... - Two-stage designs for gene-disease association studies with sample size constraintsJaya M Satagopan
Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Biometrics 60:589-97. 2004.... - Study of Nevi in Children (SONIC): baseline findings and predictors of nevus countSusan A Oliveria
Dermatology Service, Memorial Sloan Kettering Cancer Center, New York, NY 10022, USA
Am J Epidemiol 169:41-53. 2009..041), and often and always (RR = 1.32, 95% CI: 1.13, 1.54; P = 0.001) were associated with increased number of nevi. Identifying factors that predict the development of nevi will improve primary prevention efforts during early life... - Copy number and gene expression differences between African American and Caucasian American prostate cancerAmy E Rose
Department of Urology, New York University School of Medicine, New York, New York 10016, USA
J Transl Med 8:70. 2010.... - Normalization method for transcriptional studies of heterogeneous samples--simultaneous array normalization and identification of equivalent expressionLi Xuan Qin
Memorial Sloan Kettering Cancer Center
Stat Appl Genet Mol Biol 8:Article 10. 2009..Empirical illustration of the proposed method is provided using a liposarcoma study from MSKCC to identify genes differentially expressed between normal fat tissue versus liposarcoma tissue samples... - A statistical perspective on gene expression data analysisJaya M Satagopan
Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
Stat Med 22:481-99. 2003..S-plus and SAS codes to perform the statistical methods are provided. Gene expression data from an unpublished oncologic study is used to illustrate these methods... - Rare variants of ATM and risk for Hodgkin's disease and radiation-associated breast cancersKenneth Offit
Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Clin Cancer Res 8:3813-9. 2002..We next sought to determine the frequency of ATM variants in patients with Hodgkin's lymphoma, regardless of coexisting BC, compared with healthy volunteers... - Sequential quantitative trait locus mapping in experimental crossesJaya M Satagopan
Memorial Sloan Kettering Cancer Center, USA
Stat Appl Genet Mol Biol 6:Article12. 2007..We examine settings under which the two-stage analytic approach provides sufficient power to detect the putative QTLs... 
TMPRSS2-ERG gene fusion is not associated with outcome in patients treated by prostatectomyAnuradha Gopalan
Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
Cancer Res 69:1400-6. 2009....- Two-stage designs for gene-disease association studiesJaya M Satagopan
Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Biometrics 58:163-70. 2002..This translates to screening all the markers on approximately one quarter of the required sample size in stage 1... - Novel mutations of epidermal growth factor receptor in localized prostate cancerDiah A Douglas
Department of Urology, New York University School of Medicine, New York, NY 10016, USA
Front Biosci 11:2518-25. 2006..Larger population-based studies are required to define the association between EGFR mutations and the ethnic background of patients... - Optimal two-stage genotyping in population-based association studiesJaya M Satagopan
Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Genet Epidemiol 25:149-57. 2003..The results show that, compared to a one-stage approach, a two-stage procedure typically halves the cost of the study... - Genetic heterogeneity among Fanconi anemia heterozygotes and risk of cancerMarianne Berwick
Cancer Research and Treatment Center Internal Medicine, University of New Mexico, Albuquerque, New Mexico, USA
Cancer Res 67:9591-6. 2007..4; 95% CI, 1.1-5.2). Overall, there was no increased risk for cancer among FA heterozygotes in this study of Fanconi relatives, although there is some evidence that FANCC mutations are possibly breast cancer susceptibility alleles... - Quantitative trait locus study design from an information perspectiveSaunak Sen
Department of Epidemiology and Biostatistics, University of California, San Francisco, 94143, USA
Genetics 170:447-64. 2005..Software for performing power calculations for backcross and F(2) intercross incorporating selective genotyping and marker spacing is available from http://www.biostat.ucsf.edu/sen... - R/qtlDesign: inbred line cross experimental designSaunak Sen
Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California 94143, USA
Mamm Genome 18:87-93. 2007..We give examples of software usage in real-life settings. The software is available at http://www.biostat.ucsf.edu/sen/software.html ...