Research Topics
Species | J M SatagopanSummaryAffiliation: Memorial Sloan-Kettering Cancer Center Country: USA Publications
Research Grants
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Detail Information
Publications
Copy number and gene expression differences between African American and Caucasian American prostate cancerAmy E Rose
Department of Urology, New York University School of Medicine, New York, New York 10016, USA
J Transl Med 8:70. 2010....
Frequency of CHEK2*1100delC in New York breast cancer cases and controlsKenneth Offit
Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA
BMC Med Genet 4:1. 2003..While the frequency of 1100delC was 1.1-1.4% in healthy Finnish controls, the frequency of this allele in a North American control population and in North American breast cancer kindreds remains unclear...- Analysis of genetic variation in Ashkenazi Jews by high density SNP genotypingAdam B Olshen
Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
BMC Genet 9:14. 2008..435,632 SNPs overlapped and met annotation criteria in the two groups... 
Sequential quantitative trait locus mapping in experimental crossesJaya M Satagopan
Memorial Sloan Kettering Cancer Center, USA
Stat Appl Genet Mol Biol 6:Article12. 2007..We examine settings under which the two-stage analytic approach provides sufficient power to detect the putative QTLs...- Two-stage designs for gene-disease association studies with sample size constraintsJaya M Satagopan
Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Biometrics 60:589-97. 2004.... - A note on competing risks in survival data analysisJ M Satagopan
Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York 10021, USA
Br J Cancer 91:1229-35. 2004..We compare the resulting estimates with those obtained using the Kaplan-Meier approach to demonstrate the importance of appropriately estimating the cumulative incidence of an event of interest in the presence of competing risk events... - Optimal two-stage genotyping in population-based association studiesJaya M Satagopan
Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Genet Epidemiol 25:149-57. 2003..The results show that, compared to a one-stage approach, a two-stage procedure typically halves the cost of the study... - Risk-reducing salpingo-oophorectomy in women with a BRCA1 or BRCA2 mutationNoah D Kauff
Clinical Genetics Service, Memorial Sloan Kettering Cancer Center, New York 10021, USA
N Engl J Med 346:1609-15. 2002..We prospectively compared the effect of risk-reducing salpingo-oophorectomy with that of surveillance for ovarian cancer on the incidence of subsequent breast cancer and BRCA-related gynecologic cancers in women with BRCA mutations... - Frequency of BRCA1 and BRCA2 mutations in unselected Ashkenazi Jewish patients with colorectal cancerTomas Kirchhoff
Clinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
J Natl Cancer Inst 96:68-70. 2004..22 to 1.14). We thus recommend that counseling for colorectal cancer screening and prevention in individuals with BRCA mutations be based on the personal and family history of colorectal cancer or associated syndromic malignancies... - BRCA1 and BRCA2 germline mutations in lymphoma patientsOrit Yossepowitch
Clinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Leuk Lymphoma 44:127-31. 2003..This data indicate that germline BRCA mutations are not associated with an increased risk for lymphoid malignancies... - Quantitative trait locus study design from an information perspectiveSaunak Sen
Department of Epidemiology and Biostatistics, University of California, San Francisco, 94143, USA
Genetics 170:447-64. 2005..Software for performing power calculations for backcross and F(2) intercross incorporating selective genotyping and marker spacing is available from http://www.biostat.ucsf.edu/sen... - TMPRSS2-ERG gene fusion is associated with low Gleason scores and not with high-grade morphological featuresSamson W Fine
Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
Mod Pathol 23:1325-33. 2010..These findings indicate that translocation/deletion of TMPRSS2-ERG is not associated with histological features of aggressive prostate cancer... - Ovarian cancer risk in Ashkenazi Jewish carriers of BRCA1 and BRCA2 mutationsJaya M Satagopan
Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Clin Cancer Res 8:3776-81. 2002..To address this, we have used a case-control design that does not involve familial aggregation to estimate the lifetime penetrance of ovarian cancer due to BRCA1 and BRCA2 mutations... - A statistical perspective on gene expression data analysisJaya M Satagopan
Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
Stat Med 22:481-99. 2003..S-plus and SAS codes to perform the statistical methods are provided. Gene expression data from an unpublished oncologic study is used to illustrate these methods... - Study of Nevi in Children (SONIC): baseline findings and predictors of nevus countSusan A Oliveria
Dermatology Service, Memorial Sloan Kettering Cancer Center, New York, NY 10022, USA
Am J Epidemiol 169:41-53. 2009..041), and often and always (RR = 1.32, 95% CI: 1.13, 1.54; P = 0.001) were associated with increased number of nevi. Identifying factors that predict the development of nevi will improve primary prevention efforts during early life... - Two-stage designs for gene-disease association studiesJaya M Satagopan
Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Biometrics 58:163-70. 2002..This translates to screening all the markers on approximately one quarter of the required sample size in stage 1... - Normalization method for transcriptional studies of heterogeneous samples--simultaneous array normalization and identification of equivalent expressionLi Xuan Qin
Memorial Sloan Kettering Cancer Center
Stat Appl Genet Mol Biol 8:Article 10. 2009..Empirical illustration of the proposed method is provided using a liposarcoma study from MSKCC to identify genes differentially expressed between normal fat tissue versus liposarcoma tissue samples... 
TMPRSS2-ERG gene fusion is not associated with outcome in patients treated by prostatectomyAnuradha Gopalan
Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
Cancer Res 69:1400-6. 2009....- A bayesian approach to detect quantitative trait loci using Markov chain Monte CarloJ M Satagopan
Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York 10021 6094, USA
Genetics 144:805-16. 1996..High posterior density regions of the marginal densities are obtained as confidence regions. We examine flowering time data from double haploid progeny of Brassica napus to illustrate the proposed method... - The lifetime risks of breast cancer in Ashkenazi Jewish carriers of BRCA1 and BRCA2 mutationsJ M Satagopan
Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA
Cancer Epidemiol Biomarkers Prev 10:467-73. 2001..The risks appear to be different for carriers of BRCA1 and BRCA2 mutations... - R/qtlDesign: inbred line cross experimental designSaunak Sen
Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California 94143, USA
Mamm Genome 18:87-93. 2007..We give examples of software usage in real-life settings. The software is available at http://www.biostat.ucsf.edu/sen/software.html ... - Rare variants of ATM and risk for Hodgkin's disease and radiation-associated breast cancersKenneth Offit
Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Clin Cancer Res 8:3813-9. 2002..We next sought to determine the frequency of ATM variants in patients with Hodgkin's lymphoma, regardless of coexisting BC, compared with healthy volunteers... - Novel mutations of epidermal growth factor receptor in localized prostate cancerDiah A Douglas
Department of Urology, New York University School of Medicine, New York, NY 10016, USA
Front Biosci 11:2518-25. 2006..Larger population-based studies are required to define the association between EGFR mutations and the ethnic background of patients... - Type I transforming growth factor beta receptor maps to 9q22 and exhibits a polymorphism and a rare variant within a polyalanine tractB Pasche
Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Cancer Res 58:2727-32. 1998..The clinical and biological significance of TbetaR-I(6A) homozygosity needs to be further investigated... - Assessing interactions between mdm-2, p53, and bcl-2 as prognostic variables in muscle-invasive bladder cancer treated with neo-adjuvant chemotherapy followed by locoregional surgical treatmentF C Maluf
The Genitourinary Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center and the Department of Medicine, Joan and Sanford Weill Medical College of Cornell University, New York, USA
Ann Oncol 17:1677-86. 2006..Both individual and cooperative effects of these gene products may affect the biological behavior of primary bladder cancers and long-term outcome to standard therapy... - Genetic heterogeneity among Fanconi anemia heterozygotes and risk of cancerMarianne Berwick
Cancer Research and Treatment Center Internal Medicine, University of New Mexico, Albuquerque, New Mexico, USA
Cancer Res 67:9591-6. 2007..4; 95% CI, 1.1-5.2). Overall, there was no increased risk for cancer among FA heterozygotes in this study of Fanconi relatives, although there is some evidence that FANCC mutations are possibly breast cancer susceptibility alleles... - Absence of a telomere maintenance mechanism as a favorable prognostic factor in patients with osteosarcomaGary A Ulaner
Medical Service, Veterans Administration Palo Alto Health Care System, and Department of Medicine, Stanford University, Palo Alto, California 94304, USA
Cancer Res 63:1759-63. 2003..Finally, we note that OS cases with a TA-/ALT+ phenotype seem to be as clinically aggressive as TA+ cases in terms of stage and clinical outcome...
Research Grants
- TWO STAGE DESIGNS FOR LINKAGE DISEQUILIBRIUMJaya Satagopan; Fiscal Year: 2002..abstract_text> ..
- STUDY OF EXPOSURES, BEHAVIORS, AND BIOMARKERS IN CANCER EPIDEMIOLOGYJaya M Satagopan; Fiscal Year: 2010..These render data analysis a challenging task. The long-term goals of this proposal are to investigate novel methods for efficient analyses of correlated risk factors, and to develop optimal study designs for follow-up research. ..