Affiliation: Memorial Sloan-Kettering Cancer Center
- Threading with chemostructural restrictions method for predicting fold and functionally significant residues: application to dipeptidylpeptidase IV (DPP-IV)Boris Reva
Novartis Institute for Biomedical Research, Summit, New Jersey, USA
Proteins 47:180-93. 2002..Cell 1998;94:161-170) and use this structure for modeling the interaction of DPP-IV with inhibitor...
- Matrix Metalloproteinase-9 (MMP-9) polymorphisms in patients with cutaneous malignant melanomaJavier Cotignola
Memorial Sloan Kettering Cancer Center, New York, NY, USA
BMC Med Genet 8:10. 2007..Some polymorphisms are known to influence gene expression, protein activity, stability, and interactions, and they were shown to be associated with certain tumor phenotypes and cancer risk...
- Determinants of protein function revealed by combinatorial entropy optimizationBoris Reva
Computational Biology Center, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
Genome Biol 8:R232. 2007..Such predicted functional determinants are useful for interpreting the functional consequences of mutations in natural evolution and disease...
- Necdin, a p53 target gene, regulates the quiescence and response to genotoxic stress of hematopoietic stem/progenitor cellsTakashi Asai
Molecular Pharmacology and Chemistry Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA
Blood 120:1601-12. 2012..We conclude that necdin functions as a molecular switch in adult hematopoiesis, acting in a p53-like manner to promote HSC quiescence in the steady state, but suppressing p53-dependent apoptosis in response to genotoxic stress...
- The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics dataEthan Cerami
Computational Biology Center, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Cancer Discov 2:401-4. 2012....
- Predicting the functional impact of protein mutations: application to cancer genomicsBoris Reva
Computational Biology Center, Memorial Sloan Kettering Cancer Center, NY 10065, USA
Nucleic Acids Res 39:e118. 2011..In addition, we estimate that at least 5% of cancer-relevant mutations involve switch of function, rather than simply loss or gain of function...