MARILYN RESH

Summary

Affiliation: Memorial Sloan-Kettering Cancer Center
Country: USA

Publications

  1. ncbi request reprint Membrane targeting of lipid modified signal transduction proteins
    Marilyn D Resh
    Member and Professor, Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Subcell Biochem 37:217-32. 2004
  2. pmc Use of analogs and inhibitors to study the functional significance of protein palmitoylation
    Marilyn D Resh
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Ave, Box 143, New York, NY 10021, USA
    Methods 40:191-7. 2006
  3. pmc Rapid plasma membrane anchoring of newly synthesized p59fyn: selective requirement for NH2-terminal myristoylation and palmitoylation at cysteine-3
    W van't Hof
    Cell Biology and Genetics Program, Sloan Kettering Institute for Cancer Research, New York, NY 10021, USA
    J Cell Biol 136:1023-35. 1997
  4. pmc Identification of conserved regions and residues within Hedgehog acyltransferase critical for palmitoylation of Sonic Hedgehog
    John A Buglino
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America
    PLoS ONE 5:e11195. 2010
  5. pmc Covalent lipid modifications of proteins
    Marilyn D Resh
    Memorial Sloan Kettering Cancer Center, Cell Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 143, New York, NY 10065, USA Electronic address
    Curr Biol 23:R431-5. 2013
  6. pmc Targeting protein lipidation in disease
    Marilyn D Resh
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 143, New York, NY 10065, USA
    Trends Mol Med 18:206-14. 2012
  7. pmc Differential control of CXCR4 and CD4 downregulation by HIV-1 Gag
    Rajeshwari R Valiathan
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, USA
    Virol J 5:23. 2008
  8. doi request reprint The ups and downs of SRC regulation: tumor suppression by Cbp
    Marilyn D Resh
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    Cancer Cell 13:469-71. 2008
  9. ncbi request reprint Palmitoylation of ligands, receptors, and intracellular signaling molecules
    Marilyn D Resh
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 143, New York, NY 10021, USA
    Sci STKE 2006:re14. 2006
  10. ncbi request reprint Trafficking and signaling by fatty-acylated and prenylated proteins
    Marilyn D Resh
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Ave, Box 143, New York, New York 10021, USA
    Nat Chem Biol 2:584-90. 2006

Research Grants

Collaborators

  • Jennifer Lanning
  • Yun Lu
  • Mark Lemmon
  • Filippo Giancotti
  • Arevik Mosoian
  • Justin Guy
  • T M Stulnig
  • Xiquan Liang
  • John A Buglino
  • Rajeshwari R Valiathan
  • O Wolf Lindwasser
  • Tia Rai
  • Parag Patwardhan
  • Nathaniel W Martinez
  • Mrudula Donepudi
  • Grant I Miura
  • Mira Perlman
  • Bayard Clarkson
  • David Wisniewski
  • Jelena Vukmirica
  • Francois Van Laethem
  • Thomas A Neubert
  • Laurent Gagnoux-Palacios
  • Xu Chen
  • Geri Kreitzer
  • Xiaoxiao Xue
  • Reem G Berro
  • R Marshall Pope
  • Diego Alvarado
  • Darren Veach
  • Mahbod Hajivandi
  • Jessica E Treisman
  • John Buglino
  • Nicole A Draghi
  • W van't Hof
  • Meredith Wilkes
  • Fabienne Andris
  • Jane Yuan
  • Robert A Hegele
  • Khai Tran
  • Wouter van't Hof
  • Oberdan Leo
  • Zemin Yao
  • Jing Shan
  • Michel Vandenbranden
  • Guerrino Meneguzzi
  • Jacques Urbain
  • Michael Dans
  • Agnese Mariotti
  • Jean Marie Ruysschaert
  • Angela Pepe
  • Brooke A Miskie
  • - Shivakrupa
  • Annabel Strife

Detail Information

Publications34

  1. ncbi request reprint Membrane targeting of lipid modified signal transduction proteins
    Marilyn D Resh
    Member and Professor, Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Subcell Biochem 37:217-32. 2004
    ..Heterogeneity in the types of membrane subdomains, as well as in the types of lipophilic groups that are attached to proteins, provide an additional level of complexity in the regulation of signaling by membrane bound proteins...
  2. pmc Use of analogs and inhibitors to study the functional significance of protein palmitoylation
    Marilyn D Resh
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Ave, Box 143, New York, NY 10021, USA
    Methods 40:191-7. 2006
    ..Finally, general approaches to determining the effect of altered palmitoylation status on YFPP association with membranes and lipid rafts, as well as signal transduction, are described...
  3. pmc Rapid plasma membrane anchoring of newly synthesized p59fyn: selective requirement for NH2-terminal myristoylation and palmitoylation at cysteine-3
    W van't Hof
    Cell Biology and Genetics Program, Sloan Kettering Institute for Cancer Research, New York, NY 10021, USA
    J Cell Biol 136:1023-35. 1997
    ..These results serve to define a novel trafficking pathway for Src family proteins that are regulated by dual fatty acylation...
  4. pmc Identification of conserved regions and residues within Hedgehog acyltransferase critical for palmitoylation of Sonic Hedgehog
    John A Buglino
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America
    PLoS ONE 5:e11195. 2010
    ..Except for mutagenesis of two conserved residues, there has been no structure-function analysis of Hhat, and the regions of the protein required for Shh palmitoylation are unknown...
  5. pmc Covalent lipid modifications of proteins
    Marilyn D Resh
    Memorial Sloan Kettering Cancer Center, Cell Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 143, New York, NY 10065, USA Electronic address
    Curr Biol 23:R431-5. 2013
    ..Here, I provide an overview of the structural and functional consequences for proteins containing each type of lipid modification (depicted in Figure 1)...
  6. pmc Targeting protein lipidation in disease
    Marilyn D Resh
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 143, New York, NY 10065, USA
    Trends Mol Med 18:206-14. 2012
    ..Agents that alter the palmitoylation status of Ras, Wnt and Hh proteins have recently been discovered, and represent the next generation of potential chemotherapeutics...
  7. pmc Differential control of CXCR4 and CD4 downregulation by HIV-1 Gag
    Rajeshwari R Valiathan
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, USA
    Virol J 5:23. 2008
    ..Viral recruitment of ESCRT proteins could therefore impact on host cell processes such as receptor downregulation...
  8. doi request reprint The ups and downs of SRC regulation: tumor suppression by Cbp
    Marilyn D Resh
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    Cancer Cell 13:469-71. 2008
    ..However, the authors show that Cbp-mediated Src suppression is Csk independent. These findings suggest that Cbp is a tumor suppressor whose expression is downregulated during Src-driven cancer progression...
  9. ncbi request reprint Palmitoylation of ligands, receptors, and intracellular signaling molecules
    Marilyn D Resh
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 143, New York, NY 10021, USA
    Sci STKE 2006:re14. 2006
    ..The identification of the palmitoyl acyltransferases has provided new insights into the biochemistry of this posttranslational process and permitted new substrates to be identified...
  10. ncbi request reprint Trafficking and signaling by fatty-acylated and prenylated proteins
    Marilyn D Resh
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Ave, Box 143, New York, New York 10021, USA
    Nat Chem Biol 2:584-90. 2006
    ..These findings provide new insights into the biochemical and biophysical mechanisms that regulate membrane targeting, trafficking and signaling by lipid-modified proteins...
  11. ncbi request reprint Intracellular trafficking of HIV-1 Gag: how Gag interacts with cell membranes and makes viral particles
    Marilyn D Resh
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    AIDS Rev 7:84-91. 2005
    ..Given that MVB exocytosis is an essential host-cell pathway, effective antiviral agents will need to specifically target interaction of Gag with the endocytic pathway without perturbing the normal host-cell trafficking network...
  12. pmc A myristoyl switch regulates membrane binding of HIV-1 Gag
    Marilyn D Resh
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 143, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 101:417-8. 2004
  13. ncbi request reprint Regulation of cellular signalling by fatty acid acylation and prenylation of signal transduction proteins
    M D Resh
    Cell Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Cell Signal 8:403-12. 1996
    ..The biochemistry and cell biology of protein myristoylation, farnesylation and geranylgeranylation is reviewed here, with emphasis on the Src family of tyrosine kinases, Ras proteins and G protein coupled signalling systems...
  14. ncbi request reprint Fyn, a Src family tyrosine kinase
    M D Resh
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Int J Biochem Cell Biol 30:1159-62. 1998
    ..Alteration of the levels of Fyn in appropriate target tissues may lead to better treatments for alcoholism and autoimmune disease...
  15. ncbi request reprint Fatty acylation of proteins: new insights into membrane targeting of myristoylated and palmitoylated proteins
    M D Resh
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 143, New York, NY 10021, USA
    Biochim Biophys Acta 1451:1-16. 1999
    ..The use of myristoyl switches and regulated depalmitoylation as mechanisms for achieving reversible membrane binding and regulated signaling will also be explored...
  16. pmc Myristoylation as a target for inhibiting HIV assembly: unsaturated fatty acids block viral budding
    O Wolf Lindwasser
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 143, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 99:13037-42. 2002
    ..These studies suggest a strategy to attack HIV assembly by selectively altering the patterns of fatty acid modification...
  17. ncbi request reprint Cholesterol depletion from the plasma membrane triggers ligand-independent activation of the epidermal growth factor receptor
    Xu Chen
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    J Biol Chem 277:49631-7. 2002
    ..Moreover, these studies reveal a novel mode of action of MbetaCD, in addition to its ability to disrupt membrane rafts...
  18. ncbi request reprint Palmitoylation of the EGFR ligand Spitz by Rasp increases Spitz activity by restricting its diffusion
    Grant I Miura
    Department of Cell Biology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Dev Cell 10:167-76. 2006
    ..These data suggest a role for palmitoylation in restricting Spitz diffusion, allowing its local concentration to reach the threshold required for biological function...
  19. ncbi request reprint The N-terminal SH4 region of the Src family kinase Fyn is modified by methylation and heterogeneous fatty acylation: role in membrane targeting, cell adhesion, and spreading
    Xiquan Liang
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021
    J Biol Chem 279:8133-9. 2004
    ..Lysine mutants of Fyn that could not be methylated failed to promote cell adhesion and spreading, suggesting that methylation is important for Fyn function...
  20. pmc Expression of human immunodeficiency virus type 1 gag modulates ligand-induced downregulation of EGF receptor
    Rajeshwari R Valiathan
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 143, New York, NY 10021, USA
    J Virol 78:12386-94. 2004
    ..These results indicate that HIV-1 Gag can impinge upon the functioning of the cellular vacuolar protein sorting pathway and reveal yet another facet of the intricate effects of HIV-1 infection on host cell physiology...
  21. ncbi request reprint Mass spectrometric analysis of GAP-43/neuromodulin reveals the presence of a variety of fatty acylated species
    Xiquan Liang
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Biol Chem 277:33032-40. 2002
    ..These data reveal the heterogeneous nature of S-acylation in vivo and illustrate the power of mass spectrometry for identification of key regulatory protein modifications...
  22. pmc Myristoylation and membrane binding regulate c-Src stability and kinase activity
    Parag Patwardhan
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Mol Cell Biol 30:4094-107. 2010
    ..All of the pocket mutants exhibited decreased kinase activity. We concluded that myristoylation and the pocket residues regulate c-Src, but in a manner very different from that for c-Abl...
  23. pmc Human immunodeficiency virus type 1 Gag contains a dileucine-like motif that regulates association with multivesicular bodies
    O Wolf Lindwasser
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Ave, Box 143, New York, NY 10021, USA
    J Virol 78:6013-23. 2004
    ..We propose that HIV-1 Gag contains a signal that promotes interaction with the cellular endocytic machinery and that the site of particle production is regulated by the subcellular distribution of cholesterol...
  24. ncbi request reprint Phosphatidylinositol 3-kinase and Src family kinases are required for phosphorylation and membrane recruitment of Dok-1 in c-Kit signaling
    Xiquan Liang
    Cell Biology Program and the Molecular Pharmacology and Therapeutics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Biol Chem 277:13732-8. 2002
    ..Taken together, these data indicate that activation of PI 3-kinase by KL promotes binding of the Dok pleckstrin homology domain and Dok-1 recruitment to the plasma membrane where Dok-1 is phosphorylated by Src and/or Tec family kinases...
  25. pmc Annexin 2 is not required for human immunodeficiency virus type 1 particle production but plays a cell type-dependent role in regulating infectivity
    Tia Rai
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 143, New York, NY 10065, USA
    J Virol 84:9783-92. 2010
    ..These data indicate that Anx2 is not required for HIV-1 assembly or Gag processing but rather plays a cell type-dependent role in regulating production of infectious HIV-1 by macrophages...
  26. pmc Compartmentalization of integrin alpha6beta4 signaling in lipid rafts
    Laurent Gagnoux-Palacios
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Cell Biol 162:1189-96. 2003
    ..Thus, compartmentalization in lipid rafts is necessary to couple the alpha6beta4 integrin to a palmitoylated SFK and promote EGF-dependent mitogenesis...
  27. pmc Kinesin KIF4 regulates intracellular trafficking and stability of the human immunodeficiency virus type 1 Gag polyprotein
    Nathaniel W Martinez
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 143, New York, NY 10065, USA
    J Virol 82:9937-50. 2008
    ..These studies identify a novel transit station through which Gag traffics en route to particle assembly and highlight the importance of KIF4 in regulating HIV-1 Gag trafficking and stability...
  28. pmc c-Src trafficking and co-localization with the EGF receptor promotes EGF ligand-independent EGF receptor activation and signaling
    Mrudula Donepudi
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, United States
    Cell Signal 20:1359-67. 2008
    ..These data suggest that the synergy between c-Src and EGFR also occurs as these two kinases traffic together, and that their co-localization promotes EGFR-mediated signaling...
  29. ncbi request reprint Identification of an intracellular trafficking and assembly pathway for HIV-1 gag
    Mira Perlman
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Traffic 7:731-45. 2006
    ..We propose that the regulation of Gag association with MVB-like compartments regulates the site of HIV-1 budding and particle formation...
  30. pmc Hhat is a palmitoylacyltransferase with specificity for N-palmitoylation of Sonic Hedgehog
    John A Buglino
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    J Biol Chem 283:22076-88. 2008
    ..This study establishes Hhat as a bona fide Shh PAT and serves as a model for understanding how secreted morphogens are modified by distinct PATs...
  31. ncbi request reprint Signaling from integrins to Fyn to Rho family GTPases regulates morphologic differentiation of oligodendrocytes
    Xiquan Liang
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, Weill Graduate School of Medical Sciences of Cornell University, New York, New York 10021, USA
    J Neurosci 24:7140-9. 2004
    ..Taken together, these results suggest a linear signal transduction pathway of integrin-Fyn-Rho family GTPases that controls morphologic differentiation of oligodendrocytes...
  32. ncbi request reprint Assembly and secretion of very low density lipoproteins containing apolipoprotein B48 in transfected McA-RH7777 cells. Lack of evidence that palmitoylation of apolipoprotein B48 is required for lipoprotein secretion
    Jelena Vukmirica
    Lipoprotein and Atherosclerosis Group, University of Ottawa Heart Institute, Canada K1Y 4W7
    J Biol Chem 278:14153-61. 2003
    ..These results suggest that lack of palmitoylation may influence the partitioning of apoB48 between microsomal membranes and microsomal lumen, but it does not compromise the ability of apoB48 to assemble lipoproteins...
  33. ncbi request reprint Glucocorticoids alter the lipid and protein composition of membrane rafts of a murine T cell hybridoma
    Francois Van Laethem
    Laboratoire de Physiologie Animale, Institut de Biologie et de M├ędecine Mol├ęculaires, Universite Libre de Bruxelles, Gosselies, Belgium
    J Immunol 170:2932-9. 2003
    ....
  34. ncbi request reprint Quantification of change in phosphorylation of BCR-ABL kinase and its substrates in response to Imatinib treatment in human chronic myelogenous leukemia cells
    Xiquan Liang
    Proteomics, R and D Department, Invitrogen Life Science, Carlsbad, CA 92008, USA
    Proteomics 6:4554-64. 2006
    ..These results demonstrate the simplicity and utility of SILAC as a method to quantify dynamic changes in phosphorylation at specific sites in response to stimuli or drug treatment in cell culture...

Research Grants34

  1. MEMBRANE TARGETING OF FATTY ACYLATED PROTOONCOPROTEINS
    MARILYN RESH; Fiscal Year: 2001
    ..We will test the abilities of wt, dominant negative and fatty acylation mutants of Fyn to promote the oligodendrocyte differentiation process. ..
  2. STRUCTURE AND FUNCTION OF HIV GAG PROTEIN
    MARILYN RESH; Fiscal Year: 2003
    ..These experiments will complement the biochemical studies in Aims 1 and 2 and are likely to provide a fascinating view of Gag movement and dynamics in live cells. ..
  3. Glial cell differentiation and glioma formation
    MARILYN RESH; Fiscal Year: 2005
    ..The activity of the above proteins in human glioma tumor samples will be determined. ..
  4. Glial cell differentiation and glioma formation
    MARILYN RESH; Fiscal Year: 2006
    ..The activity of the above proteins in human glioma tumor samples will be determined. ..
  5. STRUCTURE AND FUNCTION OF HIV GAG PROTEIN
    MARILYN RESH; Fiscal Year: 2006
    ..Multicolor imaging with site-specific fluorescein derivatives (FLASH and ReAsH) will be used to determine the order in which Gag assembly sites are formed and maintained in the cell. ..
  6. STRUCTURE AND FUNCTION OF HIV GAG PROTEIN
    MARILYN RESH; Fiscal Year: 2005
    ..Multicolor imaging with site-specific fluorescein derivatives (FLASH and ReAsH) will be used to determine the order in which Gag assembly sites are formed and maintained in the cell. ..
  7. STRUCTURE AND FUNCTION OF HIV GAG PROTEIN
    MARILYN RESH; Fiscal Year: 2007
    ..Multicolor imaging with site-specific fluorescein derivatives (FLASH and ReAsH) will be used to determine the order in which Gag assembly sites are formed and maintained in the cell. ..
  8. Membrane targeting of fatty acylated proto-oncoproteins
    MARILYN RESH; Fiscal Year: 2003
    ..We will test whether SFKs interact with components of the endocytic machinery en route to the plasma membrane. ..
  9. Glial cell differentiation and glioma formation
    MARILYN RESH; Fiscal Year: 2004
    ..The activity of the above proteins in human glioma tumor samples will be determined. ..
  10. Membrane targeting of fatty acylated proto-oncoproteins
    MARILYN RESH; Fiscal Year: 2004
    ..We will test whether SFKs interact with components of the endocytic machinery en route to the plasma membrane. ..
  11. Glial cell differentiation and glioma formation
    MARILYN RESH; Fiscal Year: 2003
    ..The activity of the above proteins in human glioma tumor samples will be determined. ..
  12. Membrane targeting of fatty acylated proto-oncoproteins
    MARILYN RESH; Fiscal Year: 2002
    ..We will test whether SFKs interact with components of the endocytic machinery en route to the plasma membrane. ..
  13. Palmitoylation of Hedgehog Proteins
    MARILYN RESH; Fiscal Year: 2009
    ..The proposed studies will help us understand how Hh proteins work in normal and malignant cells and will aim to develop Hh inhibitors that could potentially be clinically useful as anti-tumor agents in Hh driven malignancies. ..
  14. STRUCTURE AND FUNCTION OF HIV GAG PROTEIN
    MARILYN RESH; Fiscal Year: 2009
    ..Multicolor imaging with site-specific fluorescein derivatives (FLASH and ReAsH) will be used to determine the order in which Gag assembly sites are formed and maintained in the cell. ..
  15. MEMBRANE TARGETING OF FATTY ACYLATED PROTOONCOPROTEINS
    MARILYN RESH; Fiscal Year: 2000
    ..We will test the abilities of wt, dominant negative and fatty acylation mutants of Fyn to promote the oligodendrocyte differentiation process. ..
  16. TRAINING PROGRAM IN MOLECULAR AND CELLULAR BIOLOGY
    MARILYN RESH; Fiscal Year: 2007
    ..We are therefore requesting continuation of this grant, with a level of funding to support a total of 8 first and second year graduate students. ..
  17. Palmitoylation of Hedgehog Proteins
    Marilyn D Resh; Fiscal Year: 2010
    ..The proposed studies will help us understand how Hh proteins work in normal and malignant cells and will aim to develop Hh inhibitors that could potentially be clinically useful as anti-tumor agents in Hh driven malignancies. ..
  18. Palmitoylation of Hedgehog Proteins
    MARILYN RESH; Fiscal Year: 2009
    ..abstract_text> ..
  19. STRUCTURE AND FUNCTION OF HIV GAG PROTEIN
    MARILYN RESH; Fiscal Year: 2007
    ..Multicolor imaging with site-specific fluorescein derivatives (FLASH and ReAsH) will be used to determine the order in which Gag assembly sites are formed and maintained in the cell. ..
  20. MEMBRANE TARGETING OF FATTY ACYLATED PROTOONCOPROTEINS
    MARILYN RESH; Fiscal Year: 1999
    ..We will test the abilities of wt, dominant negative and fatty acylation mutants of Fyn to promote the oligodendrocyte differentiation process. ..
  21. STRUCTURE AND FUNCTION OF HIV GAG PROTEIN
    MARILYN RESH; Fiscal Year: 2000
    ..These experiments will complement the biochemical studies in Aims 1 and 2 and are likely to provide a fascinating view of Gag movement and dynamics in live cells. ..
  22. STRUCTURE AND FUNCTION OF HIV GAG PROTEIN
    MARILYN RESH; Fiscal Year: 2001
    ..These experiments will complement the biochemical studies in Aims 1 and 2 and are likely to provide a fascinating view of Gag movement and dynamics in live cells. ..
  23. STRUCTURE AND FUNCTION OF HIV GAG PROTEIN
    MARILYN RESH; Fiscal Year: 2002
    ..These experiments will complement the biochemical studies in Aims 1 and 2 and are likely to provide a fascinating view of Gag movement and dynamics in live cells. ..
  24. Glial cell differentiation and glioma formation
    MARILYN RESH; Fiscal Year: 2002
    ..The activity of the above proteins in human glioma tumor samples will be determined. ..
  25. Membrane targeting of fatty acylated proto-oncoproteins
    MARILYN RESH; Fiscal Year: 2005
    ..We will test whether SFKs interact with components of the endocytic machinery en route to the plasma membrane. ..
  26. STRUCTURE AND FUNCTION OF HIV GAG PROTEIN
    MARILYN RESH; Fiscal Year: 2006
    ..Multicolor imaging with site-specific fluorescein derivatives (FLASH and ReAsH) will be used to determine the order in which Gag assembly sites are formed and maintained in the cell. ..
  27. Palmitoylation of Hedgehog Proteins
    Marilyn D Resh; Fiscal Year: 2010
    ..abstract_text> ..